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Volumn 8, Issue 7, 2013, Pages 822-834

Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays

Author keywords

Arrays; Maintenance; Microbioreactor; Pluripotent stem cells; Screening

Indexed keywords

ARRAYS; BROAD APPLICATION; CELL FATE DECISION; HUMAN EMBRYONIC STEM CELLS; MICRO-BIOREACTOR; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE; SPATIO-TEMPORAL VARIATION;

EID: 84879756725     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200375     Document Type: Article
Times cited : (21)

References (55)
  • 1
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts.
    • Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A. et al., Embryonic stem cell lines derived from human blastocysts. Science 1998, 282, 1145-1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3    Waknitz, M.A.4
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M. et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4
  • 3
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
    • Keirstead, H. S., Nistor, G., Bernal, G., Totoiu, M. et al., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 2005, 25, 4694-4705.
    • (2005) J. Neurosci. , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4
  • 4
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells.
    • Park, I.-H., Arora, N., Huo, H., Maherali, N. et al., Disease-specific induced pluripotent stem cells. Cell 2008, 134, 877-886.
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.-H.1    Arora, N.2    Huo, H.3    Maherali, N.4
  • 5
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells.
    • Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D. et al., A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells. Cell 2010, 143, 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.N.1    Carromeu, C.2    Acab, A.3    Yu, D.4
  • 6
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development.
    • Murry, C. E., Keller, G., Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 2008, 132, 661-680.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 7
    • 34547620338 scopus 로고    scopus 로고
    • Embryonic stem cells as a source of models for drug discovery.
    • Pouton, C. W., Haynes, J. M., Embryonic stem cells as a source of models for drug discovery. Nat. Rev. Drug Discovery 2007, 6, 605-616.
    • (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 605-616
    • Pouton, C.W.1    Haynes, J.M.2
  • 8
    • 34948895016 scopus 로고    scopus 로고
    • Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media.
    • Prowse, A. B. J., McQuade, L. R., Bryant, K. J., Marcal, H., Gray, P. P., Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media. J. Proteome Res. 2007, 6, 3796-3807.
    • (2007) J. Proteome Res. , vol.6 , pp. 3796-3807
    • Prowse, A.B.J.1    McQuade, L.R.2    Bryant, K.J.3    Marcal, H.4    Gray, P.P.5
  • 9
    • 0026701412 scopus 로고
    • Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components.
    • Vukicevic, S., Kleinman, H. K., Luyten, F. P., Roberts, A. B. et al., Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp. Cell Res. 1992, 202, 1-8.
    • (1992) Exp. Cell Res. , vol.202 , pp. 1-8
    • Vukicevic, S.1    Kleinman, H.K.2    Luyten, F.P.3    Roberts, A.B.4
  • 10
    • 0041560908 scopus 로고    scopus 로고
    • Molecular signature of human embryonic stem cells and its comparison with the mouse.
    • Sato, N., Sanjuan, I. M., Heke, M., Uchida, M. et al., Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev. Biol. 2003, 260, 404-413.
    • (2003) Dev. Biol. , vol.260 , pp. 404-413
    • Sato, N.1    Sanjuan, I.M.2    Heke, M.3    Uchida, M.4
  • 11
    • 34147113900 scopus 로고    scopus 로고
    • A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas.
    • Assou, S., Le Carrour, T., Tondeur, S., Ström, S. et al., A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells 2007, 25, 961-973.
    • (2007) Stem Cells , vol.25 , pp. 961-973
    • Assou, S.1    Le Carrour, T.2    Tondeur, S.3    Ström, S.4
  • 12
    • 46249103973 scopus 로고    scopus 로고
    • Stem cell transcriptome profiling via massive-scale mRNA sequencing.
    • Cloonan, N., Forrest, A. R. R., Kolle, G., Gardiner, B. B. A. et al., Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nat. Meth. 2008, 5, 613-619.
    • (2008) Nat. Meth. , vol.5 , pp. 613-619
    • Cloonan, N.1    Forrest, A.R.R.2    Kolle, G.3    Gardiner, B.B.A.4
  • 13
    • 63049129915 scopus 로고    scopus 로고
    • An enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture.
    • Bendall, S. C., Hughes, C., Campbell, J. L., Stewart, M. H. et al., An enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture. Mol. Cell Proteomics 2009, 8, 421-432.
