-
1
-
-
80053612940
-
Genome-wide association studies (GWAS): Impact on elucidating the aetiology of diabetes
-
Hakonarson H, Grant S. Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes. Diabetes Metab Res Rev. 2011;27(7):685-696
-
(2011)
Diabetes Metab Res Rev
, vol.27
, Issue.7
, pp. 685-696
-
-
Hakonarson, H.1
Grant, S.2
-
2
-
-
79960769096
-
The epidemic of type 1 diabetes: What is it telling us?
-
Forlenza GP, Rewers M. The epidemic of type 1 diabetes: what is it telling us? Curr Opin Endocrinol Diabetes Obes. 2011;18(4): 248-251
-
(2011)
Curr Opin Endocrinol Diabetes Obes
, vol.18
, Issue.4
, pp. 248-251
-
-
Forlenza, G.P.1
Rewers, M.2
-
4
-
-
79953757810
-
Rapid increase in the incidence of type 1 diabetes in polish children from 1989 to 2004
-
Jarosz-Chobot P, Polanska J, Szadkowska A, et al. Rapid increase in the incidence of type 1 diabetes in Polish children from 1989 to 2004, and predictions for 2010 to 2025. Diabetologia. 2011;54(3): 508-515
-
(2011)
Diabetologia
, vol.54
, Issue.3
, pp. 508-515
-
-
Jarosz-Chobot, P.1
Polanska, J.2
Szadkowska, A.3
-
5
-
-
77956353873
-
Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: The RIDI study
-
RIDI Study Group
-
Bruno G, Maule M, Merletti F, et al RIDI Study Group. Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: The RIDI study. Diabetes. 2010;59(9):2281-2287
-
(2010)
Diabetes
, vol.59
, Issue.9
, pp. 2281-2287
-
-
Bruno, G.1
Maule, M.2
Merletti, F.3
-
6
-
-
75149149946
-
Baden- Württemberg Diabetes Incidence Registry (DIARY) Group. Epidemiological perspectives on type 1 diabetes in childhood and adolescence in Germany: 20 years of the Baden- Württemberg Diabetes Incidence Registry (DIARY)
-
Ehehalt S, Dietz K, Willasch AM, Neu A; Baden- Württemberg Diabetes Incidence Registry (DIARY) Group. Epidemiological perspectives on type 1 diabetes in childhood and adolescence in Germany: 20 years of the Baden- Württemberg Diabetes Incidence Registry (DIARY). Diabetes Care. 2010;33(2):338-340
-
(2010)
Diabetes Care
, vol.33
, Issue.2
, pp. 338-340
-
-
Ehehalt, S.1
Dietz, K.2
Willasch, A.M.3
Neu, A.4
-
7
-
-
84856398701
-
Enteroviruses and causality of type 1 diabetes: How close are we?
-
Diaz-Horta O, Baj A, Maccari G, Salvatoni A, Toniolo A. Enteroviruses and causality of type 1 diabetes: how close are we? Pediatr Diabetes. 2012;13(1):92-99
-
(2012)
Pediatr Diabetes
, vol.13
, Issue.1
, pp. 92-99
-
-
Diaz-Horta, O.1
Baj, A.2
Maccari, G.3
Salvatoni, A.4
Toniolo, A.5
-
8
-
-
80054746235
-
Understanding type 1 diabetes through genetics: Advances and prospects
-
Polychronakos C, Li Q. Understanding type 1 diabetes through genetics: Advances and prospects. Nat Rev Genet. 2011;12(11):781-792
-
(2011)
Nat Rev Genet
, vol.12
, Issue.11
, pp. 781-792
-
-
Polychronakos, C.1
Li, Q.2
-
9
-
-
67049159857
-
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
-
EURODIAB Study Group
-
Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G; EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study. Lancet. 2009;373(9680):2027-2033
-
(2009)
Lancet
, vol.373
, Issue.9680
, pp. 2027-2033
-
-
Patterson, C.C.1
Dahlquist, G.G.2
Gyürüs, E.3
Green, A.4
Soltész, G.5
-
10
-
-
78649803676
-
Type 1 diabetes: A genetic Pandora's box?
