메뉴 건너뛰기




Volumn 40, Issue 7, 2010, Pages 1906-1915

CD8α+ dendritic cells prime TCR-peptide-reactive regulatory CD4+FOXP3- T cells

Author keywords

Antigen presentation processing; DC; EAE MS; TCR; Tolerance suppression anergy

Indexed keywords

CD8ALPHA ANTIGEN; TRANSCRIPTION FACTOR FOXP3; CD4 ANTIGEN; CD8 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MYELIN BASIC PROTEIN; PEPTIDE FRAGMENT; T CELL RECEPTOR VBETA8; T LYMPHOCYTE RECEPTOR;

EID: 77954129089     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939608     Document Type: Article
Times cited : (9)

References (47)
  • 1
    • 36249024247 scopus 로고    scopus 로고
    • Regulatory T cells - A brief history and perspective
    • Sakaguchi, S.,Wing, K. and Miyara, M., Regulatory T cells - a brief history and perspective. Eur. J. Immunol. 2007. 37: S116-S123.
    • (2007) Eur. J. Immunol. , vol.37
    • Sakaguchi, S.1    Wing, K.2    Miyara, M.3
  • 2
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity*
    • Shevach, E. M., Regulatory T cells in autoimmmunity*. Annu. Rev. Immunol. 2000. 18: 423-449.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 3
    • 85047690619 scopus 로고    scopus 로고
    • Homeostatic control of immunity by TCR peptide-specific Tregs
    • Kumar, V., Homeostatic control of immunity by TCR peptide-specific Tregs. J. Clin. Invest. 2004. 114: 1222-1226.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1222-1226
    • Kumar, V.1
  • 4
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • Godfrey, D. I. and Kronenberg, M., Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 2004. 114: 1379-1388.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 5
    • 58149268419 scopus 로고    scopus 로고
    • Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens
    • Arrenberg, P., Halder, R. and Kumar, V., Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens. J. Cell Physiol. 2009. 218: 246-250.
    • (2009) J. Cell Physiol. , vol.218 , pp. 246-250
    • Arrenberg, P.1    Halder, R.2    Kumar, V.3
  • 6
    • 0027249369 scopus 로고
    • The involvement of T cell receptor peptide-specific regulatory CD4+T cells in recovery from antigen-induced autoimmune disease
    • Kumar, V. and Sercarz, E. E., The involvement of T cell receptor peptide-specific regulatory CD4+T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 1993. 178: 909-916.
    • (1993) J. Exp. Med. , vol.178 , pp. 909-916
    • Kumar, V.1    Sercarz, E.E.2
  • 8
    • 25444510061 scopus 로고    scopus 로고
    • Control of type 1 autoimmune diabetes by naturally occurring CD4+ CD25+regulatory T lymphocytes in neonatal NOD mice
    • Piccirillo, C. A., Tritt, M., Sgouroudis, E., Albanese, A., Pyzik, M. and Hay, V., Control of type 1 autoimmune diabetes by naturally occurring CD4+ CD25+regulatory T lymphocytes in neonatal NOD mice. Ann. N. Y. Acad. Sci. 2005. 1051: 72-87.
    • (2005) Ann. N. Y. Acad. Sci. , vol.1051 , pp. 72-87
    • Piccirillo, C.A.1    Tritt, M.2    Sgouroudis, E.3    Albanese, A.4    Pyzik, M.5    Hay, V.6
  • 9
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+regulatory T cells in patients with multiple sclerosis
    • Viglietta, V., Baecher-Allan, C., Weiner, H. L. and Hafler, D. A., Loss of functional suppression by CD4+CD25+regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004. 199: 971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 10
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein, M. R., Evans, J. G., Singh, A., Moore, S., Warnes, G., Isenberg, D. A. and Mauri, C., Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J. Exp. Med. 2004. 200: 277-285.
    • (2004) J. Exp. Med. , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6    Mauri, C.7
  • 11
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley, S., Dayan, C. M., Bishop, A., Roep, B. O., Peakman, M. and Tree, T. I., Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005. 54: 92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 12
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25 (+)CD4(+) regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V. and Powrie, F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25 (+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 2000. 192: 295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 13