    • (2009) Mol. Cell Proteomics , vol.8 , pp. 421-432
    • Bendall, S.C.1    Hughes, C.2    Campbell, J.L.3    Stewart, M.H.4
  • 14
    • 33644648070 scopus 로고    scopus 로고
    • Microfluidic arrays for logarithmically perfused embryonic stem cell culture.
    • Kim, L., Vahey, M. D., Hsu-Yi, L., Voldman, J., Microfluidic arrays for logarithmically perfused embryonic stem cell culture. Lab Chip 2006, 6, 394-406.
    • (2006) Lab Chip , vol.6 , pp. 394-406
    • Kim, L.1    Vahey, M.D.2    Hsu-Yi, L.3    Voldman, J.4
  • 15
    • 80054017005 scopus 로고    scopus 로고
    • Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors.
    • Titmarsh, D., Hidalgo, A., Turner, J., Wolvetang, E., Cooper-White, J., Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors. Biotechnol. Bioeng. 2011, 108, 2894-2904.
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 2894-2904
    • Titmarsh, D.1    Hidalgo, A.2    Turner, J.3    Wolvetang, E.4    Cooper-White, J.5
  • 16
    • 58049213491 scopus 로고    scopus 로고
    • Micro-bioreactor arrays for controlling cellular environments: Design principles for human embryonic stem cell applications.
    • Cimetta, E., Figallo, E., Cannizzaro, C., Elvassore, N., Vunjak-Novakovic, G., Micro-bioreactor arrays for controlling cellular environments: Design principles for human embryonic stem cell applications. Methods 2009, 47, 81-89.
    • (2009) Methods , vol.47 , pp. 81-89
    • Cimetta, E.1    Figallo, E.2    Cannizzaro, C.3    Elvassore, N.4    Vunjak-Novakovic, G.5
  • 17
    • 34249821066 scopus 로고    scopus 로고
    • Micro-bioreactor array for controlling cellular microenvironments.
    • Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J. A. et al., Micro-bioreactor array for controlling cellular microenvironments. Lab Chip 2007, 4, 710-719.
    • (2007) Lab Chip , vol.4 , pp. 710-719
    • Figallo, E.1    Cannizzaro, C.2    Gerecht, S.3    Burdick, J.A.4
  • 19
    • 84873437242 scopus 로고    scopus 로고
    • Microfluidic systems: A new toolbox for pluripotent stem cells.
    • Lesher-Perez, S. C., Frampton, J. P., Takayama, S., Microfluidic systems: A new toolbox for pluripotent stem cells. Biotechnol. J. 2013, 8, 180-191.
    • (2013) Biotechnol. J. , vol.8 , pp. 180-191
    • Lesher-Perez, S.C.1    Frampton, J.P.2    Takayama, S.3
  • 20
    • 77953571969 scopus 로고    scopus 로고
    • Latest developments in microfluidic cell biology and analysis systems.
    • Salieb-Beugelaar, G. B., Simone, G., Arora, A., Philippi, A., Manz, A., Latest developments in microfluidic cell biology and analysis systems. Anal. Chem. 2010, 82, 4848-4864.
    • (2010) Anal. Chem. , vol.82 , pp. 4848-4864
    • Salieb-Beugelaar, G.B.1    Simone, G.2    Arora, A.3    Philippi, A.4    Manz, A.5
  • 21
    • 84873417297 scopus 로고    scopus 로고
    • Arrayed cellular environments for stem cells and regenerative medicine.
    • Titmarsh, D. M., Chen, H., Wolvetang, E. J., Cooper-White, J. J., Arrayed cellular environments for stem cells and regenerative medicine. Biotechnol. J. 2013, 8, 167-179.
    • (2013) Biotechnol. J. , vol.8 , pp. 167-179
    • Titmarsh, D.M.1    Chen, H.2    Wolvetang, E.J.3    Cooper-White, J.J.4
  • 22
    • 3042825341 scopus 로고    scopus 로고
    • Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.
    • Anderson, D. G., Levenberg, S., Langer, R., Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat. Biotechnol. 2004, 22, 863-866.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 863-866
    • Anderson, D.G.1    Levenberg, S.2    Langer, R.3
  • 23
    • 77957298109 scopus 로고    scopus 로고
    • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.
    • Brafman, D. A., Chang, C. W., Fernandez, A., Willert, K. et al., Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials 2010, 31, 9135-9144.
    • (2010) Biomaterials , vol.31 , pp. 9135-9144
    • Brafman, D.A.1    Chang, C.W.2    Fernandez, A.3    Willert, K.4
  • 24
    • 77956060857 scopus 로고    scopus 로고
    • Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.