-
Thomas IH, Pietropaolo M. Type 1 diabetes: A genetic Pandora's box? Pediatr Diabetes. 2010;11(8):511-512
-
(2010)
Pediatr Diabetes
, vol.11
, Issue.8
, pp. 511-512
-
-
Thomas, I.H.1
Pietropaolo, M.2
-
11
-
-
84871226479
-
Genetic susceptibility of childhood type 1 diabetes mellitus in Japan
-
Sugihara S. Genetic susceptibility of childhood type 1 diabetes mellitus in Japan. Pediatr Endocrinol Rev. 2012;10(Suppl 1):62-71
-
(2012)
Pediatr Endocrinol Rev
, vol.10
, Issue.SUPPL.1
, pp. 62-71
-
-
Sugihara, S.1
-
12
-
-
78049472461
-
Prevention of type 1 diabetes: Today and tomorrow
-
Cernea S, Dobreanu M, Raz I. Prevention of type 1 diabetes: Today and tomorrow. Diabetes Metab Res Rev. 2010;26(8):602-605
-
(2010)
Diabetes Metab Res Rev
, vol.26
, Issue.8
, pp. 602-605
-
-
Cernea, S.1
Dobreanu, M.2
Raz, I.3
-
13
-
-
53849120957
-
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: From epidemiology to mechanisms
-
Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev. 2008;29(6):697-725
-
(2008)
Endocr Rev
, vol.29
, Issue.6
, pp. 697-725
-
-
Huber, A.1
Menconi, F.2
Corathers, S.3
Jacobson, E.M.4
Tomer, Y.5
-
14
-
-
84872242782
-
Epigenetics in autoimmune diseases with focus on type 1 diabetes
-
Dang MN, Buzzetti R, Pozzilli P. Epigenetics in autoimmune diseases with focus on type 1 diabetes. Diabetes Metab Res Rev. 2013; 29(1):8-18
-
(2013)
Diabetes Metab Res Rev
, vol.29
, Issue.1
, pp. 8-18
-
-
Dang, M.N.1
Buzzetti, R.2
Pozzilli, P.3
-
15
-
-
84888321284
-
Genetics of diabetes: Are we missing the genes or the disease?
-
doi:10.1016/ j.mce.2013.04.002
-
Groop L, Pociot F. Genetics of diabetes: Are we missing the genes or the disease? Mol Cell Endocrinol. 2013. doi:10.1016/ j.mce.2013.04.002
-
(2013)
Mol Cell Endocrinol
-
-
Groop, L.1
Pociot, F.2
-
16
-
-
36849012027
-
Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
-
Nejentsev S, Howson JM, Walker NM, et al Wellcome Trust Case Control Consortium. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature. 2007;450(7171): 887-892
-
(2007)
Nature
, vol.450
, Issue.7171
, pp. 887-892
-
-
Nejentsev, S.1
Howson, J.M.2
Walker, N.M.3
-
17
-
-
84867740293
-
A functional framework for interpretation of genetic associations in T1D
-
Nepom GT, Buckner JH. A functional framework for interpretation of genetic associations in T1D. Curr Opin Immunol. 2012;24(5):516-521
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.5
, pp. 516-521
-
-
Nepom, G.T.1
Buckner, J.H.2
-
18
-
-
84864619362
-
Insights into type 1 diabetes provided by genetic analyses
-
Morahan G. Insights into type 1 diabetes provided by genetic analyses. Curr Opin Endocrinol Diabetes Obes. 2012;19(4):263-270
-
(2012)
Curr Opin Endocrinol Diabetes Obes
, vol.19
, Issue.4
, pp. 263-270
-
-
Morahan, G.1
-
19
-
-
77954288805
-
Genetics of type 1 diabetes: What's next?
