-
1
-
-
84888439466
-
Immune mechanisms in type 1 diabetes
-
Wa˚llberg M, Cooke A (2013) Immune mechanisms in type 1 diabetes. Trends Immunol 34(12):583-591.
-
(2013)
Trends Immunol
, vol.34
, Issue.12
, pp. 583-591
-
-
Wallberg, M.1
Cooke, A.2
-
2
-
-
84894542402
-
Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes
-
Jörns A, et al. (2014) Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes. Diabetologia 57(3):512-521.
-
(2014)
Diabetologia
, vol.57
, Issue.3
, pp. 512-521
-
-
Jörns, A.1
-
3
-
-
17644361955
-
The NOD mouse: A model of immune dysregulation
-
Anderson MS, Bluestone JA (2005) The NOD mouse: A model of immune dysregulation. Annu Rev Immunol 23:447-485.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
4
-
-
33748622563
-
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure
-
Lee Y, et al. (2006) Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure. Immunity 25(3):499-509.
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 499-509
-
-
Lee, Y.1
-
5
-
-
79960088916
-
Insulitis in human type 1 diabetes: The quest for an elusive lesion
-
In't Veld P (2011) Insulitis in human type 1 diabetes: The quest for an elusive lesion. Islets 3(4):131-138.
-
(2011)
Islets
, vol.3
, Issue.4
, pp. 131-138
-
-
In'T Veld, P.1
-
6
-
-
0034986859
-
Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: Close correlation between serological markers and histological evidence of cellular autoimmunity
-
Imagawa A, et al. (2001) Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: Close correlation between serological markers and histological evidence of cellular autoimmunity. Diabetes 50(6):1269-1273.
-
(2001)
Diabetes
, vol.50
, Issue.6
, pp. 1269-1273
-
-
Imagawa, A.1
-
7
-
-
58149299735
-
Analysis of islet inflammation in human type 1 diabetes
-
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009) Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 155(2):173-181.
-
(2009)
Clin Exp Immunol
, vol.155
, Issue.2
, pp. 173-181
-
-
Willcox, A.1
Richardson, S.J.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
8
-
-
34548397755
-
Screening for insulitis in adult autoantibody-positive organ donors
-
In't Veld P, et al. (2007) Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 56(9):2400-2404.
-
(2007)
Diabetes
, vol.56
, Issue.9
, pp. 2400-2404
-
-
In'T Veld, P.1
-
9
-
-
84856825977
-
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
-
Coppieters KT, et al. (2012) Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J ExpMed 209(1):51-60.
-
(2012)
J Exp Med
, vol.209
, Issue.1
, pp. 51-60
-
-
Coppieters, K.T.1
-
10
-
-
84908632192
-
Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes
-
Arif S, et al. (2014) Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes 63(11):3835-3845.
-
(2014)
Diabetes
, vol.63
, Issue.11
, pp. 3835-3845
-
-
Arif, S.1
-
11
-
-
70349745490
-
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
-
Lennon GP, et al. (2009) T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31(4):643-653.
-
(2009)
Immunity
, vol.31
, Issue.4
, pp. 643-653
-
-
Lennon, G.P.1
-
12
-
-
0037416178
-
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells
-
Savinov AY, Wong FS, Stonebraker AC, Chervonsky AV (2003) Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med 197(5):643-656.
-
(2003)
J Exp Med
, vol.197
, Issue.5
, pp. 643-656
-
-
Savinov, A.Y.1
Wong, F.S.2
Stonebraker, A.C.3
Chervonsky, A.V.4
-
13
-
-
79952143765
-
Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
-
Calderon B, Carrero JA, Miller MJ, Unanue ER (2011) Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci USA 108(4):1561-1566.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.4
, pp. 1561-1566
-
-
Calderon, B.1
Carrero, J.A.2
Miller, M.J.3
Unanue, E.R.4
-
14
-
-
85047694553
-
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
-
Stratmann T, et al. (2003) Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest 112(6):902-914.
-
(2003)
J Clin Invest
, vol.112
, Issue.6
, pp. 902-914
-
-
Stratmann, T.1
-
15
-
-
84892686874
-
Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes
-
Chee J, et al. (2014) Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes. J Immunol 192(2):572-580.
-
(2014)
J Immunol
, vol.192
, Issue.2
, pp. 572-580
-
-
Chee, J.1
-
16
-
-
0032213629
-
Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones
-
Peterson JD, Berg R, Piganelli JD, Poulin M, Haskins K (1998) Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones. Cell Immunol 189(2):92-98.
