메뉴 건너뛰기




Volumn 71, Issue , 2016, Pages 78-87

Regulatory T cell therapy for type 1 diabetes: May the force be with you

Author keywords

Autoimmunity; Regulatory T cells; Type 1 diabetes mellitus

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 84964668143     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2016.03.011     Document Type: Review
Times cited : (55)

References (85)
  • 1
    • 79957651158 scopus 로고    scopus 로고
    • National Diabetes Statistics Report 2014, http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf.
    • (2014) National Diabetes Statistics Report
  • 2
    • 84869803914 scopus 로고    scopus 로고
    • Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: dynamic modeling of incidence, mortality, and population growth
    • Imperatore G., Boyle J.P., Thompson T.J., Case D., Dabelea D., Hamman R.F., et al. Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: dynamic modeling of incidence, mortality, and population growth. Diabetes Care 2012, 35(12):2515-2520.
    • (2012) Diabetes Care , vol.35 , Issue.12 , pp. 2515-2520
    • Imperatore, G.1    Boyle, J.P.2    Thompson, T.J.3    Case, D.4    Dabelea, D.5    Hamman, R.F.6
  • 3
    • 84942755473 scopus 로고    scopus 로고
    • Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D exchange clinic registry
    • Miller K.M., Foster N.C., Beck R.W., Bergenstal R.M., DuBose S.N., DiMeglio L.A., et al. Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D exchange clinic registry. Diabetes Care 2015, 38(6):971-978.
    • (2015) Diabetes Care , vol.38 , Issue.6 , pp. 971-978
    • Miller, K.M.1    Foster, N.C.2    Beck, R.W.3    Bergenstal, R.M.4    DuBose, S.N.5    DiMeglio, L.A.6
  • 6
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone J.A., Herold K., Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464(7293):1293-1300.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 7
    • 0023709376 scopus 로고
    • Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-european randomized control trial group
    • Cyclosporin-induced remission of IDDM after early intervention Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-european randomized control trial group. Diabetes 1988, 37(11):1574-1582.
    • (1988) Diabetes , vol.37 , Issue.11 , pp. 1574-1582
  • 8
    • 0022619110 scopus 로고
    • Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
    • Feutren G., Papoz L., Assan R., Vialettes B., Karsenty G., Vexiau P., et al. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 1986, 2(8499):119-124.
    • (1986) Lancet , vol.2 , Issue.8499 , pp. 119-124
    • Feutren, G.1    Papoz, L.2    Assan, R.3    Vialettes, B.4    Karsenty, G.5    Vexiau, P.6
  • 10
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • Herold K.C., Gitelman S.E., Masharani U., Hagopian W., Bisikirska B., Donaldson D., et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005, 54(6):1763-1769.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6
  • 11
    • 84887052291 scopus 로고    scopus 로고
    • Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders
    • Herold K.C., Gitelman S.E., Ehlers M.R., Gottlieb P.A., Greenbaum C.J., Hagopian W., et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes 2013, 62(11):3766-3774.
    • (2013) Diabetes , vol.62 , Issue.11 , pp. 3766-3774
    • Herold, K.C.1    Gitelman, S.E.2    Ehlers, M.R.3    Gottlieb, P.A.4    Greenbaum, C.J.5    Hagopian, W.6
  • 12
    • 84939218518 scopus 로고    scopus 로고
    • Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
    • Rigby M.R., Harris K.M., Pinckney A., DiMeglio L.A., Rendell M.S., Felner E.I., et al. Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J. Clin. Investig. 2015, 125(8):3285-3296.
    • (2015) J. Clin. Investig. , vol.125 , Issue.8 , pp. 3285-3296
    • Rigby, M.R.1    Harris, K.M.2    Pinckney, A.3    DiMeglio, L.A.4    Rendell, M.S.5    Felner, E.I.6
  • 13
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    • Orban T., Bundy B., Becker D.J., DiMeglio L.A., Gitelman S.E., Goland R., et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011, 378(9789):412-419.
    • (2011) Lancet , vol.378 , Issue.9789 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    DiMeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 14
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein C.G., Miller J.S., Cao Q., McKenna D.H., Hippen K.L., Curtsinger J., et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117(3):1061-1070.
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3    McKenna, D.H.4    Hippen, K.L.5    Curtsinger, J.6
  • 17
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang Q., Bluestone J.A. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 2008, 9(3):239-244.