-
Pociot F, Akolkar B, Concannon P, et al. Genetics of type 1 diabetes: what's next? Diabetes. 2010;59(7):1561-1571
-
(2010)
Diabetes
, vol.59
, Issue.7
, pp. 1561-1571
-
-
Pociot, F.1
Akolkar, B.2
Concannon, P.3
-
20
-
-
77949497074
-
Bioinformatics challenges for genome-wide association studies
-
Moore JH, Asselbergs FW, Williams SM. Bioinformatics challenges for genome-wide association studies. Bioinformatics. 2010; 26(4):445-455
-
(2010)
Bioinformatics
, vol.26
, Issue.4
, pp. 445-455
-
-
Moore, J.H.1
Asselbergs, F.W.2
Williams, S.M.3
-
21
-
-
68249108329
-
Prediction and interaction in complex disease genetics: Experience in type 1 diabetes
-
Clayton DG. Prediction and interaction in complex disease genetics: Experience in type 1 diabetes. PLoS Genet. 2009;5(7): E1000540
-
(2009)
PLoS Genet
, vol.5
, Issue.7
-
-
Clayton, D.G.1
-
22
-
-
48249152671
-
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
-
Smyth DJ, Cooper JD, Howson JM, et al. PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes. 2008;57(6): 1730-1737
-
(2008)
Diabetes
, vol.57
, Issue.6
, pp. 1730-1737
-
-
Smyth, D.J.1
Cooper, J.D.2
Howson, J.M.3
-
23
-
-
77952557918
-
Missing heritability and strategies for finding the underlying causes of complex disease
-
Eichler EE, Flint J, Gibson G, et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet. 2010;11(6):446-450
-
(2010)
Nat Rev Genet
, vol.11
, Issue.6
, pp. 446-450
-
-
Eichler, E.E.1
Flint, J.2
Gibson, G.3
-
25
-
-
80855124182
-
Intracellular pathways of pancreatic b-cell apoptosis in type 1 diabetes
-
Thomas HE, Kay TW. Intracellular pathways of pancreatic b-cell apoptosis in type 1 diabetes. Diabetes Metab Res Rev. 2011;27 (8):790-796
-
(2011)
Diabetes Metab Res Rev
, vol.27
, Issue.8
, pp. 790-796
-
-
Thomas, H.E.1
Kay, T.W.2
-
26
-
-
84874544031
-
Insulin and type 1 diabetes: Immune connections
-
Culina S, Brezar V, Mallone R. Insulin and type 1 diabetes: immune connections. Eur J Endocrinol. 2013;168(2):R19-R31
-
(2013)
Eur J Endocrinol
, vol.168
, Issue.2
, pp. 19-31
-
-
Culina, S.1
Brezar, V.2
Mallone, R.3
-
27
-
-
77951158889
-
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells
-
Roggli E, Britan A, Gattesco S, et al. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes. 2010;59(4):978-986
-
(2010)
Diabetes
, vol.59
, Issue.4
, pp. 978-986
-
-
Roggli, E.1
Britan, A.2
Gattesco, S.3
-
28
-
-
79952795269
-
Diabetes mellitus, a microRNArelated disease?
-
Guay C, Roggli E, Nesca V, Jacovetti C, Regazzi R. Diabetes mellitus, a microRNArelated disease? Transl Res. 2011;157(4): 253-264
-
(2011)
Transl Res
, vol.157
, Issue.4
, pp. 253-264
-
-
Guay, C.1
Roggli, E.2
Nesca, V.3
Jacovetti, C.4
Regazzi, R.5
-
29
-
-
84875636480
-
Pathogenesis of type 1 diabetes: Lessons from natural history studies of high-risk individuals
-
Nokoff N, Rewers M. Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. Ann N Y Acad Sci. 2013;1281:1-15
-
(2013)
Ann N Y Acad Sci
, vol.1281
, pp. 1-15
-
-
Nokoff, N.1
Rewers, M.2
-
30
-
-
36749011882
-
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
-
Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA. 2007;104(43): 17040-17045
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.43
, pp. 17040-17045
-
-
Wenzlau, J.M.1
Juhl, K.2
Yu, L.3
-
31
-
-
44649198581
-
The molecular genetics of type 1 diabetes: New genes and emerging mechanisms
-
Ounissi-Benkalha H, Polychronakos C. The molecular genetics of type 1 diabetes: new genes and emerging mechanisms. Trends Mol Med. 2008;14(6):268-275
-
(2008)
Trends Mol Med
, vol.14
, Issue.6
, pp. 268-275
-
-
Ounissi-Benkalha, H.1
Polychronakos, C.2
-
32
-
-
84875674753
-
The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis
-
Padgett LE, Broniowska KA, Hansen PA, Corbett JA, Tse HM. The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann N Y Acad Sci. 2013;1281:16-35
-
(2013)
Ann N Y Acad Sci
