Silica, silicosis, and autoimmunity

Frontiers in Immunology

Volumn 7, Issue MAR, 2016, Pages

  Pollard, Kenneth Michael ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Animal model; Autoimmunity; Human; Silica; Silicosis

Indexed keywords

CATHEPSIN B; CRYOPYRIN; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1BETA; ROTTLERIN; SILICON DIOXIDE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CHRONIC INFLAMMATION; FIBROSIS; HUMAN; NONHUMAN; PNEUMONIA; POTASSIUM TRANSPORT; RHEUMATOID ARTHRITIS; SILICOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; TISSUE INJURY;

EID: 84964691652     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00097     Document Type: Article

References (72)

1. Pollard KM. Environment, autoantibodies, and autoimmunity. Front Immunol (2015) 6:60. doi: 10.3389/fimmu.2015.00060.
2. Jayapal M, Bhattacharjee RN, Melendez AJ, Hande MP. Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins. Int J Biochem Cell Biol (2010) 42:230-40. doi:10.1016/j.biocel.2009.10.007.
3. Pollard KM. Gender differences in autoimmunity associated with exposure to environmental factors. J Autoimmun (2012) 38:J177-86. doi:10.1016/j.jaut.2011.11.007.
4. Pollard KM, Kono DH. Requirements for innate immune pathways in environmentally induced autoimmunity. BMC Med (2013) 11:100. doi:10.1186/1741-7015-11-100.
5. Miller FW, Alfredsson L, Costenbader KH, Kamen DL, Nelson LM, Norris JM, et al. Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun (2012) 39:259-71. doi:10.1016/j.jaut.2012.05.002.
6. Germolec D, Kono DH, Pfau JC, Pollard KM. Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop. J Autoimmun (2012) 39:285-93. doi:10.1016/j.jaut.2012.05.020.
7. Parks CG, Miller FW, Pollard KM, Selmi C, Germolec D, Joyce K, et al. Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease. Int J Mol Sci (2014) 15:14269-97. doi:10.3390/ijms150814269.
8. Miller FW, Pollard KM, Parks CG, Germolec DR, Leung PS, Selmi C, et al. Criteria for environmentally associated autoimmune diseases. J Autoimmun (2012) 39:253-8. doi:10.1016/j.jaut.2012.05.001.
9. Kawasaki H. A mechanistic review of silica-induced inhalation toxicity. Inhal Toxicol (2015) 27:363-77. doi:10.3109/08958378.2015.1066905.
10. Leung CC, Yu IT, Chen W. Silicosis. Lancet (2012) 379:2008-18. doi:10.1016/S0140-6736(12)60235-9.
11. Mossman BT, Glenn RE. Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs). Crit Rev Toxicol (2013) 43:632-60. doi:10.3109/10408444.2013.818617.
12. Parks CG, Conrad K, Cooper GS. Occupational exposure to crystalline silica and autoimmune disease. Environ Health Perspect (1999) 107(Suppl 5):793-802. doi:10.1289/ehp.99107s5793.
13. Castranova V, Vallyathan V. Silicosis and coal workers' pneumoconiosis. Environ Health Perspect (2000) 108(Suppl 4):675-84. doi:10.2307/3454404.
14. Callis AH, Sohnle PG, Mandel GS, Wiessner J, Mandel NS. Kinetics of inflammatory and fibrotic pulmonary changes in a murine model of silicosis. J Lab Clin Med (1985) 105:547-53.
15. Davis GS, Leslie KO, Hemenway DR. Silicosis in mice: effects of dose, time, and genetic strain. J Environ Pathol Toxicol Oncol (1998) 17:81-97.
16. Ohtsuka Y, Wang XT, Saito J, Ishida T, Munakata M. Genetic linkage analysis of pulmonary fibrotic response to silica in mice. Eur Respir J (2006) 28:1013-9. doi:10.1183/09031936.06.00132505.
17. Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 105:9035-40. doi:10.1073/pnas.0803933105.
18. Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, et al. Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. Sci Rep (2014) 4:7281. doi:10.1038/srep07281.
19. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 9:847-56. doi:10.1038/ni.1631.
20. Thakur SA, Hamilton RF Jr, Holian A. Role of scavenger receptor a family in lung inflammation from exposure to environmental particles. J Immunotoxicol (2008) 5:151-7. doi:10.1080/15476910802085863.
21. Beamer CA, Holian A. Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol (2005) 289:L186-95. doi:10.1152/ajplung.00474.2004.
22. Thakur SA, Beamer CA, Migliaccio CT, Holian A. Critical role of MARCO in crystalline silica-induced pulmonary inflammation. Toxicol Sci (2009) 108:462-71. doi:10.1093/toxsci/kfp011.
23. Beamer CA, Migliaccio CT, Jessop F, Trapkus M, Yuan D, Holian A. Innate immune processes are sufficient for driving silicosis in mice. J Leukoc Biol (2010) 88:547-57. doi:10.1189/jlb.0210108.
24. Barbarin V, Arras M, Misson P, Delos M, McGarry B, Phan SH, et al. Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice. Am J Respir Cell Mol Biol (2004) 31:78-85. doi:10.1165/rcmb.2003-0299OC.
25. Re SL, Giordano G, Yakoub Y, Devosse R, Uwambayinema F, Couillin I, et al. Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice. PLoS One (2014) 9:e99383. doi:10.1371/journal.pone.0099383.
26. Rabolli V, Badissi AA, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, et al. The alarmin IL-1alpha is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles. Part Fibre Toxicol (2014) 11:69. doi:10.1186/s12989-014-0069-x.
27. Davis GS, Holmes CE, Pfeiffer LM, Hemenway DR. Lymphocytes, lymphokines, and silicosis. J Environ Pathol Toxicol Oncol (2001) 20(Suppl 1):53-65.
28. Misson P, Brombacher F, Delos M, Lison D, Huaux F. Type 2 immune response associated with silicosis is not instrumental in the development of the disease. Am J Physiol Lung Cell Mol Physiol (2007) 292:L107-13. doi:10.1152/ajplung.00503.2005.
29. Davis GS, Pfeiffer LM, Hemenway DR, Rincon M. Interleukin-12 is not essential for silicosis in mice. Part Fibre Toxicol (2006) 3:2. doi:10.1186/1743-8977-3-2.
30. Huaux F, Louahed J, Hudspith B, Meredith C, Delos M, Renauld JC, et al. Role of interleukin-10 in the lung response to silica in mice. Am J Respir Cell Mol Biol (1998) 18:51-9.
31. Barbarin V, Xing Z, Delos M, Lison D, Huaux F. Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am J Physiol Lung Cell Mol Physiol (2005) 288:L841-8. doi:10.1152/ajplung.00329.2004.
32. Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, et al. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol (2010) 184:6367-77. doi:10.4049/jimmunol.0900459.
33. Giordano G, van den Brule S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, et al. Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci (2010) 116:682-92. doi:10.1093/toxsci/kfq158.
34. Rabolli V, Lo Re S, Uwambayinema F, Yakoub Y, Lison D, Huaux F. Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. Toxicol Lett (2011) 203:127-34. doi:10.1016/j.toxlet.2011.03.009.
35. Costantini LM, Gilberti RM, Knecht DA. The phagocytosis and toxicity of amorphous silica. PLoS One (2011) 6:e14647. doi:10.1371/journal.pone.0014647.
36. Kusaka T, Nakayama M, Nakamura K, Ishimiya M, Furusawa E, Ogasawara K. Effect of silica particle size on macrophage inflammatory responses. PLoS One (2014) 9:e92634. doi:10.1371/journal.pone.0092634.
