Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity

Journal of Autoimmunity

Volumn 39, Issue 4, 2012, Pages 323-331

  Pollard, K Michael ^a   Hultman, Per ^b   Toomey, Christopher B ^a,d   Cauvi, David M ^a,c   Hoffman, Hal M ^c   Hamel, John C ^a   Kono, Dwight H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Animal model; Interferon; Mercury

Indexed keywords

CD44V ANTIGEN; CRYOPYRIN; DECAY ACCELERATING FACTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12; INTERLEUKIN 1BETA CONVERTING ENZYME; MERCURY; STAT4 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CHEMICALLY INDUCED DISORDER; CONTROLLED STUDY; GENE CONTROL; GENETIC SUSCEPTIBILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELL PROLIFERATION; GENE DELETION; GENE EXPRESSION REGULATION; HETEROZYGOTE; INJECTIONS, SUBCUTANEOUS; INTERFERON-GAMMA; MERCURIC CHLORIDE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84869861619     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.04.003     Document Type: Article

References (73)

1. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Annu Rev Immunol 1997, 15:749-795.
2. Szabo S.J., Sullivan B.M., Peng S.L., Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003, 21:713-758.
3. Carvalho-Pinto C.E., Garcia M.I., Mellado M., Rodriguez-Frade J.M., Martin-Caballero J., Flores J., et al. autocrine production of ifn-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 2002, 169:1058-1067.
4. Hertzog P., Forster S., Samarajiwa S. Systems biology of interferon responses. J Interferon Cytokine Res 2011, 31:5-11.
5. Borden E.C., Williams B.R. Interferon-stimulated genes and their protein products: what and how?. J Interferon Cytokine Res 2011, 31:1-4.
6. de Veer M.J., Holko M., Frevel M., Walker E., Der S., Paranjape J.M., et al. Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 2001, 69:912-920.
7. Bach E.A., Aguet M., Schreiber R.D. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997, 15:563-591.
8. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., Schreiber R.D. How cells respond to interferons. Annu Rev Biochem 1998, 67:227-264.
9. Hu X., Ivashkiv L.B. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 2009, 31:539-550.
10. Baudino L., Azeredo da Silveira S., Nakata M., Izui S. Molecular and cellular basis for pathogenicity of autoantibodies: lessons from murine monoclonal autoantibodies. Springer Semin Immunopathol 2006, 28:175-184.
11. Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations. Annu Rev Immunol 2010, 28:445-489.
12. Murphy K.M., Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 2010, 11:674-680.
13. Paunovic V., Carroll H.P., Vandenbroeck K., Gadina M. Signalling, inflammation and arthritis: crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity. Rheumatology (Oxford) 2008, 47:771-776.
14. Theofilopoulos A.N., Koundouris S., Kono D.H., Lawson B.R. The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res 2001, 3:136-141.
15. McMurray R.W., Hoffman R.W., Nelson W., Walker S.E. Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus-analyses of strain, gender, and age effects. Clin Immunol Immunopathol 1997, 84:260-268.
16. Chu E.B., Ernst D.N., Hobbs M.V., Weigle W.O. Maturational changes in CD4+ cell subsets and lymphokine production in BXSB mice. J Immunol 1994, 152:4129-4138.
17. Prud'homme G.J., Kono D.H., Theofilopoulos A.N. Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice. Mol Immunol 1995, 32:495-503.
18. Jacob C.O., van der Meide P.H., McDevitt H.O. In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med 1987, 166:798-803.
19. Peng S.L., Moslehi J., Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 1997, 99:1936-1946.
20. Balomenos D., Rumold R., Theofilopoulos A.N. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 1998, 101:364-371.
