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Volumn 39, Issue 9, 2014, Pages 1648-1660

Uptake and Metabolism of Iron Oxide Nanoparticles in Brain Cells

Author keywords

Endocytosis; Ferritin; Iron; Nanoparticles; ROS

Indexed keywords

FERRIC ION; FERRIC OXIDE; METAL NANOPARTICLE; PHARMACOKINETICS;

EID: 84964240602     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-014-1380-5     Document Type: Review
Times cited : (76)

References (128)
  • 1
    • 70350662344 scopus 로고    scopus 로고
    • Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
    • COI: 1:CAS:528:DC%2BD1MXht1aqsLrE, PID: 19809453
    • Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR (2009) Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 4:634–641
    • (2009) Nat Nanotechnol , vol.4 , pp. 634-641
    • Auffan, M.1    Rose, J.2    Bottero, J.Y.3    Lowry, G.V.4    Jolivet, J.P.5    Wiesner, M.R.6
  • 2
    • 84878343578 scopus 로고    scopus 로고
    • Functionalized ceramics for biomedical, biotechnological and environmental applications
    • COI: 1:CAS:528:DC%2BC3sXntF2ntLs%3D, PID: 23567940
    • Treccani L, Yvonne Klein T, Meder F, Pardun K, Rezwan K (2013) Functionalized ceramics for biomedical, biotechnological and environmental applications. Acta Biomater 9:7115–7150
    • (2013) Acta Biomater , vol.9 , pp. 7115-7150
    • Treccani, L.1    Yvonne Klein, T.2    Meder, F.3    Pardun, K.4    Rezwan, K.5
  • 3
    • 84890453749 scopus 로고    scopus 로고
    • Applications of inorganic nanoparticles as therapeutic agents
    • PID: 24334327
    • Kim T, Hyeon T (2014) Applications of inorganic nanoparticles as therapeutic agents. Nanotechnology 25:012001
    • (2014) Nanotechnology , vol.25 , pp. 012001
    • Kim, T.1    Hyeon, T.2
  • 4
    • 84903816354 scopus 로고    scopus 로고
    • Biosynthetic trends and future aspects of bimetallic nanoparticles and its medicinal applications
    • COI: 1:CAS:528:DC%2BC2cXmtlSktrc%3D, PID: 24728718
    • Roopan SM, Surendra TV, Elango G, Kumar SH (2014) Biosynthetic trends and future aspects of bimetallic nanoparticles and its medicinal applications. Appl Microbiol Biotechnol 98:5289–5300
    • (2014) Appl Microbiol Biotechnol , vol.98 , pp. 5289-5300
    • Roopan, S.M.1    Surendra, T.V.2    Elango, G.3    Kumar, S.H.4
  • 5
    • 84902137776 scopus 로고    scopus 로고
    • Theranostic nanoparticles for cancer and cardiovascular applications
    • COI: 1:CAS:528:DC%2BC2cXjsVOisrg%3D, PID: 24595494
    • Wang D, Lin B, Ai H (2014) Theranostic nanoparticles for cancer and cardiovascular applications. Pharm Res 31:1390–1406
    • (2014) Pharm Res , vol.31 , pp. 1390-1406
    • Wang, D.1    Lin, B.2    Ai, H.3
  • 6
    • 84899573655 scopus 로고    scopus 로고
    • Magnetic nanoparticles: a novel platform for cancer theranostics
    • COI: 1:CAS:528:DC%2BC3sXhslSmu7%2FE, PID: 24140592
    • Singh A, Sahoo SK (2014) Magnetic nanoparticles: a novel platform for cancer theranostics. Drug Discov Today 19:474–481
    • (2014) Drug Discov Today , vol.19 , pp. 474-481
    • Singh, A.1    Sahoo, S.K.2
  • 7
    • 84864714083 scopus 로고    scopus 로고
    • Nanotechnology in cosmetics: opportunities and challenges
    • COI: 1:CAS:528:DC%2BC2cXhtlagsLjE, PID: 22923959
    • Raj S, Jose S, Sumod US, Sabitha M (2012) Nanotechnology in cosmetics: opportunities and challenges. J Pharm Bioallied Sci 4:186–193
    • (2012) J Pharm Bioallied Sci , vol.4 , pp. 186-193
    • Raj, S.1    Jose, S.2    Sumod, U.S.3    Sabitha, M.4
  • 9
    • 84888302113 scopus 로고    scopus 로고
    • Magnetic nanoparticle-based hyperthermia for cancer treatment
    • PID: 24416585
    • Banobre-Lopez M, Teijeiro A, Rivas J (2013) Magnetic nanoparticle-based hyperthermia for cancer treatment. Rep Pract Oncol Radiother 18:397–400
    • (2013) Rep Pract Oncol Radiother , vol.18 , pp. 397-400
    • Banobre-Lopez, M.1    Teijeiro, A.2    Rivas, J.3
  • 11
    • 84883158369 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking
    • PID: 23946825
    • Li L, Jiang W, Luo K, Song H, Lan F, Wu Y, Gu Z (2013) Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking. Theranostics 3:595–615
    • (2013) Theranostics , vol.3 , pp. 595-615
    • Li, L.1    Jiang, W.2    Luo, K.3    Song, H.4    Lan, F.5    Wu, Y.6    Gu, Z.7
  • 13
    • 79959846524 scopus 로고    scopus 로고
    • Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
    • PID: 20845061
    • Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V, Jordan A (2011) Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol 103:317–324
    • (2011) J Neurooncol , vol.103 , pp. 317-324
    • Maier-Hauff, K.1    Ulrich, F.2    Nestler, D.3    Niehoff, H.4    Wust, P.5    Thiesen, B.6    Orawa, H.7    Budach, V.8    Jordan, A.9
  • 14
    • 61449118661 scopus 로고    scopus 로고
    • Nanotechnology, nanotoxicology, and neuroscience
    • COI: 1:CAS:528:DC%2BD1MXivVWrsrs%3D, PID: 18926873
    • Suh WH, Suslick KS, Stucky GD, Suh YH (2009) Nanotechnology, nanotoxicology, and neuroscience. Prog Neurobiol 87:133–170
    • (2009) Prog Neurobiol , vol.87 , pp. 133-170
    • Suh, W.H.1    Suslick, K.S.2    Stucky, G.D.3    Suh, Y.H.4
  • 15
    • 73949137249 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review
    • COI: 1:CAS:528:DC%2BC3cXos1Wj, PID: 19756021
    • Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA (2010) Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab 30:15–35
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 15-35
    • Weinstein, J.S.1    Varallyay, C.G.2    Dosa, E.3    Gahramanov, S.4    Hamilton, B.5    Rooney, W.D.6    Muldoon, L.L.7    Neuwelt, E.A.8