, vol.1281
, pp. 16-35
-
-
Padgett, L.E.1
Broniowska, K.A.2
Hansen, P.A.3
Corbett, J.A.4
Tse, H.M.5
-
33
-
-
84863378809
-
The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes
-
doi:10.1155/2012/238980
-
Zhong J, Rao X, Xu JF, Yang P, Wang CY. The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes. Exp Diabetes Res. 2012. doi:10.1155/2012/238980
-
(2012)
Exp Diabetes Res
-
-
Zhong, J.1
Rao, X.2
Xu, J.F.3
Yang, P.4
Wang, C.Y.5
-
34
-
-
84878777666
-
Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
-
Eizirik DL, Miani M, Cardozo AK. Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia. 2013; 56(2):234-241
-
(2013)
Diabetologia
, vol.56
, Issue.2
, pp. 234-241
-
-
Eizirik, D.L.1
Miani, M.2
Cardozo, A.K.3
-
35
-
-
77955248678
-
Genetic predisposition for type 1 diabetes mellitus: The role of endoplasmic reticulum stress in human disease etiopathogenesis
-
Stankov K. Genetic predisposition for type 1 diabetes mellitus: The role of endoplasmic reticulum stress in human disease etiopathogenesis. J Med Biochem. 2010;29 (3):139-149
-
(2010)
J Med Biochem
, vol.29
, Issue.3
, pp. 139-149
-
-
Stankov, K.1
-
36
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007;8(7): 519-529
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.7
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
37
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev. 2006;86(4):1133-1149
-
(2006)
Physiol Rev
, vol.86
, Issue.4
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
38
-
-
84876010343
-
Mutation in the SLC29A3 gene: A new cause of a monogenic, autoinflammatory condition
-
Available at
-
Melki I, Lambot K, Jonard L, et al. Mutation in the SLC29A3 gene: A new cause of a monogenic, autoinflammatory condition. Pediatrics. 2013;131(4). Available at: www. pediatrics.org/cgi/content/full/131/4/e1308
-
(2013)
Pediatrics
, vol.131
, Issue.4
-
-
Melki, I.1
Lambot, K.2
Jonard, L.3
-
39
-
-
79955494892
-
The subtle signs of Wolfram (DIDMOAD) syndrome: Not all juvenile diabetes is type 1 diabetes
-
Boettcher C, Brosig B, Zimmer KP, Wudy SA. The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes. J Pediatr Endocrinol Metab. 2011;24(1-2):71-74
-
(2011)
J Pediatr Endocrinol Metab
, vol.24
, Issue.1-2
, pp. 71-74
-
-
Boettcher, C.1
Brosig, B.2
Zimmer, K.P.3
Wudy, S.A.4
-
40
-
-
84874503583
-
Genome wide association studies for diabetes: Perspective on results and challenges
-
Torres JM, Cox NJ, Philipson LH. Genome wide association studies for diabetes: Perspective on results and challenges. Pediatr Diabetes. 2013;14(2):90-96
-
(2013)
Pediatr Diabetes
, vol.14
, Issue.2
, pp. 90-96
-
-
Torres, J.M.1
Cox, N.J.2
Philipson, L.H.3
-
41
-
-
70349578557
-
The diagnosis and management of monogenic diabetes in children and adolescents
-
Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue KC. The diagnosis and management of monogenic diabetes in children and adolescents. Pediatr Diabetes. 2009;10 (Suppl 12):33-42
-
(2009)
Pediatr Diabetes
, vol.10
, Issue.SUPPL.12
, pp. 33-42
-
-
Hattersley, A.1
Bruining, J.2
Shield, J.3
Njolstad, P.4
Donaghue, K.C.5
-
42
-
-
77954435633
-
Wolfram syndrome: Important implications for pediatricians and pediatric endocrinologists
-
Kumar S. Wolfram syndrome: important implications for pediatricians and pediatric endocrinologists. Pediatr Diabetes. 2010;11(1):28-37
-
(2010)
Pediatr Diabetes
, vol.11
, Issue.1
, pp. 28-37
-
-
Kumar, S.1
-
43
-
-
57049150641
-
WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon
-
Zalloua PA, Azar ST, Delépine M, et al. WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon. Hum Mol Genet. 2008;17(24):4012-4021
-
(2008)
Hum Mol Genet
, vol.17
, Issue.24
, pp. 4012-4021
-
-
Zalloua, P.A.1
Azar, S.T.2
Delépine, M.3
-
44
-
-
79451474853
-
Alström syndrome: Insights into the pathogenesis of metabolic disorders
-