37. Rider P, Carmi Y, Voronov E, Apte RN. Interleukin-1alpha. Semin Immunol (2013) 25:430-8. doi:10.1016/j.smim.2013.10.005.
38. Pfau JC, Sentissi JJ, Weller G, Putnam EA. Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA. Environ Health Perspect (2005) 113:25-30. doi:10.1289/ehp.7431.
39. Pfau JC, Serve KM, Noonan CW. Autoimmunity and asbestos exposure. Autoimmune Dis (2014) 2014:782045. doi:10.1155/2014/782045.
40. Conrad K, Mehlhorn J. Diagnostic and prognostic relevance of autoantibodies in uranium miners. Int Arch Allergy Immunol (2000) 123:77-91. doi:10.1159/000024426.
41. Conrad K, Mehlhorn J, Luthke K, Dorner T, Frank KH. Systemic lupus erythematosus after heavy exposure to quartz dust in uranium mines: clinical and serological characteristics. Lupus (1996) 5:62-9.
42. Parks CG, Cooper GS, Nylander-French LA, Sanderson WT, Dement JM, Cohen PL, et al. Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United States. Arthritis Rheum (2002) 46:1840-50. doi:10.1002/art.10368.
43. Sanchez-Roman J, Wichmann I, Salaberri J, Varela JM, Nunez-Roldan A. Multiple clinical and biological autoimmune manifestations in 50 workers after occupational exposure to silica. Ann Rheum Dis (1993) 52:534-8. doi:10.1136/ard.52.7.534.
44. Conrad K, Stahnke G, Liedvogel B, Mehlhorn J, Barth J, Blasum C, et al. Anti-CENP-B response in sera of uranium miners exposed to quartz dust and patients with possible development of systemic sclerosis (scleroderma). J Rheumatol (1995) 22:1286-94.
45. Steenland K. One agent, many diseases: exposure-response data and comparative risks of different outcomes following silica exposure. Am J Ind Med (2005) 48:16-23. doi:10.1002/ajim.20181.
46. Doll NJ, Stankus RP, Hughes J, Weill H, Gupta RC, Rodriguez M, et al. Immune complexes and autoantibodies in silicosis. J Allergy Clin Immunol (1981) 68:281-5. doi:10.1016/0091-6749(81)90152-4.
47. Lippmann M, Eckert HL, Hahon N, Morgan WK. Circulating antinuclear and rheumatoid factors in coal miners. A prevalence study in Pennsylvania and West Virginia. Ann Intern Med (1973) 79:807-11. doi:10.7326/0003-4819-79-6-807.
48. Brown JM, Archer AJ, Pfau JC, Holian A. Silica accelerated systemic autoimmune disease in lupus-prone New Zealand mixed mice. Clin Exp Immunol (2003) 131:415-21. doi:10.1046/j.1365-2249.2003.02094.x.
49. Brown JM, Pfau JC, Holian A. Immunoglobulin and lymphocyte responses following silica exposure in New Zealand mixed mice. Inhal Toxicol (2004) 16:133-9. doi:10.1080/08958370490270936.
50. Bates MA, Brandenberger C, Langohr I, Kumagai K, Harkema JR, Holian A, et al. Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse. PLoS One (2015) 10:e0125481. doi:10.1371/journal.pone.0125481.
51. Pfau JC, Sentissi JJ, Li S, Calderon-Garciduenas L, Brown JM, Blake DJ. Asbestos-induced autoimmunity in C57BL/6 mice. J Immunotoxicol (2008) 5:129-37. doi:10.1080/15476910802085756.
52. Zebedeo CN, Davis C, Pena C, Ng KW, Pfau JC. Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice. Toxicol Appl Pharmacol (2014) 275:257-64. doi:10.1016/j.taap.2014.01.018.
53. Salazar KD, Copeland CB, Luebke RW. Effects of Libby amphibole asbestos exposure on two models of arthritis in the Lewis rat. J Toxicol Environ Health A (2013) 75:351-65. doi:10.1080/15287394.2012.668164.