  • 16
    • 79959748136 scopus 로고    scopus 로고
    • Visualizing the future: enhancing neuroimaging with nanotechnology
    • PID: 21704929
    • Winer JL, Kim PE, Law M, Liu CY, Apuzzo MLJ (2011) Visualizing the future: enhancing neuroimaging with nanotechnology. World Neurosurg 75:626–637
    • (2011) World Neurosurg , vol.75 , pp. 626-637
    • Winer, J.L.1    Kim, P.E.2    Law, M.3    Liu, C.Y.4    Apuzzo, M.L.J.5
  • 17
    • 84859706269 scopus 로고    scopus 로고
    • Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC38XlvFak, PID: 22216932
    • Mahmoudi M, Hofmann H, Rothen-Rutishauser B, Petri-Fink A (2012) Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles. Chem Rev 112:2323–2338
    • (2012) Chem Rev , vol.112 , pp. 2323-2338
    • Mahmoudi, M.1    Hofmann, H.2    Rothen-Rutishauser, B.3    Petri-Fink, A.4
  • 18
    • 84860741380 scopus 로고    scopus 로고
    • Investigating the toxic effects of iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC38Xht1Gmt7jN, PID: 22568907
    • Soenen SJ, De Cuyper M, De Smedt SC, Braeckmans K (2012) Investigating the toxic effects of iron oxide nanoparticles. Methods Enzymol 509:195–224
    • (2012) Methods Enzymol , vol.509 , pp. 195-224
    • Soenen, S.J.1    De Cuyper, M.2    De Smedt, S.C.3    Braeckmans, K.4
  • 19
    • 84897365963 scopus 로고    scopus 로고
    • A delicate balance: iron metabolism and diseases of the brain
    • PID: 23874300
    • Hare D, Ayton S, Bush A, Lei P (2013) A delicate balance: iron metabolism and diseases of the brain. Front Aging Neurosci 5:34
    • (2013) Front Aging Neurosci , vol.5 , pp. 34
    • Hare, D.1    Ayton, S.2    Bush, A.3    Lei, P.4
  • 20
    • 84880805523 scopus 로고    scopus 로고
    • Iron metabolism in the CNS: implications for neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BC3sXhtVehtb7M, PID: 23820773
    • Rouault TA (2013) Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci 14:551–564
    • (2013) Nat Rev Neurosci , vol.14 , pp. 551-564
    • Rouault, T.A.1
  • 21
    • 84886662830 scopus 로고    scopus 로고
    • Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles
    • COI: 1:CAS:528:DC%2BC3sXhs1Orsb7O, PID: 24091568
    • Turcheniuk K, Tarasevych AV, Kukhar VP, Boukherroub R, Szunerits S (2013) Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles. Nanoscale 5:10729–10752
    • (2013) Nanoscale , vol.5 , pp. 10729-10752
    • Turcheniuk, K.1    Tarasevych, A.V.2    Kukhar, V.P.3    Boukherroub, R.4    Szunerits, S.5
  • 22
    • 84857706152 scopus 로고    scopus 로고
    • Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine
    • Akbarzadeh A, Samiei M, Davaran S (2012) Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Lett 7:1–13
    • (2012) Nanoscale Res Lett , vol.7 , pp. 1-13
    • Akbarzadeh, A.1    Samiei, M.2    Davaran, S.3
  • 23
    • 11044222650 scopus 로고    scopus 로고
    • Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    • COI: 1:CAS:528:DC%2BD2MXisFWr, PID: 15626447
    • Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–4021
    • (2005) Biomaterials , vol.26 , pp. 3995-4021
    • Gupta, A.K.1    Gupta, M.2
  • 24
    • 47249140441 scopus 로고    scopus 로고
    • Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications
    • COI: 1:CAS:528:DC%2BD1cXmvFCjtb0%3D, PID: 18543879
    • Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108:2064–2110
    • (2008) Chem Rev , vol.108 , pp. 2064-2110
    • Laurent, S.1    Forge, D.2    Port, M.3    Roch, A.4    Robic, C.5    Elst, L.V.6    Muller, R.N.7
  • 25
    • 84881533045 scopus 로고    scopus 로고
    • Multifunctional superparamagnetic iron oxide nanoparticles: design, synthesis and biomedical photonic applications
    • COI: 1:CAS:528:DC%2BC3sXht1ChsbbL, PID: 23877222
    • Zhang L, Dong WF, Sun HB (2013) Multifunctional superparamagnetic iron oxide nanoparticles: design, synthesis and biomedical photonic applications. Nanoscale 5:7664–7684
    • (2013) Nanoscale , vol.5 , pp. 7664-7684
    • Zhang, L.1    Dong, W.F.2    Sun, H.B.3
  • 26
    • 84878964638 scopus 로고    scopus 로고
    • Multifunctional superparamagnetic iron oxide nanoparticles: promising tools in cancer theranostics
    • COI: 1:CAS:528:DC%2BC3sXot1CntLw%3D, PID: 23664890
    • Santhosh PB, Ulrih NP (2013) Multifunctional superparamagnetic iron oxide nanoparticles: promising tools in cancer theranostics. Cancer Lett 336:8–17
    • (2013) Cancer Lett , vol.336 , pp. 8-17
    • Santhosh, P.B.1    Ulrih, N.P.2
  • 28
    • 77957372848 scopus 로고    scopus 로고
    • Development and use of iron oxide nanoparticles (Part 1): synthesis of iron oxide nanoparticles for MRI
    • COI: 1:STN:280:DC%2BC3MrkvVOlsw%3D%3D, PID: 21611034
    • Lodhia J, Mandarano G, Ferris N, Eu P, Cowell S (2010) Development and use of iron oxide nanoparticles (Part 1): synthesis of iron oxide nanoparticles for MRI. Biomed Imaging Interv J 6:e12
    • (2010) Biomed Imaging Interv J , vol.6 , pp. e12
    • Lodhia, J.1    Mandarano, G.2    Ferris, N.3    Eu, P.4    Cowell, S.5
  • 29
    • 0033560562 scopus 로고    scopus 로고
    • Synthesis of iron oxide nanoparticles used as MRI contrast agents: a parametric study
    • COI: 1:CAS:528:DyaK1MXhvF2js7o%3D, PID: 10092379
    • Babes L, Denizot B, Tanguy G, Le Jeune JJ, Jallet P (1999) Synthesis of iron oxide nanoparticles used as MRI contrast agents: a parametric study. J Colloid Interface Sci 212:474–482
    • (1999) J Colloid Interface Sci , vol.212 , pp. 474-482
    • Babes, L.1    Denizot, B.2    Tanguy, G.3    Le Jeune, J.J.4    Jallet, P.5