Girard D, Petrovsky N. Alström syndrome: insights into the pathogenesis of metabolic disorders. Nat Rev Endocrinol. 2011;7(2): 77-88
-
(2011)
Nat Rev Endocrinol
, vol.7
, Issue.2
, pp. 77-88
-
-
Girard, D.1
Petrovsky, N.2
-
45
-
-
3042696843
-
Wolcott-Rallison syndrome: Clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity
-
Senée V, Vattem KM, Delépine M, et al. Wolcott-Rallison syndrome: Clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes. 2004;53(7):1876-1883
-
(2004)
Diabetes
, vol.53
, Issue.7
, pp. 1876-1883
-
-
Senée, V.1
Vattem, K.M.2
Delépine, M.3
-
47
-
-
77953643852
-
Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
-
Grant SFA, Hakonarson H, Schwartz S. Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults? Endocr Rev. 2010;31(2):183-193
-
(2010)
Endocr Rev
, vol.31
, Issue.2
, pp. 183-193
-
-
Grant, S.F.A.1
Hakonarson, H.2
Schwartz, S.3
-
48
-
-
33746207753
-
Type 1 diabetes: Pathogenesis and prevention
-
Gillespie KM. Type 1 diabetes: Pathogenesis and prevention. CMAJ. 2006;175(2):165-170
-
(2006)
CMAJ
, vol.175
, Issue.2
, pp. 165-170
-
-
Gillespie, K.M.1
-
49
-
-
42449144715
-
Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the Type 1 Diabetes Genetics Consortium families
-
Erlich H, Valdes AM, Noble J, et al; Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the Type 1 Diabetes Genetics Consortium families. Diabetes. 2008;57(4):1084-1092
-
(2008)
Diabetes
, vol.57
, Issue.4
, pp. 1084-1092
-
-
Erlich, H.1
Valdes, A.M.2
Noble, J.3
-
50
-
-
0028957706
-
Effects of the second HLA-DQ haplotype on theassociation with childhood insulindependent diabetes mellitus
-
Sanjeevi CB, Landin-Olsson M, Kockum I, Dahlquist G, Lernmark A. Effects of the second HLA-DQ haplotype on theassociation with childhood insulindependent diabetes mellitus. Tissue Antigens. 1995;45(2):148-152
-
(1995)
Tissue Antigens
, vol.45
, Issue.2
, pp. 148-152
-
-
Sanjeevi, C.B.1
Landin-Olsson, M.2
Kockum, I.3
Dahlquist, G.4
Lernmark, A.5
-
51
-
-
0028989040
-
HLA-DQB1 0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM
-
Pugliese A, Gianani R, Moromisato R, et al. HLA-DQB1 0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes. 1995;44(6):608-613
-
(1995)
Diabetes
, vol.44
, Issue.6
, pp. 608-613
-
-
Pugliese, A.1
Gianani, R.2
Moromisato, R.3
-
52
-
-
0037386030
-
Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age
-
Hathout EH, Hartwick N, Fagoaga OR, et al. Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age. Pediatrics. 2003;111(4 pt 1):860-863
-
(2003)
Pediatrics
, vol.111
, Issue.1 PART 4
, pp. 860-863
-
-
Hathout, E.H.1
Hartwick, N.2
Fagoaga, O.R.3
-
53
-
-
34347341846
-
Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control Consortium. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Todd JA, Walker NM, Cooper JD, et al; Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control Consortium. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet. 2007;39(7): 857-864
-
(2007)
Nat Genet
, vol.39
, Issue.7
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
-
54
-
-
84969213492
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447(7145): 661-678
-
(2007)
Nature
, vol.447
, Issue.7145
, pp. 661-678
-
-
-
55
-
-
63249115398
-
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
-
DCCT/ EDIC Research Group
-
Grant SF, Qu HQ, Bradfield JP, et al DCCT/ EDIC Research Group. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes. 2009;58(1):290-295
-
(2009)
Diabetes
, vol.58
, Issue.1
, pp. 290-295
-
-
Grant, S.F.1
Qu, H.Q.2
Bradfield, J.P.3
-
56
-
-
67349199566
-
Type 1 Diabetes Genetics Consortium. Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P, et al; Type 1 Diabetes Genetics Consortium. Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41(6):703-707
-
(2009)
Nat Genet
, vol.41
, Issue.6
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
-
57
-
-
84870720760
-
What will diabetes genomes tell us?
