-
1
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimers disease
-
Selkoe, D. J. Translating cell biology into therapeutic advances in Alzheimers disease Nature 1999, 399, A23-A31
-
(1999)
Nature
, vol.399
-
-
Selkoe, D.J.1
-
2
-
-
0031052381
-
Amyloid the presenilins and Alzheimers disease
-
Hardy, J. Amyloid the presenilins and Alzheimers disease Trends Neurosci. 1997, 20, 154-159
-
(1997)
Trends Neurosci.
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
3
-
-
71249160483
-
Regulatory role of cytosolic phospholipase A2 in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42 in microglia
-
Szaingurten-Solodkin, I.; Hadad, N.; Levy, R. Regulatory role of cytosolic phospholipase A2 in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42 in microglia Glia 2009, 57, 1727-1740
-
(2009)
Glia
, vol.57
, pp. 1727-1740
-
-
Szaingurten-Solodkin, I.1
Hadad, N.2
Levy, R.3
-
4
-
-
0035936004
-
Nonsteroidal anti-inflammatory drugs and the risk of Alzheimers disease
-
Int Veld, B. A.; Ruitenberg, A.; Hofman, A.; Launer, L. J.; Van Duijn, C. M.; Stijnen, T.; Breteler, M. M. B.; Stricker, B. H. C. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimers disease N. Engl. J. Med. 2001, 22, 1515-1521
-
(2001)
N. Engl. J. Med.
, vol.22
, pp. 1515-1521
-
-
Int Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.J.4
Van Duijn, C.M.5
Stijnen, T.6
Breteler, M.M.B.7
Stricker, B.H.C.8
-
5
-
-
0030983079
-
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimers disease
-
Kaltschmidt, B.; Uherek, M.; Volk, B.; Baeuerie, P. A.; Kaltschmidt, C. Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 2642-2647
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 2642-2647
-
-
Kaltschmidt, B.1
Uherek, M.2
Volk, B.3
Baeuerie, P.A.4
Kaltschmidt, C.5
-
6
-
-
58149343686
-
Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-κB inactivation
-
Yun, K. J.; Koh, D. J.; Kim, S. H.; Park, S. J.; Ryu, J. H.; Kim, D. G.; Lee, J. Y.; Lee, K. T. Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-κB inactivation J. Agric. Food Chem. 2008, 56, 10265-10272
-
(2008)
J. Agric. Food Chem.
, vol.56
, pp. 10265-10272
-
-
Yun, K.J.1
Koh, D.J.2
Kim, S.H.3
Park, S.J.4
Ryu, J.H.5
Kim, D.G.6
Lee, J.Y.7
Lee, K.T.8
-
7
-
-
77953175681
-
S -Ethyl cysteine and S -propyl cysteine alleviate β-amyloid induced cytotoxicity in nerve growth factor differentiated PC12 cells
-
Tsai, S. J.; Lin, C. Y.; Mong, M. C.; Ho, M. W.; Yin, M. C. S -Ethyl cysteine and S -propyl cysteine alleviate β-amyloid induced cytotoxicity in nerve growth factor differentiated PC12 cells J. Agric. Food Chem. 2010, 58, 7104-7108
-
(2010)