-
(1998)
Cell Immunol
, vol.189
, Issue.2
, pp. 92-98
-
-
Peterson, J.D.1
Berg, R.2
Piganelli, J.D.3
Poulin, M.4
Haskins, K.5
-
17
-
-
79952178124
-
Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response
-
Calderon B, Carrero JA, Miller MJ, Unanue ER (2011) Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci USA 108(4):1567-1572.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.4
, pp. 1567-1572
-
-
Calderon, B.1
Carrero, J.A.2
Miller, M.J.3
Unanue, E.R.4
-
18
-
-
85047689596
-
Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient
-
Christen U, et al. (2004) Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. J Clin Invest 113(1):74-84.
-
(2004)
J Clin Invest
, vol.113
, Issue.1
, pp. 74-84
-
-
Christen, U.1
-
19
-
-
49449102376
-
Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice
-
Tomura M, et al. (2008) Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice. Proc Natl Acad Sci USA 105(31):10871-10876.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.31
, pp. 10871-10876
-
-
Tomura, M.1
-
20
-
-
77949747054
-
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice
-
Tomura M, et al. (2010) Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest 120(3):883-893.
-
(2010)
J Clin Invest
, vol.120
, Issue.3
, pp. 883-893
-
-
Tomura, M.1
-
22
-
-
84899854070
-
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut
-
Morton AM, et al. (2014) Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci USA 111(18):6696-6701.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.18
, pp. 6696-6701
-
-
Morton, A.M.1
-
23
-
-
0028223127
-
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice
-
Jansen A, et al. (1994) Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes 43(5):667-675.
-
(1994)
Diabetes
, vol.43
, Issue.5
, pp. 667-675
-
-
Jansen, A.1
-
24
-
-
0021802879
-
Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: A longitudinal study
-
Miyazaki A, et al. (1985) Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: A longitudinal study. Clin Exp Immunol 60(3):622-630.
-
(1985)
Clin Exp Immunol
, vol.60
, Issue.3
, pp. 622-630
-
-
Miyazaki, A.1
-
25
-
-
84875451200
-
Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse
-
Carrero JA, Calderon B, Towfic F, Artyomov MN, Unanue ER (2013) Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS ONE 8(3):e59701.
-
(2013)
PLoS ONE
, vol.8
, Issue.3
, pp. e59701
-
-
Carrero, J.A.1
Calderon, B.2
Towfic, F.3
Artyomov, M.N.4
Unanue, E.R.5
-
26
-
-
0025301142
-
MHC-linked protection from diabetes dissociated from clonal deletion of T cells
-
Böhme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D (1990) MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science 249(4966):293-295.
-
(1990)
Science
, vol.249
, Issue.4966
, pp. 293-295
-
-
Böhme, J.1
Schuhbaur, B.2
Kanagawa, O.3
Benoist, C.4
Mathis, D.5
-
27
-
-
0024211490
-
Evidence for initial involvement of macrophage in development of insulitis in NOD mice
-
Lee KU, Amano K, Yoon JW (1988) Evidence for initial involvement of macrophage in development of insulitis in NOD mice. Diabetes 37(7):989-991.
-
(1988)
Diabetes
, vol.37
, Issue.7
, pp. 989-991
-
-
Lee, K.U.1
Amano, K.2
Yoon, J.W.3
-
28
-
-
84857064688
-
Antigen presentation events in autoimmune diabetes
-
Calderon B, Unanue ER (2012) Antigen presentation events in autoimmune diabetes. Curr Opin Immunol 24(1):119-128.
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.1
, pp. 119-128
-
-
Calderon, B.1
Unanue, E.R.2
-
29
-
-
0036789916
-
An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein
-
Ando R, Hama H, Yamamoto-Hino M, Mizuno H, Miyawaki A (2002) An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein. Proc Natl Acad Sci USA 99(20):12651-12656.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.20
, pp. 12651-12656
-
-
Ando, R.1
Hama, H.2
Yamamoto-Hino, M.3
Mizuno, H.4
Miyawaki, A.5
-
30
-
-
4143145367
-
A mouse model for studying intrahepatic islet transplantation
-
Hara M, et al. (2004) A mouse model for studying intrahepatic islet transplantation. Transplantation 78(4):615-618.
-
(2004)
Transplantation
, vol.78
, Issue.4
, pp. 615-618
-
-
Hara, M.1
-
31
-
-
0034609968
-
T-cell function and migration. Two sides of the same coin
-
von Andrian UH, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343(14):1020-1034.