-
Mohlke KL, Scott LJ. What will diabetes genomes tell us? Curr Diab Rep. 2012;12(6): 643-650
-
(2012)
Curr Diab Rep
, vol.12
, Issue.6
, pp. 643-650
-
-
Mohlke, K.L.1
Scott, L.J.2
-
58
-
-
84867745132
-
What have we learned from six years of GWAS in autoimmune diseases, and what is next?
-
Hu X, Daly M. What have we learned from six years of GWAS in autoimmune diseases, and what is next? Curr Opin Immunol. 2012; 24(5):571-575
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.5
, pp. 571-575
-
-
Hu, X.1
Daly, M.2
-
59
-
-
80053439315
-
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
-
Bradfield JP, Qu HQ, Wang K, et al. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet. 2011;7(9):e1002293
-
(2011)
PLoS Genet
, vol.7
, Issue.9
, pp. 1002293
-
-
Bradfield, J.P.1
Qu, H.Q.2
Wang, K.3
-
60
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009;324 (5925):387-389
-
(2009)
Science
, vol.324
, Issue.5925
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
Egholm, M.4
Todd, J.A.5
-
61
-
-
33745268851
-
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
-
Senée V, Chelala C, Duchatelet S, et al. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet. 2006;38(6):682-687
-
(2006)
Nat Genet
, vol.38
, Issue.6
, pp. 682-687
-
-
Senée, V.1
Chelala, C.2
Duchatelet, S.3
-
62
-
-
61849117976
-
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/ TNFAIP3 as a susceptibility locus
-
Fung EY, Smyth DJ, Howson JM, et al. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/ TNFAIP3 as a susceptibility locus. Genes Immun. 2009;10(2):188-191
-
(2009)
Genes Immun
, vol.10
, Issue.2
, pp. 188-191
-
-
Fung, E.Y.1
Smyth, D.J.2
Howson, J.M.3
-
63
-
-
74249098458
-
Autoimmune disease classification by inverse association with SNP alleles
-
Sirota M, Schaub MA, Batzoglou S, Robinson WH, Butte AJ. Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet. 2009;5(12): E1000792
-
(2009)
PLoS Genet
, vol.5
, Issue.12
, pp. 1000792
-
-
Sirota, M.1
Schaub, M.A.2
Batzoglou, S.3
Robinson, W.H.4
Butte, A.J.5
-
64
-
-
84879419343
-
Pleiotropy in complex traits: Challenges and strategies
-
Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: Challenges and strategies. Nat Rev Genet. 2013;14(7):483-495
-
(2013)
Nat Rev Genet
, vol.14
, Issue.7
, pp. 483-495
-
-
Solovieff, N.1
Cotsapas, C.2
Lee, P.H.3
Purcell, S.M.4
Smoller, J.W.5
-
65
-
-
57749193136
-
Detecting shared pathogenesis from the shared genetics of immune-related diseases
-
Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet. 2009;10(1):43-55
-
(2009)
Nat Rev Genet
, vol.10
, Issue.1
, pp. 43-55
-
-
Zhernakova, A.1
Van Diemen, C.C.2
Wijmenga, C.3
-
66
-
-
84856070217
-
Emerging patterns of genetic overlap across autoimmune disorders
-
Richard-Miceli C, Criswell LA. Emerging patterns of genetic overlap across autoimmune disorders. Genome Med. 2012;4(1):6
-
(2012)
Genome Med
, vol.4
, Issue.1
, pp. 6
-
-
Richard-Miceli, C.1
Criswell, L.A.2
-
67
-
-
77956645141
-
Yorkshire early arthritis consortium biologics in ra control consortium. Overlapping genetic susceptibility variants between three autoimmune disorders: Rheumatoid arthritis, type 1 diabetes and coeliac disease
-
Eyre S, Hinks A, Bowes J, et al Yorkshire Early Arthritis Consortium; Biologics in RA Control Consortium. Overlapping genetic susceptibility variants between three autoimmune disorders: Rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther. 2010;12(5):R175
-
(2010)
Arthritis Res Ther
, vol.12
, Issue.5
, pp. 175
-
-
Eyre, S.1
Hinks, A.2
Bowes, J.3
-
68
-
-
80052325959
-
Pervasive sharing of genetic effects in autoimmune disease
-
FOCiS Network of Consortia
-
