Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1032, Issue , 2016, Pages 119-130

  Sandra, Koen ^a   Vanhoenacker, Gerd ^a   Vandenheede, Isabel ^a   Steenbeke, Mieke ^a   Joseph, Maureen ^b   Sandra, Pat ^a  

^a Research Institute for Chromatography   (Belgium)

^b AGILENT TECHNOLOGIES   (United States)

Author keywords

Ado trastuzumab emtansine; Antibody drug conjugate; Comprehensive; Multiple heart cutting; Two dimensional liquid chromatography

Indexed keywords

AMINO ACIDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES;

ANTIBODY-DRUG CONJUGATES; COMPREHENSIVE; HEART-CUTTING; TRASTUZUMAB; TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY;

LIQUID CHROMATOGRAPHY;

LYSINE; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; MAYTANSINE; MONOCLONAL ANTIBODY;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; MASS SPECTROMETRY; MEASUREMENT; PEPTIDE ANALYSIS; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; HUMAN; LIQUID CHROMATOGRAPHY; PROCEDURES; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; EQUIPMENT DESIGN; HUMANS; IMMUNOCONJUGATES; LYSINE; MAYTANSINE; TANDEM MASS SPECTROMETRY;

EID: 84965014487     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2016.04.040     Document Type: Article

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