Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif

Journal of Cell Science

Volumn 126, Issue 21, 2013, Pages 4900-4912

  Heukers, Raimond ^a   Vermeulen, Jeroen F ^a   Fereidouni, Farzad ^a   Bader, Arjen N ^a,b   Voortman, Jarno ^a   Roovers, Rob C ^a,c   Gerritsen, Hans C ^a   Van Bergen En Henegouwen, Paul M P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c Merus Biopharmaceuticals   (Netherlands)

Author keywords

Clustering; EGFR endocytosis; Nanobody; Transmembrane domain; VHH

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; NANOBODY; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VHH ANTIBODY;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENDOCYTOSIS; ENZYME ACTIVITY; INTERNALIZATION; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

CLUSTERING; EGFR ENDOCYTOSIS; NANOBODY; TRANSMEMBRANE DOMAIN; VHH;

ANIMALS; CELL LINE; CELL MEMBRANE; DIMERIZATION; ENDOCYTOSIS; HUMANS; MICE; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84887567274     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.128611     Document Type: Article

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