    • (2008) Nat. Immunol. , vol.9 , Issue.3 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 18
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 2010, 11(1):7-13.
    • (2010) Nat. Immunol. , vol.11 , Issue.1 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 19
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27(1):20-21.
    • (2001) Nat. Genet. , vol.27 , Issue.1 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 22
    • 84875261622 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and metabolic control of immune responses
    • Munn D.H., Mellor A.L. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013, 34(3):137-143.
    • (2013) Trends Immunol. , vol.34 , Issue.3 , pp. 137-143
    • Munn, D.H.1    Mellor, A.L.2
  • 24
    • 34547204632 scopus 로고    scopus 로고
    • Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    • You S., Leforban B., Garcia C., Bach J.F., Bluestone J.A., Chatenoud L. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(15):6335-6340.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.15 , pp. 6335-6340
    • You, S.1    Leforban, B.2    Garcia, C.3    Bach, J.F.4    Bluestone, J.A.5    Chatenoud, L.6
  • 25
    • 84905455228 scopus 로고    scopus 로고
    • Targeting cancer-derived adenosine: new therapeutic approaches
    • Young A., Mittal D., Stagg J., Smyth M.J. Targeting cancer-derived adenosine: new therapeutic approaches. Cancer Discov. 2014, 4(8):879-888.
    • (2014) Cancer Discov. , vol.4 , Issue.8 , pp. 879-888
    • Young, A.1    Mittal, D.2    Stagg, J.3    Smyth, M.J.4
  • 26
    • 84871642405 scopus 로고    scopus 로고
    • Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions
    • Heiber J.F., Geiger T.L. Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions. Cell Immunol. 2012, 279(1):60-65.
    • (2012) Cell Immunol. , vol.279 , Issue.1 , pp. 60-65
    • Heiber, J.F.1    Geiger, T.L.2
  • 27
    • 33644784891 scopus 로고    scopus 로고
    • Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes
    • Alyanakian M.A., Grela F., Aumeunier A., Chiavaroli C., Gouarin C., Bardel E., et al. Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes. Diabetes 2006, 55(1):179-185.
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 179-185
    • Alyanakian, M.A.1    Grela, F.2    Aumeunier, A.3    Chiavaroli, C.4    Gouarin, C.5    Bardel, E.6
  • 29
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • Green E.A., Gorelik L., McGregor C.M., Tran E.H., Flavell R.A. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(19):10878-10883.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.19 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3    Tran, E.H.4    Flavell, R.A.5
  • 30
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., Borriello F., Schweitzer A.N., Lynch W.P., Bluestone J.A., Sharpe A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3(5):541-547.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 31
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi O.S., Zheng Y., Nakamura K., Attridge K., Manzotti C., Schmidt E.M., et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011, 332(6029):600-603.
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 32
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B., Bluestone J.A. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 2001, 19:225-252.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 33
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12(4):431-440.
    • (2000) Immunity , vol.12 , Issue.4 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6
  • 34
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q., Adams J.Y., Penaranda C., Melli K., Piaggio E., Sgouroudis E., et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008, 28(5):687-697.
    • (2008) Immunity , vol.28 , Issue.5 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5    Sgouroudis, E.6
  • 35
    • 84861451140 scopus 로고    scopus 로고
    • Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
    • Bettini M.L., Pan F., Bettini M., Finkelstein D., Rehg J.E., Floess S., et al. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity 2012, 36(5):717-730.
    • (2012) Immunity , vol.36 , Issue.5 , pp. 717-730
    • Bettini, M.L.1    Pan, F.2    Bettini, M.3    Finkelstein, D.4    Rehg, J.E.5    Floess, S.6
  • 36
    • 79957764739 scopus 로고    scopus 로고
    • A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice
    • D'Alise A.M., Ergun A., Hill J.A., Mathis D., Benoist C. A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(21):8737-8742.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.21 , pp. 8737-8742
    • D'Alise, A.M.1    Ergun, A.2    Hill, J.A.3    Mathis, D.4    Benoist, C.5
  • 37
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005, 54(1):92-99.
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 38
    • 17844364504 scopus 로고    scopus 로고
    • Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
    • Brusko T.M., Wasserfall C.H., Clare-Salzler M.J., Schatz D.A., Atkinson M.A. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 2005, 54(5):1407-1414.
