A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes

International Immunology

Volumn 11, Issue 6, 1999, Pages 951-956

  Tikochinski, Yaron ^a   Elias, Dana ^b   Steeg, Christiana ^b   Marcus, Hadar ^b   Kantorowitz, Michael ^a   Reshef, Tamara ^b   Ablamunits, Vitaly ^b   Cohen, Irun R ^b   Friedmann, Adam ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

CDR3; Insulin dependent diabetes mellitus; TCR

Indexed keywords

CD4 ANTIGEN; EPITOPE; HEAT SHOCK PROTEIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BETA CHAIN; CELL CLONE; CONTROLLED STUDY; DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SPLEEN; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; CELL LINE; DIABETES MELLITUS, TYPE 1; FEMALE; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; MALE; MICE; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPLEEN;

EID: 0033035367     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.6.951     Document Type: Article

References (19)

1. Kikutani, H. and Makino, S. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51:285.
2. Elias, D., Reshef, T., Birk, O. S., van der Zee, R., Walker, M. D. and Cohen, I. R. 1991. Vaccination against autoimmune mouse diabetes with a T cell epitope of human 65-kDa heat shock protein. Proc. Natl Acad. Sci. USA 88:3088.
3. Elias, D. and Cohen, I. R. 1994. Peptide therapy for diabetes in NOD mice. Lancet 343:704.
4. h2 cytokine burst and down regulates autoimmunity to various β cell antigens. Diabetes 46:758.
5. Elias, D., Marcus, H., Reshef, T., Ablamunits, V. and Cohen, I. R. 1995. Induction of diabetes in standard mice by immunization to the p277 peptide of hsp60. Eur. J. Immunol. 25:2851.
6. Lider, O., Reshef, T., Beraud, E., Ben-Nun, A. and Cohen, I. R. 1988. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 239:181.
7. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.
8. Gotoh, M., Maki, T., Satomi., S., Porter, J., Bonner-Weir, S., O'Hara, C. J. and Monaco, A. P. 1987. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase digestion. Transplantation 43:725.
9. Schäfer, R., Zischler, H., Birsner, U., Becker, A. and Epplen, J. T. 1988. Optimizing oligonucleotide probes for DNA fingerprinting. Electrophoresis 9:369.
10. Casanova, J.-L., Pannetier, C., Jaulin, C. and Kourilsky, P. 1990. Optimal conditions for directly sequencing double-stranded PCR products with Sequenase. Nucleic Acids Res. 18:4028.
11. Acha-Orbea, H., Mitchell, D. J., Timmermann, L., Wraith, D. C., Tausch, G. S., Waldor, M. K., Zamvil, S. S., McDevitt, H. O. and Steinman, L. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
12. δ region. Genomics 13:1209.
13. Sherman, D. H., Hochman, P. S., Dick, R., Tizard, R., Ramachandran, K. L., Flavell, R. A. and Huber, B. T. 1987. Molecular analysis of antigen recognition by insulin-specific T cell hybridomas from B6 wild-type and bm12 mutant mice. Mol. Cell Biol. 7:1865.
14. Nakano, N., Kikutani, H., Nishimoto, H. and Kishimoto, T. 1991. T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice. J Exp. Med. 173:1091.
15. Duranovic-Bello, I., A. Steinle, A. G. Ziegler, and D. J. Schendel. 1994. HLA-DQ-restricted, iselt-specific T cell clones of a type I diabetic patient. T cell receptor sequence similarities to insulitis-inducing T cells of nonobese diabetic mice. Diabetes 43:1318.
16. Epplen, J. Chluba, T., Hardt, J., Hinkkanen, C., Steimel, A. and Stockinger, H. 1987. Mammalian T-lymphocyte antigen receptor genes: genetic and nongenetic potential to generate variability. Hum. Genet. 75:300.
17. Mori, L., Riccardi-Castagnoli, P. and Steinmetz, M. 1988. A mouse T lymphoma that lacks T cell receptor surface expression exhibits allelic exclusion of its beta chain genes. Immunogenetics 28:136.
18. Elias, D., Tikochinski, Y., Frankel, G. and Cohen, I. R. 1999. Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide. Int. Immunol. 11:957.
19. Cohen, I. R. 1992. The cognitive paradigm and the immunological homunculus. Immunol. Today 13:490.