    • Mei, Y., Saha, K., Bogatyrev, S. R., Yang, J. et al., Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat. Mater. 2010, 9, 768-778.
    • (2010) Nat. Mater. , vol.9 , pp. 768-778
    • Mei, Y.1    Saha, K.2    Bogatyrev, S.R.3    Yang, J.4
  • 25
    • 33846045536 scopus 로고    scopus 로고
    • Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments.
    • Soen, Y., Mori, A., Palmer, T. D., Brown, P. O., Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol. Syst. Biol. 2006, 2, 37.
    • (2006) Mol. Syst. Biol. , vol.2 , pp. 37
    • Soen, Y.1    Mori, A.2    Palmer, T.D.3    Brown, P.O.4
  • 26
    • 75849116893 scopus 로고    scopus 로고
    • Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments.
    • Brafman, D. A., Minicis, S. D., Seki, E., Shah, K. D. et al., Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr. Biol. 2009, 1, 513-524.
    • (2009) Integr. Biol. , vol.1 , pp. 513-524
    • Brafman, D.A.1    Minicis, S.D.2    Seki, E.3    Shah, K.D.4
  • 27
    • 70350776634 scopus 로고    scopus 로고
    • Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology.
    • Brafman, D. A., Shah, K. D., Fellner, T., Chien, S., Willert, K., Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev. 2009, 18, 1141-1154.
    • (2009) Stem Cells Dev. , vol.18 , pp. 1141-1154
    • Brafman, D.A.1    Shah, K.D.2    Fellner, T.3    Chien, S.4    Willert, K.5
  • 28
    • 18744376054 scopus 로고    scopus 로고
    • An extracellular matrix microarray for probing cellular differentiation.
    • Flaim, C. J., Chien, S., Bhatia, S. N., An extracellular matrix microarray for probing cellular differentiation. Nat. Meth. 2005, 2, 119-125.
    • (2005) Nat. Meth. , vol.2 , pp. 119-125
    • Flaim, C.J.1    Chien, S.2    Bhatia, S.N.3
  • 29
    • 39449127641 scopus 로고    scopus 로고
    • Combinatorial signaling microenvironments for studying stem cell fate.
    • Flaim, C. J., Teng, D., Chien, S., Bhatia, S. N., Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 2008, 17, 29-40.
    • (2008) Stem Cells Dev. , vol.17 , pp. 29-40
    • Flaim, C.J.1    Teng, D.2    Chien, S.3    Bhatia, S.N.4
  • 30
    • 33751336911 scopus 로고    scopus 로고
    • Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation.
    • Nakajima, M., Ishimuro, T., Kato, K., Ko, I.-K. et al., Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation. Biomaterials 2007, 28, 1048-1060.
    • (2007) Biomaterials , vol.28 , pp. 1048-1060
    • Nakajima, M.1    Ishimuro, T.2    Kato, K.3    Ko, I.-K.4
  • 31
    • 77957966079 scopus 로고    scopus 로고
    • Using growth factor arrays and micropatterned co-cultures to induce hepatic differentiation of embryonic stem cells.
    • Tuleuova, N., Lee, J. Y., Lee, J., Ramanculov, E. et al., Using growth factor arrays and micropatterned co-cultures to induce hepatic differentiation of embryonic stem cells. Biomaterials 2010, 31, 9221-9231.
    • (2010) Biomaterials , vol.31 , pp. 9221-9231
    • Tuleuova, N.1    Lee, J.Y.2    Lee, J.3    Ramanculov, E.4
  • 32
    • 68949135330 scopus 로고    scopus 로고
    • Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells.
    • Ellison, D., Munden, A., Levchenko, A., Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells. Mol. BioSyst. 2009, 5, 1004-1012.
    • (2009) Mol. BioSyst. , vol.5 , pp. 1004-1012
    • Ellison, D.1    Munden, A.2    Levchenko, A.3
  • 33
    • 79959830458 scopus 로고    scopus 로고
    • High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays.
    • Lecault, V., VanInsberghe, M., Sekulovic, S., Knapp, D. J. H. F. et al., High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat. Meth. 2011, 8, 581-586.
    • (2011) Nat. Meth. , vol.8 , pp. 581-586
    • Lecault, V.1    VanInsberghe, M.2    Sekulovic, S.3    Knapp, D.J.H.F.4
  • 34
    • 37349067768 scopus 로고    scopus 로고
    • Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments.