21. Schwarting A., Wada T., Kinoshita K., Tesch G., Kelley V.R. IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J Immunol 1998, 161:494-503.
22. Haas C., Ryffel B., Le Hir M. IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol 1998, 160:3713-3718.
23. Lawson B.R., Prud'homme G.J., Chang Y., Gardner H.A., Kuan J., Kono D.H., et al. Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc. J Clin Invest 2000, 106:207-215.
24. Peng S.L., Szabo S.J., Glimcher L.H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A 2002, 99:5545-5550.
25. Kono D.H., Balomenos D., Pearson D.L., Park M.S., Hildebrandt B., Hultman P., et al. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN- gamma and not Th1/Th2 imbalance. J Immunol 1998, 161:234-240.
26. Schiraldi M., Monestier M. How can a chemical element elicit complex immunopathology? lessons from mercury-induced autoimmunity. Trends Immunol 2009, 30:502-509.
27. Toomey C.B., Cauvi D.M., Song W.C., Pollard K.M. Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity. Immunology 2010, 131:99-106.
28. Kroger A., Koster M., Schroeder K., Hauser H., Mueller P.P. Activities of IRF-1. J Interferon Cytokine Res 2002, 22:5-14.
29. Brydges S.D., Mueller J.L., McGeough M.D., Pena C.A., Misaghi A., Gandhi C., et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 2009, 30:875-887.
30. Pollard K.M., Arnush M., Hultman P., Kono D.H. Costimulation requirements of induced murine systemic autoimmune disease. J Immunol 2004, 173:5880-5887.
31. Burlingame R.W., Rubin R.L. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J Immunol Methods 1990, 134:187-199.
32. Kotzin B.L., Lafferty J.A., Portanova J.P., Rubin R.L., Tan E.M. Monoclonal anti-histone autoantibodies derived from murine models of lupus. J Immunol 1984, 133:2554-2559.
33. Cauvi D.M., Cauvi G., Pollard K.M. Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease. Arthritis Rheum 2007, 56:1934-1944.
34. Dinarello C.A. Interleukin-18 and the pathogenesis of inflammatory diseases. Semin Nephrol 2007, 27:98-114.
35. Franchi L., Eigenbrod T., Munoz-Planillo R., Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009, 10:241-247.
36. Gris D., Ye Z., Iocca H.A., Wen H., Craven R.R., Gris P., et al. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol 2010, 185:974-981.
37. Lalor S.J., Dungan L.S., Sutton C.E., Basdeo S.A., Fletcher J.M., Mills K.H. Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity. J Immunol 2011, 186:5738-5748.
38. Korman B.D., Kastner D.L., Gregersen P.K., Remmers E.F. STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep 2008, 8:398-403.
39. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003, 3:133-146.
40. Cooper A.M., Khader S.A. IL-12p40: an inherently agonistic cytokine. Trends Immunol 2007, 28:33-38.
41. Watford W.T., Hissong B.D., Bream J.H., Kanno Y., Muul L., O'Shea J.J. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 2004, 202:139-156.
42. Nardelli B., Belvedere O., Roschke V., Moore P.A., Olsen H.S., Migone T.S., et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 2001, 97:198-204.
43. Liu Z., Davidson A. BAFF and selection of autoreactive B cells. Trends Immunol 2011, 32:388-394.
44. Zheng Y., Gallucci S., Gaughan J.P., Gross J.A., Monestier M. A role for B cell-activating factor of the TNF family in chemically induced autoimmunity. J Immunol 2005, 175:6163-6168.
45. Mackay F., Schneider P. Cracking the BAFF code. Nat Rev Immunol 2009, 9:491-502.
46. Arend W.P., Palmer G., Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 2008, 223:20-38.
47. Schott W.H., Haskell B.D., Tse H.M., Milton M.J., Piganelli J.D., Choisy-Rossi C.M., et al. Caspase-1 is not required for type 1 diabetes in the NOD mouse. Diabetes 2004, 53:99-104.
48. Lin L., Peng S.L. Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus. Arthritis Rheum 2005, 52:984-986.
49. Esfandiari E., McInnes I.B., Lindop G., Huang F.P., Field M., Komai-Koma M., et al. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J Immunol 2001, 167:5338-5347.
