Marine microorganisms as a promising and sustainable source of bioactive molecules

Marine Environmental Research

Volumn 128, Issue , 2017, Pages 58-69

  Romano, G ^a   Costantini, M ^a   Sansone, C ^a   Lauritano, C ^a   Ruocco, N ^a,b,c   Ianora, A ^a  

^a STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR   (Italy)

Author keywords

Bacteria; Blue growth; Cultivation methods; Drug discovery; Marine natural products; Microalgae; Molecular biology approaches

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOLOGY; DATA MINING; MARINE BIOLOGY; MICROORGANISMS; MOLECULAR BIOLOGY; NEURODEGENERATIVE DISEASES;

BIOACTIVE MOLECULES; DRUG DISCOVERY; EXPLORED RESOURCES; MARINE MICROORGANISM; MARINE NATURAL PRODUCTS; MICRO-ALGAE; NEURODEGENERATIVE; PHARMACEUTICAL INDUSTRY;

DRUG PRODUCTS;

BRENTUXIMAB VEDOTIN; CYTARABINE; ERIBULIN; NATURAL PRODUCT; OMEGA CONOTOXIN MVIIA; TRABECTEDIN; BIOLOGICAL PRODUCT;

ANTIBIOTICS; BACTERIUM; BIOTECHNOLOGY; DRUG DEVELOPMENT; MARINE RESOURCE; MICROALGA; PHARMACEUTICAL INDUSTRY;

ARTICLE; BIOTECHNOLOGY; CYANOBACTERIUM; DRUG DEVELOPMENT; ENVIRONMENTAL IMPACT; ENVIRONMENTAL SUSTAINABILITY; GREEN CHEMISTRY; HUMAN; MARICULTURE; MARINE SPECIES; MICROALGA; MICROORGANISM; NONHUMAN; PHOTOAUTOTROPH; SPONGE (PORIFERA); AQUATIC SPECIES; ECOSYSTEM; ENVIRONMENTAL PROTECTION; MARINE BIOLOGY; MICROBIOLOGY;

BACTERIA (MICROORGANISMS);

AQUATIC ORGANISMS; BIOLOGICAL PRODUCTS; BIOTECHNOLOGY; CONSERVATION OF NATURAL RESOURCES; ECOSYSTEM; MARINE BIOLOGY; WATER MICROBIOLOGY;

EID: 84965048217     PISSN: 01411136     EISSN: 18790291     Source Type: Journal    
DOI: 10.1016/j.marenvres.2016.05.002     Document Type: Article

References (159)

1. Abadie, E., Kaci, L., Berteaux, T., Hess, P., Sechet, V., Masseret, E., Rolland, J.L., Laabir, M., Effect of nitrate, ammonium and urea on growth and pinnatoxin G production of Vulcanodinium rugosum. Mar. Drugs 13 (2015), 5642–5656.
2. Aburai, N., Sumida, D., Abe, K., Effect of light level and salinity on the composition and accumulation of free and ester-type carotenoids in the aerial microalga Scenedesmus sp. (Chlorophyceae). Algal Res. 8 (2015), 30–36.
3. Alonso, E., Otero, P., Vale, C., Alfonso, A., Antelo, A., Giménez-Llort, L., Chabaud, L., Guillou, C., Botana, L.M., Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement. Curr. Alzheimer Res. 10:3 (2013), 279–289.
4. Argulis, L., Schwartz, K.V., Five Kingdoms: an Illustrated Guide to the Phyla of Life on Earth. 1982, Freeman WH and Company, New York, 16–17.
5. Atkin, S. L., Backett, S. T., Mackenzie, G., 2006. Topical formulations containing Sporopollenin. US 20080311213 A1- Google Patent.
6. Balskus, E.P., Walsh, C.T., The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria. Science 329:5999 (2010), 1653–1656.
7. Bashir, Y., Singh, S.P., Konwar, B.K., Metagenomics: an application based perspective. Chin. J. Biol., 2014, 2014 Article ID 146030, 7 pages.
8. Baudelet, P.H., Gagez, A.L., Bérard, J.B., Juin, C., Bridiau, N., Kaas, R., Thiéry, V., Cadoret, J.P., Picot, L., Antiproliferative activity of Cyanophora paradoxa pigments in melanoma, breast and lung cancer cells. Mar. Drugs 11 (2013), 4390–4406.
9. Beeble, A., Calestani, C., Expression pattern of polyketide synthase-2 during sea urchin development. Gene Expr. Patterns 12 (2012), 7–10.
10. Beedessee, G., Hisata, K., Roy, M.C., Satoh, N., Shoguchi, E., Multifunctional polyketide synthase genes identified by genomic survey of the symbiotic dinoflagellate, Symbiodinium minutum. BMC Genom., 16, 2015, 941.
11. Bergmann, S., Schumann, J., Scherlach, K., Lange, C., Brakhage, A.A., Hertweck, C., Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat. Chem. Biol. 3 (2007), 213–217.
12. Blunt, J.W., Copp, B.R., Hu, W.P., Munro, M.H., Northcote, P.T., Prinsep, M.R., Marine natural products. Nat. Product. Rep. 24 (2007), 31–86.
13. Blunt, J.W., Copp, B.R., Keyzers, R.A., Munro, M.H.G., Prinsep, M.R., Marine natural products. Nat. Product. Rep. 29 (2012), 144–222.
14. Blunt, J.W., Copp, B.R., Keyzers, R.A., Munro, M.H.G., Prinsep, M.R., Marine natural products. Nat. Product. Rep. 30 (2013), 237–323.
15. Blunt, J.W., Copp, B.R., Keyzers, R.A., Munro, M.H.G., Prinsep, M.R., Marine natural products. Nat. Product. Rep. 32 (2015), 116–211.
16. Blunt, J.W., Copp, B.R., Keyzers, R.A., Munro, M.H.G., Prinsep, M.R., Marine natural products. Nat. Product. Rep. 33 (2016), 382–431.
17. Boyer, M., Wisniewski-Dyé, F., Cell-cell signalling in bacteria: not simply a matter of quorum. FEMS Microbiol. Ecol. 70 (2009), 1–19.
18. Britstein, M., Devescovi, G., Handley, K.M., Malik, A., Haber, M., Saurav, K., Teta, R., Costantino, V., Burgsdorf, I., Gilbert, J.A., Sher, N., Venturi, V., Steindler, L., A new N-Acyl homoserine lactone synthase in an uncultured symbiont of the Red Sea sponge Theonella swinhoei. Appl. Environ. Microbiol. 82:4 (2015), 1274–1285.
19. Bruns, A., Cypionka, H., Overmann, J., Cyclic Amp and Acyl homoserine lactones increase the cultivation efficiency of heterotrophic bacteria from the central Baltic Sea. Appl. Environ. Microbiol. 68 (2002), 3978–3987.
20. Castoe, T.A., Stephens, T., Noonan, B.P., Calestani, C., A novel group of type I polyketide synthases (PKS) in animals and the complex phylogenomics of PKSs. Gene 392 (2007), 47–58.
21. Chang, F.Y., Brady, S.F., Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017. J. Am. Chem. Soc. 133 (2011), 9996–9999.
22. Chast, F., A history of drug discovery. Wermuth, C.G., (eds.) The Practice of Medicinal Chemistry, third ed., 2008, Academic Press, Burlington, MA, 3–62.
23. Cheung, F., TCM: made in China. Nature 480 (2011), 82–83.
24. Chiang, Y.M., Szewczyk, E., Davidson, A.D., Keller, N., Oakley, B.R., Wang, C.C., A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 131 (2009), 2965–2970.
