Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

Proteomics

Volumn 15, Issue 16, 2015, Pages 2756-2765

  Gautier, Violette ^a,b   Boumeester, Anja J ^a,b   Lössl, Philip ^a,b   Heck, Albert J R ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antibody drug conjugates; Covalent chemical labeling; IgGs; Lysine conjugation; Native mass spectrometry; Technology

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; LYSINE; N HYDROXYSUCCINIMIDE; ANTIBODY CONJUGATE;

ARTICLE; CHEMICAL LABELING; CONJUGATION; CRYSTAL STRUCTURE; GLYCOSYLATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; INTEGRATING HIGH RESOLUTION NATIVE MASS SPECTROMETRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMICS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; MOLECULAR GENETICS; PROCEDURES;

AMINO ACID SEQUENCE; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; LYSINE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEOMICS;

EID: 84938750181     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201400462     Document Type: Article

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