Metformin facilitates amyloid-β generation by β- And γ -secretases via autophagy activation

Journal of Alzheimer's Disease

Volumn 51, Issue 4, 2016, Pages 1197-1208

  Son, Sung Min ^a   Shin, Hong Joon ^a   Byun, Jayoung ^a   Kook, Sun Young ^a   Moon, Minho ^a   Chang, Yu Jin ^a   Mook Jung, Inhee ^a  

^a Seoul National University   (South Korea)

Author keywords

Alzheimer's disease; amyloid peptides; amyloid protein precursor; autophagy; metformin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; ANTIDIABETIC AGENT; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL ACTIVATION; CELL VACUOLE; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL LINE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SH SY5Y CELL; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ELECTRON MICROSCOPY; FEMALE; GENETICS; LYSOSOME; METABOLISM; MUTATION; NEUROBLASTOMA; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LYSOSOMES; METFORMIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MUTATION; NEUROBLASTOMA; SIGNAL TRANSDUCTION;

EID: 84964854975     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-151200     Document Type: Article

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