25. Chiang, Y.M., Chang, S.L., Oakley, B.R., Wang, C.C.C., Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr. Opin. Chem. Biol. 15 (2011), 137–143.
26. Chiang, Y.M., Oakley, C.E., Ahuja, M., Entwistle, R., Schultz, A., Chang, S.L., Sung, C.T., Wang, C.C.C., Oakley, B.R., An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. J. Am. Chem. Soc. 135 (2013), 7720–7731.
27. Colwell, R.R., Fulfilling the promise of biotechnology. Biotechnol. Adv. 20 (2002), 215–228.
28. Cuendet, M., Oteham, C.P., Moon, R.C., Pezzuto, J.M., Quinone reductase induction as a biomarker for Cancer Chemoprevention. J. Nat. Prod. 3 (2006), 460–463.
29. de Morais, M.G., da Silva Vaz, B., de Morais, E.G., Vieira Costa, J., Biologically active metabolites synthesized by microalgae. BioMed Res. Int., 2015, 2015, 10.1155/2015/835761 Article ID 835761, 15 pages.
30. Dias, D.A., Urban, S., Roessner, U., A historical overview of natural products in drug discovery. Metabolites 2 (2012), 303–336.
31. Dionisio-Se Se, M.L., Aquatic microalgae as potential sources of UV-screening compounds. Philipp. J. Sci. 139 (2010), 5–19.
32. Edwards, D.J., Marquez, B.L., Nogle, L.M., McPhail, K., Goeger, D.E., Roberts, M.A., Gerwick, W.H., Structure and biosynthesis of the Jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem. Biol. 11 (2004), 817–833.
33. Eicholz, K., Beszteri, B., John, U., Putative monofunctional type I polyketide synthase units: a dinoflagellate-specific feature?. PLoS One, 7(11), 2012, e48624.
34. Engene, N., Rottacker, E.C., Kastovsky, J., Byrum, T., Choi, H., Ellismanm, M.H., Komàrek, J., Gerwick, W.H., Moorea producens gen.nov., sp. nov and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int. J. Syst. Evol. Microbiol., 62, 2012, 1171.
35. Epstein, S.S., The phenomenon of microbial uncultivability. Curr. Opin. Microbiol. 16 (2013), 636–642.
36. Esposito, G., Teta, R., Miceli, R., Ceccarelli, L.S., Della Sala, G., Camerlingo, R., Irollo, E., Mangoni, A., Pirozzi, G., Costantino, V., Isolation and assessment of the in vitro anti-tumor activity of Smenothiazole a and B, Chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge Smenospongia aurea. Mar. Drugs 2015:13 (2015), 444–459, 10.3390/md13010444.
37. Faulkner, D.J., Marine natural products. Nat. Product. Rep. 19 (2000), 1–48.
38. Fieseler, L., Horn, M., Wagner, M., Hentschel, U., Discovery of the novel candidate phylum “Poribacteria” in marine sponges. Appl. Environ. Microbiol. 70 (2004), 3724–3732.
39. Foster, K.R., Bell, T., Competition, not cooperation, dominates interactions among culturable microbial species. Curr. Biol. 22 (2012), 1845–1850.
40. Gerwick, W.H., Fenner, A.M., Drug discovery from marine microbes. Microb. Ecol. 65 (2013), 800–806.
41. Gierhart, D. L., Fox, J. A., 2013. Protection against Sunburn and Skin problems with orally-ingested high-dosage zeaxanthin. US 8088363 B2- Google Patent.
42. Gong, Y., Guo, X., Wan, X., Liang, Z., Jiang, M., Triacylglycerol accumulation and change in fatty acid content of four marine oleaginous microalgae under nutrient limitation and at different culture ages. J. Basic Microbiol. 53 (2013), 29–36.
43. Gross, H., Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl. Microbiol. Biotechnol. 75 (2007), 267–277.
44. Guedes, C., Gião, M.S., Seabra, R., Silva Ferreira, A.C., Tamagnini, P., Moradas-Ferreira, P., Xavier Malcata, F., Evaluation of the antioxidant activity of cell extracts from microalgae. Mar. Drugs 11 (2013), 1256–1270.
45. Guerin, M., Huntley, M.E., Olaizola, M., Haematococcus astanxanthin: applications for human health and nutrition. Trends Biotechnol. 21:5 (2003), 210–216.
46. Gupta, N., Pal, M., Sachdeva, M., Yadav, M., Tiwari, A., Thermophilic biohydrogen production for commercial application: the whole picture. Int. J. Energy Res. 40 (2015), 127–145.
47. Haefner, B., Drugs from the deep: marine natural products as drug candidates. Drug Discov. Ther. 8 (2003), 536–544.
48. Halberstein, R.A., Medicinal plants: historical and cross-cultural usage patterns. Ann. Epidemiol. 15 (2005), 686–699.
49. Harvey, A.L., Natural products in drug discovery. Drug Discov. Today 13 (2008), 894–901.
