Type I interferon signaling is decoupled from specific receptor orientation through lenient requirements of the transmembrane domain

Journal of Biological Chemistry

Volumn 291, Issue 7, 2016, Pages 3371-3384

  Sharma, Nanaocha ^a   Longjam, Geeta ^a   Schreiber, Gideon ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; ANTIBIOTICS; BINDING ENERGY; BINS; BIOINFORMATICS; CELL MEMBRANES; CHEMICAL ACTIVATION; ENZYME ACTIVITY; GLYCOPROTEINS; INTERFERONS; TISSUE;

BIOINFORMATIC ANALYSIS; CELL SURFACE RECEPTORS; CONFORMATIONAL CHANGE; DIFFERENTIAL SIGNALING; SEQUENCE CONSERVATION; STRUCTURAL PERTURBATION; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES;

CELL SIGNALING;

ALANINE; CELL SURFACE RECEPTOR; INTERFERON; INTERFERON RECEPTOR; INTERFERON RECEPTOR 1; INTERFERON RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SERINE; STAT1 PROTEIN; STAT2 PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR; ALPHA INTERFERON; HYBRID PROTEIN; IFNA2 PROTEIN, HUMAN; IFNAR1 PROTEIN, HUMAN; IFNAR2 PROTEIN, HUMAN; MUTANT PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BIOINFORMATICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; GENE INDUCTION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; AGONISTS; AMINO ACID SEQUENCE; BIOLOGY; CELL LINE; CHEMISTRY; CONSERVED SEQUENCE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; KINETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CELL LINE; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; GENE KNOCKOUT TECHNIQUES; HUMANS; INTERFERON-ALPHA; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INTERFERON ALPHA-BETA; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84964595928     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.686071     Document Type: Article

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