Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

EMBO Journal

Volumn 34, Issue 13, 2015, Pages 1759-1772

  Russ, Holger A ^a   Parent, Audrey V ^a   Ringler, Jennifer J ^a   Hennings, Thomas G ^a   Nair, Gopika G ^a   Shveygert, Mayya ^a   Guo, Tingxia ^a,d   Puri, Sapna ^a   Haataja, Leena ^b   Cirulli, Vincenzo ^c   Blelloch, Robert ^a   Szot, Greg L ^a   Arvan, Peter ^b   Hebrok, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d FLUIDIGM CORPORATION   (United States)

Author keywords

beta like cells; diabetes; human embryonic stem cells; insulin producing cells pancreas

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCOSE; GREEN FLUORESCENT PROTEIN; NEUROGENIN 3; RETINOIC ACID; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; GLUCOSE BLOOD LEVEL; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS CELL; PANCREAS ISLET BETA CELL; PANCREAS ORGANOGENESIS; PANCREATIC PROGENITOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL TRANSPLANTATION; ANIMAL; BLOOD; CELL CULTURE; CULTURE TECHNIQUE; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; EMBRYONIC STEM CELL; METABOLISM; PANCREAS; PHYSIOLOGY; PROCEDURES; SCID MOUSE; TRANSGENIC MOUSE; TRANSPLANTATION;

MUS;

ANIMALS; BLOOD GLUCOSE; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; EMBRYONIC STEM CELLS; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; MICE; MICE, SCID; MICE, TRANSGENIC; PANCREAS; STREPTOZOCIN;

EID: 84933674159     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591058     Document Type: Article

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