  • 30
    • 79958776497 scopus 로고    scopus 로고
    • Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment
    • COI: 1:CAS:528:DC%2BC3MXntFGiu7Y%3D, PID: 21359397
    • Schladt TD, Schneider K, Schild H, Tremel W (2011) Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment. Dalton Trans 40:6315–6343
    • (2011) Dalton Trans , vol.40 , pp. 6315-6343
    • Schladt, T.D.1    Schneider, K.2    Schild, H.3    Tremel, W.4
  • 32
    • 33745473776 scopus 로고    scopus 로고
    • Fluorescence-modified superparamagnetic nanoparticles: intracellular uptake and use in cellular imaging
    • COI: 1:CAS:528:DC%2BD28XktlKmurs%3D, PID: 16732667
    • Bertorelle F, Wilhelm C, Roger J, Gazeau F, Menager C, Cabuil V (2006) Fluorescence-modified superparamagnetic nanoparticles: intracellular uptake and use in cellular imaging. Langmuir 22:5385–5391
    • (2006) Langmuir , vol.22 , pp. 5385-5391
    • Bertorelle, F.1    Wilhelm, C.2    Roger, J.3    Gazeau, F.4    Menager, C.5    Cabuil, V.6
  • 33
    • 59849092639 scopus 로고    scopus 로고
    • Fluorescence modified chitosan-coated magnetic nanoparticles for high-efficient cellular imaging
    • COI: 1:CAS:528:DC%2BD1MXitFOnt7o%3D, PID: 20596545
    • Ge YQ, Zhang Y, He SY, Nie F, Teng GJ, Gu N (2009) Fluorescence modified chitosan-coated magnetic nanoparticles for high-efficient cellular imaging. Nanoscale Res Lett 4:287–295
    • (2009) Nanoscale Res Lett , vol.4 , pp. 287-295
    • Ge, Y.Q.1    Zhang, Y.2    He, S.Y.3    Nie, F.4    Teng, G.J.5    Gu, N.6
  • 34
    • 84895186374 scopus 로고    scopus 로고
    • Uptake of fluorescent iron oxide nanoparticles by oligodendroglial OLN-93 cells
    • COI: 1:CAS:528:DC%2BC3sXhvF2rsrjN, PID: 24368627
    • Petters C, Bulcke F, Thiel K, Bickmeyer U, Dringen R (2014) Uptake of fluorescent iron oxide nanoparticles by oligodendroglial OLN-93 cells. Neurochem Res 39:372–383
    • (2014) Neurochem Res , vol.39 , pp. 372-383
    • Petters, C.1    Bulcke, F.2    Thiel, K.3    Bickmeyer, U.4    Dringen, R.5
  • 35
    • 84885178971 scopus 로고    scopus 로고
    • Transferrin-conjugated, fluorescein-loaded magnetic nanoparticles for targeted delivery across the blood-brain barrier
    • COI: 1:CAS:528:DC%2BC3sXhsVyltrzE, PID: 23793566
    • Yan F, Wang Y, He SZ, Ku ST, Gu W, Ye L (2013) Transferrin-conjugated, fluorescein-loaded magnetic nanoparticles for targeted delivery across the blood-brain barrier. J Mater Sci Mater Med 24:2371–2379
    • (2013) J Mater Sci Mater Med , vol.24 , pp. 2371-2379
    • Yan, F.1    Wang, Y.2    He, S.Z.3    Ku, S.T.4    Gu, W.5    Ye, L.6
  • 37
    • 84870314992 scopus 로고    scopus 로고
    • Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells
    • COI: 1:CAS:528:DC%2BC38XhtVKkurnN
    • Kumar M, Singh G, Arora V, Mewar S, Sharma U, Jagannathan NR, Sapra S, Dinda AK, Kharbanda S, Singh H (2012) Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells. Int J Nanomed 7:3503–3516
    • (2012) Int J Nanomed , vol.7 , pp. 3503-3516
    • Kumar, M.1    Singh, G.2    Arora, V.3    Mewar, S.4    Sharma, U.5    Jagannathan, N.R.6    Sapra, S.7    Dinda, A.K.8    Kharbanda, S.9    Singh, H.10
  • 38
    • 0027870537 scopus 로고
    • Targeting anticancer drugs to the brain. I: enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres
    • COI: 1:CAS:528:DyaK3sXmtFSgu7g%3D, PID: 8069547
    • Hassan EE, Gallo JM (1993) Targeting anticancer drugs to the brain. I: enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres. J Drug Target 1:7–14
    • (1993) J Drug Target , vol.1 , pp. 7-14
    • Hassan, E.E.1    Gallo, J.M.2
  • 39
    • 80052047993 scopus 로고    scopus 로고
    • Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies
    • COI: 1:CAS:528:DC%2BC3MXovVOit78%3D, PID: 21721568
    • Jenkins SI, Pickard MR, Granger N, Chari DM (2011) Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies. ACS Nano 5:6527–6538
    • (2011) ACS Nano , vol.5 , pp. 6527-6538
    • Jenkins, S.I.1    Pickard, M.R.2    Granger, N.3    Chari, D.M.4
  • 40
    • 0038190867 scopus 로고    scopus 로고
    • Magnetofection—a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD3sXjtVKhsrY%3D, PID: 12718913
    • Krotz F, de Wit C, Sohn HY, Zahler S, Gloe T, Pohl U, Plank C (2003) Magnetofection—a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol Ther 7:700–710
    • (2003) Mol Ther , vol.7 , pp. 700-710
    • Krotz, F.1    de Wit, C.2    Sohn, H.Y.3    Zahler, S.4    Gloe, T.5    Pohl, U.6    Plank, C.7
  • 41
    • 77957358317 scopus 로고    scopus 로고
    • Image-guided breast tumor therapy using a small interfering RNA nanodrug
    • COI: 1:CAS:528:DC%2BC3cXht1akt7nK, PID: 20702603
    • Kumar M, Yigit M, Dai G, Moore A, Medarova Z (2010) Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res 70:7553–7561
    • (2010) Cancer Res , vol.70 , pp. 7553-7561
    • Kumar, M.1    Yigit, M.2    Dai, G.3    Moore, A.4    Medarova, Z.5
  • 42
    • 84885292717 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide based nanoprobes for imaging and theranostics
    • PID: 23891347
    • Lam T, Pouliot P, Avti PK, Lesage F, Kakkar AK (2013) Superparamagnetic iron oxide based nanoprobes for imaging and theranostics. Adv Colloid Interface Sci 199–200:95–113
    • (2013) Adv Colloid Interface Sci , vol.199-200 , pp. 95-113
    • Lam, T.1    Pouliot, P.2    Avti, P.K.3    Lesage, F.4    Kakkar, A.K.5
  • 43
    • 84879840410 scopus 로고    scopus 로고
    • Ferumoxytol: a silver lining in the treatment of anemia of chronic kidney disease or another dark cloud?
