-
1
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon M.A., Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010, 141:1117-1134.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
2
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
3
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
4
-
-
84896091512
-
ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics
-
Arteaga C.L., Engelman J.A. ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 2014, 25:282-303.
-
(2014)
Cancer Cell
, vol.25
, pp. 282-303
-
-
Arteaga, C.L.1
Engelman, J.A.2
-
5
-
-
84883821225
-
Antibody therapeutics in cancer
-
Sliwkowski M.X., Mellman I. Antibody therapeutics in cancer. Science 2013, 341:1192-1198.
-
(2013)
Science
, vol.341
, pp. 1192-1198
-
-
Sliwkowski, M.X.1
Mellman, I.2
-
6
-
-
69949151386
-
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
-
Jänne P.A., Gray N., Settleman J. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov 2009, 8:709-723.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 709-723
-
-
Jänne, P.A.1
Gray, N.2
Settleman, J.3
-
7
-
-
0023686033
-
Signal transduction by allosteric receptor oligomerization
-
Schlessinger J. Signal transduction by allosteric receptor oligomerization. Trends Biochem Sci 1988, 13:443-447.
-
(1988)
Trends Biochem Sci
, vol.13
, pp. 443-447
-
-
Schlessinger, J.1
-
8
-
-
0024521844
-
Signal transduction by the platelet-derived growth factor receptor
-
Williams L.T. Signal transduction by the platelet-derived growth factor receptor. Science 1989, 243:1564-1570.
-
(1989)
Science
, vol.243
, pp. 1564-1570
-
-
Williams, L.T.1
-
9
-
-
84874727313
-
The insulin receptor: both a prototypical and atypical receptor tyrosine kinase
-
Hubbard S.R. The insulin receptor: both a prototypical and atypical receptor tyrosine kinase. Cold Spring Harb Perspect Biol 2013, 5:a008946.
-
(2013)
Cold Spring Harb Perspect Biol
, vol.5
, pp. a008946
-
-
Hubbard, S.R.1
-
10
-
-
79953308071
-
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
-
Jura N., Zhang X., Endres N.F., Seeliger M.A., Schindler T., Kuriyan J. Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell 2011, 42:9-22.
-
(2011)
Mol Cell
, vol.42
, pp. 9-22
-
-
Jura, N.1
Zhang, X.2
Endres, N.F.3
Seeliger, M.A.4
Schindler, T.5
Kuriyan, J.6
-
12
-
-
78649548465
-
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor
-
Lu C., Mi L.Z., Grey M.J., Zhu J., Graef E., Yokoyama S., Springer T.A. Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol 2010, 30:5432-5443.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5432-5443
-
-
Lu, C.1
Mi, L.Z.2
Grey, M.J.3
Zhu, J.4
Graef, E.5
Yokoyama, S.6
Springer, T.A.7
-
13
-
-
84868323253
-
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor
-
Lu C., Mi L.Z., Schurpf T., Walz T., Springer T.A. Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor. J Biol Chem 2012, 287:38244-38253.
-
(2012)
J Biol Chem
, vol.287
, pp. 38244-38253
-
-
Lu, C.1
Mi, L.Z.2
Schurpf, T.3
Walz, T.4
Springer, T.A.5
-
14
-
-
80052511894
-
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
-
Mi L.Z., Lu C., Li Z., Nishida N., Walz T., Springer T.A. Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol 2011, 18:984-989.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 984-989
-
-
Mi, L.Z.1
Lu, C.2
Li, Z.3
Nishida, N.4
Walz, T.5
Springer, T.A.6
-
15
-
-
82955249253
-
Mechanistic insights into the activation of oncogenic forms of EGF receptor
-
Wang Z., Longo P.A., Tarrant M.K., Kim K., Head S., Leahy D.J., Cole P.A. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nat Struct Mol Biol 2011, 18:1388-1893.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 1388-1893
-
-
Wang, Z.1
Longo, P.A.2
Tarrant, M.K.3
Kim, K.4
Head, S.5
Leahy, D.J.6
Cole, P.A.7
-
16
-
-
84863601338
-
A single ligand is sufficient to activate EGFR dimers
-
Liu P., Cleveland T.E., 4th, Bouyain S., Byrne P.O., Longo P.A., Leahy D.J. A single ligand is sufficient to activate EGFR dimers. Proc Natl Acad Sci U S A 2012, 109:10861-10866.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 10861-10866
-
-
Liu, P.1
Cleveland, T.E.2
Bouyain, S.3
Byrne, P.O.4
Longo, P.A.5
Leahy, D.J.6
-
17
-
-
84865238071
-
Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation
-
Scheck R.A., Lowder M.A., Appelbaum J.S., Schepartz A. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. ACS Chem Biol 2012, 7:1367-1376.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 1367-1376
-
-
Scheck, R.A.1
Lowder, M.A.2
Appelbaum, J.S.3
Schepartz, A.4
-
18
-
-
67449146917
-
The juxtamembrane region of the EGF receptor functions as an activation domain
-
Red Brewer M., Choi S.H., Alvarado D., Moravcevic K., Pozzi A., Lemmon M.A., Carpenter G. The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell 2009, 34:641-651.