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura, K., Kitani, A. and Strober, W., Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 2001. 194: 629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 14
    • 0028202792 scopus 로고
    • Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • Weiner, H. L., Friedman, A., Miller, A., Khoury, S. J., al-Sabbagh, A., Santos, L., Sayegh, M. et al., Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 1994. 12: 809-837.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 809-837
    • Weiner, H.L.1    Friedman, A.2    Miller, A.3    Khoury, S.J.4    Al-Sabbagh, A.5    Santos, L.6    Sayegh, M.7
  • 15
    • 0037443404 scopus 로고    scopus 로고
    • Regulatory T cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes
    • Madakamutil, L. T., Maricic, I., Sercarz, E. and Kumar, V., Regulatory T cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes. J Immunol. 2003. 170: 2985-2992. (Pubitemid 36302171)
    • (2003) Journal of Immunology , vol.170 , Issue.6 , pp. 2985-2992
    • Madakamutil, L.T.1    Maricic, I.2    Sercarz, E.3    Kumar, V.4
  • 16
    • 0030915318 scopus 로고    scopus 로고
    • Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis
    • Kumar, V., Aziz, F., Sercarz, E. and Miller, A., Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis. J. Exp. Med. 1997. 185: 1725-1733.
    • (1997) J. Exp. Med. , vol.185 , pp. 1725-1733
    • Kumar, V.1    Aziz, F.2    Sercarz, E.3    Miller, A.4
  • 17
    • 0029806588 scopus 로고    scopus 로고
    • Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE)
    • Kumar, V., Stellrecht, K. and Sercarz, E., Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J. Exp. Med. 1996. 184: 1609-1617. (Pubitemid 26404454)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.5 , pp. 1609-1617
    • Kumar, V.1    Stellrecht, K.2    Sercarz, E.3
  • 18
    • 34248203713 scopus 로고    scopus 로고
    • + regulatory T cells and prevents experimental autoimmune encephalomyelitis
    • Tang, X., Maricic, I. and Kumar, V., Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+TCR alpha beta+regulatory T cells and prevents experimental autoimmune encephalomyelitis. J. Immunol. 2007. 178: 6043-6050. (Pubitemid 46717383)
    • (2007) Journal of Immunology , vol.178 , Issue.10 , pp. 6043-6050
    • Tang, X.1    Maricic, I.2    Kumar, V.3
  • 20
    • 0029065604 scopus 로고
    • Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: Further evidence of apoptotic deletion of autoreactive T cells in the central nervous system
    • Tabi, Z., McCombe, P. A. and Pender, M. P., Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T cells in the central nervous system. Int. Immunol. 1995. 7: 967-973.
    • (1995) Int. Immunol. , vol.7 , pp. 967-973
    • Tabi, Z.1    McCombe, P.A.2    Pender, M.P.3
  • 21
    • 0027773017 scopus 로고
    • Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain
    • Schmied, M., Breitschopf, H., Gold, R., Zischler, H., Rothe, G., Wekerle, H. and Lassmann, H., Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 1993. 143: 446-452.
    • (1993) Am. J. Pathol. , vol.143 , pp. 446-452
    • Schmied, M.1    Breitschopf, H.2    Gold, R.3    Zischler, H.4    Rothe, G.5    Wekerle, H.6    Lassmann, H.7
  • 23
    • 0031798137 scopus 로고    scopus 로고
    • Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
    • Inaba, K., Turley, S., Yamaide, F., Iyoda, T., Mahnke, K., Inaba, M., Pack, M. et al., Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 1998. 188: 2163-2173.
    • (1998) J. Exp. Med. , vol.188 , pp. 2163-2173
    • Inaba, K.1    Turley, S.2    Yamaide, F.3    Iyoda, T.4    Mahnke, K.5    Inaba, M.6    Pack, M.7
  • 24
    • 67449110676 scopus 로고    scopus 로고
    • Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphalpha+TCRalphabeta+T cells with regulatory properties
    • Smith, T. R., Tang, X., Maricic, I., Garcia, Z., Fanchiang, S. and Kumar, V., Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphalpha+TCRalphabeta+T cells with regulatory properties. J. Immunol. 2009.182: 6959-6968.
