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Volumn 36, Issue 17, 2016, Pages 4859-4875

Behavioral, neurophysiological, and synaptic impairment in a transgenic neuregulin1 (NRG1-IV) murine schizophrenia model

Author keywords

AKT; ErbB; IC87114; Neuregulin; PIK3CD; Schizophrenia

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 4; NEU DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; EPIDERMAL GROWTH FACTOR RECEPTOR; NEUROLEPTIC AGENT; NRG1 PROTEIN, HUMAN;

EID: 84966686834     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4632-15.2016     Document Type: Article
Times cited : (47)

References (98)
  • 3
    • 84871864286 scopus 로고    scopus 로고
    • Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia
    • CrossRef Medline
    • Agim ZS, Esendal M, Briollais L, Uyan O, Meschian M, Martinez LA, Ding Y, Basak AN, Ozcelik H (2013) Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. PloS One 8: e53042. CrossRef Medline
    • (2013) PloS One , vol.8
    • Agim, Z.S.1    Esendal, M.2    Briollais, L.3    Uyan, O.4    Meschian, M.5    Martinez, L.A.6    Ding, Y.7    Basak, A.N.8    Ozcelik, H.9
  • 4
    • 33645280056 scopus 로고    scopus 로고
    • Meeting of minds: The medial frontal cortex and social cognition
    • CrossRef Medline
    • Amodio DM, Frith CD (2006) Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci 7: 268-277. CrossRef Medline
    • (2006) Nat Rev Neurosci , vol.7 , pp. 268-277
    • Amodio, D.M.1    Frith, C.D.2
  • 5
    • 0036258079 scopus 로고    scopus 로고
    • Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia
    • CrossRef Medline
    • Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7: 405-411. CrossRef Medline
    • (2002) Mol Psychiatry , vol.7 , pp. 405-411
    • Badner, J.A.1    Gershon, E.S.2
  • 6
    • 79960678522 scopus 로고    scopus 로고
    • When is the hippocampus involved in recognition memory?
    • CrossRef Medline
    • Barker GR, Warburton EC (2011) When is the hippocampus involved in recognition memory? J Neurosci 31: 10721-10731. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 10721-10731
    • Barker, G.R.1    Warburton, E.C.2
  • 7
    • 33947302270 scopus 로고    scopus 로고
    • Recognition memory for objects, place, and temporal order: A disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex
    • CrossRef Medline
    • Barker GR, Bird F, Alexander V, Warburton EC (2007) Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. J Neurosci 27: 2948-2957. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 2948-2957
    • Barker, G.R.1    Bird, F.2    Alexander, V.3    Warburton, E.C.4
  • 8
    • 63149158010 scopus 로고    scopus 로고
    • Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system
    • CrossRef Medline
    • Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Müller U (2009) Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106: 4507-4512. CrossRef Medline
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4507-4512
    • Barros, C.S.1    Calabrese, B.2    Chamero, P.3    Roberts, A.J.4    Korzus, E.5    Lloyd, K.6    Stowers, L.7    Mayford, M.8    Halpain, S.9    Müller, U.10
  • 9
    • 0033860986 scopus 로고    scopus 로고
    • A network of electrically coupled interneurons drives synchronized inhibition in neocortex
    • CrossRef Medline
    • Beierlein M, Gibson JR, Connors BW (2000) A network of electrically coupled interneurons drives synchronized inhibition in neocortex. Nat Neurosci 3: 904-910. CrossRef Medline
    • (2000) Nat Neurosci , vol.3 , pp. 904-910
    • Beierlein, M.1    Gibson, J.R.2    Connors, B.W.3
  • 10
    • 0242371634 scopus 로고    scopus 로고
    • Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    • CrossRef Medline
    • Beierlein M, Gibson JR, Connors BW (2003) Two dynamically distinct inhibitory networks in layer 4 of the neocortex. J Neurophysiol 90: 2987-3000. CrossRef Medline
    • (2003) J Neurophysiol , vol.90 , pp. 2987-3000
