A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

ACS Chemical Neuroscience

Volumn 7, Issue 4, 2016, Pages 505-518

  Yang, Shigao ^a   Liu, Wen ^a,b   Lu, Shuai ^a   Tian, Yong Zhen ^b   Wang, Wei Yun ^b   Ling, Tie Jun ^b   Liu, Rui Tian ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b ANHUI AGRICULTURAL UNIVERSITY   (China)

Author keywords

aggregation; Amyloid beta; camellikaempferoside B; microglia; neurotoxicity; secretase

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; CAMELLIKAEMPFEROSIDE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAEMPFEROL DERIVATIVE; OLIGOMER; PARA COUMARIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CAMELLIASIDE B; GLYCOSIDE; PEPTIDE FRAGMENT; PROTEIN BINDING; QUERCETIN; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FUZHUAN BRICK TEA; MICROGLIA; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TEA; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CELL DEATH; CHEMISTRY; CHO CELL LINE; COMPUTER SIMULATION; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GLIA; HAMSTER; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; NERVE CELL; RAT; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL DEATH; CELLS, CULTURED; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDES; HUMANS; MODELS, MOLECULAR; MUTATION; NEUROGLIA; NEURONS; PEPTIDE FRAGMENTS; PROTEIN BINDING; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84966355888     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00091     Document Type: Article

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