    • (2009) J. Immunol. , vol.182 , pp. 6959-6968
    • Smith, T.R.1    Tang, X.2    Maricic, I.3    Garcia, Z.4    Fanchiang, S.5    Kumar, V.6
  • 25
    • 0028887507 scopus 로고
    • Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis
    • Kumar, V., Tabibiazar, R., Geysen, H. M. and Sercarz, E., Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls murine experimental autoimmune encephalomyelitis. J. Immunol. 1995. 154: 1941-1950.
    • (1995) J. Immunol. , vol.154 , pp. 1941-1950
    • Kumar, V.1    Tabibiazar, R.2    Geysen, H.M.3    Sercarz, E.4
  • 26
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M. L., Sauter, B. and Bhardwaj, N., Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998. 392: 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 28
    • 0033068180 scopus 로고    scopus 로고
    • CD8alpha+and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo
    • Maldonado-Lopez, R., De, S. T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K. et al., CD8alpha+and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med. 1999. 189: 587-592.
    • (1999) J. Exp. Med. , vol.189 , pp. 587-592
    • Maldonado-Lopez, R.1    De, S.T.2    Michel, P.3    Godfroid, J.4    Pajak, B.5    Heirman, C.6    Thielemans, K.7
  • 29
    • 0037438597 scopus 로고    scopus 로고
    • Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10
    • Braciak, T. A., Pedersen, B., Chin, J., Hsiao, C., Ward, E. S., Maricic, I., Jahng, A. et al., Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10. J. Immunol. 2003. 170: 765-774.
    • (2003) J. Immunol. , vol.170 , pp. 765-774
    • Braciak, T.A.1    Pedersen, B.2    Chin, J.3    Hsiao, C.4    Ward, E.S.5    Maricic, I.6    Jahng, A.7
  • 30
    • 45549107134 scopus 로고    scopus 로고
    • Revival of CD8(+) Treg-mediated suppression
    • Smith, T. R. and Kumar, V., Revival of CD8(+) Treg-mediated suppression. Trends Immunol. 2008. 29: 337-342.
    • (2008) Trends Immunol. , vol.29 , pp. 337-342
    • Smith, T.R.1    Kumar, V.2
  • 31
    • 0023864061 scopus 로고
    • Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
    • Lider, O., Reshef, T., Beraud, E., Ben-Nun, A. and Cohen, I. R., Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 1988. 239: 181-183. (Pubitemid 18026682)
    • (1988) Science , vol.239 , Issue.4836 , pp. 181-183
    • Lider, O.1    Reshef, T.2    Beraud, E.3    Ben-Nun, A.4    Cohen, I.R.5
  • 32
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang, J., Medaer, R., Stinissen, P., Hafler, D. and Raus, J., MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993. 261: 1451-1454.
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.4    Raus, J.5
  • 33
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
    • Vandenbark, A. A., Hashim, G. and Offner, H., Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989. 341: 541-544.
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 34
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
    • Howell, M. D., Winters, S. T., Olee, T., Powell, H. C., Carlo, D. J. and Brostoff, S. W., Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 1989. 246: 668-670.
    • (1989) Science , vol.246 , pp. 668-670
    • Howell, M.D.1    Winters, S.T.2    Olee, T.3    Powell, H.C.4    Carlo, D.J.5    Brostoff, S.W.6
  • 35
    • 0037039379 scopus 로고    scopus 로고
    • Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
    • Steinman, R. M. and Nussenzweig, M. C., Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 2002. 99: 351-358.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 351-358
    • Steinman, R.M.1    Nussenzweig, M.C.2
  • 36
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. and Enk, A. H., Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 2000. 192: 1213-1222.
    • (2000) J. Exp. Med. , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.H.5
  • 37
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+CD4+regulatory T cells by antigen-processing dendritic cells
    • Yamazaki, S., Iyoda, T., Tarbell, K., Olson, K., Velinzon, K., Inaba, K. and Steinman, R. M., Direct expansion of functional CD25+CD4+regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 2003. 198: 235-247.