    • Beierlein, M.1    Gibson, J.R.2    Connors, B.W.3
  • 12
    • 0025190458 scopus 로고
    • Sensorimotor gating and schizophrenia: Human and animal model studies
    • CrossRef Medline
    • Braff DL, GeyerMA (1990) Sensorimotor gating and schizophrenia: human and animal model studies. Arch Gen Psychiatry 47: 181-188. CrossRef Medline
    • (1990) Arch Gen Psychiatry , vol.47 , pp. 181-188
    • Braff, D.L.1    Geyer, M.A.2
  • 13
    • 0035870801 scopus 로고    scopus 로고
    • Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    • CrossRef Medline
    • Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS, Swerdlow NR (2001) Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res 49: 171-178. CrossRef Medline
    • (2001) Schizophr Res , vol.49 , pp. 171-178
    • Braff, D.L.1    Geyer, M.A.2    Light, G.A.3    Sprock, J.4    Perry, W.5    Cadenhead, K.S.6    Swerdlow, N.R.7
  • 17
    • 10744230431 scopus 로고    scopus 로고
    • Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs. 97362, as a potential susceptibility gene at the Neuregulin-1 locus
    • CrossRef Medline
    • Corvin AP, Morris DW, McGhee K, Schwaiger S, Scully P, Quinn J, Meagher D, Clair DS, Waddington JL, Gill M (2004) Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs. 97362, as a potential susceptibility gene at the Neuregulin-1 locus. Mol Psychiatry 9: 208-213. CrossRef Medline
    • (2004) Mol Psychiatry , vol.9 , pp. 208-213
    • Corvin, A.P.1    Morris, D.W.2    McGhee, K.3    Schwaiger, S.4    Scully, P.5    Quinn, J.6    Meagher, D.7    Clair, D.S.8    Waddington, J.L.9    Gill, M.10
  • 22
    • 0034481144 scopus 로고    scopus 로고
    • Cognitive impairment in schizophrenia is the core of the disorder
    • Medline
    • Elvevåg B, Goldberg TE (2000) Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 14: 1-21. Medline
    • (2000) Crit Rev Neurobiol , vol.14 , pp. 1-21
    • Elvevåg, B.1    Goldberg, T.E.2
  • 24
    • 0033985644 scopus 로고    scopus 로고
    • Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia
    • CrossRef Medline
    • Glantz LA, Lewis DA (2000) Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 57: 65-73. CrossRef Medline
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 65-73
    • Glantz, L.A.1    Lewis, D.A.2
  • 25
    • 81255123215 scopus 로고    scopus 로고
    • GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia
    • CrossRef Medline
    • Gonzalez-Burgos G, Fish KN, Lewis DA (2011) GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. Neural Plast 2011: 723184. CrossRef Medline
    • (2011) Neural Plast , vol.2011
    • Gonzalez-Burgos, G.1    Fish, K.N.2    Lewis, D.A.3
  • 29
    • 33745684066 scopus 로고    scopus 로고
    • Neuregulin 1 and schizophrenia: Genetics, gene expression, and neurobiology
    • CrossRef Medline
    • Harrison PJ, Law AJ (2006) Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60: 132-140. CrossRef Medline
    • (2006) Biol Psychiatry , vol.60 , pp. 132-140
    • Harrison, P.J.1    Law, A.J.2
  • 30
    • 80055065460 scopus 로고    scopus 로고
    • LTS and FS inhibitory interneurons, short-term synaptic plasticity, and cortical circuit dynamics
    • CrossRef Medline
    • Hayut I, Fanselow EE, Connors BW, Golomb D (2011) LTS and FS inhibitory interneurons, short-term synaptic plasticity, and cortical circuit dynamics. PLoS Comput Biol 7: e1002248. CrossRef Medline
    • (2011) PLoS Comput Biol , vol.7
    • Hayut, I.1    Fanselow, E.E.2    Connors, B.W.3    Golomb, D.4
  • 32
    • 84900324712 scopus 로고    scopus 로고
    • Schizophrenia: An integrated sociodevelopmental-cognitive model
    • CrossRef Medline
    • Howes OD, Murray RM (2014) Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet 383: 1677-1687. CrossRef Medline
    • (2014) Lancet , vol.383 , pp. 1677-1687
    • Howes, O.D.1    Murray, R.M.2
  • 33
  • 34
    • 79951811861 scopus 로고    scopus 로고
    • Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: Implication in neurodevelopmental hypothesis for schizophrenia
    • CrossRef Medline
    • Kato T, Abe Y, Sotoyama H, Kakita A, Kominami R, Hirokawa S, Ozaki M, Takahashi H, Nawa H (2011) Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia. Mol Psychiatry 16: 307-320. CrossRef Medline
    • (2011) Mol Psychiatry , vol.16 , pp. 307-320
    • Kato, T.1    Abe, Y.2    Sotoyama, H.3    Kakita, A.4    Kominami, R.5    Hirokawa, S.6    Ozaki, M.7    Takahashi, H.8    Nawa, H.9
  • 35
    • 0028922024 scopus 로고
    • Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex
    • Medline
    • Kawaguchi Y (1995) Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex. J Neurosci 15: 2638-2655. Medline
    • (1995) J Neurosci , vol.15 , pp. 2638-2655
    • Kawaguchi, Y.1
  • 36
    • 0030796369 scopus 로고    scopus 로고
    • Selective cholinergic modulation of cortical GABAergic cell subtypes
    • Medline
    • Kawaguchi Y (1997) Selective cholinergic modulation of cortical GABAergic cell subtypes. J Neurophysiol 78: 1743-1747. Medline
    • (1997) J Neurophysiol , vol.78 , pp. 1743-1747
    • Kawaguchi, Y.1
  • 37
    • 58549098047 scopus 로고    scopus 로고
    • Effects of a neuregulin 1 variant on conversion to schizophrenia and schizophreniform disorder in people at high risk for psychosis
    • CrossRef Medline
    • Kéri S, Kiss I, Kelemen O (2009) Effects of a neuregulin 1 variant on conversion to schizophrenia and schizophreniform disorder in people at high risk for psychosis. Mol Psychiatry 14: 118-119. CrossRef Medline
    • (2009) Mol Psychiatry , vol.14 , pp. 118-119
    • Kéri, S.1    Kiss, I.2    Kelemen, O.3
  • 40
    • 33644876567 scopus 로고    scopus 로고
    • Reduced prepulse inhibition in unaffected siblings of schizophrenia patients
    • CrossRef Medline
    • Kumari V, Das M, Zachariah E, Ettinger U, Sharma T (2005) Reduced prepulse inhibition in unaffected siblings of schizophrenia patients. Psychophysiology 42: 588-594. CrossRef Medline
    • (2005) Psychophysiology , vol.42 , pp. 588-594
    • Kumari, V.1    Das, M.2    Zachariah, E.3    Ettinger, U.4    Sharma, T.5
  • 41
    • 26844565095 scopus 로고    scopus 로고
    • Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses
    • CrossRef Medline
    • Kwon OB, Longart M, Vullhorst D, Hoffman DA, Buonanno A (2005) Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses. J Neurosci 25: 9378-9383. CrossRef Medline
    • (2005) J Neurosci , vol.25 , pp. 9378-9383
    • Kwon, O.B.1    Longart, M.2    Vullhorst, D.3    Hoffman, D.A.4    Buonanno, A.5
  • 42
    • 84903183226 scopus 로고    scopus 로고
    • Genetic mouse models of neuregulin 1: Gene dosage effects, isoform-specific functions, and relevance to schizophrenia
    • CrossRef Medline
    • Law AJ (2014) Genetic mouse models of neuregulin 1: gene dosage effects, isoform-specific functions, and relevance to schizophrenia. Biol Psychiatry 76: 89-90. CrossRef Medline
    • (2014) Biol Psychiatry , vol.76 , pp. 89-90
    • Law, A.J.1
  • 44
    • 33846589304 scopus 로고    scopus 로고
    • Diseaseassociated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
    • Medline
    • Law AJ, Kleinman JE, Weinberger DR, Weickert CS (2007) Diseaseassociated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet 16: 129-141. Medline
    • (2007) Hum Mol Genet , vol.16 , pp. 129-141
    • Law, A.J.1    Kleinman, J.E.2    Weinberger, D.R.3    Weickert, C.S.4
  • 46
    • 2342434512 scopus 로고    scopus 로고
    • Social cognition, brain networks and schizophrenia
    • CrossRef Medline
    • Lee KH, Farrow TF, Spence SA, Woodruff PW (2004) Social cognition, brain networks and schizophrenia. Psychol Med 34: 391-400. CrossRef Medline
    • (2004) Psychol Med , vol.34 , pp. 391-400
    • Lee, K.H.1    Farrow, T.F.2    Spence, S.A.3    Woodruff, P.W.4
  • 47
    • 0036127407 scopus 로고    scopus 로고
    • Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death