    • PID: 22973119
    • Pai AB, Garba AO (2012) Ferumoxytol: a silver lining in the treatment of anemia of chronic kidney disease or another dark cloud? J Blood Med 3:77–85
    • (2012) J Blood Med , vol.3 , pp. 77-85
    • Pai, A.B.1    Garba, A.O.2
  • 44
    • 84867311318 scopus 로고    scopus 로고
    • Ferumoxytol: in iron deficiency anaemia in adults with chronic kidney disease
    • COI: 1:CAS:528:DC%2BC38XhvVWhtbbJ, PID: 22994536
    • McCormack PL (2012) Ferumoxytol: in iron deficiency anaemia in adults with chronic kidney disease. Drugs 72:2013–2022
    • (2012) Drugs , vol.72 , pp. 2013-2022
    • McCormack, P.L.1
  • 45
    • 0031572786 scopus 로고    scopus 로고
    • Thiolation of maghemite nanoparticles by dimercaptosuccinic acid
    • COI: 1:CAS:528:DyaK2sXnsVOmtbw%3D, PID: 9398425
    • Fauconnier N, Pons JN, Roger J, Bee A (1997) Thiolation of maghemite nanoparticles by dimercaptosuccinic acid. J Colloid Interface Sci 194:427–433
    • (1997) J Colloid Interface Sci , vol.194 , pp. 427-433
    • Fauconnier, N.1    Pons, J.N.2    Roger, J.3    Bee, A.4
  • 46
    • 68649097338 scopus 로고    scopus 로고
    • Easy route to functionalize iron oxide nanoparticles via long-term stable thiol groups
    • COI: 1:CAS:528:DC%2BD1MXotVGlurk%3D, PID: 19572525
    • Maurizi L, Bisht H, Bouyer F, Millot N (2009) Easy route to functionalize iron oxide nanoparticles via long-term stable thiol groups. Langmuir 25:8857–8859
    • (2009) Langmuir , vol.25 , pp. 8857-8859
    • Maurizi, L.1    Bisht, H.2    Bouyer, F.3    Millot, N.4
  • 47
    • 84865198205 scopus 로고    scopus 로고
    • Functionalization of magnetic nanoparticles with dendritic–linear–brush-like triblock copolymers and their drug release properties
    • COI: 1:CAS:528:DC%2BC38XhtVCmtLnM, PID: 22799877
    • He X, Wu X, Cai X, Lin S, Xie M, Zhu X, Yan D (2012) Functionalization of magnetic nanoparticles with dendritic–linear–brush-like triblock copolymers and their drug release properties. Langmuir 28:11929–11938
    • (2012) Langmuir , vol.28 , pp. 11929-11938
    • He, X.1    Wu, X.2    Cai, X.3    Lin, S.4    Xie, M.5    Zhu, X.6    Yan, D.7
  • 48
    • 84883176397 scopus 로고    scopus 로고
    • Protein corona affects the relaxivity and MRI contrast efficiency of magnetic nanoparticles
    • COI: 1:CAS:528:DC%2BC3sXhtlWlu7jK, PID: 23896964
    • Amiri H, Bordonali L, Lascialfari A, Wan S, Monopoli MP, Lynch I, Laurent S, Mahmoudi M (2013) Protein corona affects the relaxivity and MRI contrast efficiency of magnetic nanoparticles. Nanoscale 5:8656–8665
    • (2013) Nanoscale , vol.5 , pp. 8656-8665
    • Amiri, H.1    Bordonali, L.2    Lascialfari, A.3    Wan, S.4    Monopoli, M.P.5    Lynch, I.6    Laurent, S.7    Mahmoudi, M.8
  • 49
    • 65249141184 scopus 로고    scopus 로고
    • Characterization of protein clusters of diverse magnetic nanoparticles and their dynamic interactions with human cells
    • COI: 1:CAS:528:DC%2BD1MXjtlSitLo%3D
    • Mu QX, Li ZW, Li X, Mishra SR, Zhang B, Si ZK, Yang L, Jiang W, Yan B (2009) Characterization of protein clusters of diverse magnetic nanoparticles and their dynamic interactions with human cells. J Phys Chem C 113:5390–5395
    • (2009) J Phys Chem C , vol.113 , pp. 5390-5395
    • Mu, Q.X.1    Li, Z.W.2    Li, X.3    Mishra, S.R.4    Zhang, B.5    Si, Z.K.6    Yang, L.7    Jiang, W.8    Yan, B.9
  • 50
    • 84859432732 scopus 로고    scopus 로고
    • Adsorption kinetics of plasma proteins on ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles
    • COI: 1:CAS:528:DC%2BC38XktFGitL0%3D, PID: 22342465
    • Jansch M, Stumpf P, Graf C, Ruhl E, Muller RH (2012) Adsorption kinetics of plasma proteins on ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. Int J Pharm 428:125–133
    • (2012) Int J Pharm , vol.428 , pp. 125-133
    • Jansch, M.1    Stumpf, P.2    Graf, C.3    Ruhl, E.4    Muller, R.H.5
  • 51
    • 84880334959 scopus 로고    scopus 로고
    • Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
    • COI: 1:CAS:528:DC%2BC3sXht1GksrnF
    • Saptarshi SR, Duschl A, Lopata AL (2013) Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle. J Nanobiotechnol 11:26–37
    • (2013) J Nanobiotechnol , vol.11 , pp. 26-37
    • Saptarshi, S.R.1    Duschl, A.2    Lopata, A.L.3
  • 52
    • 80052785486 scopus 로고    scopus 로고
    • Protein-nanoparticle interactions: opportunities and challenges
    • COI: 1:CAS:528:DC%2BC3MXnslKjtbg%3D, PID: 21688848
    • Mahmoudi M, Lynch I, Ejtehadi MR, Monopoli MP, Bombelli FB, Laurent S (2011) Protein-nanoparticle interactions: opportunities and challenges. Chem Rev 111:5610–5637
    • (2011) Chem Rev , vol.111 , pp. 5610-5637
    • Mahmoudi, M.1    Lynch, I.2    Ejtehadi, M.R.3    Monopoli, M.P.4    Bombelli, F.B.5    Laurent, S.6
  • 53
    • 84873853768 scopus 로고    scopus 로고
    • Biomolecular coronas provide the biological identity of nanosized materials
    • COI: 1:CAS:528:DC%2BC38XhslKqsbjI, PID: 23212421