J. Agric. Food Chem.
, vol.58
, pp. 7104-7108
-
-
Tsai, S.J.1
Lin, C.Y.2
Mong, M.C.3
Ho, M.W.4
Yin, M.C.5
-
8
-
-
0025975795
-
DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide
-
Nolan, G. P.; Ghosh, S.; Liou, H. C.; Tempst, P.; Baltimore, D. DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide Cell 1991, 64, 961-969
-
(1991)
Cell
, vol.64
, pp. 961-969
-
-
Nolan, G.P.1
Ghosh, S.2
Liou, H.C.3
Tempst, P.4
Baltimore, D.5
-
9
-
-
33847219960
-
Inflammatory signaling in cartilage: MAPK and NF-κB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis
-
Saklatvala, J. Inflammatory signaling in cartilage: MAPK and NF-κB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis Drug Targets 2007, 8, 305-313
-
(2007)
Drug Targets
, vol.8
, pp. 305-313
-
-
Saklatvala, J.1
-
10
-
-
0027165150
-
The mitogen-activated protein kinase signal transduction pathway
-
Davis, R. The mitogen-activated protein kinase signal transduction pathway J. Biol. Chem. 1993, 268, 14553-14556
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14553-14556
-
-
Davis, R.1
-
11
-
-
0030175485
-
Mitogen-activated protein kinase cascades and regulation of gene expression
-
Su, B.; Karin, M. Mitogen-activated protein kinase cascades and regulation of gene expression Curr. Opin. Immunol. 1996, 8, 402-411
-
(1996)
Curr. Opin. Immunol.
, vol.8
, pp. 402-411
-
-
Su, B.1
Karin, M.2
-
12
-
-
0033231020
-
From receptors to stress-activated MAP kinases
-
Ichijo, H. From receptors to stress-activated MAP kinases Oncogene 1999, 18, 6087-6093
-
(1999)
Oncogene
, vol.18
, pp. 6087-6093
-
-
Ichijo, H.1
-
13
-
-
0030805596
-
Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide
-
Hwang, D.; Jang, B. C.; Yu, G.; Boudreau, M. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide Biochem. Pharmacol. 1997, 54, 87-96
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 87-96
-
-
Hwang, D.1
Jang, B.C.2
Yu, G.3
Boudreau, M.4
-
14
-
-
64849092478
-
Study of the extraction, purification and antidiabetic potential of ursolic acid from Cornus officinalis Sieb. et Zucc
-
Gao, D.; Li, N.; Li, Q.; Li, J.; Han, Z.; Fan, Y.; Liu, Z. Study of the extraction, purification and antidiabetic potential of ursolic acid from Cornus officinalis Sieb. et Zucc Therapy 2008, 5, 697-705
-
(2008)
Therapy
, vol.5
, pp. 697-705
-
-
Gao, D.1
Li, N.2
Li, Q.3
Li, J.4
Han, Z.5
Fan, Y.6
Liu, Z.7
-
15
-
-
77950269484
-
Effects of morroniside isolated from Corni fructus on renal lipids and inflammation in type 2 diabetic mice
-
Park, C. H.; Noh, J. S.; Tanaka, T.; Yokozawa, T. Effects of morroniside isolated from Corni fructus on renal lipids and inflammation in type 2 diabetic mice J. Pharm. Pharmacol. 2010, 62, 374-380
-
(2010)
J. Pharm. Pharmacol.
, vol.62
, pp. 374-380
-
-
Park, C.H.1
Noh, J.S.2
Tanaka, T.3
Yokozawa, T.4
-
16
-
-
84867867951
-
Effects of key compounds isolated from Corni fructus on BACE1 inhibition
-
Youn, K.; Jun, M. Effects of key compounds isolated from Corni fructus on BACE1 inhibition Phytother. Res. 2012, 26, 1714-1718
-
(2012)
Phytother. Res.
, vol.26
, pp. 1714-1718
-
-
Youn, K.1
Jun, M.2
-
17
-
-
84866931832
-
Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells
-
Hong, S. Y.; Jeong, W. S.; Jun, M. Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 cells Molecules 2012, 17, 10831-10845
-
(2012)
Molecules
, vol.17
, pp. 10831-10845
-
-
Hong, S.Y.1
Jeong, W.S.2
Jun, M.3
-
18
-
-
0035922171
-
Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells
-
Jang, J. H.; Surh, Y. J. Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells Mutat. Res. 2001, 496, 181-190
-
(2001)
Mutat. Res.