    • CrossRef Medline
    • Lesuisse C, Martin LJ (2002) Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death. J Neurobiol 51: 9-23. CrossRef Medline
    • (2002) J Neurobiol , vol.51 , pp. 9-23
    • Lesuisse, C.1    Martin, L.J.2
  • 48
    • 0031727755 scopus 로고    scopus 로고
    • Axonal arborization of corticostriatal and corticothalamic fibers arising from prelimbic cortex in the rat
    • CrossRef Medline
    • Lévesque M, Parent A (1998) Axonal arborization of corticostriatal and corticothalamic fibers arising from prelimbic cortex in the rat. Cereb Cortex 8: 602-613. CrossRef Medline
    • (1998) Cereb Cortex , vol.8 , pp. 602-613
    • Lévesque, M.1    Parent, A.2
  • 49
    • 34248531426 scopus 로고    scopus 로고
    • The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity
    • CrossRef Medline
    • Li B, Woo RS, Mei L, Malinow R (2007) The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54: 583-597. CrossRef Medline
    • (2007) Neuron , vol.54 , pp. 583-597
    • Li, B.1    Woo, R.S.2    Mei, L.3    Malinow, R.4
  • 50
    • 84903128926 scopus 로고    scopus 로고
    • Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice
    • CrossRef Medline
    • Luo X, He W, Hu X, Yan R (2014) Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice. Biol Psychiatry 76: 120-127. CrossRef Medline
    • (2014) Biol Psychiatry , vol.76 , pp. 120-127
    • Luo, X.1    He, W.2    Hu, X.3    Yan, R.4
  • 54
    • 84878261678 scopus 로고    scopus 로고
    • The contextual brain: Implications for fear conditioning, extinction and psychopathology
    • CrossRef Medline
    • Maren S, Phan KL, Liberzon I (2013) The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14: 417-428. CrossRef Medline
    • (2013) Nat Rev Neurosci , vol.14 , pp. 417-428
    • Maren, S.1    Phan, K.L.2    Liberzon, I.3
  • 56
    • 84903650231 scopus 로고    scopus 로고
    • Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
    • CrossRef Medline
    • Mei L, Nave KA (2014) Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron 83: 27-49. CrossRef Medline
    • (2014) Neuron , vol.83 , pp. 27-49
    • Mei, L.1    Nave, K.A.2
  • 59
    • 84888835568 scopus 로고    scopus 로고
    • Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models
    • CrossRef Medline
    • Moore H, Geyer MA, Carter CS, Barch DM (2013) Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models. Neurosci Biobehav Rev 37: 2087-2091. CrossRef Medline
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 2087-2091
    • Moore, H.1    Geyer, M.A.2    Carter, C.S.3    Barch, D.M.4
  • 60
    • 4644373224 scopus 로고    scopus 로고
    • Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice
    • CrossRef Medline
    • Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, Piven J, Crawley JN (2004) Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav 3: 287-302. CrossRef Medline
    • (2004) Genes Brain Behav , vol.3 , pp. 287-302
    • Moy, S.S.1    Nadler, J.J.2    Perez, A.3    Barbaro, R.P.4    Johns, J.M.5    Magnuson, T.R.6    Piven, J.7    Crawley, J.N.8
  • 61
    • 0036138908 scopus 로고    scopus 로고
    • A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
    • CrossRef Medline
    • Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, Miyawaki A (2002) A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 20: 87-90. CrossRef Medline
    • (2002) Nat Biotechnol , vol.20 , pp. 87-90
    • Nagai, T.1    Ibata, K.2    Park, E.S.3    Kubota, M.4    Mikoshiba, K.5    Miyawaki, A.6
  • 62
    • 84923077204 scopus 로고    scopus 로고
    • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
    • CrossRef Medline
    • Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium (2015) Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 18: 199-209. CrossRef Medline
    • (2015) Nat Neurosci , vol.18 , pp. 199-209
  • 63
    • 33845268661 scopus 로고    scopus 로고
    • Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls
    • CrossRef Medline
    • Nicodemus KK, Luna A, Vakkalanka R, Goldberg T, Egan M, Straub RE, Weinberger DR (2006) Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls. Mol Psychiatry 11: 1062-1065. CrossRef Medline
    • (2006) Mol Psychiatry , vol.11 , pp. 1062-1065
    • Nicodemus, K.K.1    Luna, A.2    Vakkalanka, R.3    Goldberg, T.4    Egan, M.5    Straub, R.E.6    Weinberger, D.R.7
  • 64
    • 67651156220 scopus 로고    scopus 로고
    • A 5ʹ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression
    • CrossRef Medline
    • Nicodemus KK, Law AJ, Luna A, Vakkalanka R, Straub RE, Kleinman JE, WeinbergerDR (2009) A 5ʹ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression. Mol Psychiatry 14: 741-743. CrossRef Medline
    • (2009) Mol Psychiatry , vol.14 , pp. 741-743
    • Nicodemus, K.K.1    Law, A.J.2    Luna, A.3    Vakkalanka, R.4    Straub, R.E.5    Kleinman, J.E.6    Weinberger, D.R.7
  • 65
    • 0028054345 scopus 로고
    • Phencyclidine-and dizocilpine-induced hyperlocomotion are differentially mediated
    • CrossRef Medline
    • Ogren SO, GoldsteinM (1994) Phencyclidine-and dizocilpine-induced hyperlocomotion are differentially mediated. Neuropsychopharmacology 11: 167-177. CrossRef Medline
    • (1994) Neuropsychopharmacology , vol.11 , pp. 167-177
    • Ogren, S.O.1    Goldstein, M.2
  • 66
    • 0032784823 scopus 로고    scopus 로고
    • Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D1 agonist C-APB in mice
    • CrossRef Medline
    • O'Neill MF, Shaw G (1999) Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D1 agonist C-APB in mice. Psychopharmacology (Berl) 145: 237-250. CrossRef Medline
    • (1999) Psychopharmacology (Berl) , vol.145 , pp. 237-250
    • O'Neill, M.F.1    Shaw, G.2
  • 67
    • 52049116298 scopus 로고    scopus 로고
    • Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
    • CrossRef Medline
    • Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger DR, Chen J (2008) Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. J Neurosci 28: 8709-8723. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 8709-8723
    • Papaleo, F.1    Crawley, J.N.2    Song, J.3    Lipska, B.K.4    Pickel, J.5    Weinberger, D.R.6    Chen, J.7
  • 68
    • 79960724861 scopus 로고    scopus 로고
    • Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice
    • CrossRef Medline
    • Papaleo F, Silverman JL, Aney J, Tian Q, Barkan CL, Chadman KK, Crawley JN (2011) Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice. Learn Mem 18: 534-544. CrossRef Medline
    • (2011) Learn Mem , vol.18 , pp. 534-544
    • Papaleo, F.1    Silverman, J.L.2    Aney, J.3    Tian, Q.4    Barkan, C.L.5    Chadman, K.K.6    Crawley, J.N.7
  • 69
    • 84855340012 scopus 로고    scopus 로고
    • Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways
    • CrossRef Medline
    • Papaleo F, Yang F, Garcia S, Chen J, Lu B, Crawley JN, Weinberger DR (2012) Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways. Mol Psychiatry 17: 85-98. CrossRef Medline
    • (2012) Mol Psychiatry , vol.17 , pp. 85-98
    • Papaleo, F.1    Yang, F.2    Garcia, S.3    Chen, J.4    Lu, B.5    Crawley, J.N.6    Weinberger, D.R.7
  • 70
    • 84905662220 scopus 로고    scopus 로고
    • Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood
    • CrossRef Medline
    • Paterson C, Law AJ (2014) Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood. PLoS One 9: e104172. CrossRef Medline
    • (2014) PLoS One , vol.9
    • Paterson, C.1    Law, A.J.2
  • 71
    • 84921665900 scopus 로고    scopus 로고
    • Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development
    • CrossRef Medline
    • Paterson C, Wang Y, Kleinman JE, Law AJ (2014) Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry 171: 979-989. CrossRef Medline
    • (2014) Am J Psychiatry , vol.171 , pp. 979-989
    • Paterson, C.1    Wang, Y.2    Kleinman, J.E.3    Law, A.J.4
  • 73
    • 84864152357 scopus 로고    scopus 로고