Cotsapas C, Voight BF, Rossin E, et al FOCiS Network of Consortia. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet. 2011;7(8):e1002254
-
(2011)
PLoS Genet
, vol.7
, Issue.8
, pp. 1002254
-
-
Cotsapas, C.1
Voight, B.F.2
Rossin, E.3
-
69
-
-
84875432419
-
Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
-
Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol. 2013;13(4):243-256
-
(2013)
Nat Rev Immunol
, vol.13
, Issue.4
, pp. 243-256
-
-
Herold, K.C.1
Vignali, D.A.2
Cooke, A.3
Bluestone, J.A.4
-
70
-
-
77956257716
-
IL- 2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer Y, Baeyens A, You S, et al. IL- 2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010;207(9): 1871-1878
-
(2010)
J Exp Med
, vol.207
, Issue.9
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
Baeyens, A.2
You, S.3
-
71
-
-
79952797194
-
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells
-
Stanford SM, Krishnamurthy D, Falk MD, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011;54(6):1640-1654
-
(2011)
J Med Chem
, vol.54
, Issue.6
, pp. 1640-1654
-
-
Stanford, S.M.1
Krishnamurthy, D.2
Falk, M.D.3
-
72
-
-
84874189972
-
Genotype to phenotype: Lessons from model organisms for human genetics
-
Lehner B. Genotype to phenotype: lessons from model organisms for human genetics. Nat Rev Genet. 2013;14(3):168-178
-
(2013)
Nat Rev Genet
, vol.14
, Issue.3
, pp. 168-178
-
-
Lehner, B.1
-
73
-
-
79957604678
-
Principles for the post-GWAS functional characterization of cancer risk loci
-
Freedman ML, Monteiro AN, Gayther SA, et al. Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet. 2011;43(6):513-518
-
(2011)
Nat Genet
, vol.43
, Issue.6
, pp. 513-518
-
-
Freedman, M.L.1
Monteiro, A.N.2
Gayther, S.A.3
-
74
-
-
84867398818
-
The role of nutrition on epigenetic modifications and their implications on health
-
Jiménez-Chillarón JC, Díaz R, Martínez D, et al. The role of nutrition on epigenetic modifications and their implications on health. Biochimie. 2012;94(11): 2242-2263
-
(2012)
Biochimie
, vol.94
, Issue.11
, pp. 2242-2263
-
-
Jiménez-Chillarón, J.C.1
Díaz, R.2
Martínez, D.3
-
76
-
-
84255178422
-
Type 1 diabetes: Role of intestinal microbiome in humans and mice
-
Boerner BP, Sarvetnick NE. Type 1 diabetes: Role of intestinal microbiome in humans and mice. Ann N Y Acad Sci. 2011;1243:103-118
-
(2011)
Ann N Y Acad Sci
, vol.1243
, pp. 103-118
-
-
Boerner, B.P.1
Sarvetnick, N.E.2
-
77
-
-
72849129001
-
Epigenetics: Deciphering how environmental factors may modify autoimmune type 1 diabetes
-
MacFarlane AJ, Strom A, Scott FW. Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome. 2009;20(9-10): 624-632
-
(2009)
Mamm Genome
, vol.20
, Issue.9-10
, pp. 624-632
-
-
MacFarlane, A.J.1
Strom, A.2
Scott, F.W.3
-
78
-
-
55949123748
-
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats
-
Williams KT, Garrow TA, Schalinske KL. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr. 2008; 138(11):2064-2069
-
(2008)
J Nutr
, vol.138
, Issue.11
, pp. 2064-2069
-
-
Williams, K.T.1
Garrow, T.A.2
Schalinske, K.L.3
-
79
-
-
84860485825
-
Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes
-
Fradin D, Le Fur S, Mille C, et al. Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes. PLoS ONE. 2012;7(5):e36278
-
(2012)
PLoS ONE
, vol.7
, Issue.5
, pp. 36278
-
-
Fradin, D.1
Le Fur, S.2
Mille, C.3
-
80
-
-
84868113134
-
Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes
-
Husseiny MI, Kuroda A, Kaye AN, Nair I, Kandeel F, Ferreri K. Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes. PLoS ONE. 2012;7(10):e47942
-
(2012)
PLoS ONE
, vol.7
, Issue.10
, pp. 47942
-
-
Husseiny, M.I.1
Kuroda, A.2
Kaye, A.N.3
Nair, I.4
Kandeel, F.5
Ferreri, K.6
-
81
-
-
80053457972
