Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice

Biological Psychiatry

Volumn 76, Issue 2, 2014, Pages 120-127

  Luo, Xiaoyang ^a   He, Wanxia ^a   Hu, Xiangyou ^a   Yan, Riqiang ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Bace1; neuregulin; NMDA receptor; schizophrenia; tetracycline control expression; transgenic mice

Indexed keywords

BETA SECRETASE 1; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MYELIN PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEU DIFFERENTIATION FACTOR; TETRACYCLINE; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; GLUTAMATE RECEPTOR; SECRETASE;

ABNORMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN DEVELOPMENT; BRAIN FUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; GENOTYPE; MOUSE; MYELINATION; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; TRANSGENIC MOUSE; ANIMAL; ANIMAL BEHAVIOR; BRAIN; C57BL MOUSE; CHEMISTRY; GENETICS; METABOLISM; PHYSIOLOGY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BEHAVIOR, ANIMAL; BRAIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUREGULIN-1; PHENOTYPE; RECEPTORS, GLUTAMATE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 84903128926     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.09.026     Document Type: Article

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