    • Genetic models of sensorimotor gating: Relevance to neuropsychiatric disorders
    • CrossRef Medline
    • Powell SB, Weber M, Geyer MA (2012) Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders. Curr Top Behav Neurosci 12: 251-318. CrossRef Medline
    • (2012) Curr Top Behav Neurosci , vol.12 , pp. 251-318
    • Powell, S.B.1    Weber, M.2    Geyer, M.A.3
  • 74
    • 77952689858 scopus 로고    scopus 로고
    • Unraveling mechanisms of homeostatic synaptic plasticity
    • CrossRef Medline
    • Pozo K, Goda Y (2010) Unraveling mechanisms of homeostatic synaptic plasticity. Neuron 66: 337-351. CrossRef Medline
    • (2010) Neuron , vol.66 , pp. 337-351
    • Pozo, K.1    Goda, Y.2
  • 75
    • 84862331236 scopus 로고    scopus 로고
    • Wherefore art thou, homeo (stasis) ? Functional diversity in homeostatic synaptic plasticity
    • CrossRef Medline
    • Queenan BN, Lee KJ, Pak DT (2012) Wherefore art thou, homeo (stasis) ? Functional diversity in homeostatic synaptic plasticity. Neural Plast 2012: 718203. CrossRef Medline
    • (2012) Neural Plast , vol.2012
    • Queenan, B.N.1    Lee, K.J.2    Pak, D.T.3
  • 76
    • 84870064466 scopus 로고    scopus 로고
    • Neurodevelopmental model of schizophrenia: Update 2012
    • CrossRef Medline
    • Rapoport JL, Giedd JN, Gogtay N (2012) Neurodevelopmental model of schizophrenia: update 2012. Mol Psychiatry 17: 1228-1238. CrossRef Medline
    • (2012) Mol Psychiatry , vol.17 , pp. 1228-1238
    • Rapoport, J.L.1    Giedd, J.N.2    Gogtay, N.3
  • 77
    • 83055160768 scopus 로고    scopus 로고
    • Altered cortical network dynamics: A potential intermediate phenotype for schizophrenia and association with ZNF804A
    • CrossRef Medline
    • Rasetti R, Sambataro F, Chen Q, Callicott JH, Mattay VS, Weinberger DR (2011) Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch Gen Psychiatry 68: 1207-1217. CrossRef Medline
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 1207-1217
    • Rasetti, R.1    Sambataro, F.2    Chen, Q.3    Callicott, J.H.4    Mattay, V.S.5    Weinberger, D.R.6
  • 78
    • 84884148956 scopus 로고    scopus 로고
    • The global cognitive impairment in schizophrenia: Consistent over decades and around the world
    • CrossRef Medline
    • Schaefer J, Giangrande E, Weinberger DR, Dickinson D (2013) The global cognitive impairment in schizophrenia: consistent over decades and around the world. Schizophr Res 150: 42-50. CrossRef Medline
    • (2013) Schizophr Res , vol.150 , pp. 42-50
    • Schaefer, J.1    Giangrande, E.2    Weinberger, D.R.3    Dickinson, D.4
  • 79
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • CrossRef Medline
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature 511: 421-427. CrossRef Medline
    • (2014) Nature , vol.511 , pp. 421-427
  • 80
    • 84929697244 scopus 로고    scopus 로고
    • Dysfunctional prefrontal gamma-band oscillations reflect working memory and other cognitive deficits in schizophrenia
    • CrossRef Medline
    • Senkowski D, Gallinat J (2015) Dysfunctional prefrontal gamma-band oscillations reflect working memory and other cognitive deficits in schizophrenia. Biol Psychiatry 77: 1010-1019. CrossRef Medline
    • (2015) Biol Psychiatry , vol.77 , pp. 1010-1019
    • Senkowski, D.1    Gallinat, J.2
  • 81
    • 32244444322 scopus 로고    scopus 로고
    • The involvement of ErbB4 with schizophrenia: Association and expression studies
    • CrossRef Medline
    • Silberberg G, Darvasi A, Pinkas-Kramarski R, Navon R (2006) The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet 141B: 142-148. CrossRef Medline
    • (2006) Am J Med Genet , vol.141 B , pp. 142-148
    • Silberberg, G.1    Darvasi, A.2    Pinkas-Kramarski, R.3    Navon, R.4
  • 85
    • 34548291521 scopus 로고    scopus 로고
    • Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia
    • CrossRef Medline
    • Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem 282: 24343-24351. CrossRef Medline