    • Monopoli MP, Aberg C, Salvati A, Dawson KA (2012) Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol 7:779–786
    • (2012) Nat Nanotechnol , vol.7 , pp. 779-786
    • Monopoli, M.P.1    Aberg, C.2    Salvati, A.3    Dawson, K.A.4
  • 55
    • 69249181265 scopus 로고    scopus 로고
    • Stability, toxicity and differential cellular uptake of protein passivated-Fe3O4 nanoparticles
    • COI: 1:CAS:528:DC%2BD1MXhtVeiur3K
    • Bajaj A, Samanta B, Yan HH, Jerry DJ, Rotello VM (2009) Stability, toxicity and differential cellular uptake of protein passivated-Fe3O4 nanoparticles. J Mater Chem 19:6328–6331
    • (2009) J Mater Chem , vol.19 , pp. 6328-6331
    • Bajaj, A.1    Samanta, B.2    Yan, H.H.3    Jerry, D.J.4    Rotello, V.M.5
  • 56
    • 84870825003 scopus 로고    scopus 로고
    • The presence of serum alters the properties of iron oxide nanoparticles and lowers their accumulation by cultured brain astrocytes
    • Geppert M, Petters C, Thiel K, Dringen R (2013) The presence of serum alters the properties of iron oxide nanoparticles and lowers their accumulation by cultured brain astrocytes. J Nanopart Res 15:1349–1363
    • (2013) J Nanopart Res , vol.15 , pp. 1349-1363
    • Geppert, M.1    Petters, C.2    Thiel, K.3    Dringen, R.4
  • 57
    • 80053595081 scopus 로고    scopus 로고
    • The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXht1Oqu77I, PID: 21911254
    • Safi M, Courtois J, Seigneuret M, Conjeaud H, Berret JF (2011) The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles. Biomaterials 32:9353–9363
    • (2011) Biomaterials , vol.32 , pp. 9353-9363
    • Safi, M.1    Courtois, J.2    Seigneuret, M.3    Conjeaud, H.4    Berret, J.F.5
  • 58
    • 35048893279 scopus 로고    scopus 로고
    • Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observation
    • COI: 1:CAS:528:DC%2BD2sXhtV2nsbfL, PID: 17916926
    • Wang B, Feng WY, Wang M, Shi JW, Zhang F, Ouyang H, Zhao YL, Chai ZF, Huang YY, Xie YN, Wang HF, Wang J (2007) Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 118:233–243
    • (2007) Biol Trace Elem Res , vol.118 , pp. 233-243
    • Wang, B.1    Feng, W.Y.2    Wang, M.3    Shi, J.W.4    Zhang, F.5    Ouyang, H.6    Zhao, Y.L.7    Chai, Z.F.8    Huang, Y.Y.9    Xie, Y.N.10    Wang, H.F.11    Wang, J.12
  • 59
    • 84872675495 scopus 로고    scopus 로고
    • Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus
    • COI: 1:CAS:528:DC%2BC3sXhs1eqt7o%3D, PID: 22995439
    • Wu J, Ding TT, Sun J (2013) Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology 34:243–253
    • (2013) Neurotoxicology , vol.34 , pp. 243-253
    • Wu, J.1    Ding, T.T.2    Sun, J.3
  • 62
    • 84860912958 scopus 로고    scopus 로고
    • Noninvasive detection of neural progenitor cells in living brains by MRI
    • COI: 1:CAS:528:DC%2BC38XlsVChtrc%3D, PID: 22198388
    • Liu CH, Ren JQ, You Z, Yang J, Liu CM, Uppal R, Liu PK (2012) Noninvasive detection of neural progenitor cells in living brains by MRI. FASEB J 26:1652–1662
    • (2012) FASEB J , vol.26 , pp. 1652-1662
    • Liu, C.H.1    Ren, J.Q.2    You, Z.3    Yang, J.4    Liu, C.M.5    Uppal, R.6    Liu, P.K.7
  • 63
    • 42549152143 scopus 로고    scopus 로고
    • Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats
    • COI: 1:CAS:528:DC%2BD1cXhtVyitbg%3D, PID: 18217714
    • Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V (2008) Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm 5:316–327
    • (2008) Mol Pharm , vol.5 , pp. 316-327
    • Jain, T.K.1    Reddy, M.K.2    Morales, M.A.3    Leslie-Pelecky, D.L.4    Labhasetwar, V.5
  • 65
    • 77950859837 scopus 로고    scopus 로고
    • The blood-brain barrier penetration and distribution of PEGylated fluorescein-doped magnetic silica nanoparticles in rat brain
    • COI: 1:CAS:528:DC%2BC3cXkvFChu7o%3D, PID: 20206605
    • Ku S, Yan F, Wang Y, Sun Y, Yang N, Ye L (2010) The blood-brain barrier penetration and distribution of PEGylated fluorescein-doped magnetic silica nanoparticles in rat brain. Biochem Biophys Res Commun 394:871–876
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 871-876
    • Ku, S.1    Yan, F.2    Wang, Y.3    Sun, Y.4    Yang, N.5    Ye, L.6
  • 66
    • 0023547088 scopus 로고
    • Receptor-mediated transcytosis of transferrin across the blood–brain-barrier
    • COI: 1:CAS:528:DyaL1cXjsFaktQ%3D%3D, PID: 3694713
    • Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE (1987) Receptor-mediated transcytosis of transferrin across the blood–brain-barrier. J Neurosci Res 18:299–304
    • (1987) J Neurosci Res , vol.18 , pp. 299-304
    • Fishman, J.B.1    Rubin, J.B.2    Handrahan, J.V.3    Connor, J.R.4    Fine, R.E.5
  • 67
    • 84894272589 scopus 로고    scopus 로고
    • Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery
    • PID: 24278373
    • Dan M, Cochran DB, Yokel RA, Dziubla TD (2013) Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery. PLoS One 8:e81051