54. Salazar KD, Copeland CB, Wood CE, Schmid JE, Luebke RW. Evaluation of anti-nuclear antibodies and kidney pathology in Lewis rats following exposure to Libby amphibole asbestos. J Immunotoxicol (2013) 10:329-33. doi:10.3109/1547691X.2012.747230.
55. Al-Mogairen SM, Al-Arfaj AS, Meo SA, Adam M, Al-Hammad A, Gad El Rab MO. Induction of autoimmunity in Brown Norway rats by oral and parenteral administration of sodium silicate. Lupus (2009) 18:413-7. doi:10.1177/0961203308098192.
56. Al-Mogairen SM. Role of sodium silicate in induction of scleroderma-related autoantibodies in brown Norway rats through oral and subcutaneous administration. Rheumatol Int (2011) 31:611-5. doi:10.1007/s00296-009-1327-3.
57. Pfau JC, Brown JM, Holian A. Silica-exposed mice generate autoantibodies to apoptotic cells. Toxicology (2004) 195:167-76. doi:10.1016/j.tox.2003.09.011.
58. Blake DJ, Wetzel SA, Pfau JC. Autoantibodies from mice exposed to Libby amphibole asbestos bind SSA/Ro52-enriched apoptotic blebs of murine macrophages. Toxicology (2008) 246:172-9. doi:10.1016/j.tox.2008.01.008.
59. Soltoff SP. Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. Trends Pharmacol Sci (2007) 28:453-8. doi:10.1016/j.tips.2007.07.003.
60. Brown JM, Schwanke CM, Pershouse MA, Pfau JC, Holian A. Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. Am J Physiol Lung Cell Mol Physiol (2005) 289:L990-8. doi:10.1152/ajplung.00078.2005.
61. Brown JM, Pfau JC, Pershouse MA, Holian A. Silica, apoptosis, and autoimmunity. J Immunotoxicol (2005) 1:177-87. doi:10.1080/15476910490911922.
62. Pollard KM, Kono DH. Requirements for "Fire and ICE" differ between animal models of autoimmunity: comment on the article by Kahlenberg et al. Arthritis Rheumatol (2014) 66:2310-1. doi:10.1002/art.38678.
63. Kahlenberg JM, Yalavarthi S, Zhao W, Hodgin JB, Reed TJ, Tsuji NM, et al. An essential role for caspase-1 in the induction of murine lupus and its associated vascular damage. Arthritis Rheum (2014) 66:152-62. doi:10.1002/art.38225.
64. Pollard KM, Hultman P, Toomey CB, Cauvi DM, Hoffman HM, Hamel JC, et al. Definition of IFN-gamma-related pathways critical for chemically-induced systemic autoimmunity. J Autoimmun (2012) 39:323-31. doi:10.1016/j.jaut.2012.04.003.
65. Baccala R, Kono DH, Theofilopoulos AN. Interferons as pathogenic effectors in autoimmunity. Immunol Rev (2005) 204:9-26. doi:10.1111/j.0105-2896.2005.00252.x.
66. Nacionales DC, Kelly KM, Lee PY, Zhuang H, Li Y, Weinstein JS, et al. Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). Am J Pathol (2006) 168:1227-40. doi:10.2353/ajpath.2006.050125.
67. Pollard KM, Cauvi DM, Toomey CB, Morris KV, Kono DH. Interferon-gamma and systemic autoimmunity. Discov Med (2013) 16:123-31.
68. Burkett PR, Meyer zu Horste G, Kuchroo VK. Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest (2015) 125:2211-9. doi:10.1172/JCI78085.
69. Wermeling F, Chen Y, Pikkarainen T, Scheynius A, Winqvist O, Izui S, et al. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med (2007) 204:2259-65. doi:10.1084/jem.20070600.
70. Michels-van Amelsfort JM, Walter GJ, Taams LS. CD4+CD25+ regulatory T cells in systemic sclerosis and other rheumatic diseases. Expert Rev Clin Immunol (2011) 7:499-514. doi:10.1586/eci.11.28.
71. Okamoto A, Fujio K, Okamura T, Yamamoto K. Regulatory T-cell-associated cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 2011:463412. doi:10.1155/2011/463412.
72. von Herrath M, Nepom GT. Animal models of human type 1 diabetes. Nat Immunol (2009) 10:129-32. doi:10.1038/ni0209-129.