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Atkinson, M.A.5
  • 39
    • 77449143100 scopus 로고    scopus 로고
    • Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
    • Long S.A., Cerosaletti K., Bollyky P.L., Tatum M., Shilling H., Zhang S., et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 2010, 59(2):407-415.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 407-415
    • Long, S.A.1    Cerosaletti, K.2    Bollyky, P.L.3    Tatum, M.4    Shilling, H.5    Zhang, S.6
  • 40
    • 69349102624 scopus 로고    scopus 로고
    • Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    • Dendrou C.A., Plagnol V., Fung E., Yang J.H., Downes K., Cooper J.D., et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat. Genet. 2009, 41(9):1011-1015.
    • (2009) Nat. Genet. , vol.41 , Issue.9 , pp. 1011-1015
    • Dendrou, C.A.1    Plagnol, V.2    Fung, E.3    Yang, J.H.4    Downes, K.5    Cooper, J.D.6
  • 41
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • Maier L.M., Lowe C.E., Cooper J., Downes K., Anderson D.E., Severson C., et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009, 5(1):e1000322.
    • (2009) PLoS Genet. , vol.5 , Issue.1
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3    Downes, K.4    Anderson, D.E.5    Severson, C.6
  • 42
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
    • Long S.A., Rieck M., Sanda S., Bollyky J.B., Samuels P.L., Goland R., et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes 2012, 61(9):2340-2348.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3    Bollyky, J.B.4    Samuels, P.L.5    Goland, R.6
  • 43
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Grinberg-Bleyer Y., Baeyens A., You S., Elhage R., Fourcade G., Gregoire S., et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. 2010, 207(9):1871-1878.
    • (2010) J. Exp. Med. , vol.207 , Issue.9 , pp. 1871-1878
    • Grinberg-Bleyer, Y.1    Baeyens, A.2    You, S.3    Elhage, R.4    Fourcade, G.5    Gregoire, S.6
  • 46
  • 47
    • 80051931752 scopus 로고    scopus 로고
    • Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
    • Penaranda C., Tang Q., Bluestone J.A. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J. Immunol. 2011, 187(4):2015-2022.
    • (2011) J. Immunol. , vol.187 , Issue.4 , pp. 2015-2022
    • Penaranda, C.1    Tang, Q.2    Bluestone, J.A.3
  • 48
    • 84887624109 scopus 로고    scopus 로고
    • Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
    • Gitelman S.E., Gottlieb P.A., Rigby M.R., Felner E.I., Willi S.M., Fisher L.K., et al. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol. 2013, 1(4):306-316.
    • (2013) Lancet Diabetes Endocrinol. , vol.1 , Issue.4 , pp. 306-316
    • Gitelman, S.E.1    Gottlieb, P.A.2    Rigby, M.R.3    Felner, E.I.4    Willi, S.M.5    Fisher, L.K.6
  • 49
    • 84920413163 scopus 로고    scopus 로고
    • Anti-thymocyte globulin/G-CSF treatment preserves beta cell function in patients with established type 1 diabetes
    • Haller M.J., Gitelman S.E., Gottlieb P.A., Michels A.W., Rosenthal S.M., Shuster J.J., et al. Anti-thymocyte globulin/G-CSF treatment preserves beta cell function in patients with established type 1 diabetes. J. Clin. Investig. 2015, 125(1):448-455.
    • (2015) J. Clin. Investig. , vol.125 , Issue.1 , pp. 448-455
    • Haller, M.J.1    Gitelman, S.E.2    Gottlieb, P.A.3    Michels, A.W.4    Rosenthal, S.M.5    Shuster, J.J.6
  • 50
    • 84953839594 scopus 로고    scopus 로고
    • Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes
    • Tooley J.E., Vudattu N., Choi J., Cotsapas C., Devine L., Raddassi K., et al. Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes. Eur. J. Immunol. 2016, 46(1):230-241.
    • (2016) Eur. J. Immunol. , vol.46 , Issue.1 , pp. 230-241
    • Tooley, J.E.1    Vudattu, N.2    Choi, J.3    Cotsapas, C.4    Devine, L.5    Raddassi, K.6
  • 51
    • 62749201002 scopus 로고    scopus 로고
    • Expansion of human regulatory T-cells from patients with type 1 diabetes
    • Putnam A.L., Brusko T.M., Lee M.R., Liu W., Szot G.L., Ghosh T., et al. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 2009, 58(3):652-662.
