Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC-MS analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 981-982, Issue , 2015, Pages 9-13

  Janin Bussat, Marie Claire ^a   Dillenbourg, Marina ^a   Corvaia, Nathalie ^a   Beck, Alain ^a   Klinguer Hamour, Christine ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Antibody drug conjugates; Brentuximab vedotin; Drug loaded peptide mapping; IdeS; Liquid chromatography mass spectrometry; Payload positional isomers

Indexed keywords

AMINO ACIDS; CHROMATOGRAPHY; HYDROPHOBICITY; ISOMERS; LIQUID CHROMATOGRAPHY; MAPPING; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PEPTIDES; TOXICITY;

ANTIBODY-DRUG CONJUGATES; BRENTUXIMAB VEDOTIN; IDES; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; PEPTIDE MAPPING; POSITIONAL ISOMERS;

ANTIBODIES;

BRENTUXIMAB VEDOTIN; CYSTEINE; DISULFIDE; PEPTIDE DERIVATIVE; ANTIBODY CONJUGATE; PEPTIDE FRAGMENT;

ALKYLATION; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DENATURATION; DISSOCIATION; DISULFIDE BOND; DRUG CONJUGATION; ELECTRON TRANSPORT; HYDROPHOBICITY; ISOMER; MASS SPECTROMETRY; PEPTIDE MAPPING; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; PROCEDURES;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; IMMUNOCONJUGATES; ISOMERISM; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; PEPTIDE MAPPING;

EID: 84921033525     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.12.017     Document Type: Article

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