50. Harvey, A.L., Edrada-Ebel, R., Quinn, R.J., The re-emergence of natural products for drug discovery in the genomics era. Nat. Rev. Drug Discov. 14 (2015), 111–129.
51. Hirata, Y., Uemura, D., Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl. Chem. 58 (1986), 701–710.
52. Hosaka, T., Ohnishi-Kameyama, M., Muramatsu, H., Murakami, K., Tsurumi, Y., Kodani, S., Yoshida, M., Fujie, A., Ochi, K., Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat. Biotechnol. 27 (2009), 462–464.
53. Hu, Y., Chen, J., Hu, G., Yu, J., Zhu, X., Lin, Y., Chen, S., Yuan, J., Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar. Drugs 13 (2015), 202–221.
54. Hughes, D.T., Sperandio, V., Inter-kingdom signalling: communication between bacteria and their hosts. Nat. Rev. Microbiol. 6:2 (2008), 111–120.
55. Hur, M., Campbell, A.A., Almeida-de-Macedo, M., Li, L., Ransom, N., Jose, A., Crispin, M., Nikolau, B.J., Wurtele, E.S., A global approach to analysis and interpretation of metabolic data for plant natural product discovery. Nat. Product. Rep. 30 (2013), 565–583.
56. Igarashi, Y., Shimasaki, R., Miyanaga, S., Oku, N., Onaka, H., Sakurai, H., Saiki, I., Kitani, S., Nihira, T., Wimonsiravude, W., Panbangred, W., Rakicidin, D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp. J. Antibiot. 63 (2010), 563–565.
57. Ingebrigtsen, R.A., Hansen, E., Andersen, J.H., Eilertsen, H.C., Light and temperature effects on bioactivity in diatoms. J. Appl. Phycol., 2015, 10.1007/s10811-015-0631-4.
58. Jaspars, M., De Pascale, D., Andersen, J.H., Reyes, F., Crawford, A.D., Ianora, A., The marine biodiscovery pipeline and ocean medicines of tomorrow. J. Mar. Biol. Assoc. U. K. 96 (2016), 151–158.
59. Jha, R.K., Zi-rong, X., Biomedical compounds from marine organisms. Mar. Drugs 2 (2004), 123–146.
60. Jimeno, J., Faircloth, G., Fernández Sousa-Faro, J.M., Scheuer, P., Rinehart, K., New marine derived anticancer therapeutics. A journey from the sea to clinical trials. Mar. Drugs 2 (2004), 14–29.
61. Joint, I., Mühling, M., Querellou, J., Culturing marine bacteria – an essential prerequisite for biodiscovery. Microb. Biotechnol. 3 (2010), 564–575.
62. Kaeberlein, T., Lewis, K., Epstein, S.S., Isolating “uncultivable” microorganisms in pure culture in a simulated natural environment. Science 296 (2002), 1127–1129.
63. Kathiresan, S., Melander, O., Anevski, D., Guiducci, C., Burtt, N.P., Roos, C., Hirschhorn, J.N., Berglund, G., Hedblad, B., Groop, L., Altshuler, D.M., Newton-Cheh, C., Orho-Melander, M., Polymorphisms associated with cholesterol and risk of cardiovascular events. N. Engl. J. Med. 358 (2008), 1240–1249.
64. Katz, J., Janik, J.E., Younes, A., Brentuximab vedotin (SGN-35). Clin. Cancer Res. 17 (2011), 6428–6436.
65. Kellmann, R., Stüken, A., Orr, R.J.S., Svendsen, H.M., Jakobsen, K.S., Biosynthesis and molecular genetics of polyketides in marine dinoflagellates. Mar. Drugs 8 (2010), 1011–1048.
66. Kersten, R.D., Yang, Y.-L., Xu, Y., Cimermancic, P., Nam, S.-J., Nam, Sang-Jip, Fenical, W., Fischbach, M.A., Moore, B.S., Dorrestein, P.C., A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat. Chem. Biol. 7 (2011), 794–802.
67. Kijjoa, A., Sawangwong, P., Drugs and cosmetics from the sea. Mar. Drugs 2 (2004), 73–82.
68. Kim, E.J., Lee, J.H., Cjoi, H., Pereira, A.R., Ban, Y.H., Yoo, Y.J., Won Park, J., Sherman, D.H., Gerwick, W.H., Yoon, Y.J., Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Org. Lett. 14 (2012), 5824–5827.
69. Kim, T.K., Fuerst, J.A., Diversity of polyketide synthase genes from bacteria associated with the marine sponge Pseudoceratina clavata: culture-dependent and culture-independent approaches. Environ. Microbiol. 8 (2006), 1460–1470.
70. Kobayashi, J., Amphidinolides and its related macrolides from marine dinoflagellates. J. Antibiot. 61:5 (2008), 271–284.
71. Kohli, G.S., John, U., Van Dolah, F.M., Murray, S.A., Evolutionary distinctiveness of fatty acid and polyketide synthesis in eukaryotes. ISME J., 2016, 10.1038/ismej.2015.263.