    • (2009) Diabetes , vol.58 , Issue.3 , pp. 652-662
    • Putnam, A.L.1    Brusko, T.M.2    Lee, M.R.3    Liu, W.4    Szot, G.L.5    Ghosh, T.6
  • 53
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont S.A., Putnam A.L., Lee M.R., Esensten J.H., Liu W., Hulme M.A., et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 2011, 186(7):3918-3926.
    • (2011) J. Immunol. , vol.186 , Issue.7 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3    Esensten, J.H.4    Liu, W.5    Hulme, M.A.6
  • 54
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X., Bailey-Bucktrout S.L., Jeker L.T., Penaranda C., Martinez-Llordella M., Ashby M., et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 2009, 10(9):1000-1007.
    • (2009) Nat. Immunol. , vol.10 , Issue.9 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3    Penaranda, C.4    Martinez-Llordella, M.5    Ashby, M.6
  • 55
  • 56
    • 84863840517 scopus 로고    scopus 로고
    • Regulatory T-cell therapy for transplantation: how many cells do we need?
    • Tang Q., Lee K. Regulatory T-cell therapy for transplantation: how many cells do we need?. Curr. Opin. Organ Transpl. 2012, 17(4):349-354.
    • (2012) Curr. Opin. Organ Transpl. , vol.17 , Issue.4 , pp. 349-354
    • Tang, Q.1    Lee, K.2
  • 57
    • 84865483192 scopus 로고    scopus 로고
    • Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children
    • Marek-Trzonkowska N., Mysliwiec M., Dobyszuk A., Grabowska M., Techmanska I., Juscinska J., et al. Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children. Diabetes Care 2012, 35(9):1817-1820.
    • (2012) Diabetes Care , vol.35 , Issue.9 , pp. 1817-1820
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Techmanska, I.5    Juscinska, J.6
  • 58
    • 84899144218 scopus 로고    scopus 로고
    • Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up
    • Marek-Trzonkowska N., Mysliwiec M., Dobyszuk A., Grabowska M., Derkowska I., Juscinska J., et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. Clin. Immunol. 2014, 153(1):23-30.
    • (2014) Clin. Immunol. , vol.153 , Issue.1 , pp. 23-30
    • Marek-Trzonkowska, N.1    Mysliwiec, M.2    Dobyszuk, A.3    Grabowska, M.4    Derkowska, I.5    Juscinska, J.6
  • 60
    • 84881023549 scopus 로고    scopus 로고
    • Altering the course of type 1 diabetes: an update on prevention and new-onset clinical trials
    • Thomas H.R., Gitelman S.E. Altering the course of type 1 diabetes: an update on prevention and new-onset clinical trials. Pediatr. Diabetes 2013, 14(5):311-321.
    • (2013) Pediatr. Diabetes , vol.14 , Issue.5 , pp. 311-321
    • Thomas, H.R.1    Gitelman, S.E.2
  • 61
    • 84872018209 scopus 로고    scopus 로고
    • Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials
    • Staeva T.P., Chatenoud L., Insel R., Atkinson M.A. Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 2013, 62(1):9-17.
    • (2013) Diabetes , vol.62 , Issue.1 , pp. 9-17
    • Staeva, T.P.1    Chatenoud, L.2    Insel, R.3    Atkinson, M.A.4
  • 62
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • Malek T.R. The biology of interleukin-2. Annu. Rev. Immunol. 2008, 26:453-479.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 64
    • 82555196118 scopus 로고    scopus 로고
    • Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    • Saadoun D., Rosenzwajg M., Joly F., Six A., Carrat F., Thibault V., et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N. Engl. J. Med. 2011, 365(22):2067-2077.
    • (2011) N. Engl. J. Med. , vol.365 , Issue.22 , pp. 2067-2077
    • Saadoun, D.1    Rosenzwajg, M.2    Joly, F.3    Six, A.4    Carrat, F.5    Thibault, V.6
  • 65
    • 84904130542 scopus 로고    scopus 로고
    • Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata
    • Castela E., Le Duff F., Butori C., Ticchioni M., Hofman P., Bahadoran P., et al. Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata. JAMA Dermatol. 2014, 150(7):748-751.
    • (2014) JAMA Dermatol. , vol.150 , Issue.7 , pp. 748-751
    • Castela, E.1    Le Duff, F.2    Butori, C.3    Ticchioni, M.4    Hofman, P.5    Bahadoran, P.6
  • 66
    • 84887625676 scopus 로고    scopus 로고
    • Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
    • Hartemann A., Bensimon G., Payan C.A., Jacqueminet S., Bourron O., Nicolas N., et al. Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2013, 1(4):295-305.
