Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12503-12508

  Morgado, Isabel ^a,g   Wieligmann, Karin ^b   Bereza, Magdalena ^b   Rönicke, Raik ^c   Meinhardt, Katrin ^d   Annamalai, Karthikeyan ^d   Baumann, Monika ^a   Wacker, Jessica ^d   Hortschansky, Peter ^b   Malešević, Miroslav ^d   Parthier, Christoph ^a   Mawrin, Christian ^e   Schiene Fischer, Cordelia ^d   Reymann, Klaus G ^c   Stubbs, Milton T ^a   Balbach, Jochen ^a   Görlach, Matthias ^f   Horn, Uwe ^b   Fändrich, Marcus ^a,d  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f FRITZ LIPMANN INSTITUTE   (Germany)

^g UNIVERSITY OF ALGARVE   (Portugal)

Author keywords

Camelid antibody fragments; Immunotherapy; Protein aggregation

Indexed keywords

AMYLOID BETA PROTEIN; ANTIBODY; KW1; OLIGOMER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BIOTECHNOLOGICAL PROCEDURES; CHEMICAL ANALYSIS; CONTROLLED STUDY; FIBER; HUMAN; HYDROPHOBICITY; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MICROARRAY; SYNAPSE;

AMINO ACID MOTIFS; AMYLOID BETA-PEPTIDES; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

CAMELIDAE;

EID: 84864502830     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206433109     Document Type: Article

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