Behavioural characterization of neuregulin 1 type i overexpressing transgenic mice

NeuroReport

Volumn 20, Issue 17, 2009, Pages 1523-1528

  Deakin, Inga H ^a   Law, Amanda J ^a,c   Oliver, Peter L ^b   Schwab, Markus H ^d   Nave, Klaus Armin ^d   Harrison, Paul J ^a   Bannerman, David M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MRC Functional Genetics Unit   (United Kingdom)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Behavioural phenotype; Neuregulin; Schizophrenia; Transgenic

Indexed keywords

NEU DIFFERENTIATION FACTOR;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; FEMALE; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROTAROD TEST; STARTLE REFLEX; TRANSGENIC MOUSE; TREMOR;

ANIMALS; ANXIETY DISORDERS; BEHAVIOR, ANIMAL; BRAIN; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOVEMENT DISORDERS; NEURAL INHIBITION; NEUREGULIN-1; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SENSORY GATING; STARTLE REACTION; TREMOR;

EID: 75149143999     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328330f6e7     Document Type: Article

References (25)

1. Mei L, Xiong WC. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci 2008; 9:437-452.
2. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71:877-892.
3. Li DW, Collier DA, He L. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 2006; 15:1995-2002.
4. Keri S, Kiss I, Kelemen O. Effects of a neuregulin 1 variant on conversion to schizophrenia and schizophreniform disorder in people at high risk for psychosis. Mol Psychiatry 2009; 14:118-119.
5. Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 2006; 60:132-140.
6. Hall J, Whalley HC, Job DE, Baig BJ, McIntosh AM, Evans KL, et al. A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci 2006; 9:1477-1478.
7. Michailov GV, SeredaMW, Brinkmann BG, Fischer TM, Haug B, Birchmeier C, et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science 2004; 304:700-703.
8. Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Mueller T, Wende H, et al. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 2008; 59:581-595.
9. Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, et al. Short-and long-range attraction of cortical GABAergic interneurons by Neuregulin-1. Neuron 2004; 44:251-261.
10. Law AJ, Lipska BK,Weickert CS, Hyde TM, Straub RE, Hashimoto R, et al. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 50 SNPs associated with the disease. Proc Natl Acad Sci USA 2006; 103:6747-6752.
11. Hashimoto R, Straub RE,Weickert CS, Hyde TM, Kleinman JE,Weinberger DR. Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol Psychiatry 2004; 9:299-307.
12. Contet C, Rawlins JN, Deacon RM. A comparison of 129S2/SvHsd and C57BL/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice. Behav Brain Res 2001; 124:33-46.
13. Deacon RM, Rawlins JN. Hippocampal lesions, species-typical behaviours and anxiety in mice. Behav Brain Res 2005; 156:241-249.
14. Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, et al. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm Genome 2006; 17:129-146.
15. Deacon RMJ. Assessing nest building in mice. Nat Protoc 2006; 1:1117-1119.
16. Deacon RMJ. Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. Nat Protoc 2006; 1:118-121.
17. Caroni P. Overexpression of growth-associated proteins in the neurons of adult transgenic mice. J Neurosci Meth 1997; 71:3-9.
18. O'Tuathaigh CM, O'Sullivan GJ, Kinsella A, Harvey RP, Tighe O, Croke WT, et al. Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. Neuroreport 2006; 17:79-83.
19. O'Tuathaigh CM, O'Connor AM, O'Sullivan GJ, Lai D, Harvey R, Croke DT, et al. Disruption to social dyadic interactions but not emotional/anxietyrelated behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Prog Neuropsychopharm Biol Psychiatry 2008; 32:462-466.
20. Swerdlow NR,Weber M, Qu Y, Light GA, Braff DL. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology 2008; 199:331-388.
21. Role LW, Talmage DA. Neurobiology-new order for thought disorders. Nature 2007; 448:263-265.
22. Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, et al. Schizophreniarelated neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci 2008; 28:10893-10904.
23. Kellendonk C, Simpson EH, Kandel ER. Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci 2009; 32:347-358.
24. Chen J, Lipska BK, Weinberger DR. Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models. Biol Psychiatry 2006; 59:1180-1188.
25. Duffy L, Cappas E, Schofield PR, Scimone A, Karl T. Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1. Behav Neurosci 2008; 122:748-759.