72. Kong, D.X., Jiang, Y.Y., Zhang, H.Y., Marine natural products as sources of novel scaffolds: achievement and concern. Drug Discov. Today 15 (2010), 884–886.
73. Kusama, T., Tanaka, N., Takahashi-Nakaguchi, A., Gonoi, T., Fromont, J., Kobayashi, J., Bromopyrrole alkaloids from a marine sponge Agelas sp. Chem. Pharm. Bull. 62 (2014), 499–503.
74. Laport, M., Santos, O., Muricy, G., Marine sponges: potential sources of new antimicrobial drugs. Curr. Pharm. Biotechnol. 10 (2009), 86–105.
75. Lauritano, C., Andersen, J.H., Hansen, E, Albrigtsen, M., Escalera, L., Esposito, F., Helland, K., Hanssen, K.Ø., Romano, G., Ianora, A., Bioactivity screening of microalgae for antioxidant, anti-inflammatory, anticancer, anti-diabetes and antibacterial activities. Front. Mar. Sci. (Marine Biotechnology Section 3), 68, 2016.
76. Lee, H.S., Kwon, K.K., Kang, S.G., Cha, S.S., Kim, S.J., Lee, J.H., Approaches for novel enzyme discovery from marine environments. Curr. Opin. Biotechnol. 21 (2010), 353–357.
77. Lee, J.C., Hou, M.F., Huang, H.W., Chang, F.R., Yeh, C.C., Tang, J., Chang, H.W., Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties. Cancer Cell Int., 13, 2013, 55.
78. Lewis, K., Epstein, S., D'Onofrio, A., Ling, L.L., Uncultured microorganisms as a source of secondary metabolites. J. Antibiot. 63 (2010), 468–476.
79. Li, X., Qin, L., Metagenomics-based drug discovery and marine microbial diversity. Trends Biotechnol. 23 (2005), 539–543.
80. Liu, Q.A., Shao, C.L., Gu, Y.C., Blum, M., Gan, L.S., Wang, K.L., Chen, M., Wang, C.Y., Antifouling and fungicidal resorcylic acid lactones from the sea anemone-derived fungus Cochliobolus lunatus. J. Agric. Food Chem. 62 (2014), 3183–3191.
81. Lopanik, N.B., Chemical defensive symbioses in the marine environment. Funct. Ecol. 28 (2014), 328–340.
82. Lordan, S., Paul Ross, R., Stanton, C., Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases. Mar. Drugs 9 (2011), 1056–1100.
83. Luo, X., Su, P., Zhang, W., Advances in microalgae-derived phytosterols for functional food and pharmaceutical applications. Mar. Drugs 13 (2015), 4231–4254.
84. Macdougall, J.D., A Short History of Planet Heart. 1996, John Wiley, New York, 5.
85. MacKinnon, S.L., Cembella, A.D., Burton, I.W., Lewisn, N., LeBlanc, P., Walter, J.A., Biosynthesis of 13-Desmethyl spirolide C by the dinoflagellate Alexandrium ostenfeldii. J. Org. Chem. 71:23 (2006), 8724–8731.
86. Mata, T.M., Martins, A.A., Caetano, N.S., Microalgae for biodiesel production and other applications: a review. Renew. Sustain. Energy Rev. 14 (2010), 217–232.
87. Mayer, A., Rodríguez, A.D., Taglialatela-Scafati, O., Fusetani, N., Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar. Drugs 11 (2013), 2510–2573.
88. Mehbub, M.F., Lei, J., Franco, C., Zhang, W., Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives. Mar. Drugs 12 (2014), 4539–4577.
89. Menis, J., Twelves, C., Eribulin (Halaven): a new, effective treatment for women with heavily pretreated metastatic breast cancer. Breast Cancer Targets Ther. 3 (2011), 101–111.
90. Meyer, J., Rödelsperger, C., Eichholz, K., Tillmann, U., Cembella, A., McGaughran, A., John, U., Transcriptomic characterisation and genomic glimps into the toxigenic dinoflagellate Azadinium spinosum, with emphasis on polykeitde synthase genes. BMC Genom., 16(1), 2015, 27.
91. Mimouni, V., Ulmann, L., Pasquet, V., Mathieu, M., Picot, L., Bougaran, G., Cadoret, J.P., Morant-Manceau, A., Schoefs, B., The potential of microalgae for the production of bioactive molecules of pharmaceutical interest. Curr. Pharm. Biotechnol. 13 (2012), 2733–2750.
92. Mohan, S.V., Rohit, M.V., Chiranjeevi, P., Chandra, R., Navaneeth, B., Heterotrophic microalgae cultivation to synergize biodiesel production with waste remediation: progress and perspectives. Bioresour. Technol. 184 (2014), 169–178.
93. Molinski, T.F., Dalisay, D.S., Lievens, S.L., Saludes, J.P., Drug development from marine natural products. Nat. Rev. Drug Discov. 8 (2009), 69–85.
94. Montaser, R., Luesch, H., Marine natural products: a new wave of drugs?. Future Med. Chem. 3 (2011), 1475–1489.