, vol.496
, pp. 181-190
-
-
Jang, J.H.1
Surh, Y.J.2
-
19
-
-
34147181810
-
Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: A comparison of different flavonoids in activating estrogenic effect and in preventing β-amyloid-induced cell death
-
Zhu, J. T.; Choi, R. C.; Chu, G. K.; Cheung, A. W.; Gao, Q. T.; Li, J.; Jiang, Z. Y.; Dong, T. T.; Tsim, K. W. Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing β-amyloid-induced cell death J. Agric. Food. Chem. 2007, 55, 2438-2445
-
(2007)
J. Agric. Food. Chem.
, vol.55
, pp. 2438-2445
-
-
Zhu, J.T.1
Choi, R.C.2
Chu, G.K.3
Cheung, A.W.4
Gao, Q.T.5
Li, J.6
Jiang, Z.Y.7
Dong, T.T.8
Tsim, K.W.9
-
20
-
-
83555165958
-
Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons
-
Qu, M.; Li, L.; Chen, C.; Li, M.; Pei, L.; Chu, F.; Yang, J.; Yu, Z.; Wang, D.; Zhou, Z. Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons Neurosci. Lett. 2011, 505, 286-290
-
(2011)
Neurosci. Lett.
, vol.505
, pp. 286-290
-
-
Qu, M.1
Li, L.2
Chen, C.3
Li, M.4
Pei, L.5
Chu, F.6
Yang, J.7
Yu, Z.8
Wang, D.9
Zhou, Z.10
-
22
-
-
64749111428
-
Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells
-
Zhang, X.; Cao, J.; Zhong, L. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells Naunyn. Schmiedebergs Arch. Pharmacol. 2009, 379, 581-586
-
(2009)
Naunyn. Schmiedebergs Arch. Pharmacol.
, vol.379
, pp. 581-586
-
-
Zhang, X.1
Cao, J.2
Zhong, L.3
-
23
-
-
0034746288
-
NFκB in neuronal plasticity and neurodegenerative disorders
-
Mattson, M. P.; Camandola, S. NFκB in neuronal plasticity and neurodegenerative disorders J. Clin. Invest. 2001, 107, 247-254
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 247-254
-
-
Mattson, M.P.1
Camandola, S.2
-
24
-
-
80053198125
-
Protective effects of -conotoxin on amyloid-β-induced damage in PC12 cells
-
Fang, M.; Wang, J.; Han, S.; Hu, Z.; Zhan, J.; Ling, S.; Rudd, J. A.; Geng, Y. Protective effects of -conotoxin on amyloid-β-induced damage in PC12 cells Toxicol. Lett. 2011, 206, 325-338
-
(2011)
Toxicol. Lett.
, vol.206
, pp. 325-338
-
-
Fang, M.1
Wang, J.2
Han, S.3
Hu, Z.4
Zhan, J.5
Ling, S.6
Rudd, J.A.7
Geng, Y.8
-
26
-
-
26844436963
-
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NFκB and ERK/p38 MAP kinase pathway through antioxidant mechanisms
-
Lee, S. Y.; Lee, J. W.; Lee, H.; Yoo, H. S.; Yun, Y. P.; Oh, K. W.; Ha, T. Y.; Hong, J. T. Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NFκB and ERK/p38 MAP kinase pathway through antioxidant mechanisms Mol. Brain Res. 2005, 140, 45-54
-
(2005)
Mol. Brain Res.
