메뉴 건너뛰기




Volumn 17, Issue 3, 2013, Pages 406-411

Analytical and bioanalytical technologies for characterizing antibody-drug conjugates

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; AURISTATIN; CALICHEAMICIN; DRUG ANTIBODY; MAYTANSINE; UNCLASSIFIED DRUG;

EID: 84878857691     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2013.03.022     Document Type: Review
Times cited : (44)

References (31)
  • 1
    • 77955312203 scopus 로고    scopus 로고
    • Antibody-drug conjugates: targeted drug delivery for cancer
    • Alley S.C., Okeley N.M., Senter P.D. Antibody-drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol 2010, 14:529-537.
    • (2010) Curr Opin Chem Biol , vol.14 , pp. 529-537
    • Alley, S.C.1    Okeley, N.M.2    Senter, P.D.3
  • 2
    • 38949192547 scopus 로고    scopus 로고
    • Targeted cancer therapy: conferring specificity to cytotoxic drugs
    • Chari R.V. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res 2008, 41:98-107.
    • (2008) Acc Chem Res , vol.41 , pp. 98-107
    • Chari, R.V.1
  • 6
    • 72449121780 scopus 로고    scopus 로고
    • Molecularly defined antibody conjugation through a selenocysteine interface
    • Hofer T., Skeffington L.R., Chapman C.M., Rader C. Molecularly defined antibody conjugation through a selenocysteine interface. Biochemistry 2009, 48:12047-12057.
    • (2009) Biochemistry , vol.48 , pp. 12047-12057
    • Hofer, T.1    Skeffington, L.R.2    Chapman, C.M.3    Rader, C.4
  • 7
    • 79952718320 scopus 로고    scopus 로고
    • Analytical methods for physicochemical characterization of antibody drug conjugates
    • Wakankar A., Chen Y., Gokarn Y., Jacobson F.S. Analytical methods for physicochemical characterization of antibody drug conjugates. MAbs 2011, 3:161-172.
    • (2011) MAbs , vol.3 , pp. 161-172
    • Wakankar, A.1    Chen, Y.2    Gokarn, Y.3    Jacobson, F.S.4
  • 10
    • 77957590621 scopus 로고    scopus 로고
    • Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer
    • Junutula J.R., Flagella K.M., Graham R.A., Parsons K.L., Ha E., Raab H., Bhakta S., Nguyen T., Dugger D.L., Li G., et al. Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. Clin Cancer Res 2010, 16:4769-4778.
    • (2010) Clin Cancer Res , vol.16 , pp. 4769-4778
    • Junutula, J.R.1    Flagella, K.M.2    Graham, R.A.3    Parsons, K.L.4    Ha, E.5    Raab, H.6    Bhakta, S.7    Nguyen, T.8    Dugger, D.L.9    Li, G.10
  • 11
    • 21244469077 scopus 로고    scopus 로고
    • Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry
    • Lazar A.C., Wang L., Blattler W.A., Amphlett G., Lambert J.M., Zhang W. Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry. Rapid Commun Mass Spectrom 2005, 19:1806-1814.
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 1806-1814
    • Lazar, A.C.1    Wang, L.2    Blattler, W.A.3    Amphlett, G.4    Lambert, J.M.5    Zhang, W.6
  • 12
    • 24344456964 scopus 로고    scopus 로고
    • Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
    • Wang L., Amphlett G., Blattler W.A., Lambert J.M., Zhang W. Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry. Protein Sci 2005, 14:2436-2446.
    • (2005) Protein Sci , vol.14 , pp. 2436-2446
    • Wang, L.1    Amphlett, G.2    Blattler, W.A.3    Lambert, J.M.4    Zhang, W.5
  • 14
    • 79952450423 scopus 로고    scopus 로고
    • Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry
    • Xu K., Liu L., Saad O.M., Baudys J., Williams L., Leipold D., Shen B., Raab H., Junutula J.R., Kim A., et al. Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry. Anal Biochem 2011, 412:56-66.
    • (2011) Anal Biochem , vol.412 , pp. 56-66
    • Xu, K.1    Liu, L.2    Saad, O.M.3    Baudys, J.4    Williams, L.5    Leipold, D.6    Shen, B.7    Raab, H.8    Junutula, J.R.9    Kim, A.10
  • 15
    • 84858727362 scopus 로고    scopus 로고
    • Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues
    • Valliere-Douglass J.F., McFee W.A., Salas-Solano O. Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues. Anal Chem 2012, 84:2843-2849.
    • (2012) Anal Chem , vol.84 , pp. 2843-2849
