High-Throughput Sequencing of Islet-Infiltrating Memory CD4+ T Cells Reveals a Similar Pattern of TCR Vβ Usage in Prediabetic and Diabetic NOD Mice

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Marrero, Idania ^a   Hamm, David E ^b   Davies, Joanna D ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b Adaptive Biotechnologies Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HERMES ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN; CD4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL EXPANSION; CELL INFILTRATION; CELL ISOLATION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; DNA SYNTHESIS; ENTROPY; FEMALE; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; IMMUNOREACTIVITY; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE CLONE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; ANIMAL; CELL CLONE; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROCEDURES;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD44; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; IMMUNOLOGIC MEMORY; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; PREDIABETIC STATE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 84885792599     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076546     Document Type: Article

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