-
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis
-
Rakyan VK, Beyan H, Down TA, et al. Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet. 2011;7(9):e1002300
-
(2011)
PLoS Genet
, vol.7
, Issue.9
, pp. 1002300
-
-
Rakyan, V.K.1
Beyan, H.2
Down, T.A.3
-
82
-
-
84872533627
-
RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond
-
Castel SE, Martienssen RA. RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet. 2013;14(2):100-112
-
(2013)
Nat Rev Genet
, vol.14
, Issue.2
, pp. 100-112
-
-
Castel, S.E.1
Martienssen, R.A.2
-
83
-
-
84865581182
-
Emerging roles of noncoding RNAs in pancreatic b-cell function and dysfunction
-
Guay C, Jacovetti C, Nesca V, Motterle A, Tugay K, Regazzi R. Emerging roles of noncoding RNAs in pancreatic b-cell function and dysfunction. Diabetes Obes Metab. 2012;14(suppl 3):12-21
-
(2012)
Diabetes Obes Metab
, vol.14
, Issue.SUPPL.3
, pp. 12-21
-
-
Guay, C.1
Jacovetti, C.2
Nesca, V.3
Motterle, A.4
Tugay, K.5
Regazzi, R.6
-
84
-
-
84872746026
-
Circulating miR-375 as a biomarker of b-cell death and diabetes in mice
-
Erener S, Mojibian M, Fox JK, Denroche HC, Kieffer TJ. Circulating miR-375 as a biomarker of b-cell death and diabetes in mice. Endocrinology. 2013;154(2):603-608
-
(2013)
Endocrinology
, vol.154
, Issue.2
, pp. 603-608
-
-
Erener, S.1
Mojibian, M.2
Fox, J.K.3
Denroche, H.C.4
Kieffer, T.J.5
-
85
-
-
84864981566
-
Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: Evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression
-
Nielsen LB, Wang C, Sørensen K, et al. Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: Evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression. Exp Diabetes Res. 2012;2012:896362
-
(2012)
Exp Diabetes Res
, vol.2012
, pp. 896362
-
-
Nielsen, L.B.1
Wang, C.2
Sørensen, K.3
-
86
-
-
80855124151
-
Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity
-
Sebastiani G, Grieco FA, Spagnuolo I, Galleri L, Cataldo D, Dotta F. Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity. Diabetes Metab Res Rev. 2011;27(8):862-866
-
(2011)
Diabetes Metab Res Rev
, vol.27
, Issue.8
, pp. 862-866
-
-
Sebastiani, G.1
Grieco, F.A.2
Spagnuolo, I.3
Galleri, L.4
Cataldo, D.5
Dotta, F.6
-
87
-
-
71349083569
-
MicroRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients
-
Hezova R, Slaby O, Faltejskova P, et al. microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol. 2010;260(2):70-74
-
(2010)
Cell Immunol
, vol.260
, Issue.2
, pp. 70-74
-
-
Hezova, R.1
Slaby, O.2
Faltejskova, P.3
-
88
-
-
33645395980
-
In vivo RNA interference demonstrates a role for Nramp1 inmodifying susceptibility to type 1 diabetes
-
Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS. In vivo RNA interference demonstrates a role for Nramp1 inmodifying susceptibility to type 1 diabetes. Nat Genet. 2006;38(4):479-483
-
(2006)
Nat Genet
, vol.38
, Issue.4
, pp. 479-483
-
-
Kissler, S.1
Stern, P.2
Takahashi, K.3
Hunter, K.4
Peterson, L.B.5
Wicker, L.S.6
-
89
-
-
58149345088
-
Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: An epigenetic study in diabetes
-
Miao F, Smith DD, Zhang L, Min A, Feng W, Natarajan R. Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: An epigenetic study in diabetes. Diabetes. 2008;57(12):3189-3198
-
(2008)
Diabetes
, vol.57
, Issue.12
, pp. 3189-3198
-
-
Miao, F.1
Smith, D.D.2
Zhang, L.3
Min, A.4
Feng, W.5
Natarajan, R.6
-
90
-
-
84860849822
-
Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes
-
Miao F, Chen Z, Zhang L, et al. Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes. J Biol Chem. 2012;287(20):16335-16345
-
(2012)
J Biol Chem
, vol.287
, Issue.20
, pp. 16335-16345
-
-
Miao, F.1
Chen, Z.2
Zhang, L.3
|