    • King, K. R., Wang, S., Jayaraman, A., Yarmush, M. L., Toner, M., Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab Chip 2008, 8, 107-116.
    • (2008) Lab Chip , vol.8 , pp. 107-116
    • King, K.R.1    Wang, S.2    Jayaraman, A.3    Yarmush, M.L.4    Toner, M.5
  • 35
    • 79961146650 scopus 로고    scopus 로고
    • Microfluidic perfusion for regulating diffusible signaling in stem cells.
    • Blagovic, K., Kim, L. Y., Voldman, J., Microfluidic perfusion for regulating diffusible signaling in stem cells. PLoS ONE 2011, 6, e22892.
    • (2011) PLoS ONE , vol.6
    • Blagovic, K.1    Kim, L.Y.2    Voldman, J.3
  • 36
    • 84857735045 scopus 로고    scopus 로고
    • Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells.
    • Moledina, F., Clarke, G., Oskooei, A., Onishi, K. et al., Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells. Proc. Natl. Acad. Sci. USA 2012.
    • (2012) Proc. Natl. Acad. Sci. USA
    • Moledina, F.1    Clarke, G.2    Oskooei, A.3    Onishi, K.4
  • 37
    • 84871593878 scopus 로고    scopus 로고
    • Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation.
    • Titmarsh, D. M., Hudson, J. E., Hidalgo, A., Elefanty, A. G. et al., Microbioreactor Arrays for Full Factorial Screening of Exogenous and Paracrine Factors in Human Embryonic Stem Cell Differentiation. PLoS ONE 2012. 7, e52405.
    • (2012) PLoS ONE , vol.7
    • Titmarsh, D.M.1    Hudson, J.E.2    Hidalgo, A.3    Elefanty, A.G.4
  • 39
    • 0035866594 scopus 로고    scopus 로고
    • Generation of gradients having complex shapes using microfluidic networks.
    • Dertinger, S. K. W., Chiu, D. T., Noo Li, J., Whitesides, G. M., Generation of gradients having complex shapes using microfluidic networks. Anal. Chem. 2001, 73, 1240-1246.
    • (2001) Anal. Chem. , vol.73 , pp. 1240-1246
    • Dertinger, S.K.W.1    Chiu, D.T.2    Noo Li, J.3    Whitesides, G.M.4
  • 40
    • 67649382695 scopus 로고    scopus 로고
    • Generation of arbitrary monotonic concentration profiles by a serial dilution microfluidic network composed of microchannels with a high fluidic-resistance ratio.
    • Hattori, K., Sugiura, S., Kanamori, T., Generation of arbitrary monotonic concentration profiles by a serial dilution microfluidic network composed of microchannels with a high fluidic-resistance ratio. Lab Chip 2009, 9, 1763-1772.
    • (2009) Lab Chip , vol.9 , pp. 1763-1772
    • Hattori, K.1    Sugiura, S.2    Kanamori, T.3
  • 41
    • 4344572516 scopus 로고    scopus 로고
    • Combinatorial mixing of microfluidic streams.
    • Neils, C., Tyree, Z., Finlayson, B., Folch, A., Combinatorial mixing of microfluidic streams. Lab Chip 2004, 4, 342-350.
    • (2004) Lab Chip , vol.4 , pp. 342-350
    • Neils, C.1    Tyree, Z.2    Finlayson, B.3    Folch, A.4
  • 42
    • 70350507217 scopus 로고    scopus 로고
    • Microbioreactor array for full-factorial analysis of provision of multiple soluble factors in cellular microenvironments.
    • Titmarsh, D., Cooper-White, J., Microbioreactor array for full-factorial analysis of provision of multiple soluble factors in cellular microenvironments. Biotechnol. Bioeng. 2009, 104, 1240-1244.
    • (2009) Biotechnol. Bioeng. , vol.104 , pp. 1240-1244
    • Titmarsh, D.1    Cooper-White, J.2
  • 43
    • 65449121435 scopus 로고    scopus 로고
    • Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency.
    • Hotta, A., Cheung, A. Y. L., Farra, N., Vijayaragavan, K. et al., Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat. Meth. 2009, 6, 370-376.
    • (2009) Nat. Meth. , vol.6 , pp. 370-376
    • Hotta, A.1    Cheung, A.Y.L.2    Farra, N.3    Vijayaragavan, K.4
  • 44
    • 0032403465 scopus 로고    scopus 로고
    • Rapid prototyping of microfluidic systems in poly(dimethylsiloxane).