    • Valliere-Douglass, J.F.1    McFee, W.A.2    Salas-Solano, O.3
  • 17
  • 20
    • 84865706368 scopus 로고    scopus 로고
    • Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism
    • Shen B.Q., Bumbaca D., Saad O., Yue Q., Pastuskovas C.V., Khojasteh S.C., Tibbitts J., Kaur S., Wang B., Chu Y.W., et al. Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism. Curr Drug Metab 2012, 13:901-910.
    • (2012) Curr Drug Metab , vol.13 , pp. 901-910
    • Shen, B.Q.1    Bumbaca, D.2    Saad, O.3    Yue, Q.4    Pastuskovas, C.V.5    Khojasteh, S.C.6    Tibbitts, J.7    Kaur, S.8    Wang, B.9    Chu, Y.W.10
  • 22
    • 84872957381 scopus 로고    scopus 로고
    • Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics
    • Kaur S., Xu K., Saad O.M., Dere R.C., Carrasco-Triguero M. Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics. Bioanalysis 2013, 5:201-226.
    • (2013) Bioanalysis , vol.5 , pp. 201-226
    • Kaur, S.1    Xu, K.2    Saad, O.M.3    Dere, R.C.4    Carrasco-Triguero, M.5
  • 23
    • 79953149070 scopus 로고    scopus 로고
    • Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates
    • Stephan J.P., Kozak K.R., Wong W.L.T. Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates. Bioanalysis 2011, 3:677-700.
    • (2011) Bioanalysis , vol.3 , pp. 677-700
    • Stephan, J.P.1    Kozak, K.R.2    Wong, W.L.T.3
  • 25
    • 0037440038 scopus 로고    scopus 로고
    • Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study
    • Tolcher A.W., Ochoa L., Hammond L.A., Patnaik A., Edwards T., Takimoto C., Smith L., de Bono J., Schwartz G., Mays T., et al. Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol 2003, 21:211-222.
    • (2003) J Clin Oncol , vol.21 , pp. 211-222
    • Tolcher, A.W.1    Ochoa, L.2    Hammond, L.A.3    Patnaik, A.4    Edwards, T.5    Takimoto, C.6    Smith, L.7    de Bono, J.8    Schwartz, G.9    Mays, T.10
  • 26
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris H.A., Rugo H.S., Vukelja S.J., Vogel C.L., Borson R.A., Limentani S., Tan-Chiu E., Krop I.E., Michaelson R.A., Girish S., et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011, 29:398-405.
    • (2011) J Clin Oncol , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3    Vogel, C.L.4    Borson, R.A.5    Limentani, S.6    Tan-Chiu, E.7    Krop, I.E.8    Michaelson, R.A.9    Girish, S.10
  • 28
    • 84864544136 scopus 로고    scopus 로고
    • Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma
    • Younes A., Kim S., Romaguera J., Copeland A., Farial S.D.C., Kwak L.W., Fayad L., Hagemeister F., Fanale M., Neelapu S., et al. Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma. J Clin Oncol 2012, 30:2776-2782.
    • (2012) J Clin Oncol , vol.30 , pp. 2776-2782
    • Younes, A.1    Kim, S.2    Romaguera, J.3    Copeland, A.4    Farial, S.D.C.5    Kwak, L.W.6    Fayad, L.7    Hagemeister, F.8    Fanale, M.9    Neelapu, S.10
  • 29
    • 84867571080 scopus 로고    scopus 로고
    • A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer
    • Bender B.C., Schaedeli-Stark F., Koch R., Joshi A., Chu Y.W., Rugo H., Krop I.E., Girish S., Friberg L.E., Gupta M. A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer. Cancer Chemother Pharmacol 2012, 70:591-601.
    • (2012) Cancer Chemother Pharmacol , vol.70 , pp. 591-601
    • Bender, B.C.1    Schaedeli-Stark, F.2    Koch, R.3    Joshi, A.4    Chu, Y.W.5    Rugo, H.6    Krop, I.E.7    Girish, S.8    Friberg, L.E.9    Gupta, M.10
  • 30
    • 84860307997 scopus 로고    scopus 로고
    • Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer
    • Gupta M., Lorusso P.M., Wang B., Yi J.H., Burris H.A., Beeram M., Modi S., Chu Y.W., Agresta S., Klencke B., et al. Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer. J Clin Pharmacol 2012, 52:691-703.
    • (2012) J Clin Pharmacol , vol.52 , pp. 691-703
    • Gupta, M.1    Lorusso, P.M.2    Wang, B.3    Yi, J.H.4    Burris, H.A.5    Beeram, M.6    Modi, S.7    Chu, Y.W.8    Agresta, S.9    Klencke, B.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.