50. Bossu P., Neumann D., Del Giudice E., Ciaramella A., Gloaguen I., Fantuzzi G., et al. IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A 2003, 100:14181-14186.
51. Voronov E., Dayan M., Zinger H., Gayvoronsky L., Lin J.P., Iwakura Y., et al. IL-1 beta-deficient mice are resistant to induction of experimental SLE. Eur Cytokine Netw 2006, 17:109-116.
52. Zdolsek J.M., Soder O., Hultman P. Mercury induces in vivo and in vitro secretion of interleukin-1 in mice. Immunopharmacology 1994, 28:201-208.
53. Pollard K.M., Landberg G.P. The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent. Int Immunopharmacol 2001, 1:581-593.
54. Rosenzweig S.D., Holland S.M. Defects in the interferon-gamma and interleukin-12 pathways. Immunol Rev 2005, 203:38-47.
55. Calvani N., Satoh M., Croker B.P., Reeves W.H., Richards H.B. Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupus. Kidney Int 2003, 64:897-905.
56. Kikawada E., Lenda D.M., Kelley V.R. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 2003, 170:3915-3925.
57. Collison L.W., Vignali D.A. Interleukin-35: odd one out or part of the family?. Immunol Rev 2008, 226:248-262.
58. Kaplan M.H. STAT4: a critical regulator of inflammation in vivo. Immunol Res 2005, 31:231-242.
59. Menke J., Bork T., Kutska B., Byrne K.T., Blanfeld M., Relle M., et al. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int 2011, 79:452-463.
60. Xu Z., Duan B., Croker B.P., Morel L. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 2006, 120:189-198.
61. Jacob C.O., Zang S., Li L., Ciobanu V., Quismorio F., Mizutani A., et al. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol 2003, 171:1564-1571.
62. Singh R.R., Saxena V., Zang S., Li L., Finkelman F.D., Witte D.P., et al. Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 2003, 170:4818-4825.
63. Scapini P., Hu Y., Chu C.L., Migone T.S., Defranco A.L., Cassatella M.A., et al. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 2010, 207:1757-1773.
64. Pollard K.M., Hultman P., Arnush M., Hildebrandt B., Kono D.H. Immunology and genetics of xenobiotic-induced autoimmunity. From animal models to human genetics: research in the induction and pathogenicity of autoantiS200bodies, Lengerich: Pabst 2004, 130-144. K. Conrad, M.P. Bachmann, E.K. Chan, M.J. Fritzler, R.L. Humbel, U. Sack, Y. Shoenfeld (Eds.).
65. Pollard K.M., Hultman P., Toomey C.B., Cauvi D.M., Konoc D.H. beta2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity. J Immunotoxicol 2011, 8:228-237.
66. Shi L., Perin J.C., Leipzig J., Zhang Z., Sullivan K.E. Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene 2011, 487:21-28.
67. Reilly C.M., Olgun S., Goodwin D., Gogal R.M., Santo A., Romesburg J.W., et al. Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice. Eur J Immunol 2006, 36:1296-1308.
68. Nakazawa T., Satoh J., Takahashi K., Sakata Y., Ikehata F., Takizawa Y., et al. Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1. J Autoimmun 2001, 17:119-125.
69. Motrich R.D., van Etten E., Baeke F., Riera C.M., Mathieu C., Rivero V.E. Crucial role of interferon-gamma in experimental autoimmune prostatitis. J Urol 2010, 183:1213-1220.
70. Ren Z., Wang Y., Liebenson D., Liggett T., Goswami R., Stefoski D., et al. IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination. J Neuroimmunol 2011, 233:147-159.
71. Hultman P., Johansson U., Dagnaes-Hansen F. Murine mercury-induced autoimmunity: the role of T-helper cells. J Autoimmun 1995, 8:809-823.
72. Hurgin V., Novick D., Werman A., Dinarello C.A., Rubinstein M. Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha. Proc Natl Acad Sci U S A 2007, 104:5044-5049.
73. Von Stebut E., Ehrchen J.M., Belkaid Y., Kostka S.L., Molle K., Knop J., et al. Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J Exp Med 2003, 198:191-199.