Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 5, 2015, Pages 1017-1025

  Halim, Khairul Bariyyah Abd ^a   Koldsø, Heidi ^a   Sansom, Mark S P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

EGFR; Juxtamembrane domain; Lipid bilayer; Molecular dynamics; PIP2

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN TYROSINE KINASE; LIPID BILAYER; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; LIPID BILAYER; MEMBRANE BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN MOTIF; PROTEIN STABILITY; CHEMISTRY; ENZYME STABILITY; GENETICS; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

MAMMALIA;

ENZYME ACTIVATION; ENZYME STABILITY; LIPID BILAYERS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923171607     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.09.006     Document Type: Article

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