    • (2013) Lancet Diabetes Endocrinol. , vol.1 , Issue.4 , pp. 295-305
    • Hartemann, A.1    Bensimon, G.2    Payan, C.A.3    Jacqueminet, S.4    Bourron, O.5    Nicolas, N.6
  • 67
    • 84928589620 scopus 로고    scopus 로고
    • Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
    • Rosenzwajg M., Churlaud G., Mallone R., Six A., Derian N., Chaara W., et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J. Autoimmun. 2015, 58:48-58.
    • (2015) J. Autoimmun. , vol.58 , pp. 48-58
    • Rosenzwajg, M.1    Churlaud, G.2    Mallone, R.3    Six, A.4    Derian, N.5    Chaara, W.6
  • 68
    • 84920747699 scopus 로고    scopus 로고
    • The relative merits of cord blood as a cell source for autologous T regulatory cell therapy in type 1 diabetes
    • Theil A., Wilhelm C., Guhr E., Reinhardt J., Bonifacio E. The relative merits of cord blood as a cell source for autologous T regulatory cell therapy in type 1 diabetes. Horm. Metab. Res. 2015, 47(1):48-55.
    • (2015) Horm. Metab. Res. , vol.47 , Issue.1 , pp. 48-55
    • Theil, A.1    Wilhelm, C.2    Guhr, E.3    Reinhardt, J.4    Bonifacio, E.5
  • 69
    • 84960337895 scopus 로고    scopus 로고
    • Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile and clinical effect
    • Brunstein C.G., Miller J.S., McKenna D.H., Hippen K.L., DeFor T.E., Sumstad D., et al. Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile and clinical effect. Blood 2016, 127(8):1044-1051.
    • (2016) Blood , vol.127 , Issue.8 , pp. 1044-1051
    • Brunstein, C.G.1    Miller, J.S.2    McKenna, D.H.3    Hippen, K.L.4    DeFor, T.E.5    Sumstad, D.6
  • 70
    • 84857841147 scopus 로고    scopus 로고
    • Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide
    • Haller M.J., Wasserfall C.H., Hulme M.A., Cintron M., Brusko T.M., McGrail K.M., et al. Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide. Diabetes Care 2011, 34(12):2567-2569.
    • (2011) Diabetes Care , vol.34 , Issue.12 , pp. 2567-2569
    • Haller, M.J.1    Wasserfall, C.H.2    Hulme, M.A.3    Cintron, M.4    Brusko, T.M.5    McGrail, K.M.6
  • 71
    • 84896401653 scopus 로고    scopus 로고
    • Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial
    • Giannopoulou E.Z., Puff R., Beyerlein A., von Luettichau I., Boerschmann H., Schatz D., et al. Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial. Pediatr. Diabetes 2014, 15(2):100-109.
    • (2014) Pediatr. Diabetes , vol.15 , Issue.2 , pp. 100-109
    • Giannopoulou, E.Z.1    Puff, R.2    Beyerlein, A.3    von Luettichau, I.4    Boerschmann, H.5    Schatz, D.6
  • 73
    • 73149093194 scopus 로고    scopus 로고
    • Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
    • Wright G.P., Notley C.A., Xue S.A., Bendle G.M., Holler A., Schumacher T.N., et al. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(45):19078-19083.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , Issue.45 , pp. 19078-19083
    • Wright, G.P.1    Notley, C.A.2    Xue, S.A.3    Bendle, G.M.4    Holler, A.5    Schumacher, T.N.6
  • 74
    • 65249120858 scopus 로고    scopus 로고
    • Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor
    • Elinav E., Adam N., Waks T., Eshhar Z. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. Gastroenterology 2009, 136(5):1721-1731.
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1721-1731
    • Elinav, E.1    Adam, N.2    Waks, T.3    Eshhar, Z.4
  • 75
    • 44649157803 scopus 로고    scopus 로고
    • Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice
    • Elinav E., Waks T., Eshhar Z. Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice. Gastroenterology 2008, 134(7):2014-2024.
    • (2008) Gastroenterology , vol.134 , Issue.7 , pp. 2014-2024
    • Elinav, E.1    Waks, T.2    Eshhar, Z.3
  • 76
    • 84861542408 scopus 로고    scopus 로고
    • CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
    • Fransson M., Piras E., Burman J., Nilsson B., Essand M., Lu B., et al. CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery. J. Neuroinflamm. 2012, 9:112.