    • (2003) J. Exp. Med. , vol.198 , pp. 235-247
    • Yamazaki, S.1    Iyoda, T.2    Tarbell, K.3    Olson, K.4    Velinzon, K.5    Inaba, K.6    Steinman, R.M.7
  • 38
    • 48249147441 scopus 로고    scopus 로고
    • Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+regulatory T cells
    • Wang, L., Pino-Lagos, K., de Vries, V. C., Guleria, I., Sayegh, M. H. and Noelle, R. J., Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+regulatory T cells. Proc. Natl. Acad. Sci. USA 2008. 105: 9331-9336.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9331-9336
    • Wang, L.1    Pino-Lagos, K.2    De Vries, V.C.3    Guleria, I.4    Sayegh, M.H.5    Noelle, R.J.6
  • 39
    • 0037268145 scopus 로고    scopus 로고
    • Intracellular pathways of CD1 antigen presentation
    • Moody, D. B. and Porcelli, S. A., Intracellular pathways of CD1 antigen presentation. Nat. Rev. Immunol. 2003. 3: 11-22.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 11-22
    • Moody, D.B.1    Porcelli, S.A.2
  • 40
    • 49149101316 scopus 로고    scopus 로고
    • Involvement of secretory and endosomal compartments in presentation of an exogenous self-glycolipid to type II NKT cells
    • Roy, K. C., Maricic, I., Khurana, A., Smith, T. R., Halder, R. C. and Kumar, V., Involvement of secretory and endosomal compartments in presentation of an exogenous self-glycolipid to type II NKT cells. J. Immunol. 2008. 180: 2942-2950.
    • (2008) J. Immunol. , vol.180 , pp. 2942-2950
    • Roy, K.C.1    Maricic, I.2    Khurana, A.3    Smith, T.R.4    Halder, R.C.5    Kumar, V.6
  • 41
    • 3543099130 scopus 로고    scopus 로고
    • Helping the CD8(+) T-cell response
    • Bevan, M. J., Helping the CD8(+) T-cell response. Nat. Rev. Immunol. 2004. 4: 595-602.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 595-602
    • Bevan, M.J.1
  • 42
    • 71849102141 scopus 로고    scopus 로고
    • Cutting edge: CD4+T cell-derived IL-2 is essential for help-dependent primary CD8+T cell responses
    • Wilson, E. B. and Livingstone, A. M., Cutting edge: CD4+T cell-derived IL-2 is essential for help-dependent primary CD8+T cell responses. J. Immunol. 2008. 181: 7445-7448.
    • (2008) J. Immunol. , vol.181 , pp. 7445-7448
    • Wilson, E.B.1    Livingstone, A.M.2
  • 43
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman, R. M., Turley, S., Mellman, I. and Inaba, K., The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 2000. 191: 411-416.
    • (2000) J. Exp. Med. , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 44
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • Steinman, R. M. and Banchereau, J., Taking dendritic cells into medicine. Nature 2007. 449: 419-426.
    • (2007) Nature , vol.449 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 45
    • 0026694021 scopus 로고
    • Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice
    • Koh, D. R., Fung-Leung, W. P., Ho, A., Gray, D., cha-Orbea, H. and Mak, T. W., Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 1992. 256: 1210-1213.
    • (1992) Science , vol.256 , pp. 1210-1213
    • Koh, D.R.1    Fung-Leung, W.P.2    Ho, A.3    Gray, D.4    Cha-Orbea, H.5    Mak, T.W.6
  • 46
    • 0022637226 scopus 로고
    • Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3
    • Clark-Lewis, I., Aebersold, R., Ziltener, H., Schrader, J. W., Hood, L. E. and Kent, S. B., Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3. Science 1986. 231: 134-139. (Pubitemid 16154700)
    • (1986) Science , vol.231 , Issue.4734 , pp. 134-139
    • Clark-Lewis, I.1    Aebersold, R.2    Ziltener, H.3
  • 47
    • 0028849807 scopus 로고
    • Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells
    • Kumar, V., Bhardwaj, V., Soares, L., Alexander, J., Sette, A. and Sercarz, E., Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells. Proc. Natl. Acad. Sci. USA 1995. 92: 9510-9514.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9510-9514
    • Kumar, V.1    Bhardwaj, V.2    Soares, L.3    Alexander, J.4    Sette, A.5    Sercarz, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.