Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: Implications in diabetic retinopathy and metabolic memory phenomenon

Experimental Eye Research

Volumn 121, Issue , 2014, Pages 168-177

  Santos, Julia M ^a   Mishra, Manish ^a   Kowluru, Renu A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Diabetic retinopathy; Mitochondria; Mitochondrial transcription factor A; MtDNA; Posttranslational modifications; Ubiquitination

Indexed keywords

CHAPERONE; CYTOCHROME B; GLUCOSE; HEAT SHOCK PROTEIN 70; INSULIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTEIN INHIBITOR; PYR 41; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE SUBUNIT 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA TRANSCRIPTION; ENDOTHELIUM CELL; EXPERIMENTAL RETINOPATHY; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HISTOPATHOLOGY; HYPERGLYCEMIA; KETOACIDOSIS; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN PROCESSING; RAT; RETINA CELL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRANSCRIPTION INITIATION; UBIQUITINATION; WEIGHT REDUCTION; WESTERN BLOTTING;

DIABETIC RETINOPATHY; MITOCHONDRIA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MTDNA; POSTTRANSLATIONAL MODIFICATIONS; UBIQUITINATION;

ANIMALS; BENZOATES; CATTLE; CELLS, CULTURED; CYTOCHROMES B; DIABETIC RETINOPATHY; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; FURANS; GLUCOSE; HSP70 HEAT-SHOCK PROTEINS; MALE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL TURNOVER; NADH DEHYDROGENASE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRAZOLES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL VESSELS; RNA, MESSENGER; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84896304013     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.02.010     Document Type: Article

References (47)