    • (2013) PLoS One , vol.8 , pp. e81051
    • Dan, M.1    Cochran, D.B.2    Yokel, R.A.3    Dziubla, T.D.4
  • 68
    • 84905393725 scopus 로고    scopus 로고
    • Cupaioli FA, Zucca FA, Boraschi D, Zecca L (2014) Engineered nanoparticles. How brain friendly is this new guest? Prog Neurobiol (in press)
    • Cupaioli FA, Zucca FA, Boraschi D, Zecca L (2014) Engineered nanoparticles. How brain friendly is this new guest? Prog Neurobiol (in press)
  • 69
    • 84875154058 scopus 로고    scopus 로고
    • Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier
    • COI: 1:CAS:528:DC%2BC38Xhs12mtrbP, PID: 23157552
    • Krol S, Macrez R, Docagne F, Defer G, Laurent S, Rahman M, Hajipour MJ, Kehoe PG, Mahmoudi M (2013) Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier. Chem Rev 113:1877–1903
    • (2013) Chem Rev , vol.113 , pp. 1877-1903
    • Krol, S.1    Macrez, R.2    Docagne, F.3    Defer, G.4    Laurent, S.5    Rahman, M.6    Hajipour, M.J.7    Kehoe, P.G.8    Mahmoudi, M.9
  • 70
    • 84873974672 scopus 로고    scopus 로고
    • Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood–brain barrier
    • Hoff D, Sheikh L, Bhattacharya S, Nayar S, Webster TJ (2013) Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood–brain barrier. Int J Nanomed 8:703–710
    • (2013) Int J Nanomed , vol.8 , pp. 703-710
    • Hoff, D.1    Sheikh, L.2    Bhattacharya, S.3    Nayar, S.4    Webster, T.J.5
  • 71
    • 84886037433 scopus 로고    scopus 로고
    • Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells
    • COI: 1:CAS:528:DC%2BC3sXht1Wqt7jO, PID: 23919894
    • Thomsen LB, Linemann T, Pondman KM, Lichota J, Kim KS, Pieters RJ, Visser GM, Moos T (2013) Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells. ACS Chem Neurosci 4:1352–1360
    • (2013) ACS Chem Neurosci , vol.4 , pp. 1352-1360
    • Thomsen, L.B.1    Linemann, T.2    Pondman, K.M.3    Lichota, J.4    Kim, K.S.5    Pieters, R.J.6    Visser, G.M.7    Moos, T.8
  • 72
    • 84555202693 scopus 로고    scopus 로고
    • Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells
    • COI: 1:CAS:528:DC%2BC3MXhs1KqsL3E, PID: 22191777
    • Kenzaoui BH, Bernasconi CC, Hofmann H, Juillerat-Jeanneret L (2012) Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells. Nanomedicine 7:39–53
    • (2012) Nanomedicine , vol.7 , pp. 39-53
    • Kenzaoui, B.H.1    Bernasconi, C.C.2    Hofmann, H.3    Juillerat-Jeanneret, L.4
  • 73
    • 84874556915 scopus 로고    scopus 로고
    • Magnetic resonance imaging of blood brain/nerve barrier dysfunction and leukocyte infiltration: closely related or discordant?
    • PID: 23267343
    • Weise G, Stoll G (2012) Magnetic resonance imaging of blood brain/nerve barrier dysfunction and leukocyte infiltration: closely related or discordant? Front Neurol 3:178
    • (2012) Front Neurol , vol.3 , pp. 178
    • Weise, G.1    Stoll, G.2
  • 75
  • 77
    • 0029118142 scopus 로고
    • Cerebral iron-oxide distribution: in vivo mapping with MR imaging
    • COI: 1:STN:280:DyaK2MzktlWhsA%3D%3D, PID: 7617871
    • Zimmer C, Weissleder R, Oconnor D, Lapointe L, Brady TJ, Enochs WS (1995) Cerebral iron-oxide distribution: in vivo mapping with MR imaging. Radiology 196:521–527
    • (1995) Radiology , vol.196 , pp. 521-527
    • Zimmer, C.1    Weissleder, R.2    Oconnor, D.3    Lapointe, L.4    Brady, T.J.5    Enochs, W.S.6
  • 78
    • 79959925771 scopus 로고    scopus 로고
    • Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure
    • COI: 1:CAS:528:DC%2BC3MXoslWrsL8%3D, PID: 21596115
    • Wang Y, Wang B, Zhu MT, Li M, Wang HJ, Wang M, Ouyang H, Chai ZF, Feng WY, Zhao YL (2011) Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure. Toxicol Lett 205:26–37
    • (2011) Toxicol Lett , vol.205 , pp. 26-37
    • Wang, Y.1    Wang, B.2    Zhu, M.T.3    Li, M.4    Wang, H.J.5    Wang, M.6    Ouyang, H.7    Chai, Z.F.8    Feng, W.Y.9    Zhao, Y.L.10
  • 79
    • 84871236691 scopus 로고    scopus 로고
    • Biochemical alterations induced by acute oral doses of iron oxide nanoparticles in Wistar rats
    • COI: 1:CAS:528:DC%2BC38XhvVeltbbF, PID: 23025823
    • Kumari M, Rajak S, Singh SP, Murty US, Mahboob M, Grover P, Rahman MF (2013) Biochemical alterations induced by acute oral doses of iron oxide nanoparticles in Wistar rats. Drug Chem Toxicol 36:296–305
    • (2013) Drug Chem Toxicol , vol.36 , pp. 296-305
    • Kumari, M.1    Rajak, S.2    Singh, S.P.3    Murty, U.S.4    Mahboob, M.5    Grover, P.6    Rahman, M.F.7
  • 80
    • 28344454947 scopus 로고    scopus 로고
    • Imaging, distribution, and toxicity of superparamagnetic iron oxide magnetic resonance nanoparticles in the rat brain and intracerebral tumor
    • PID: 16239893
    • Muldoon LL, Sandor M, Pinkston KE, Neuwelt EA (2005) Imaging, distribution, and toxicity of superparamagnetic iron oxide magnetic resonance nanoparticles in the rat brain and intracerebral tumor. Neurosurgery 57:785–796