    • Duffy, D. C., McDonald, J. C., Schueller, O. J. A., Whitesides, G. M., Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal. Chem. 1998, 70, 4974-4984.
    • (1998) Anal. Chem. , vol.70 , pp. 4974-4984
    • Duffy, D.C.1    McDonald, J.C.2    Schueller, O.J.A.3    Whitesides, G.M.4
  • 45
    • 0035387449 scopus 로고    scopus 로고
    • A method for filling complex polymeric microfluidic devices and arrays.
    • Monahan, J., Gewirth, A. A., Nuzzo, R. G., A method for filling complex polymeric microfluidic devices and arrays. Anal. Chem. 2001, 73, 3193-3197.
    • (2001) Anal. Chem. , vol.73 , pp. 3193-3197
    • Monahan, J.1    Gewirth, A.A.2    Nuzzo, R.G.3
  • 46
    • 33746392927 scopus 로고    scopus 로고
    • Feeder-independent culture of human embryonic stem cells.
    • Ludwig, T. E., Bergendahl, V., Levenstein, M. E., Yu, J. et al., Feeder-independent culture of human embryonic stem cells. Nat. Meth. 2006, 3, 637-646.
    • (2006) Nat. Meth. , vol.3 , pp. 637-646
    • Ludwig, T.E.1    Bergendahl, V.2    Levenstein, M.E.3    Yu, J.4
  • 48
    • 84879769448 scopus 로고
    • Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, Wiley, New York, Chichester, Brisbane
    • Box, G. E. P., Hunter, W. G., Hunter, J. S., Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, Wiley, New York, Chichester, Brisbane 1978.
    • (1978)
    • Box, G.E.P.1    Hunter, W.G.2    Hunter, J.S.3
  • 49
    • 84879746424 scopus 로고    scopus 로고
    • Handbook of Biological Statistics, 2nd Edn., Sparky House Publishing, Baltimore, Maryland
    • McDonald, J. H., Handbook of Biological Statistics, 2nd Edn., Sparky House Publishing, Baltimore, Maryland 2009.
    • (2009)
    • McDonald, J.H.1
  • 50
    • 34447295350 scopus 로고    scopus 로고
    • Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
    • Adewumi, O., Aflatoonian, B., Ahrlund-Richter, L., Amit, M. et al., Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat. Biotechnol. 2007, 25, 803-816.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 803-816
    • Adewumi, O.1    Aflatoonian, B.2    Ahrlund-Richter, L.3    Amit, M.4
  • 51
    • 33846879559 scopus 로고    scopus 로고
    • Adaptation to culture of human embryonic stem cells and oncogenesis in vivo.
    • Baker, D. E., Harrison, N. J., Maltby, E., Smith, K. et al., Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat. Biotechnol. 2007, 25, 207-215.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 207-215
    • Baker, D.E.1    Harrison, N.J.2    Maltby, E.3    Smith, K.4
  • 52
    • 78049366735 scopus 로고    scopus 로고
    • Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media.
    • Chen, X., Chen, A., Woo, T. L., Choo, A. B. H. et al., Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media. Stem Cells Dev. 2010, 19, 1781-1792.
    • (2010) Stem Cells Dev. , vol.19 , pp. 1781-1792
    • Chen, X.1    Chen, A.2    Woo, T.L.3    Choo, A.B.H.4
  • 53
    • 70450193138 scopus 로고    scopus 로고
    • A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells.
    • Hough, S. R., Laslett, A. L., Grimmond, S. B., Kolle, G., Pera, M. F., A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells. PLoS ONE 2009, 4, e7708.
    • (2009) PLoS ONE , vol.4
    • Hough, S.R.1    Laslett, A.L.2    Grimmond, S.B.3    Kolle, G.4    Pera, M.F.5
  • 54
    • 36249022693 scopus 로고    scopus 로고
    • Niche-mediated control of human embryonic stem cell self-renewal and differentiation.
    • Peerani, R., Rao, B. M., Bauwens, C., Yin, T. et al., Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. 2007, 26, 4744-4755.
    • (2007) EMBO J. , vol.26 , pp. 4744-4755
    • Peerani, R.1    Rao, B.M.2    Bauwens, C.3    Yin, T.4
  • 55
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells.
    • Xiao, L., Yuan, X., Sharkis, S. J., Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 2006, 24, 1476-1486.
    • (2006) Stem Cells , vol.24 , pp. 1476-1486
    • Xiao, L.1    Yuan, X.2    Sharkis, S.J.3


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