-
(2009)
Mol Cell
, vol.34
, pp. 641-651
-
-
Red Brewer, M.1
Choi, S.H.2
Alvarado, D.3
Moravcevic, K.4
Pozzi, A.5
Lemmon, M.A.6
Carpenter, G.7
-
19
-
-
67549145398
-
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
-
Jura N., Endres N.F., Engel K., Deindl S., Das R., Lamers M.H., Wemmer D.E., Zhang X., Kuriyan J. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 2009, 137:1293-1307.
-
(2009)
Cell
, vol.137
, pp. 1293-1307
-
-
Jura, N.1
Endres, N.F.2
Engel, K.3
Deindl, S.4
Das, R.5
Lamers, M.H.6
Wemmer, D.E.7
Zhang, X.8
Kuriyan, J.9
-
20
-
-
84873280409
-
Conformational coupling across the plasma membrane in activation of the EGF receptor
-
Endres N.F., Das R., Smith A.W., Arkhipov A., Kovacs E., Huang Y., Pelton J.G., Shan Y., Shaw D.E., Wemmer D.E., et al. Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell 2013, 152:543-556.
-
(2013)
Cell
, vol.152
, pp. 543-556
-
-
Endres, N.F.1
Das, R.2
Smith, A.W.3
Arkhipov, A.4
Kovacs, E.5
Huang, Y.6
Pelton, J.G.7
Shan, Y.8
Shaw, D.E.9
Wemmer, D.E.10
-
21
-
-
67649391241
-
The intracellular juxtamembrane domain of the EGF receptor is responsible for the allosteric regulation of EGF binding
-
MacDonald-Obermann J.L., Pike L.J. The intracellular juxtamembrane domain of the EGF receptor is responsible for the allosteric regulation of EGF binding. J Biol Chem 2009, 284:13570-13576.
-
(2009)
J Biol Chem
, vol.284
, pp. 13570-13576
-
-
MacDonald-Obermann, J.L.1
Pike, L.J.2
-
22
-
-
84455161571
-
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding
-
Adak S., Yang K.S., Macdonald-Obermann J., Pike L.J. The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding. J Biol Chem 2011, 286:45146-45155.
-
(2011)
J Biol Chem
, vol.286
, pp. 45146-45155
-
-
Adak, S.1
Yang, K.S.2
Macdonald-Obermann, J.3
Pike, L.J.4
-
23
-
-
0018774782
-
Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors
-
Shoyab M., De Larco J.E., Todaro G.J. Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors. Nature 1979, 279:387-391.
-
(1979)
Nature
, vol.279
, pp. 387-391
-
-
Shoyab, M.1
De Larco, J.E.2
Todaro, G.J.3
-
24
-
-
77950460037
-
Spatial control of EGF receptor activation by reversible dimerization on living cells
-
Chung I., Akita R., Vandlen R., Toomre D., Schlessinger J., Mellman I. Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature 2010, 464:783-787.
-
(2010)
Nature
, vol.464
, pp. 783-787
-
-
Chung, I.1
Akita, R.2
Vandlen, R.3
Toomre, D.4
Schlessinger, J.5
Mellman, I.6
-
25
-
-
84893258774
-
The spatiotemporal organization of ErbB receptors: insights from microscopy
-
Valley C.C., Lidke K.A., Lidke D.S. The spatiotemporal organization of ErbB receptors: insights from microscopy. Cold Spring Harb Perspect Biol 2014, 6:a020735.
