Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy

Journal of Cellular Physiology

Volumn 231, Issue 8, 2016, Pages 1709-1718

  Mishra, Manish ^a   Flaga, Jadwiga ^a   Kowluru, Renu A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; GLUCOSE; PROTEIN C FOS; PROTEIN C JUN; SIRTUIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; GLUCOSE BLOOD LEVEL; MMP9 PROTEIN, HUMAN; MMP9 PROTEIN, MOUSE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA BLOOD VESSEL; TRANSCRIPTION INITIATION; ACETYLATION; ANIMAL; BINDING SITE; BLOOD; BOVINE; C57BL MOUSE; CELL CULTURE; COMPLICATION; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; PATHOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE;

ACETYLATION; AGED; ANIMALS; APOPTOSIS; BINDING SITES; BLOOD GLUCOSE; CATTLE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MATRIX METALLOPROTEINASE 9; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RETINAL VESSELS; RNA INTERFERENCE; SIRTUIN 1; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84952683674     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25268     Document Type: Article

References (39)

1. Bar-Shai M, Hasnis E, Wiener-Megnazi Z, Reznick AZ. 2006. The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes. J Physiol Pharmacol 57:39-44.
2. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. 2003. Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem 253:285-303.
3. Chinenov Y, Kerppola TK. 2001. Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 20:2438-2452.
4. Eferl R, Wagner EF. 2003. AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer 3:859-868.
5. Farina AR, Mackay AR. 2014. Gelatinase B/MMP-9 in tumour pathogenesis and progression. Cancers (Basel) 6:240-296.
6. Frank RN. 2004. Diabetic Retinopathy. N Engl J Med 350:48-58.
7. Gao Z, Ye J. 2008. Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun 376:793-796.
8. Hess J, Angel P, Schorpp-Kistner M. 2004. AP-1 subunits: Quarrel and harmony among siblings. J Cell Sci 117:5965-5973.
9. Kanwar M, Chan PS, Kern TS, Kowluru RA. 2007. Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48:3805-3811.
10. Kanwar M, Kowluru R. 2009. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes 58:227-234.
11. Kanwar M, Kowluru RA. 2008. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy. Microvasc Res 76:189-193.
12. Kern TS, Tang J, Mizutani M, Kowluru R, Nagraj R, Lorenzi M. 2000. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci 41:3972-3978.
13. Kowluru RA. 2010. Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras. Invest Ophthalmol Vis Sci 51:4320-4326.
14. Kowluru RA, Abbas SN. 2003. Diabetes-induced mitochondrial dysfunction in the retina. Invest Ophthalmol Vis Sci 44:5327-5334.
15. Kowluru RA, Kanwar M. 2009. Oxidative stress and the development of diabetic retinopathy: Contributory role of matrix metalloproteinase-2. Free Radic Biol Med 46:1677-1685.
16. Kowluru RA, Mohammad G, dos Santos JM, Zhong Q. 2011. Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage. Diabetes 60:3023-3033.
17. Kowluru RA, Santos JM, Zhong Q. 2014. Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol Vis Sci 55:5653-5660.
18. Luo J, Li M, Tang Y, Laszkowska M, Roeder RG, Gu W. 2004. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 101:2259-2264.
19. Ma Z, Shah R, Chang M, Benveniste E. 2004. Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription. Mol Cell Biol 24:5496-5509.
20. Macian F, Lopez-Rodriguez C, Rao A. 2001. Partners in transcription: NFAT and AP-1. Oncogene 20:2476-2489.
21. Mishra M, Kowluru RA. 2014. Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia. Invest Ophthalmol Vis Sci 55:6960-6967.
22. Mishra M, Kowluru RA. 2015. Epigenetic modification of mitochondrial DNA in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 56:5133-5142.
23. Mishra M, Zhong Q, Kowluru RA. 2014. Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: Implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. Free Radic Biol Med 75C:129-139.
24. Mizutani M, Kern TS, Lorenzi M. 1996. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 97:2883-2890.
25. Mohammad G, Kowluru RA. 2010. Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction. Lab Invest 90:1365-1372.
26. Mohan R, Rinehart WB, Bargagna-Mohan P, Fini ME. 1998. Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling. J Biol Chem 273:25903-25914.
27. Ozanne BW, Spence HJ, McGarry LC, Hennigan RF. 2007. Transcription factors control invasion: AP-1 the first among equals. Oncogene 26:1-10.
28. Robert I, Aussems M, Keutgens A, Zhang X, Hennuy B, Viatour P, Vanstraelen G, Merville MP, Chapelle JP, de Leval L, Lambert F, Dejardin E, Gothot A, Chariot A. 2009. Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. Oncogene 28:1626-1628.
29. Santos JM, Kowluru RA. 2013. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab Res Rev 29:204-213.
30. Santos JM, Tewari S, Lin JY, Kowluru RA. 2013. Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy. Biochem Biophys Res Commun 438:760-764.
31. Shaulian E, Karin M. 2002. AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131-E136.
32. Tewari S, Santos JM, Kowluru RA. 2012. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antioxid Redox Signal 17:492-504.
33. Vries RG, Prudenziati M, Zwartjes C, Verlaan M, Kalkhoven E, Zantema A. 2001. A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300. EMBO J 20:6095-6103.
34. Xie J, Zhang X, Zhang L. 2013. Negative regulation of inflammation by SIRT1. Pharmacol Res 67:60-67.
35. Ye X, Xu G, Chang Q, Fan J, Sun Z, Qin Y, Jiang AC. 2010. ERK1/2 signaling pathways involved in VEGF release in diabetic rat retina. Invest Ophthalmol Vis Sci 51:5226-5233.
36. Zhang D, Suganuma T, Workman JL. 2013. Acetylation regulates Jun protein turnover in drosophila. Biochim Biophys Acta 1829:1218-1224.
37. Zhang R, Chen HZ, Liu JJ, Jia YY, Zhang ZQ, Yang RF, Zhang Y, Xu J, Wei YS, Liu DP, Liang CC. 2010. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem 285:7097-7110.
38. Zhong Q, Kowluru RA. 2013. Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes 62:2559-2568.
39. Zhong Q, Mishra M, Kowluru RA. 2013. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 54:3941-3948.