Drugs from the seas - Current status and microbiological implications

Applied Microbiology and Biotechnology

Volumn 59, Issue 2-3, 2002, Pages 125-134

  Proksch, P ^a   Edrada, R A ^a   Ebel, R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1,3,4 OCTADECANETRIOL; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ANALGESIC AGENT; BRYOSTATIN; BRYOSTATIN 1; CEMADOTIN; CONTIGNASTEROL; DEHYDRODIDEMNIN B; DIDEMNIN B; DOLASTATIN 10; IPL 576092; MANOALIDE; METHOPTEROSIN; OMEGA CONOTOXIN MVIIA; SQUALAMINE; SQUALAMINE LACTATE; TRABECTEDIN; UNCLASSIFIED DRUG;

BIOTECHNOLOGY; DRUG DEVELOPMENT; MARINE RESOURCE; MICROBIOLOGY; SYMBIONT;

BIOACCUMULATION; BIODIVERSITY; BIOSYNTHESIS; BRYOZOA; CANCER THERAPY; CONTROLLED STUDY; DRUG MECHANISM; INVERTEBRATE; MARINE ENVIRONMENT; MICROORGANISM; MOLLUSC; NONHUMAN; SEA; SHORT SURVEY; SPONGE (PORIFERA);

ANIMALS; BRYOZOA; MARINE BIOLOGY; MOLLUSCA; PORIFERA; UROCHORDATA; WATER MICROBIOLOGY;

BRYOZOA; BUGULA; BUGULA NERITINA; CONUS MAGUS; CYANOBACTERIA; GASTROPODA; INVERTEBRATA; MOLLUSCA; NERITINA; PORIFERA; UROCHORDATA;

EID: 0036314931     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-002-1006-8     Document Type: Short Survey

References (75)

1. Inhibition of protein synthesis by didemnins: Cell potency and SAR
2. Inhibition of protein synthesis by didemnin B: How EF-1 mediates inhibition of translocation
3. The ultrastructure of Oscillatoria spongeliae, the blue-green algal endosymbiont of the sponge Dysidea herbacea
4. Lithistid sponges: Star performers or hosts to the stars?
5. Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts
6. A phase I and pharmacokinetic study of squalamine, a novel antiangio-genic agent, in patients with advanced cancers
7. A phase II trial of bryostatin 1 in patients with non-Hodgkin's lymphoma
8. Partitioning herbivory and its effects on coral algal communities
9. The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea-pigs in vivo
10. Jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis sp.
11. Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
12. Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina
13. Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues
14. Ecteinascidin-743: A marine-derived compound in advanced, pretreated sarcoma patients-preliminary evidence of activity
15. In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumor cells and hematopoietic precursor cells
16. Wound activation of pro-toxins in the marine sponge Aplysina aerophoba
17. Highlights of marine natural products chemistry (1972-1999)
18. Marine pharmacology
19. Marine natural products
20. Microbial diversity in the marine sponge Aplysina cavernicola (formerly Verongia cavernicola) analyzed by fluorescence in situ hybridization (FISH)
21. Temporal variation of the microbial community associated with the Mediterranean sponge Aplysina aerophoba
22. Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays
23. In vitro hematotoxicity of aplidine on human bone marrow and cord blood progenitor cells
24. Symplostatin 1. A dolastatin 10 analogue from marine cyanobacterium Symploca hydnoides
25. The halichondrins: Chemistry, biology, supply and delivery
26. Small-subunit rRNA genes and in situ hybridization with oligonucleotides specific for the bacterial symbionts in the larvae of the bryozoan Bugula neritina and proposal of "Candidatus Endobugula sertula"
27. Common molecular mechanisms of symbiosis and pathogenesis
28. Isolation and phylogenetic analysis of bacteria with antimicrobial activities from the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola
29. Safracins, new antitumor antibiotics. II. Physicochemical properties and chemical structures
30. Isolation of myxobacteria from the marine environment
31. Chondramides A - D, new cytostatic and antifungal cyclodepsipeptides from Chondromyces crocatus (Myxobacteria): Isolation and structure elucidation
32. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
33. The brain?7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21)
34. Biosynthesis of bioactive marine natural products
35. In vitro anti-tumour activity of α-galactosylceramide-stimulated human invariant Vα24+NKT cells against melanoma
36. Piscivorous gastropods of the genus Conus
37. Defense of ascidians and their conspicuous larvae: Adults vs. larval chemical defenses
38. The pseudopterosins: A new class of antiinflammatory and analgesic diterpene pentosides from the marine sea whip Pseudopterogorgia elisabethae (Octocorallia)
39. The pseudopterosins: Anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae
40. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1
41. Pharmacological characterization of the pseudopterosins: Novel anti-inflammatory natural products isolated from the Caribbean soft coral, Pseudopterogorgia elisabethae
42. ω-conotoxins: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle
43. Aquacultural production of bryostatin 1 and ecteinascidin 743
44. Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743
45. Phase II clinical trial of didemnin B in patients with recurrent or refractory anaplastic astrocytoma or glioblastoma multiforme (NSC 325319)
46. Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima
47. Chemistry and clinical biology of the bryostatins
48. ?-conotoxin MVIIA: >From marine snail venom to analgesic drug
49. Neuraxial infusion in patients with chronic intractable cancer and noncancer pain
50. Chemical defense in marine ecosystems
51. Ecological significance of alkaloids from marine invertebrates
52. Biologically active secondary metabolites from myxobacteria
53. Antitumor compounds from tunicates
54. Structure-activity relationships of the didemnins
55. Identification of the antifungal peptide-containing symbiont of the marine sponge Theonella swinhoei as a novel δ-proteobacterium, "Candidatus Entotheonella palauensis"
56. Staurosporine derivatives from the ascidican Eudistoma toealensis and its predatory flatworm Pseudoceros sp.
57. Microalgae as a drug source
58. Activity of the dolastatin analogue, LU103793, in malignant melanoma
59. Symbiosis and pathogenesis: Evolution of the microbe-host interaction
60. Okadaic acid: A cytotoxic polyether from two marine sponges of the genus Halichondria
61. Cyanobacterial symbiont biosynthesis of chlorinated metabolites from Dysidea herbacea (Porifera)
62. Etude en microscopie électronique de l'association entre bactéries et spongiaires du genre Verongia (Dictyoceratida)
63. Electron microscope study of the association between some sponges and bacteria
64. Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma
65. Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts
66. Phase II study of bryostatin 1 in patients with relapsed multiple myeloma
67. A phase I and pharmacokinetic study of ecteinascidin-743 on a daily × 5 schedule in patients with solid malignancies
68. Phylogenetic diversity of bacteria associated with the marine sponge Rhopaloeides odorabile
69. 2 and its acetate, methyl ester) in the gorgonian Plexaura homomalla. Chemistry of coelenterates. XV
70. Symbiotic interactions between marine sponges and algae
71. Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity
72. Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove