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Volumn 22, Issue 1, 2010, Pages 97-105

FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice

Author keywords

Alzheimer's disease; amyloid ; A PP PS1 double transgenic mouse; calcineurin; FK506; MMP 9

Indexed keywords

AMYLOID BETA PROTEIN; CALCINEURIN; GELATINASE B; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; TACROLIMUS;

EID: 78650668291     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100261     Document Type: Article
Times cited : (37)

References (51)
  • 1
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 2
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy Physiol Rev 81, 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 3
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399, A23-31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 4
    • 0037378001 scopus 로고    scopus 로고
    • Amyloid, presenilins, and Alzheimer's disease
    • Van Gassen G, Annaert W (2003) Amyloid, presenilins, and Alzheimer's disease. Neuroscientist 9, 117-126.
    • (2003) Neuroscientist , vol.9 , pp. 117-126
    • Van Gassen, G.1    Annaert, W.2
  • 7
    • 0034069795 scopus 로고    scopus 로고
    • Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
    • Chen QS, Kagan BL, Hirakura Y, Xie CW (2000) Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 60, 65-72.
    • (2000) J Neurosci Res , vol.60 , pp. 65-72
    • Chen, Q.S.1    Kagan, B.L.2    Hirakura, Y.3    Xie, C.W.4
  • 8
    • 9644284689 scopus 로고    scopus 로고
    • Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity
    • Rowan MJ, Klyubin I, Wang Q, Anwyl R (2004) Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity. Exp Gerontol 39, 1661-1667.
    • (2004) Exp Gerontol , vol.39 , pp. 1661-1667
    • Rowan, M.J.1    Klyubin, I.2    Wang, Q.3    Anwyl, R.4
  • 10
    • 0028649481 scopus 로고
    • The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging
    • Disterhoft JF, Moyer JR, Jr., Thompson LT (1994) The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging. Ann N Y Acad Sci 747, 382-406.
    • (1994) Ann N y Acad Sci , vol.747 , pp. 382-406
    • Disterhoft, J.F.1    Moyer Jr., J.R.2    Thompson, L.T.3
  • 12
    • 47749113650 scopus 로고    scopus 로고
    • Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks
    • Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ (2008) Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214-225.
    • (2008) Neuron , vol.59 , pp. 214-225
    • Kuchibhotla, K.V.1    Goldman, S.T.2    Lattarulo, C.R.3    Wu, H.Y.4    Hyman, B.T.5    Bacskai, B.J.6
  • 13
    • 0028670272 scopus 로고
    • Beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease
    • Arispe N, Pollard HB, Rojas E (1994) beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease. Mol CellBiochem 140, 119-125.
    • (1994) Mol CellBiochem , vol.140 , pp. 119-125
    • Arispe, N.1    Pollard, H.B.2    Rojas, E.3
  • 14
    • 0034319190 scopus 로고    scopus 로고
    • Molecular mechanism of neu-rodegeneration induced by Alzheimer's beta-amyloid protein: Channel formation and disruption of calcium homeostasis
    • Kawahara M, Kuroda Y (2000) Molecular mechanism of neu-rodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res Bull 53, 389-397.
    • (2000) Brain Res Bull , vol.53 , pp. 389-397
    • Kawahara, M.1    Kuroda, Y.2
  • 15
    • 0034728670 scopus 로고    scopus 로고
    • Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
    • Ekinci FJ, Linsley MD, Shea TB (2000) Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Brain Res Mol Brain Res 76, 389-395.
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 389-395
    • Ekinci, F.J.1    Linsley, M.D.2    Shea, T.B.3
  • 16
    • 0034681208 scopus 로고    scopus 로고
    • Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-β1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta
    • MacManus A, Ramsden M, Murray M, Henderson Z, Pearson HA, Campbell VA (2000) Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-β1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem 275, 4713-4718.
    • (2000) J Biol Chem , vol.275 , pp. 4713-4718
    • MacManus, A.1    Ramsden, M.2    Murray, M.3    Henderson, Z.4    Pearson, H.A.5    Campbell, V.A.6
  • 17
    • 0242690133 scopus 로고    scopus 로고
    • Calcineurin in memory and bidirectional plasticity
    • Mansuy IM (2003) Calcineurin in memory and bidirectional plasticity. Biochem Biophys Res Commun 311, 1195-1208.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 1195-1208