-
(2014)
Cold Spring Harb Perspect Biol
, vol.6
, pp. a020735
-
-
Valley, C.C.1
Lidke, K.A.2
Lidke, D.S.3
-
26
-
-
84908657323
-
Structure-function relationships of ErbB RTKs in the plasma membrane of living cells
-
Arndt-Jovin D.J., Botelho M.G., Jovin TM: Structure-function relationships of ErbB RTKs in the plasma membrane of living cells. Cold Spring Harb Perspect Biol 2014, 6:a008961.
-
(2014)
Cold Spring Harb Perspect Biol
, vol.6
, pp. a008961
-
-
Arndt-Jovin, D.J.1
Botelho, M.G.2
Jovin, T.M.3
-
27
-
-
79959336760
-
Regulation of human EGF receptor by lipids
-
Coskun Ü., Grzybek M., Drechsel D., Simons K. Regulation of human EGF receptor by lipids. Proc Natl Acad Sci U S A 2011, 108:9044-9048.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9044-9048
-
-
Coskun, Ü.1
Grzybek, M.2
Drechsel, D.3
Simons, K.4
-
28
-
-
22244449320
-
An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family
-
McLaughlin S., Smith S.O., Hayman M.J., Murray D. An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family. J Gen Physiol 2005, 126:41-53.
-
(2005)
J Gen Physiol
, vol.126
, pp. 41-53
-
-
McLaughlin, S.1
Smith, S.O.2
Hayman, M.J.3
Murray, D.4
-
29
-
-
68949108024
-
EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction
-
Sengupta P., Bosis E., Nachliel E., Gutman M., Smith S.O., Mihályné G., Zaitseva I., McLaughlin S. EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction. Biophys J 2009, 96:4887-4895.
-
(2009)
Biophys J
, vol.96
, pp. 4887-4895
-
-
Sengupta, P.1
Bosis, E.2
Nachliel, E.3
Gutman, M.4
Smith, S.O.5
Mihályné, G.6
Zaitseva, I.7
McLaughlin, S.8
-
30
-
-
84873292211
-
Architecture and membrane interactions of the EGF receptor
-
Arkhipov A., Shan Y., Das R., Endres N.F., Eastwood M.P., Wemmer D.E., Kuriyan J., Shaw D.E. Architecture and membrane interactions of the EGF receptor. Cell 2013, 152:557-569.
-
(2013)
Cell
, vol.152
, pp. 557-569
-
-
Arkhipov, A.1
Shan, Y.2
Das, R.3
Endres, N.F.4
Eastwood, M.P.5
Wemmer, D.E.6
Kuriyan, J.7
Shaw, D.E.8
-
31
-
-
84873181474
-
Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides
-
Matsushita C., Tamagaki H., Miyazawa Y., Aimoto S., Smith S.O., Sato T. Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides. Proc Natl Acad Sci U S A 2013, 29:1646-1651.
-
(2013)
Proc Natl Acad Sci U S A
, vol.29
, pp. 1646-1651
-
-
Matsushita, C.1
Tamagaki, H.2
Miyazawa, Y.3
Aimoto, S.4
Smith, S.O.5
Sato, T.6
-
32
-
-
79958071305
-
Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry
-
Tynan C.J., Roberts S.K., Rolfe D.J., Clarke D.T., Loeffler H.H., Kästner J., Winn M.D., Parker P.J., Martin-Fernandez M.L. Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry. Mol Cell Biol 2011, 31:2241-2252.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2241-2252
-
-
Tynan, C.J.1
Roberts, S.K.2
Rolfe, D.J.3
Clarke, D.T.4
Loeffler, H.H.5
Kästner, J.6
Winn, M.D.7
Parker, P.J.8
Martin-Fernandez, M.L.9
-
33
-
-
38549132873
-
Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells
-
Webb S.E., Roberts S.K., Needham S.R., Tynan C.J., Rolfe D.J., Winn M.D., Clarke D.T., Barraclough R., Martin-Fernandez M.L. Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells. Biophys J 2008, 94:803-819.