    • (2005) Neurosurgery , vol.57 , pp. 785-796
    • Muldoon, L.L.1    Sandor, M.2    Pinkston, K.E.3    Neuwelt, E.A.4
  • 81
    • 79251551060 scopus 로고    scopus 로고
    • Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques
    • COI: 1:STN:280:DC%2BC3M%2Fit1aqtA%3D%3D, PID: 21135466
    • Wang FH, Kim DK, Yoshitake T, Johansson SM, Bjelke B, Muhammed M, Kehr J (2011) Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques. Nanotechnology 22:015103
    • (2011) Nanotechnology , vol.22 , pp. 015103
    • Wang, F.H.1    Kim, D.K.2    Yoshitake, T.3    Johansson, S.M.4    Bjelke, B.5    Muhammed, M.6    Kehr, J.7
  • 82
    • 7044253728 scopus 로고    scopus 로고
    • Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours
    • COI: 1:CAS:528:DC%2BD2cXhtVektLnE, PID: 15488022
    • Neuwelt EA, Várallyay P, Bagó AG, Muldoon LL, Nesbit G, Nixon R (2004) Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours. Neuropathol Appl Neurobiol 30:456–471
    • (2004) Neuropathol Appl Neurobiol , vol.30 , pp. 456-471
    • Neuwelt, E.A.1    Várallyay, P.2    Bagó, A.G.3    Muldoon, L.L.4    Nesbit, G.5    Nixon, R.6
  • 83
    • 84884283916 scopus 로고    scopus 로고
    • In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms
    • COI: 1:CAS:528:DC%2BC3sXptFOgsL0%3D, PID: 23669369
    • Kim Y, Kong SD, Chen LH, Pisanic TR 2nd, Jin S, Shubayev VI (2013) In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms. Nanomedicine 9:1057–1066
    • (2013) Nanomedicine , vol.9 , pp. 1057-1066
    • Kim, Y.1    Kong, S.D.2    Chen, L.H.3    Pisanic, T.R.4    Jin, S.5    Shubayev, V.I.6
  • 84
    • 0035805163 scopus 로고    scopus 로고
    • Nanoscale biogenic iron oxides and neurodegenerative disease
    • COI: 1:CAS:528:DC%2BD3MXjtlCitrg%3D, PID: 11343696
    • Dobson J (2001) Nanoscale biogenic iron oxides and neurodegenerative disease. FEBS Lett 496:1–5
    • (2001) FEBS Lett , vol.496 , pp. 1-5
    • Dobson, J.1
  • 85
    • 84864457874 scopus 로고    scopus 로고
    • Cognitive impairment in rats induced by nano-CuO and its possible mechanisms
    • COI: 1:CAS:528:DC%2BC38Xht1SktbnO, PID: 22820425
    • An L, Liu S, Yang Z, Zhang T (2012) Cognitive impairment in rats induced by nano-CuO and its possible mechanisms. Toxicol Lett 213:220–227
    • (2012) Toxicol Lett , vol.213 , pp. 220-227
    • An, L.1    Liu, S.2    Yang, Z.3    Zhang, T.4
  • 86
    • 77956012861 scopus 로고    scopus 로고
    • Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    • COI: 1:CAS:528:DC%2BC3cXhtVyit77O, PID: 20692697
    • Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, Zhou M, Liu C, Wang H, Hong F (2010) Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 31:8043–8050
    • (2010) Biomaterials , vol.31 , pp. 8043-8050
    • Hu, R.1    Gong, X.2    Duan, Y.3    Li, N.4    Che, Y.5    Cui, Y.6    Zhou, M.7    Liu, C.8    Wang, H.9    Hong, F.10
  • 87
    • 84860343496 scopus 로고    scopus 로고
    • Neurotoxicity of engineered nanoparticles from metals
    • COI: 1:CAS:528:DC%2BC38XltFSmsr4%3D, PID: 22229317
    • Sharma HS, Sharma A (2012) Neurotoxicity of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 11:65–80
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , pp. 65-80
    • Sharma, H.S.1    Sharma, A.2
  • 88
    • 77958614390 scopus 로고    scopus 로고
    • Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties
    • PID: 20820094
    • Levy M, Lagarde F, Maraloiu VA, Blanchin MG, Gendron F, Wilhelm C, Gazeau F (2010) Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties. Nanotechnology 21:395103
    • (2010) Nanotechnology , vol.21 , pp. 395103
    • Levy, M.1    Lagarde, F.2    Maraloiu, V.A.3    Blanchin, M.G.4    Gendron, F.5    Wilhelm, C.6    Gazeau, F.7
  • 89
    • 78650982804 scopus 로고    scopus 로고
    • Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity
    • COI: 1:CAS:528:DC%2BC3cXhsFCltbbK, PID: 21141957
    • Voinov MA, Pagan JOS, Morrison E, Smirnova TI, Smirnov AI (2011) Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity. J Am Chem Soc 133:35–41
    • (2011) J Am Chem Soc , vol.133 , pp. 35-41
    • Voinov, M.A.1    Pagan, J.O.S.2    Morrison, E.3    Smirnova, T.I.4    Smirnov, A.I.5
  • 90
    • 84921855400 scopus 로고    scopus 로고
    • Tulpule K, Hohnholt MC, Hirrlinger J, Dringen R (2014) Primary cultures of astrocytes and neurons as model systems to study the metabolism and metabolite export from brain cells. In: Waagepetersen H, Hirrlinger J (eds) Neuromethods: brain energy metabolism. Springer, Heidelberg (in press)
    • Tulpule K, Hohnholt MC, Hirrlinger J, Dringen R (2014) Primary cultures of astrocytes and neurons as model systems to study the metabolism and metabolite export from brain cells. In: Waagepetersen H, Hirrlinger J (eds) Neuromethods: brain energy metabolism. Springer, Heidelberg (in press)
  • 91
    • 84871410588 scopus 로고    scopus 로고
    • Primary cultures of astrocytes: their value in understanding astrocytes in health and disease
