Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators

Novartis Foundation Symposium

Volumn 287, Issue , 2007, Pages 60-63

  Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PPARGC1A PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; DEGENERATIVE DISEASE; ENERGY METABOLISM; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ENERGY METABOLISM; HUMANS; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 38449092832     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (16)

1. Handschin C, Spiegelman BM 2006 PGC-1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27:728-735
2. Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM 2003 An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc Natl Acad Sci USA 100:7111-7116
3. Lecker SH, Jagoe RT, Gilbert A et al 2004 Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J 18:39-51
4. Lin J, Tarr P, Puigserver P et al 2002 Transcriptional coactivator PGC-1alpha drives the expression of slow-twitch muscle fibres. Nature 418:797-801
5. Lin J, Wu PH, Tarr PT et al 2004 Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119:121-135
6. Lin MT, Beal MF 2006 Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795
7. Mootha VK, Lindgren CM, Eriksson KF et al 2003 PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273
8. Mootha VK, Handschin C, Arlow D et al 2004 Errα and Gabpβ specify PGC-1α-dependent OXPHOS gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 101:6570-6575
9. Patti ME, Butte AJ, Crunkhorn S et al 2003 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100:8466-8471
10. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
11. St Pierre J, Lin J, Krauss S et al 2003 Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells. J Biol Chem 278:26597-26603
12. St Pierre J, Drori D, Uldry M et al 2006 Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127:397-402
13. Sandri M, Lin J, Handschin C et al 2006 PGC-1alpha protects skeletal muscle from atrophy by suppressing Fox03 action and atrophy-specific gene transcription. Proc Natl Acad Sci USA 103:16260-16265
14. Schreiber SN, Emter R, Hock MB et al 2004 The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101:6472-6647
15. Tiraby C, Tavernier G, Lefort C et al 2003 Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278:33370-33376
16. Wu Z, Puigserver P, Andersson U et al 1999 Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124