High-throughput sequencing reveals restricted TCR Vβ usage and public TCRβ clonotypes among pancreatic lymph node memory CD4+ T cells and their involvement in autoimmune diabetes

Molecular Immunology

Volumn 74, Issue , 2016, Pages 82-95

  Marrero, Idania ^a,b   Aguilera, Carlos ^a,e   Hamm, David E ^c   Quinn, Anthony ^d   Kumar, Vipin ^a,b  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ADAPTIVE BIOTECHNOLOGIES   (United States)

^d UNIVERSITY OF TOLEDO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune diabetes; CDR3 sequences; Memory CD4; NOD; Public clonotypes; TCR

Indexed keywords

CD4 ANTIGEN; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREATIC LYMPH NODE; PRIORITY JOURNAL; ANIMAL; CELL SEPARATION; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPH NODE; NONOBESE DIABETIC MOUSE; PANCREAS; POLYMERASE CHAIN REACTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; DIABETES MELLITUS, TYPE 1; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; IMMUNOLOGIC MEMORY; LYMPH NODES; MICE; MICE, INBRED NOD; PANCREAS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 84964987484     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2016.04.013     Document Type: Article

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