    • Mansuy, I.M.1
  • 18
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: Choreographing the social lives of cells
    • Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell 109 Suppl, S67-79.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Crabtree, G.R.1    Olson, E.N.2
  • 19
    • 0028169349 scopus 로고
    • The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: Relationship to calcineurin
    • Dawson TM, Steiner JP, Lyons WE, Fotuhi M, Blue M, Snyder SH (1994) The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience 62, 569-580.
    • (1994) Neuroscience , vol.62 , pp. 569-580
    • Dawson, T.M.1    Steiner, J.P.2    Lyons, W.E.3    Fotuhi, M.4    Blue, M.5    Snyder, S.H.6
  • 21
    • 0034307421 scopus 로고    scopus 로고
    • Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury
    • Springer JE, Azbill RD, Nottingham SA, Kennedy SE (2000) Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci 20, 7246-7251.
    • (2000) J Neurosci , vol.20 , pp. 7246-7251
    • Springer, J.E.1    Azbill, R.D.2    Nottingham, S.A.3    Kennedy, S.E.4
  • 24
    • 43449096932 scopus 로고    scopus 로고
    • Selective inhibitors of nuclear factor of activated T cells: Potential therapeutic drugs for the treatment of immunological and inflammatory diseases
    • Kaminuma O (2008) Selective inhibitors of nuclear factor of activated T cells: potential therapeutic drugs for the treatment of immunological and inflammatory diseases. Inflamm Allergy Drug Targets 7, 35-40.
    • (2008) Inflamm Allergy Drug Targets , vol.7 , pp. 35-40
    • Kaminuma, O.1
  • 25
    • 21544459062 scopus 로고    scopus 로고
    • The role of calcineurin in amyloid-beta-peptides-mediated cell death
    • Cardoso SM, Oliveira CR (2005) The role of calcineurin in amyloid-beta-peptides-mediated cell death. Brain Res 1050, 1-7.
    • (2005) Brain Res , vol.1050 , pp. 1-7
    • Cardoso, S.M.1    Oliveira, C.R.2
  • 26
    • 34547653708 scopus 로고    scopus 로고
    • Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
    • Dineley KT, Hogan D, Zhang WR, Taglialatela G (2007) Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol Learn Mem 88, 217-224.
    • (2007) Neurobiol Learn Mem , vol.88 , pp. 217-224
    • Dineley, K.T.1    Hogan, D.2    Zhang, W.R.3    Taglialatela, G.4
  • 28
    • 0030850505 scopus 로고    scopus 로고
    • Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism
    • Butcher SP, Henshall DC, Teramura Y, Iwasaki K, Sharkey J (1997) Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. J Neurosci 17, 6939-6946.
    • (1997) J Neurosci , vol.17 , pp. 6939-6946
    • Butcher, S.P.1    Henshall, D.C.2    Teramura, Y.3    Iwasaki, K.4    Sharkey, J.5
  • 29
    • 20044383377 scopus 로고    scopus 로고
    • Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to beta-amyloid deposition and neurotransmitter abnormalities
    • Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR (2005) Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neu-robiolDis 18, 602-617.
    • (2005) Neu-robiolDis , vol.18 , pp. 602-617
    • Savonenko, A.1    Xu, G.M.2    Melnikova, T.3    Morton, J.L.4    Gonzales, V.5    Wong, M.P.6    Price, D.L.7    Tang, F.8    Markowska, A.L.9    Borchelt, D.R.10
  • 30
    • 0033064431 scopus 로고    scopus 로고
    • Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells
    • Kochi S, Takanaga H, Matsuo H, Naito M, Tsuruo T, Sawada Y (1999) Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells. Eur J Pharmacol 372, 287-295.
    • (1999) Eur J Pharmacol , vol.372 , pp. 287-295
    • Kochi, S.1    Takanaga, H.2    Matsuo, H.3    Naito, M.4    Tsuruo, T.5    Sawada, Y.6
  • 31
    • 62649147319 scopus 로고    scopus 로고
    • Intermediate-and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
    • Taglialatela G, Hogan D, Zhang WR, Dineley KT (2009) Intermediate-and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res 200, 95-99.
    • (2009) Behav Brain Res , vol.200 , pp. 95-99
    • Taglialatela, G.1    Hogan, D.2    Zhang, W.R.3    Dineley, K.T.4
  • 33
    • 0037466395 scopus 로고    scopus 로고
    • Beta-amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes
    • Deb S, Wenjun Zhang J, Gottschall PE (2003) Beta-amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes. Brain Res 970, 205-213.
    • (2003) Brain Res , vol.970 , pp. 205-213
    • Deb, S.1    Wenjun Zhang, J.2    Gottschall, P.E.3
