Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1

Experimental Eye Research

Volumn 147, Issue , 2016, Pages 72-77

  Kowluru, Renu A ^a   Mishra, Manish ^a   Kumar, Binit ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Acetylation; Diabetic retinopathy; Rac1; Sirtuin 1; Transcriptional regulation

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC1 PROTEIN; SIRTUIN 1; SYNAPTOTAGMIN I; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN EXPRESSION; RAT; RETINA BLOOD VESSEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANALYSIS OF VARIANCE; ANIMAL; DNA DAMAGE; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MICROVASCULATURE; MITOCHONDRION; PHYSIOLOGY; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; DNA DAMAGE; GENE EXPRESSION PROFILING; MALE; MICROVESSELS; MITOCHONDRIA; NADPH OXIDASE; NF-KAPPA B; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; RETINAL VESSELS; SIRTUIN 1; TRANSCRIPTION, GENETIC;

EID: 84965036171     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2016.04.014     Document Type: Article

References (31)

1. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005, 54:1615-1625.
2. Goldberg H.J., Whiteside C.I., Hart G.W., Fantus I.G. Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology 2006, 147:222-231.
3. Helzer K.T., Hooper C., Miyamoto S., Alarid E.T. Ubiquitylation of nuclear receptors: new linkages and therapeutic implications. J. Mol. Endo 2015, 54:R151-R167.
4. Ibrahim A.S., Elshafey S., Sellak H., Hussein K.A., El-Sherbiny M., Abdelsaid M., Rizk N., Beasley S., Tawfik A.M., Smith S.B., Al-Shabrawey M. A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase. J. Lipid Res. 2015, 56:599-611.
5. Jung Y.J., Lee J.E., Lee A.S., Kang K.P., Lee S., Park S.K., Lee S.Y., Han M.K., Kim D.H., Kim W. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells. Biochem. Biophys. Res. Comm. 2012, 419:206-210.
6. Kato M., Natarajan R. Diabetic nephropathy-emerging epigenetic mechanisms. Nat. Rev. Nephrol. 2014, 10:517-530.
7. Kauppinen A., Suuronen T., Ojala J., Kaarniranta K., Salminen A. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal 2013, 25:1939-1948.
8. Kern T.S., Tang J., Mizutani M., Kowluru R., Nagraj R., Lorenzi M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol. Vis. Sci. 2000, 41:3972-3978.
9. Kowluru A., Kowluru R.A. Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes. Biochem. Pharmacol. 2014, 88:275-283.
10. Kowluru R.A., Chan P.S. Metabolic memory in diabetes - from in vitro oddity to in vivo problem: role of apoptosis. Brain Res. Bull. 2010, 81:297-302.
11. Kowluru R.A., Koppolu P., Chakrabarti S., Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Rad. Res. 2003, 37:1169-1180.
12. Kowluru R.A., Kowluru A., Mishra M., Kumar B. Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy. Prog. Ret Eye Res. 2015, 48:40-61.
13. Kowluru R.A., Kowluru A., Veluthakal R., Mohammad G., Syed I., Santos J.M., Mishra M. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia 2014, 57:1047-1056.
14. Kowluru R.A., Mishra M. Contribution of epigenetics in diabetic retinopathy. Science China. Life Sci. 2015, 58:556-563.
15. Kowluru R.A., Mohammad G., dos Santos J.M., Zhong Q. Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage. Diabetes 2011, 60:3023-3033.
16. Kowluru R.A., Santos J.M., Zhong Q. Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol. Vis. Sci. 2014, 55:5653-5660.
17. Kumar B., Kowluru A., Kowluru R.A. Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy. Invest Ophthalmol. Vis. Sci. 2015, 56:2985-2992.
18. Li J., Wang J.J., Yu Q., Chen K., Mahadev K., Zhang S.X. Inhibition of reactive oxygen species by lovastatin down-regulates VEGF expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4. Diabetes 2010, 59:1528-1538.
19. Madsen-Bouterse S.A., Mohammad G., Kanwar M., Kowluru R.A. Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression. Antiox Redox Signal 2010, 13:797-805.
20. Maghbooli Z., Hossein-Nezhad A., Larijani B., Amini M., Keshtkar A. Global DNA methylation as a possible biomarker for diabetic retinopathy. Diab Metab. Res. Rev. 2015, 31:183-189.
21. Mishra M., Flaga J., Kowluru R.A. Molecular mechanism of transcriptional regulation of matrix Metalloproteinase-9 in diabetic retinopathy. J. Cell. Physiol. 2016, 231:1709-1718.
22. Pavlova S., Klucska K., Vasicek D., Ryban L., Harrath A.H., Alwasel S.H., Sirotkin A.V. The involvement of SIRT1 and transcription factor NF-kappaB (p50/p65) in regulation of porcine ovarian cell function. Anim. Reprod. Sci. 2013, 140:180-188.
23. Reddy M.A., Natarajan R. Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res. 2011, 90:421-429.
24. Romeo G., Liu W.H., Asnaghi V., Kern T.S., Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 2002, 51:2241-2248.
25. Santos J.M., Mishra M., Kowluru R.A. Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: implications in diabetic retinopathy and metabolic memory phenomenon. Exp. Eye Res. 2014, 121:168-177.
26. Sarfstein R., Gorzalczany Y., Mizrahi A., Berdichevsky Y., Molshanski-Mor S., Weinbaum C., Hirshberg M., Dagher M.C., Pick E. Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras. J. Biol. Chem. 2004, 279:16007-16016.
27. Stankov K., Benc D., Draskovic D. Genetic and epigenetic factors in etiology of diabetes mellitus type 1. Pediatrics 2013, 132:1112-1122.
28. Veluthakal R., Kumar B., Mohammad G., Kowluru A., Kowluru R.A. Tiam1-Rac1 Axis promotes activation of p38 MAP kinase in the development of diabetic retinopathy: evidence for a requisite role for protein palmitoylation. Cell Physiol. Biochem. 2015, 36:208-220.
29. Yang X.D., Tajkhorshid E., Chen L.F. Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol. Cell Biol. 2010, 30:2170-2180.
30. Zhong Q., Kowluru R.A. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J. Cell Biochem. 2010, 110:1306-1313.
31. Zhong Q., Kowluru R.A. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes 2011, 60:1304-1313.