, vol.140
, pp. 45-54
-
-
Lee, S.Y.1
Lee, J.W.2
Lee, H.3
Yoo, H.S.4
Yun, Y.P.5
Oh, K.W.6
Ha, T.Y.7
Hong, J.T.8
-
27
-
-
0000920292
-
Amyloid-β peptide-receptor for advanced glycation end product interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimers disease
-
Yan, S. D.; Zhu, H.; Fu, J.; Yan, S. F.; Roher, A.; Tourtellotte, W. W.; Rajavashisth, T.; Chen, X.; Godman, G. C.; Stern, D.; Schmidt, A. M. Amyloid-β peptide-receptor for advanced glycation end product interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 5296-5301
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 5296-5301
-
-
Yan, S.D.1
Zhu, H.2
Fu, J.3
Yan, S.F.4
Roher, A.5
Tourtellotte, W.W.6
Rajavashisth, T.7
Chen, X.8
Godman, G.C.9
Stern, D.10
Schmidt, A.M.11
-
28
-
-
1842738222
-
Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-β onto the hippocampus in vivo
-
Rosales-Corral, S.; Tan, D. X.; Reiter, R. J.; Valdivia-Velázquez, M.; Acosta-Marti nez, J. P.; Ortiz, G. G. Kinetics of the neuroinflammation- oxidative stress correlation in rat brain following the injection of fibrillar amyloid-β onto the hippocampus in vivo J. Neuroimmunol. 2004, 150, 20-28
-
(2004)
J. Neuroimmunol.
, vol.150
, pp. 20-28
-
-
Rosales-Corral, S.1
Tan, D.X.2
Reiter, R.J.3
Valdivia-Velázquez, M.4
Acosta-Marti'nez, J.P.5
Ortiz, G.G.6
-
29
-
-
0032900439
-
New insights into the role of nuclear factor-κB, aubiquitous transcription factor in the initiation of diseases
-
Chen, F.; Castranova, V.; Shi, X.; Demers, L. M. New insights into the role of nuclear factor-κB, aubiquitous transcription factor in the initiation of diseases Clin. Chem. 1999, 45, 7-17
-
(1999)
Clin. Chem.
, vol.45
, pp. 7-17
-
-
Chen, F.1
Castranova, V.2
Shi, X.3
Demers, L.M.4
-
30
-
-
70349515074
-
Molecular basis of the anti-inflammatory effects of terpenoids
-
Heras, B.; Hortelano, S. Molecular basis of the anti-inflammatory effects of terpenoids Inflamm. Allergy Drug Targets 2009, 8, 28-39
-
(2009)
Inflamm. Allergy Drug Targets
, vol.8
, pp. 28-39
-
-
Heras, B.1
Hortelano, S.2
-
31
-
-
34047271603
-
P -Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo
-
Luceri, C.; Giannini, L.; Lodovici, M.; Antonucci, E.; Abbate, R. p -Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo Br. J. Nutr. 2007, 97, 458-463
-
(2007)
Br. J. Nutr.
, vol.97
, pp. 458-463
-
-
Luceri, C.1
Giannini, L.2
Lodovici, M.3
Antonucci, E.4
Abbate, R.5
-
32
-
-
8844269151
-
Plant phenolic 4-coumaric acid protects against intestinal inflammation in rats
-
Luceri, C.; Guglielmi, F.; Lodovici, M.; Giannini, L.; Messerini, L.; Dolara, P. Plant phenolic 4-coumaric acid protects against intestinal inflammation in rats Scand. J. Gastroenterol. 2004, 39, 1128-1133
-
(2004)
Scand. J. Gastroenterol.
, vol.39
, pp. 1128-1133
-
-
Luceri, C.1
Guglielmi, F.2
Lodovici, M.3
Giannini, L.4
Messerini, L.5
Dolara, P.6
-
33
-
-
57349132885
-
Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-κB signaling pathway in lung epithelial cells
-
Lee, C. H.; Wu, S. L.; Chen, J. C.; Li, C. C.; Lo, H. Y.; Cheng, W. Y.; Lin, J. G.; Chang, Y. H.; Hsiang, C. Y.; Ho, T. Y. Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-κB signaling pathway in lung epithelial cells Am. J. Chin. Med. 2008, 36, 1185-1198
-
(2008)
Am. J. Chin. Med.
