Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signaling in aging chondrocytes

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 6641-6654

  Collins, John A ^a   Wood, Scott T ^a   Nelson, Kimberly J ^b   Rowe, Meredith A ^a,c   Carlson, Cathy S ^d   Chubinskaya, Susan ^e   Poole, Leslie B ^b   Furdui, Cristina M ^c   Loeser, Richard F ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Departments of Biochemistry   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CARTILAGE; MAMMALS; MITOCHONDRIA; SIGNALING;

CARTILAGE EXPLANTS; CELLULAR DYSFUNCTION; DISEASE PROGRESSION; INTRACELLULAR SIGNALING; MITOCHONDRIAL DYSFUNCTION; OSTEOARTHRITIC CARTILAGE; POST-TRANSLATIONAL MODIFICATIONS; POTENTIAL MECHANISM;

OXIDATIVE STRESS;

CATALASE; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXIREDOXIN 1; PEROXIREDOXIN 2; PEROXIREDOXIN 3; PROTEIN KINASE B; HOMEODOMAIN PROTEIN; PRRX2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SHOX2 PROTEIN, MOUSE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL AGING; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXPLANT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INTRACELLULAR SIGNALING; MITOCHONDRION; MOUSE; NONHUMAN; OSTEOARTHRITIS; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGING; ANIMAL; CHONDROCYTE; DRUG EFFECTS; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PRIMARY CELL CULTURE; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUE; TRANSGENE; TRANSGENIC MOUSE;

ADULT; AGING; ANIMALS; CARTILAGE; CATALASE; CELL AGING; CHONDROCYTES; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIA; OSTEOARTHRITIS; OXIDATIVE STRESS; PRIMARY CELL CULTURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; TRANSGENES; VITAMIN K 3;

EID: 84964880156     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.693523     Document Type: Article

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