Transplantation of PC1/3-expressing α-cells improves glucose handling and cold tolerance in leptin-resistant mice

Molecular Therapy

Volumn 17, Issue 1, 2009, Pages 191-198

  Wideman, Rhonda D ^a   Gray, Sarah L ^a   Covey, Scott D ^a   Webb, Gene C ^b   Kieffer, Timothy J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; LEPTIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2;

ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; COLD TOLERANCE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPERGLYCEMIA; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET ALPHA CELL TRANSPLANTATION; PANCREAS ISLET TRANSPLANTATION; PROTEIN EXPRESSION; THERMOGENESIS; THERMOREGULATION;

ANIMALS; BODY COMPOSITION; CELLS, CULTURED; COLD TEMPERATURE; DIABETES MELLITUS, EXPERIMENTAL; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE; LEPTIN; MICE; PROGLUCAGON; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2;

MUS;

EID: 58149215525     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.219     Document Type: Article

References (40)

1. Kieffer, TJ and Habener, JF (1999). The glucagon-like peptides. Endocr Rev 20: 876-913.
2. Furuta, M, Zhou, A, Webb, G, Carroll, R, Ravazzola, M, Orci, L et al. (2001). Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem 276: 27197-27202.
3. Rouille, Y, Bianchi, M, Irminger, JC and Halban, PA (1997). Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon. FEBS Lett 413: 119-123.
4. Unger, RH (1975). Letter: Glucagon in pathogenesis of diabetes. Lancet 1: 1036-1042.
5. Rouille, Y, Kantengwa, S, Irminger, JC and Halban, PA (1997). Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem 272: 32810-32816.
6. Zhu, X, Zhou, A, Dey, A, Norrbom, C, Carroll, R, Zhang, C et al. (2002). Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA 99: 10293-10298.
7. Drucker, DJ (2006). The biology of incretin hormones. Cell Metab 3: 153-165.
8. Wynne, K and Bloom, SR (2006). The role of oxyntomodulin and peptide tyrosinetyrosine (PYY) in appetite control. Nat Clin Pract Endocrinol Metab 2: 612-620.
9. Meier, JJ, Nauck, MA, Pott, A, Heinze, K, Goetze, O, Bulut, K et al. (2006). Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology 130: 44-54.
10. Wideman, RD, Covey, SD, Webb, GC, Drucker, DJ and Kieffer, TJ (2007). A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes 56: 2744-2752.
11. Wideman, RD, Yu, IL, Webber, TD, Verchere, CB, Johnson, JD, Cheung, AT et al. (2006). Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc Natl Acad Sci USA 103: 13468-13473.
12. Webb, GC, Dey, A, Wang, J, Stein, J, Milewski, M and Steiner, DF (2004). Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets. J Biol Chem 279: 31068-31075.
13. Hummel, KP, Dickie, MM and Coleman, DL (1966). Diabetes, a new mutation in the mouse. Science 153: 1127-1128.
14. Trayhurn, P (1979). Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch 380: 227-232.
15. Duvivier-Kali, VF, Omer, A, Lopez-Avalos, MD, O'Neil, JJ and Weir, GC (2004). Survival of microencapsulated adult pig islets in mice in spite of an antibody response. Am J Transplant 4: 1991-2000.
16. Suzuki, K, Bonner-Weir, S, Trivedi, N, Yoon, KH, Hollister-Lock, J, Colton, CK et al. (1998). Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation 66: 21-28.
17. Mojsov, S, Weir, GC and Habener, JF (1987). Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79: 616-619.
18. Unger, RH, Eisentraut, AM, Mccall, MS and Madison, LL (1962). Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion. J Clin Invest 41: 682-689.
19. Xu, G, Kaneto, H, Laybutt, DR, Duvivier-Kali, VF, Trivedi, N, Suzuma, K et al. (2007). Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes. Diabetes 56: 1551-1558.
20. Tang-Christensen, M, Larsen, PJ, Goke, R, Fink-Jensen, A, Jessop, DS, Moller, M et al. (1996). Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 271 R848-R856.
21. Turton, MD, O'Shea, D, Gunn, I, Beak, SA, Edwards, CM, Meeran, K et al. (1996). A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72.
22. Dakin, CL, Gunn, I, Small, CJ, Edwards, CM, Hay, DL, Smith, DM et al. (2001). Oxyntomodulin inhibits food intake in the rat. Endocrinology 142: 4244-4250.
23. Baggio, LL, Kim, JG and Drucker, DJ (2004). Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo. Diabetes 53 (suppl. 3): S205-S214.
24. Buse, JB, Henry, RR, Han, J, Kim, DD, Fineman, MS and Baron, AD (2004). Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27: 2628-2635.
25. Chen, H, Charlat, O, Tartaglia, LA, Woolf, EA, Weng, X, Ellis, SJ et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/ db mice. Cell 84: 491-495.
26. Lee, GH, Proenca, R, Montez, JM, Carroll, KM, Darvishzadeh, JG, Lee, JI et al. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635.
27. Cannon, B and Nedergaard, J (2004). Brown adipose tissue: Function and physiological significance. Physiol Rev 84: 277-359.
28. Young, JB and Landsberg, L (1983). Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse. Am J Physiol 245 E148-E154.
29. Nedergaard, J, Golozoubova, V, Matthias, A, Asadi, A, Jacobsson, A and Cannon, B (2001). UCP1: The only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504: 82-106.
30. Golozoubova, V, Hohtola, E, Matthias, A, Jacobsson, A, Cannon, B and Nedergaard, J (2001). Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 15: 2048-2050.
31. Kuroshima, A and Yahata, T (1979). Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats. Jpn J Physiol 29: 683-690.
32. Dicker, A, Zhao, J, Cannon, B and Nedergaard, J (1998). Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. Am J Physiol 275: R1674-R1682.
33. O'Shea, D, Gunn, I, Chen, X, Bloom, S and Herbert, J (1996). A role for central glucagon-like peptide-1 in temperature regulation. Neuroreport 7: 830-832.
34. Osaka, T, Endo, M, Yamakawa, M and Inoue, S (2005). Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system. Peptides 26: 1623-1631.
35. Shousha, S, Nakahara, K, Nasu, T, Sakamoto, T and Murakami, N (2007). Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail. Neurosci Lett 415: 102-107.
36. Yamamoto, H, Kishi, T, Lee, CE, Choi, BJ, Fang, H, Hollenberg, AN et al. (2003). Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 23: 2939-2946.
37. Yamamoto, H, Lee, CE, Marcus, JN, Williams, TD, Overton, JM, Lopez, ME et al. (2002). Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 110: 43-52.
38. Scrocchi, LA, Brown, TJ, MaClusky, N, Brubaker, PL, Auerbach, AB, Joyner, AL et al. (1996). Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2: 1254-1258.
39. Kunnecke, B, Verry, P, Benardeau, A and von Kienlin, M (2004). Quantitative body composition analysis in awake mice and rats by magnetic resonance relaxometry. Obes Res 12: 1604-1615.
40. Cannon, B, Hedin, A and Nedergaard, J (1982). Exclusive occurrence of thermogenin antigen in brown adipose tissue. FEBS Lett 150: 129-132.