-
(2008)
Biophys J
, vol.94
, pp. 803-819
-
-
Webb, S.E.1
Roberts, S.K.2
Needham, S.R.3
Tynan, C.J.4
Rolfe, D.J.5
Winn, M.D.6
Clarke, D.T.7
Barraclough, R.8
Martin-Fernandez, M.L.9
-
34
-
-
84883049567
-
Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy
-
Ziomkiewicz I., Loman A., Klement R., Fritsch C., Klymchenko A.S., Bunt G., Jovin T.M., Arndt-Jovin D.J. Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy. Cytometry A 2013, 83:794-805.
-
(2013)
Cytometry A
, vol.83
, pp. 794-805
-
-
Ziomkiewicz, I.1
Loman, A.2
Klement, R.3
Fritsch, C.4
Klymchenko, A.S.5
Bunt, G.6
Jovin, T.M.7
Arndt-Jovin, D.J.8
-
35
-
-
34447641458
-
Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor
-
Yoon S.J., Nakayama K., Hikita T., Handa K., Hakomori S.I. Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. Proc Natl Acad Sci U S A 2006, 103:18891-18987.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18891-18987
-
-
Yoon, S.J.1
Nakayama, K.2
Hikita, T.3
Handa, K.4
Hakomori, S.I.5
-
36
-
-
38349190632
-
Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system
-
MacDonald J.L., Pike L.J. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. Proc Natl Acad Sci U S A 2008, 105:112-117.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 112-117
-
-
MacDonald, J.L.1
Pike, L.J.2
-
37
-
-
0015809277
-
Insulin interactions with its receptors: experimental evidence for negative cooperativity
-
De Meyts P., Roth J., Neville D.M., Gavin J.R., Lesniak M.A. Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun 1973, 55:154-161.
-
(1973)
Biochem Biophys Res Commun
, vol.55
, pp. 154-161
-
-
De Meyts, P.1
Roth, J.2
Neville, D.M.3
Gavin, J.R.4
Lesniak, M.A.5
-
38
-
-
48149095486
-
The insulin receptor: a prototype for dimeric, allosteric membrane receptors?
-
De Meyts P. The insulin receptor: a prototype for dimeric, allosteric membrane receptors?. Trends Biochem Sci 2008, 33:376-384.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 376-384
-
-
De Meyts, P.1
-
39
-
-
0031028273
-
Two EGF molecules contribute additively to stabilization of the EGFR dimer
-
Lemmon M.A., Bu Z., Ladbury J.E., Zhou M., Pinchasi D., Lax I., Engelman D.M., Schlessinger J. Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J 1997, 16:281-294.
-
(1997)
EMBO J
, vol.16
, pp. 281-294
-
-
Lemmon, M.A.1
Bu, Z.2
Ladbury, J.E.3
Zhou, M.4
Pinchasi, D.5
Lax, I.6
Engelman, D.M.7
Schlessinger, J.8
-
40
-
-
0036782071
-
Structural biology of insulin and IGF1 receptors: implications for drug design
-
De Meyts P., Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 2002, 1:769-783.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 769-783
-
-
De Meyts, P.1
Whittaker, J.2
-
41
-
-
33645821892
-
On the nature of low- and high-affinity EGF receptors on living cells
-
Ozcan F., Klein P., Lemmon M.A., Lax I., Schlessinger J. On the nature of low- and high-affinity EGF receptors on living cells. Proc Natl Acad Sci U S A 2006, 103:5735-5740.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5735-5740
-
-
Ozcan, F.1
Klein, P.2
Lemmon, M.A.3
Lax, I.4
Schlessinger, J.5
-
42
-
-
0030444789
-
The structural basis of negative cooperativity: receptors and enzymes
-
Koshland D.E. The structural basis of negative cooperativity: receptors and enzymes. Curr Opin Struct Biol 1996, 6:757-761.
-
(1996)
Curr Opin Struct Biol
, vol.6
, pp. 757-761
-
-
Koshland, D.E.1
-
43
-
-
77955627615
-
Structural basis for negative cooperativity in growth factor binding to an EGF receptor
-
Alvarado D., Klein D.E., Lemmon M.A. Structural basis for negative cooperativity in growth factor binding to an EGF receptor. Cell 2010, 142:568-579.
-
(2010)
Cell
, vol.142
, pp. 568-579
-
-
Alvarado, D.1
Klein, D.E.2
Lemmon, M.A.3
-
44
-
-
62649159075
-
Ligand-induced ErbB receptor dimerization
-
Lemmon M.A. Ligand-induced ErbB receptor dimerization. Exp Cell Res 2009, 315:638-648.