-
(2000)
N Engl J Med
, vol.343
, Issue.14
, pp. 1020-1034
-
-
Von Andrian, U.H.1
Mackay, C.R.2
-
32
-
-
34047210905
-
Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells
-
Mellanby RJ, Thomas D, Phillips JM, Cooke A (2007) Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells. Immunology 121(1):15-28.
-
(2007)
Immunology
, vol.121
, Issue.1
, pp. 15-28
-
-
Mellanby, R.J.1
Thomas, D.2
Phillips, J.M.3
Cooke, A.4
-
33
-
-
77952686356
-
In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation
-
Wang J, et al. (2010) In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation. Proc Natl Acad Sci USA 107(20):9317-9322.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.20
, pp. 9317-9322
-
-
Wang, J.1
-
34
-
-
0029978038
-
Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
-
André I, et al. (1996) Checkpoints in the progression of autoimmune disease: Lessons from diabetes models. Proc Natl Acad Sci USA 93(6):2260-2263.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.6
, pp. 2260-2263
-
-
André, I.1
-
35
-
-
34547230077
-
CD3-specific antibodies: A portal to the treatment of autoimmunity
-
Chatenoud L, Bluestone JA (2007) CD3-specific antibodies: A portal to the treatment of autoimmunity. Nat Rev Immunol 7(8):622-632.
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.8
, pp. 622-632
-
-
Chatenoud, L.1
Bluestone, J.A.2
-
36
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, et al. (2005) Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 352(25):2598-2608.
-
(2005)
N Engl J Med
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
-
37
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, et al. (2002) Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346(22):1692-1698.
-
(2002)
N Engl J Med
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
-
38
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
-
Keymeulen B, et al. (2010) Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 53(4):614-623.
-
(2010)
Diabetologia
, vol.53
, Issue.4
, pp. 614-623
-
-
Keymeulen, B.1
-
39
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L, Thervet E, Primo J, Bach JF (1994) Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 91(1):123-127.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.1
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
40
-
-
77956254994
-
Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints
-
Nishio J, Feuerer M, Wong J, Mathis D, Benoist C (2010) Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med 207(9):1879-1889.
-
(2010)
J Exp Med
, vol.207
, Issue.9
, pp. 1879-1889
-
-
Nishio, J.1
Feuerer, M.2
Wong, J.3
Mathis, D.4
Benoist, C.5
-
42
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3-gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
Herold KC, et al. (2005) A single course of anti-CD3 monoclonal antibody hOKT3-gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54(6):1763-1769.
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-1769
-
-
Herold, K.C.1
-
43
-
-
0033579875
-
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
-
Höglund P, et al. (1999) Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 189(2):331-339.
-
(1999)
J Exp Med
, vol.189
, Issue.2
, pp. 331-339
-
-
Höglund, P.1
-
44
-
-
0037025990
-
Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice
-
Gagnerault MC, Luan JJ, Lotton C, Lepault F (2002) Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J Exp Med 196(3):369-377.
-
(2002)
J Exp Med
, vol.196
, Issue.3
, pp. 369-377
-
-
Gagnerault, M.C.1
Luan, J.J.2
Lotton, C.3
Lepault, F.4
-
45
-
-
84903458886
-
An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function
-
Friedman RS, et al. (2014) An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci USA 111(25):9223-9228.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.25
, pp. 9223-9228
-
-
Friedman, R.S.1
-
46
-
-
77953232399
-
In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response
-
Fan Z, et al. (2010) In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med 16(6):718-722.
-
(2010)
Nat Med
, vol.16
, Issue.6
, pp. 718-722
-
-
Fan, Z.1
-
47
-
-
84887998165
-
+cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes
-
+cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes. Diabetologia 56(12):2669-2678.
-
(2013)
Diabetologia
, vol.56
, Issue.12
, pp. 2669-2678
-
-
Schmidt-Christensen, A.1
-
48
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
Tang Q, et al. (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28(5):687-697.
-
(2008)
Immunity
, vol.28
, Issue.5
, pp. 687-697
-
-
Tang, Q.1
-
49
-
-
0027362474
-
Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium
-
Hönninen A, et al. (1993) Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest 92(5):2509-2515.
-
(1993)
J Clin Invest
, vol.92
, Issue.5
, pp. 2509-2515
-
-
Hönninen, A.1
|