95. Mora, C., Tittensor, D.P., Adl, S., Simpson, A.G.B., Worm, B., How many species are there on Earth and in the ocean?. PLoS Biol., 9, 2011, e1001127.
96. Morris, J.J., Kirkegaard, R., Szul, M., Johnson, Z.I., Zinser, E.R., Facilitation of robust growth of Prochlorococcus colonies and dilute liquid cultures by “helper” heterotrophic bacteria. Appl. Environ. Microbiol. 74 (2008), 4530–4534.
97. Müller, W.E.G., Brümmer, F., Batel, R., Müller, I.M., Schröder, H.C., Molecular biodiversity. Case study: Porifera (sponges). Naturwissenschaften 90 (2003), 103–120.
98. Munro, M.H.G., Blunt, J.W., Dumdei, E.J., Hickford, S.J.H., Lill, R.E., Li, S., Battershill, C.N., Duckworth, A.R., The discovery and development of marine compounds with pharmaceutical potential. J. Biotechnol. 70 (1999), 15–25.
99. Nair, N.U., Denard, C.A., Zhao, H., Engineering of enzymes for selective catalysis. Curr. Org. Chem. 14 (2010), 1870–1882.
100. Newman, D.J., Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. J. Med. Chem. 51 (2008), 2589–2599.
101. Nichols, D., Lewis, K., Orjala, J., Mo, S., Ortenberg, R., O'Connor, P., Zhao, C., Vouros, P., Kaeberlein, T., Epstein, S.S., Short peptide induces an “uncultivable” microorganism to grow in vitro. Appl. Environ. Microbiol. 74 (2008), 4889–4897.
102. Nichols, D., Cahoon, N., Trakhtenberg, E.M., Pham, L., Mehta, A., Belanger, A., Kanigan, T., Lewis, K., Epstein, S.S., Use of ichip for high-throughput in situ cultivation of “uncultivable” microbial species. Appl. Environ. Microbiol. 76 (2010), 2445–2450.
103. Niedermeyer, T., Brönstrup, M., Natural product drug discovery from microalgae. Posten, Clemens, Walter, Christian, (eds.) Microalgal Biotechnology: Integration and Economy, 2012, 169–200.
104. Nigjeh, S.E., Yusoff, F.M., Alitheen, N.B.M., Rasoli, M., Keong, Y.S., bin Omar, A.R., Cytotoxic Effect of Ethanol Extract of Microalga, Chaetoceros Calcitrans, and its Mechanisms in Inducing Apoptosis in Human Breast cancer Cell Line. 2013, Hindawi Publishing Corporation BioMed Research International ID 783690, 8 pages.
105. Nigreli, R.F., Stempien, M.F., Ruggieri, G.D., Liguori, B.R., Cecil, J.T., Substances of potential biomedical importance from marine organisms. Fed. Proc. 26 (1967), 1197–1205.
106. Noaman, M.N., Effect of potassium and nitrogen fertilizers on the growth and biomass of some halophytes grown under high levels of salinity. J. Agron. 3 (2004), 25–30.
107. Noyer, C., Thomas, O.P., Becerro, M.A., Patterns of chemical diversity in the Mediterranean sponge Spongia lamella. PLoS One, 6, 2011, e20844.
108. Pasquet, V., Morisset, P., Ihammouine, S., Chepied, A., Aumailley, L., Berard, J., Serive, B., Kaas, R., Lanneluc, I., Thiery, V., Lafferriere, M., Piot, J.M., Patrice, T., Cadoret, J.P., Picot, L., Antiproliferative activity of violaxanthin isolated from bioguided fractionation of Dunaliella tertiolecta extracts. Mar. Drugs 9 (2011), 819–831.
109. Penesyan, A., Kjelleberg, S., Egan, S., Development of novel drugs from marine surface associated microorganisms. Mar. Drugs 8 (2010), 438–459.
110. Perez, R., Liu, L., Lopez, J., An, T., Rein, K.S., Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates. Mar. Drugs 6 (2008), 164–179.
111. Pisut, D.P., Pawlik, J.R., Anti-predatory chemical defenses of ascidians: secondary metabolites or inorganic acids?. J. Exp. Mar. Biol. Ecol. 207 (2002), 203–214.
112. Pomponi, S.A., The bioprocess-technological potential of the sea. J. Biotechnol. 70 (1999), 5–13.
113. Prestegard, S.K., Oftedal, L., Coyne, R.T., Nygaard, G., Skjærven, K.H., Knutsen, G., Døskeland, S.O., Herfindal, L., Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity. Mar. Drugs 7 (2009), 605–623.
114. Priyadarshani, L., Rath, B., Commercial and industrial applications of microalgae- A review. J. Algal Biomass Util. 3 (2012), 89–100.
115. Proksch, P., Edrada, R., Ebel, R., Drugs from the seas-current status and microbiological implications. Appl. Microbiol. Biotechnol. 59 (2002), 125–134.
116. Qian, P.Y., Li, Z., Xu, Y., Li, Y., Fusetani, N., Mini-review: marine natural products and their synthetic analogs as antifouling compounds: 2009-2014. Biofouling 31 (2015), 101–122.