    • (2012) J. Neuroinflamm. , vol.9 , pp. 112
    • Fransson, M.1    Piras, E.2    Burman, J.3    Nilsson, B.4    Essand, M.5    Lu, B.6
  • 77
    • 70249122695 scopus 로고    scopus 로고
    • First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
    • Trzonkowski P., Bieniaszewska M., Juscinska J., Dobyszuk A., Krzystyniak A., Marek N., et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin. Immunol. 2009, 133(1):22-26.
    • (2009) Clin. Immunol. , vol.133 , Issue.1 , pp. 22-26
    • Trzonkowski, P.1    Bieniaszewska, M.2    Juscinska, J.3    Dobyszuk, A.4    Krzystyniak, A.5    Marek, N.6
  • 78
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M., Falzetti F., Carotti A., Terenzi A., Castellino F., Bonifacio E., et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011, 117(14):3921-3928.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3    Terenzi, A.4    Castellino, F.5    Bonifacio, E.6
  • 79
    • 80053597291 scopus 로고    scopus 로고
    • Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
    • Edinger M., Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr. Opin. Immunol. 2011, 23(5):679-684.
    • (2011) Curr. Opin. Immunol. , vol.23 , Issue.5 , pp. 679-684
    • Edinger, M.1    Hoffmann, P.2
  • 80
    • 84895561909 scopus 로고    scopus 로고
    • Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells
    • Bacchetta R., Lucarelli B., Sartirana C., Gregori S., Lupo Stanghellini M.T., et al. Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells. Front. Immunol. 2014, 5:16.
    • (2014) Front. Immunol. , vol.5 , pp. 16
    • Bacchetta, R.1    Lucarelli, B.2    Sartirana, C.3    Gregori, S.4    Lupo Stanghellini, M.T.5
  • 81
    • 84904899365 scopus 로고    scopus 로고
    • HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
    • Martelli M.F., Di Ianni M., Ruggeri L., Falzetti F., Carotti A., Terenzi A., et al. HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood 2014, 124(4):638-644.
    • (2014) Blood , vol.124 , Issue.4 , pp. 638-644
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3    Falzetti, F.4    Carotti, A.5    Terenzi, A.6
  • 82
    • 84868109200 scopus 로고    scopus 로고
    • Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease
    • 1207-17 e1201-1202
    • Desreumaux P., Foussat A., Allez M., Beaugerie L., Hebuterne X., Bouhnik Y., et al. Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology 2012, 143(5). 1207-17 e1201-1202.
    • (2012) Gastroenterology , vol.143 , Issue.5
    • Desreumaux, P.1    Foussat, A.2    Allez, M.3    Beaugerie, L.4    Hebuterne, X.5    Bouhnik, Y.6
  • 83
    • 84930019397 scopus 로고    scopus 로고
    • Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
    • Canavan J.B., Scotta C., Vossenkamper A., Goldberg R., Elder M.J., Shoval I., et al. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease. Gut 2016, 65(4):584-594.
    • (2016) Gut , vol.65 , Issue.4 , pp. 584-594
    • Canavan, J.B.1    Scotta, C.2    Vossenkamper, A.3    Goldberg, R.4    Elder, M.J.5    Shoval, I.6
  • 84
    • 84961994310 scopus 로고    scopus 로고
    • Treatment of uveitis by in situ administration of ex vivo-activated polyclonal regulatory t cells
    • Gregoire S., Terrada C., Martin G.H., Fourcade G., Baeyens A., Marodon G., et al. Treatment of uveitis by in situ administration of ex vivo-activated polyclonal regulatory t cells. J. Immunol. 2016, 196(5):2109-2118.
    • (2016) J. Immunol. , vol.196 , Issue.5 , pp. 2109-2118
    • Gregoire, S.1    Terrada, C.2    Martin, G.H.3    Fourcade, G.4    Baeyens, A.5    Marodon, G.6
  • 85
    • 84930272455 scopus 로고    scopus 로고
    • Now or never? the case for cell-based immunosuppression in kidney transplantation
    • Hutchinson J.A., Geissler E.K. Now or never? the case for cell-based immunosuppression in kidney transplantation. Kidney Int. 2015, 87(6):1116-1124.
    • (2015) Kidney Int. , vol.87 , Issue.6 , pp. 1116-1124
    • Hutchinson, J.A.1    Geissler, E.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.