1. Antelman J., Manandhar G., et al. Expression of mitochondrial transcription factor A (TFAM) during porcine gametogenesis and preimplantation embryo development. J.Cell. Physiol. 2008, 217:529-543.
2. Atalay M., Oksala N., et al. Heat shock proteins in diabetes and wound healing. Curr. Protein Pept. Sci. 2009, 10:85-95.
3. Bergink S., Jentsch S. Principles of ubiquitin and SUMO modifications in DNA repair. Nature 2009, 458(7237):461-467.
4. The effect of intensive treatment of diabetes on the development of long-term complications in insulin-dependent diabetes mellitus. N.Engl. J. Med. 1993, 329:977-986. Diabetes Control and Complications Trial Research Group.
5. Early worsening of diabetic retinopathy in the diabetes control and complication trial. Arch. Ophthalmol. 1998, 116:874-886. Diabetes Control and Complications Trial Research Group.
6. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N.Engl. J. Med. 2000, 342:381-389. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group.
7. Engerman R.L., Kern T.S. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes 1987, 36:808-812.
8. Frank R.N. Diabetic retinopathy. N.Engl. J. Med. 2004, 350:48-58.
9. Gao C., Chen G., et al. Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells. J.Diabetes Res. 2013, 2013. 589474.
10. Goldberg H.J., Whiteside C.I., et al. Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology 2006, 147:222-231.
11. Guan H., Ricciardi R.P. Transformation by E1A oncoprotein involves ubiquitin-mediated proteolysis of the neuronal and tumor repressor REST in the nucleus. J.Virol. 2012, 86:5594-5602.
12. Harcourt B.E., Penfold S.A., et al. Coming full circle in diabetes mellitus: from complications to initiation. Nat. Rev. Endocrinol. 2013, 9(2):113-123.
13. Kanwar M., Chan P.S., et al. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Investig. Ophthalmol. Vis. Sci. 2007, 48:3805-3811.
14. Kanwar M., Kowluru R. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes 2009, 58:227-234.
15. Kern T.S., Tang J., et al. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Investig. Ophthalmol. Vis. Sci. 2000, 41:3972-3978.
16. Komander D. The emerging complexity of protein ubiquitination. Biochem. Soc. Trans. 2009, 37:937-953.
17. Kowluru R.A. Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 2003, 52:818-823.
18. Kowluru R.A., Abbas S.N. Diabetes-induced mitochondrial dysfunction in the retina. Investig. Ophthalmol. Vis. Sci. 2003, 44:5327-5334.
19. Kowluru R.A., Mohammad G., et al. Abrogation of MMP9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage. Diabetes 2011, 60:3023-3033.
20. Lu B., Lee J., et al. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Mol. Cell 2013, 49:121-132.
21. Madsen-Bouterse S., Mohammad G., et al. Glyceraldehyde 3 phosphate dehydrogenase in retinal microvasculature: implications for the development and progression of diabetic retinopathy. Investig. Ophthalmol. Vis. Sci. 2010, 51:1765-1772.
22. Madsen-Bouterse S., Zhong Q., et al. Oxidative damage of mitochondrial DNA in diabetes, and its protection by manganese superoxide dismutase. Free Radic. Res. 2010, 44:313-321.
23. Madsen-Bouterse S.A., Mohammad G., et al. Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression. Antioxid. Redox Signal. 2010, 13:797-805.
24. Malarkey C.S., Bestwick M., et al. Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA. Nucleic Acids Res. 2012, 40:614-624.
25. Neutzner A., Benard G., et al. Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Ann. N. Y. Acad. Sci. 2008, 1147:242-253.
26. Ohgaki K., Kanki T., et al. The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA. J.Biochem. 2007, 141:201-211.
27. Piantadosi C.A., Suliman H.B. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J.Biol. Chem. 2006, 281:324-333.
28. Reddy M.A., Natarajan R. Epigenetic mechanisms in diabetic vascular complications. Cardiovasc. Res. 2011, 90:421-429.
29. Rosenbaum J.C., Fredrickson E.K., et al. Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol. Cell 2011, 41:93-106.
30. Santos J.M., Kowluru R.A. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy. Investig. Ophthalmol. Vis. Sci. 2011, 52:8791-8798.
31. Santos J.M., Kowluru R.A. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab. Res. Rev. 2013, 29:204-213.
32. Santos J.M., Mohammad G., et al. Diabetic retinopathy, superoxide damage and antioxidant. Curr. Pharm. Biotechnol. 2011, 12:352-361.
33. Santos J.M., Tewari S., et al. Mitochondria biogenesis and the development of diabetic retinopathy. Free Radic. Biol. Med. 2011, 51:1849-1860.
34. Santos J.M., Tewari S., et al. Acompensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy. Free Radic. Biol. Med. 2012, 53:1729-1737.
35. Santos J.M., Tewari S., et al. Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy. Biochem. Biophys. Res. Commun. 2013, 438:760-764.
36. Scarpulla R.C. Nuclear control of respiratory gene expression in mammalian cells. J.Cell. Biochem. 2006, 97:673-683.
37. Scarpulla R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 2008, 88:611-638.
38. Schmidt O., Pfanner N., et al. Mitochondrial protein import: from proteomics to functional mechanisms. Nat. Rev. Mol. Cell Biol. 2010, 11:655-667.
39. Song R., Peng W., et al. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature 2013, 494:375-379.
40. Suarez J., Hu Y., et al. Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes. Am. J. Physiol. Cell Physiol. 2008, 296:C1561-C1568.
41. Takada A., Miki T., et al. Role of ER stress in ventricular contractile dysfunction in type 2 diabetes. PLoS One 2012, 7:e39893.
42. Tewari S., Santos J.M., et al. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antioxid. Redox Signal. 2012, 17:492-504.
43. Tewari S., Zhong Q., et al. Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy. Investig. Ophthalmol. Vis. Sci. 2012, 53:4881-4888.
44. Zhong Q., Kowluru R.A. Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Investig. Ophthalmol. Vis. Sci. 2011, 52:8739-8746.
45. Zhong Q., Kowluru R.A. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes 2011, 60:1304-1313.
46. Zhong Q., Kowluru R.A. Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. Investig. Ophthalmol. Vis. Sci. 2013, 54:244-250.
47. Zhong Q., Kowluru R.A. Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes 2013, 62:2559-2568.