, vol.36
, pp. 1185-1198
-
-
Lee, C.H.1
Wu, S.L.2
Chen, J.C.3
Li, C.C.4
Lo, H.Y.5
Cheng, W.Y.6
Lin, J.G.7
Chang, Y.H.8
Hsiang, C.Y.9
Ho, T.Y.10
-
34
-
-
77957854250
-
Ursolic acid attenuates d -galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/ NFκB pathway activation
-
Lu, J.; Wu, D.; Zheng, Y.; Hu, B.; Zhang, Z.; Ye, Q.; Liu, C.; Shan, Q.; Wang, Y. Ursolic acid attenuates d -galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/ NFκB pathway activation Cereb. Cortex 2010, 20, 2540-2548
-
(2010)
Cereb. Cortex
, vol.20
, pp. 2540-2548
-
-
Lu, J.1
Wu, D.2
Zheng, Y.3
Hu, B.4
Zhang, Z.5
Ye, Q.6
Liu, C.7
Shan, Q.8
Wang, Y.9
-
35
-
-
78650359169
-
Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization
-
Lee, A.; Chen, T. L.; Shih, C. M.; Huang, C. Y.; Tsao, N. W.; Chang, N. C.; Chen, Y. H.; Fong, T. H.; Lin, F. Y. Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization J. Agric. Food Chem. 2010, 58 (24) 12941-12949
-
(2010)
J. Agric. Food Chem.
, vol.58
, Issue.24
, pp. 12941-12949
-
-
Lee, A.1
Chen, T.L.2
Shih, C.M.3
Huang, C.Y.4
Tsao, N.W.5
Chang, N.C.6
Chen, Y.H.7
Fong, T.H.8
Lin, F.Y.9
-
36
-
-
0026559650
-
Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells
-
Najid, A.; Simon, A.; Cook, J.; Chable-Robinovitch, H.; Delage, C.; Chulia, A. J.; Rugaud, M. Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells FEBS Lett. 1992, 299, 213-217
-
(1992)
FEBS Lett.
, vol.299
, pp. 213-217
-
-
Najid, A.1
Simon, A.2
Cook, J.3
Chable-Robinovitch, H.4
Delage, C.5
Chulia, A.J.6
Rugaud, M.7
-
37
-
-
17144439794
-
Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
-
Suh, N.; Honda, T.; Finlay, H. J.; Barchowsky, A.; Williams, C.; Benoit, N. E.; Xie, Q. W.; Nathan, C.; Gribble, G. W.; Sporn, M. B. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages Cancer Res. 1998, 58, 717-723
-
(1998)
Cancer Res.
, vol.58
, pp. 717-723
-
-
Suh, N.1
Honda, T.2
Finlay, H.J.3
Barchowsky, A.4
Williams, C.5
Benoit, N.E.6
Xie, Q.W.7
Nathan, C.8
Gribble, G.W.9
Sporn, M.B.10
-
38
-
-
77953696173
-
Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NFκB using ursolic acid
-
Li, Y.; Xing, D.; Chen, Q.; Chen, W. R. Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NFκB using ursolic acid Int. J. Cancer 2009, 127, 462-473
-
(2009)
Int. J. Cancer
, vol.127
, pp. 462-473
-
-
Li, Y.1
Xing, D.2
Chen, Q.3
Chen, W.R.4
-
39
-
-
77952625527
-
Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling
-
Yeh, C. T.; Wu, C. H.; Yen, G. C. Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling Mol. Nutr. Food Res. 2010, 54, 1285-1295
-
(2010)
Mol. Nutr. Food Res.
, vol.54
, pp. 1285-1295
-
-
Yeh, C.T.1
Wu, C.H.2
Yen, G.C.3
-
40
-
-
79954422847
-
Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: Application to the pharmacokinetic and tissue distribution study
-
Chen, Q.; Luo, S.; Zhang, Y. Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study Anal. Bioanal. Chem. 2011, 399, 2877-2884
-
(2011)
Anal. Bioanal. Chem.
, vol.399
, pp. 2877-2884
-
-
Chen, Q.1
Luo, S.2
Zhang, Y.3
|