117. Qiao, Y., He, H., Jonsson, P., Sinha, I., Zhao, C., Dahlman-Wright, K., AP-1 is a key regulator of pro-inflammatory cytokine TNFα-mediated triple-negative breast cancer progression. J. Biol. Chem., 2016, 10.1074/jbc.M115.702571.
118. Reen, F., Gutiérrez-Barranquero, J., Dobson, A., Adams, C., O'Gara, F., Emerging concepts promising new horizons for marine biodiscovery and synthetic biology. Mar. Drugs, 13, 2015 294–2954.
119. Reveillaud, J., Maignien, L., Eren, A.M., Huber, J.A., Apprill, A., Sogin, M.L., Vanreusel, A., Host-specificity among abundant and rare taxa in the sponge microbiome. ISME J. 8 (2014), 1198–1209.
120. Ribalet, F., Wichard, T., Pohnert, G., Ianora, A., Miralto, A., Casotti, R., Age and nutrient limitation enhance polyunsaturated aldehyde production in marine diatoms. Phytochemistry 68 (2007), 2059–2067.
121. Rua, C.P.J., Trindade-Silva, A.E., Appolinario, L.R., Venas, T.M., Garcia, G.D., Carvalho, L.S., Lima, A., Kruger, R., Pereira, R.C., Berlinck, R.G.S., Valle, R.A.B., Thompson, C.C., Thompson, F., Diversity and antimicrobial potential of culturable heterotrophic bacteria associated with the endemic marine sponge Arenosclera brasiliensis. PeerJ, 2, 2014, e419.
122. Ruggieri, G.D., Drug from the sea. Science 194 (1976), 491–496.
123. Sacristán-Soriano, O., Banaigs, B., Casamayor, E.O., Becerro, M.A., Exploring the links between natural products and bacterial assemblages in the sponge Aplysina aerophoba. Appl. Environ. Microbiol. 77 (2011), 862–870.
124. Sagar, S., Kaur, M., Minneman, K.P., Antiviral lead compounds from marine sponges. Mar. Drugs 8 (2010), 2619–2638.
125. Samarakoon, K.W., Ko, J.Y., Rahman Shah, M., Lee, J.H., Kang, M.C., O-Nam, K., Lee, J.B., Jeon, Y.J., In vitro studies of anti-inflammatory and anticancer activities of organic solvent extracts from cultured marine microalgae. Algae 28 (2013), 111–119.
126. Sanmukh, S., Bruno, B., Ramakrishnan, U., Khairnar, K., Swaminathan, S., Paunikar, W., Bioactive compounds derived from microalgae showing antimicrobial activities. J. Aquac. Res. Dev., 5, 2014, 224.
127. Sansone, C., Braca, A., Ercolesi, E., Romano, G., Palumbo, A., Casotti, R., Francone, M., Ianora, A., Diatom-derived polyunsaturated aldehydes activate cell death in human cancer cell lines but not normal cells. PLoS ONE, 9(7), 2014, e101220, 10.1371/journal.pone.0101220.
128. Sasso, S., Pohnert, G., Loh, M., Mittag, M., Hertweck, C., Microalgae in the postgenomic era: a blooming reservoir for new natural products. FEMS Microbiol. Rev. 36 (2012), 761–785.
129. Saurav, K., Burgsdorf, I., Teta, R., Esposito, G., Bar-Shalom, R., Costantino, V., Steindler, L., Isolation of marine Paracoccus sp. Ss63 from the sponge Sarcotragus sp. and characterization of its quorum sensing chemical signaling molecules by LC-MS/MS analysis. Israel J. Chem., 2016, 10.1002/ijch.201600003.
130. Scherholz, M.L., Curtis, W.R., Achieving pH control in microalgal cultures through fed-batch addition of stoichiometrically-balanced growth media. BMC Biotechnol., 13, 2013, 39.
131. Schirmer, A., Gadkari, R., Reeves, C.D., Ibrahim, F., DeLong, E.F., Hutchinson, C.R., Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta. Appl. Environ. Microbiol. 71 (2005), 4840–4849.
132. Schmitt, S., Tsai, P., Bell, J., Fromont, J., Ilan, M., Lindquist, N., Perez, T., Rodrigo, A., Schupp, P.J., Vacelet, J., Webster, N., Hentschel, U., Taylor, M.W., Assessing the complex sponge microbiota: Core, variable and species-specific bacterial communities in marine sponges. ISME J. 6 (2012), 564–576.
133. Schneemann, I., Wiese, J., Kunz, A.L., Imhoff, J.F., Genetic approach for the fast discovery of phenazine producing bacteria. Mar. Drugs 9 (2011), 772–789.
134. Schoffski, P., Dumez, H., Wolter, P., Stefan, C., Wozniak, A., Jimeno, J., Van Oosterom, A.T., Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma. Expert Opin. Pharmacother. 9 (2008), 1609–1618.
135. Schupp, P., Eder, C., Paul, V., Proksch, P., Distribution of secondary metabolites in the sponge Oceanapia sp. and its ecological implications. Mar. Biol. 135 (1999), 573–580.