-
(2009)
Exp Cell Res
, vol.315
, pp. 638-648
-
-
Lemmon, M.A.1
-
45
-
-
79251564386
-
High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways
-
Krall J.A., Beyer E.M., MacBeath G. High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. PLoS One 2011, 6:e15945.
-
(2011)
PLoS One
, vol.6
, pp. e15945
-
-
Krall, J.A.1
Beyer, E.M.2
MacBeath, G.3
-
46
-
-
63049100044
-
Functional selectivity of EGF family peptide growth factors: implications for cancer
-
Wilson K.J., Gilmore J.L., Foley J., Lemmon M.A., Riese D.J. Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol Ther 2009, 122:1-8.
-
(2009)
Pharmacol Ther
, vol.122
, pp. 1-8
-
-
Wilson, K.J.1
Gilmore, J.L.2
Foley, J.3
Lemmon, M.A.4
Riese, D.J.5
-
47
-
-
84855999013
-
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging
-
Macdonald-Obermann J.L., Piwnica-Worms D., Pike L.J. Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proc Natl Acad Sci U S A 2012, 109:137-142.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 137-142
-
-
Macdonald-Obermann, J.L.1
Piwnica-Worms, D.2
Pike, L.J.3
-
48
-
-
84905460438
-
Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor
-
Arkhipov A., Shan Y., Kim E.T., Shaw D.E. Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor. PLoS Comput Biol 2014, 10:e1003742.
-
(2014)
PLoS Comput Biol
, vol.10
, pp. e1003742
-
-
Arkhipov, A.1
Shan, Y.2
Kim, E.T.3
Shaw, D.E.4
-
49
-
-
0037291769
-
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
-
Ferguson K.M., Berger M.B., Mendrola J.M., Cho H.S., Leahy D.J., Lemmon M.A. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 2003, 11:507-517.
-
(2003)
Mol Cell
, vol.11
, pp. 507-517
-
-
Ferguson, K.M.1
Berger, M.B.2
Mendrola, J.M.3
Cho, H.S.4
Leahy, D.J.5
Lemmon, M.A.6
-
50
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X., Gureasko J., Shen K., Cole P.A., Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006, 125:1137-1149.
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
-
51
-
-
23844471971
-
EGF receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
-
Dawson J.P., Berger M.B., Lin D., Schlessinger J., Lemmon M.A., Ferguson K.M. EGF receptor dimerization and activation require ligand-induced conformational changes in the dimer interface. Mol Cell Biol 2005, 25:7734-7742.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7734-7742
-
-
Dawson, J.P.1
Berger, M.B.2
Lin, D.3
Schlessinger, J.4
Lemmon, M.A.5
Ferguson, K.M.6
-
52
-
-
18644386251
-
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
-
Ogiso H., Ishitani R., Nureki O., Fukai S., Yamanaka M., Kim J.H., Saito K., Sakamoto A., Inoue M., Shirouzu M., et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 2002, 110:775-787.
-
(2002)
Cell
, vol.110
, pp. 775-787
-
-
Ogiso, H.1
Ishitani, R.2
Nureki, O.3
Fukai, S.4
Yamanaka, M.5
Kim, J.H.6
Saito, K.7
Sakamoto, A.8
Inoue, M.9
Shirouzu, M.10
-
53
-
-
0742323362
-
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function
-
Mattoon D., Klein P., Lemmon M.A., Lax I., Schlessinger J. The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. Proc Natl Acad Sci U S A 2004, 101:923-928.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 923-928
-
-
Mattoon, D.1
Klein, P.2
Lemmon, M.A.3
Lax, I.4
Schlessinger, J.5
-
54
-
-
2542427325
-
CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor
-
Walker F., Orchard S.G., Jorissen R.N., Hall N.E., Zhang H.H., Hoyne P.A., Adams T.E., Johns T.G., Ward C., Garrett T.P.J., et al. CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor. J Biol Chem 2004, 279:22387-22398.
-
(2004)
J Biol Chem
, vol.279
, pp. 22387-22398
-
-
Walker, F.1
Orchard, S.G.2
Jorissen, R.N.3
Hall, N.E.4
Zhang, H.H.5
Hoyne, P.A.6
Adams, T.E.7
Johns, T.G.8
Ward, C.9
Garrett, T.P.J.10
|