Islet-associated T-cell receptor-β CDR sequence repertoire in prediabetic NOD mice reveals antigen-driven T-cell expansion and shared usage of VβJβ TCR chains

Molecular Immunology

Volumn 64, Issue 1, 2015, Pages 127-135

  Toivonen, R ^a   Arstila, T P ^b   Hanninen A ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Antigen driven expansion; Insulin dependent diabetes mellitus; Nonobese diabetic mice; T cell repertoire; V CDR3 sequencing

Indexed keywords

ANTIGEN; DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN; T CELL RECEPTOR BETA COMPLEMENTARY DETERMINING REGION; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; AUTOANTIGEN; COMPLEMENTARITY DETERMINING REGION; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL EXPANSION; CLONE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DIABETES MELLITUS; DNA EXTRACTION; FEMALE; GENE EXPRESSION; GENE SEQUENCE; HIGH THROUGHPUT SEQUENCING; INSULITIS; INTESTINE; LYMPH NODE; MOUSE; NONHUMAN; PANCREAS ISLET; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CELL CLONE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; GENETICS; ILEUM; IMMUNOLOGY; IMPAIRED GLUCOSE TOLERANCE; MOLECULAR GENETICS; NONOBESE DIABETIC MOUSE; PATHOLOGY;

MUS;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; CELL PROLIFERATION; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; ILEUM; ISLETS OF LANGERHANS; LYMPH NODES; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; PEPTIDES; PREDIABETIC STATE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 84920065951     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.11.009     Document Type: Article

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