136. Shah, M.R., Samarakoon, K.W., Ko, J.Y., Lakmal, H.H.Chaminda, Lee, J.H., An, S.J., Jeon, Y.J., Lee, J.B., Potentiality of benthic dinoflagellate cultures and screening of their bioactivities in Jeju Island, Korea. Afr. J. Biotechnol. 13 (2014), 792–805.
137. Shwab, E.K., Bok, J.W., Tribus, M., Galehr, J., Graessle, S., Keller, N.P., Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 6 (2007), 1656–1664.
138. Steindler, L., Venturi, V., Detection of quorum-sensing N -acyl homoserine lactone signal molecules by bacterial biosensors. FEMS Microbiol. Lett. 266 (2007), 1–9.
139. Stengel, D.B., Connan, S., Marine algae: a source of biomass for biotechnological applications. Methods Mol. Biol. 1308 (2015), 1–37.
140. Stonik, V.A., Fedorov, S.N., Marine low molecular weight natural products as potential cancer preventive compounds. Mar. Drugs 12 (2014), 636–671.
141. Taylor, M.W., Tsai, P., Simister, R., Deines, P., Botte, E., Schmitt, S., Webster, N., ‘Sponge-specific’ bacteria are widespread (but rare) in diverse marine environments. ISME J. 7 (2012), 438–443.
142. Teta, R., Della Sala, G., Glukhov, E., Gerwick, L., Gerwick, W.H., Mangoni, A., Costantino, V., Combined LC–MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in green lake, Seattle. Environ. Sci. Technol. 49:24 (2015), 14301–14310.
143. Teta, R., Irollo, E., Della Sala, G., Pirozzi, G., Mangoni, A., Costantino, V., Smenamides a and B, Chlorinated peptide/polyketide hybrids containing a Dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research. Mar. Drugs 11 (2013), 4451–4463.
144. Thakur, N.L., Anil, A.C., Antibacterial activity of the sponge Ircinia ramose: importance of its surface-associated bacteria. J. Chem. Ecol. 26 (2000), 57–71.
145. Thakur, N.L., Studies on Some Bioactivity Aspects of Selected Marine Organisms. (Ph.D. thesis), 2001, Goa University, India.
146. Thakur, N.L., Hentschel, U., Krasko, A., Pabel, C.T., Anil, A.C., Müller, W.E.G., Antibacterial activity of the sponge Suberites domuncula and its primmorphs: potential basis for epibacterial chemical defense. Aquat. Microb. Ecol. 31 (2003), 83–87.
147. Thakur, N.L., Müller, W.E.G., Biotechnological potential of marine sponge. Curr. Sci. 86 (2004), 1506–1512.
148. Thakur, N.L., Thakur, A.N., Müller, W.E.G., Marine natural products in drug discovery. Nat. Product. Radiance 4 (2005), 471–477.
149. Tominaga, K., Hongo, N., Karato, M., Yamashita, E., Cosmetic benefits od astaxanthin on humans sujects. Acta Biochim. Pol. 59:1 (2012), 43–47.
150. Ugwu, C.U., Aoyagi, H., Uchiyama, H., Photobioreactors for mass cultivation of algae. Bioresour. Technol. 99 (2008), 4021–4028.
151. Van Dolah, F.M., Zippay, M.L., Pezzolesi, L., Rein, K.S., Johnson, J.G., Morey, J.S., Wang, Z., Pistocchi, R., Subcellular localization of dinoflagellate polyketide synthases and fatty acid synthase activity. J. Phycol., 49, 2013 118–1127.
152. Wahl, M., Jensen, P.R., Fenical, W., Chemical control of bacterial epibiosis on Ascidians. Mar. Ecol. Prog. Ser. 110 (1994), 45–57.
153. Walker, T.L., Purton, S., Becker, D.K., Collet, C., Microalgae as bioreactors. Plant Cell Rep. 24:11 (2005), 629–641.
154. Waters, A.L., Hill, R.T., Place, A.R., Hamann, M.T., The expanding role of marine microbes in pharmaceutical development. Curr. Opin. Biotechnol. 21 (2010), 780–786.
155. Wilson, M.C., Piel, J., Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology. Chem. Biol. 20 (2013), 636–647.
156. Winter, J.M., Behnken, S., Hertweck, C., Genomics inspired discovery of natural products. Curr. Opin. Chem. Biol. 15 (2011), 22–31.
157. Xiong, Z.Q., Zhang, Z.P., Li, J.H., Wei, S.J., Tu, G.Q., Characterization of Streptomyces padanus JAU4234, a producer of actinomycin X2, fungichromin, and a new polyene macrolide antibiotic. Appl. Environ. Microbiol. 78 (2012), 589–592.
158. Xiong, Z.Q., Wang, J.F., Hao, Y.Y., Wang, Y., Recent advances in the discovery and development of marine microbial natural products. Mar. Drugs 11 (2013), 700–717.
159. Zhang, X., Wei, W., Tan, R., Symbionts, a promising source of bioactive natural products. Sci. China Chem. 58 (2015), 1097–1109.