  • 34
    • 67349213205 scopus 로고    scopus 로고
    • Synaptic degeneration in Alzheimer's disease
    • Arendt T (2009) Synaptic degeneration in Alzheimer's disease. Acta Neuropathol 118, 167-179.
    • (2009) Acta Neuropathol , vol.118 , pp. 167-179
    • Arendt, T.1
  • 35
    • 0042733062 scopus 로고    scopus 로고
    • Anti-inflammatory drugs and Alzheimer's disease
    • Martyn C (2003) Anti-inflammatory drugs and Alzheimer's disease. BMJ 327, 353-354.
    • (2003) BMJ , vol.327 , pp. 353-354
    • Martyn, C.1
  • 36
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mTOR, A{beta} and tau: Effects on cognitive impairments
    • Caccamo A, Majumder S, Richardson A, Strong R, Oddo S (2010) Molecular interplay between mTOR, A{beta} and tau: Effects on cognitive impairments. J Biol Chem 285, 1310713120.
    • (2010) J Biol Chem , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 40
    • 1842534887 scopus 로고    scopus 로고
    • Inhibitors of the calcineurin/NFAT pathway
    • Martinez-Martinez S, Redondo JM (2004) Inhibitors of the calcineurin/NFAT pathway. CurrMed Chem 11, 997-1007.
    • (2004) CurrMed Chem , vol.11 , pp. 997-1007
    • Martinez-Martinez, S.1    Redondo, J.M.2
  • 41
    • 0029559927 scopus 로고
    • Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin
    • Cardenas ME, Zhu D, Heitman J (1995) Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. Curr Opin Nephrol Hypertens 4, 472-477.
    • (1995) Curr Opin Nephrol Hypertens , vol.4 , pp. 472-477
    • Cardenas, M.E.1    Zhu, D.2    Heitman, J.3
  • 42
    • 0242690189 scopus 로고    scopus 로고
    • Structures of calcineurin and its complexes with immunophilins- immunosuppressants
    • Ke H, Huai Q (2003) Structures of calcineurin and its complexes with immunophilins-immunosuppressants. Biochem Bio-phys Res Commun 311, 1095-1102.
    • (2003) Biochem Bio-phys Res Commun , vol.311 , pp. 1095-1102
    • Ke, H.1    Huai, Q.2
  • 43
    • 33846654163 scopus 로고    scopus 로고
    • Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells
    • Doller A, Akool el S, Muller R, Gutwein P, Kurowski C, Pfeilschifter J, Eberhardt W (2007) Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells. J Am Soc Nephrol 18, 581-592.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 581-592
    • Doller, A.1    Akool El, S.2    Muller, R.3    Gutwein, P.4    Kurowski, C.5    Pfeilschifter, J.6    Eberhardt, W.7
  • 45
    • 0037363599 scopus 로고    scopus 로고
    • Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides
    • Agostinho P, Oliveira CR (2003) Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. Eur J Neurosci 17, 1189-1196.
    • (2003) Eur J Neurosci , vol.17 , pp. 1189-1196
    • Agostinho, P.1    Oliveira, C.R.2
  • 48
    • 3142705798 scopus 로고    scopus 로고
    • Molecular mechanisms of neuroprotective action of immunosuppressants- facts and hypotheses
    • Kaminska B, Gaweda-Walerych K, Zawadzka M (2004) Molecular mechanisms of neuroprotective action of immunosuppressants-facts and hypotheses. J Cell Mol Med 8, 45-58.
    • (2004) J Cell Mol Med , vol.8 , pp. 45-58
    • Kaminska, B.1    Gaweda-WaleryKawas, C.H.2    Zawadzka, M.3
  • 49
    • 1342325726 scopus 로고    scopus 로고
    • Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: Risk factors and strategies for prevention and treatment
    • Baran DA, Galin ID, Gass AL (2004) Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. Am J Cardiovasc Drugs 4, 21-29.
    • (2004) Am J Cardiovasc Drugs , vol.4 , pp. 21-29
    • Baran, D.A.1    Galin, I.D.2    Gass, A.L.3
  • 50
    • 3242772986 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and phar-macodynamics of tacrolimus in solid organ transplantation
    • Staatz CE, Tett SE (2004) Clinical pharmacokinetics and phar-macodynamics of tacrolimus in solid organ transplantation. Clin Pharmacokinet 43, 623-653.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 623-653
    • Staatz, C.E.1    Tett, S.E.2
  • 51
    • 0035659395 scopus 로고    scopus 로고
    • Nephrotoxic-ity of immunosuppressive drugs: New insight and preventive strategies
    • Olyaei AJ, de Mattos AM, Bennett WM (2001) Nephrotoxic-ity of immunosuppressive drugs: new insight and preventive strategies. Curr Opin Crit Care 7, 384-389.
    • (2001) Curr Opin Crit Care , vol.7 , pp. 384-389
    • Olyaei, A.J.1    De Mattos, A.M.2    Bennett, W.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.