    • (2007) J Biol Chem , vol.282 , pp. 24343-24351
    • Tan, W.1    Wang, Y.2    Gold, B.3    Chen, J.4    Dean, M.5    Harrison, P.J.6    Weinberger, D.R.7    Law, A.J.8
  • 86
    • 75849151480 scopus 로고    scopus 로고
    • Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression
    • CrossRef Medline
    • Tang TT, Yang F, Chen BS, Lu Y, Ji Y, Roche KW, Lu B (2009) Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc Natl Acad Sci U S A 106: 21395-21400. CrossRef Medline
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21395-21400
    • Tang, T.T.1    Yang, F.2    Chen, B.S.3    Lu, Y.4    Ji, Y.5    Roche, K.W.6    Lu, B.7
  • 87
    • 78650860729 scopus 로고    scopus 로고
    • Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons
    • CrossRef Medline
    • Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L (2011) Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci 31: 15-25. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 15-25
    • Ting, A.K.1    Chen, Y.2    Wen, L.3    Yin, D.M.4    Shen, C.5    Tao, Y.6    Liu, X.7    Xiong, W.C.8    Mei, L.9
  • 89
    • 84859791378 scopus 로고    scopus 로고
    • Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity
    • CrossRef Medline
    • Weickert CS, Tiwari Y, Schofield PR, Mowry BJ, Fullerton JM (2012) Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity. Transl Psychiatry 2: e104. CrossRef Medline
    • (2012) Transl Psychiatry , vol.2
    • Weickert, C.S.1    Tiwari, Y.2    Schofield, P.R.3    Mowry, B.J.4    Fullerton, J.M.5
  • 90
    • 0033850462 scopus 로고    scopus 로고
    • Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect
    • CrossRef Medline
    • Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR (2000) Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry 57: 907-913. CrossRef Medline
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 907-913
    • Weickert, T.W.1    Goldberg, T.E.2    Gold, J.M.3    Bigelow, L.B.4    Egan, M.F.5    Weinberger, D.R.6
  • 91
    • 0023215296 scopus 로고
    • Implications of normal brain development for the pathogenesis of schizophrenia
    • CrossRef Medline
    • Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660-669. CrossRef Medline
    • (1987) Arch Gen Psychiatry , vol.44 , pp. 660-669
    • Weinberger, D.R.1
  • 93
    • 5044225291 scopus 로고    scopus 로고
    • Genes, dopamine and cortical signalto-noise ratio in schizophrenia
    • CrossRef Medline
    • Winterer G, Weinberger DR (2004) Genes, dopamine and cortical signalto-noise ratio in schizophrenia. Trends Neurosci 27: 683-690. CrossRef Medline
    • (2004) Trends Neurosci , vol.27 , pp. 683-690
    • Winterer, G.1    Weinberger, D.R.2
  • 95
    • 0032007994 scopus 로고    scopus 로고
    • GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex
    • CrossRef Medline
    • Xiang Z, Huguenard JR, Prince DA (1998) GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J Physiol 506: 715-730. CrossRef Medline
    • (1998) J Physiol , vol.506 , pp. 715-730
    • Xiang, Z.1    Huguenard, J.R.2    Prince, D.A.3
  • 96
    • 0029868479 scopus 로고    scopus 로고
    • Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: Modulation of dendritic-somatic signal integration
    • Medline
    • Yang CR, Seamans JK (1996) Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration. J Neurosci 16: 1922-1935. Medline
    • (1996) J Neurosci , vol.16 , pp. 1922-1935
    • Yang, C.R.1    Seamans, J.K.2
  • 98
    • 84922258094 scopus 로고    scopus 로고
    • Developing treatments for cognitive deficits in schizophrenia: The challenge of translation
    • CrossRef Medline
    • Young JW, GeyerMA (2015) Developing treatments for cognitive deficits in schizophrenia: the challenge of translation. J Psychopharmacol 29: 178-196. CrossRef Medline
    • (2015) J Psychopharmacol , vol.29 , pp. 178-196
    • Young, J.W.1    Geyer, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.