    • COI: 1:CAS:528:DC%2BC38Xht1Grt7nL, PID: 22926576
    • Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD (2012) Primary cultures of astrocytes: their value in understanding astrocytes in health and disease. Neurochem Res 37:2569–2588
    • (2012) Neurochem Res , vol.37 , pp. 2569-2588
    • Lange, S.C.1    Bak, L.K.2    Waagepetersen, H.S.3    Schousboe, A.4    Norenberg, M.D.5
  • 92
    • 84887959333 scopus 로고    scopus 로고
    • Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes
    • COI: 1:CAS:528:DC%2BC3sXhvVSmtb%2FE, PID: 24256259
    • Hohnholt MC, Dringen R (2013) Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes. Biochem Soc Trans 41:1588–1592
    • (2013) Biochem Soc Trans , vol.41 , pp. 1588-1592
    • Hohnholt, M.C.1    Dringen, R.2
  • 93
    • 84875043885 scopus 로고    scopus 로고
    • Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models
    • Sun ZZ, Yathindranath V, Worden M, Thliveris JA, Chu S, Parkinson FE, Hegmann T, Miller DW (2013) Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models. Int J Nanomed 8:961–970
    • (2013) Int J Nanomed , vol.8 , pp. 961-970
    • Sun, Z.Z.1    Yathindranath, V.2    Worden, M.3    Thliveris, J.A.4    Chu, S.5    Parkinson, F.E.6    Hegmann, T.7    Miller, D.W.8
  • 94
    • 84655162221 scopus 로고    scopus 로고
    • Magnetic field-induced acceleration of the accumulation of magnetic iron oxide nanoparticles by cultured brain astrocytes
    • COI: 1:CAS:528:DC%2BC3MXhs1Ghtr3E
    • Lamkowsky MC, Geppert M, Schmidt MM, Dringen R (2012) Magnetic field-induced acceleration of the accumulation of magnetic iron oxide nanoparticles by cultured brain astrocytes. J Biomed Mater Res A 100A:323–334
    • (2012) J Biomed Mater Res A , vol.100A , pp. 323-334
    • Lamkowsky, M.C.1    Geppert, M.2    Schmidt, M.M.3    Dringen, R.4
  • 95
    • 84862329262 scopus 로고    scopus 로고
    • Evaluation of uptake and transport of cationic and anionic ultrasmall iron oxide nanoparticles by human colon cells
    • COI: 1:CAS:528:DC%2BC38XkslamsL4%3D
    • Kenzaoui BH, Vila MR, Miquel JM, Cengelli F, Juillerat-Jeanneret L (2012) Evaluation of uptake and transport of cationic and anionic ultrasmall iron oxide nanoparticles by human colon cells. Int J Nanomed 7:1275–1286
    • (2012) Int J Nanomed , vol.7 , pp. 1275-1286
    • Kenzaoui, B.H.1    Vila, M.R.2    Miquel, J.M.3    Cengelli, F.4    Juillerat-Jeanneret, L.5
  • 96
    • 84863567487 scopus 로고    scopus 로고
    • Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge
    • COI: 1:CAS:528:DC%2BC38XhslyisbjL, PID: 22781560
    • Schweiger C, Hartmann R, Zhang F, Parak WJ, Kissel TH, Rivera Gil P (2012) Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge. J Nanobiotechnology 10:28–38
    • (2012) J Nanobiotechnology , vol.10 , pp. 28-38
    • Schweiger, C.1    Hartmann, R.2    Zhang, F.3    Parak, W.J.4    Kissel, T.H.5    Rivera Gil, P.6
  • 100
    • 84865452207 scopus 로고    scopus 로고
    • Ferritin up-regulation and transient ROS production in cultured brain astrocytes after loading with iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC38Xht1KkurjK, PID: 22750736
    • Geppert M, Hohnholt MC, Nurnberger S, Dringen R (2012) Ferritin up-regulation and transient ROS production in cultured brain astrocytes after loading with iron oxide nanoparticles. Acta Biomater 8:3832–3839
    • (2012) Acta Biomater , vol.8 , pp. 3832-3839
    • Geppert, M.1    Hohnholt, M.C.2    Nurnberger, S.3    Dringen, R.4
  • 101
    • 84858732725 scopus 로고    scopus 로고
    • Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia
    • COI: 1:CAS:528:DC%2BC38XnsVGhs7s%3D, PID: 22439862
    • Pinkernelle J, Calatayud P, Goya GF, Fansa H, Keilhoff G (2012) Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia. BMC Neurosci 13:32–48
    • (2012) BMC Neurosci , vol.13 , pp. 32-48
    • Pinkernelle, J.1    Calatayud, P.2    Goya, G.F.3    Fansa, H.4    Keilhoff, G.5
  • 102
    • 0035215981 scopus 로고    scopus 로고
    • Magnetic labeling of activated microglia in experimental gliomas
    • COI: 1:STN:280:DC%2BD38%2FkvFWguw%3D%3D, PID: 11774031
    • Fleige G, Nolte C, Synowitz M, Seeberger F, Kettenmann H, Zimmer C (2001) Magnetic labeling of activated microglia in experimental gliomas. Neoplasia 3:489–499
    • (2001) Neoplasia , vol.3 , pp. 489-499
    • Fleige, G.1    Nolte, C.2    Synowitz, M.3    Seeberger, F.4    Kettenmann, H.5    Zimmer, C.6
  • 103
    • 84880924107 scopus 로고    scopus 로고
    • Endocytotic uptake of iron oxide nanoparticles by cultured brain microglial cells
    • COI: 1:CAS:528:DC%2BC3sXpvVynsLo%3D, PID: 23727247
    • Luther EM, Petters C, Bulcke F, Kaltz A, Thiel K, Bickmeyer U, Dringen R (2013) Endocytotic uptake of iron oxide nanoparticles by cultured brain microglial cells. Acta Biomater 9:8454–8465
    • (2013) Acta Biomater , vol.9 , pp. 8454-8465
    • Luther, E.M.1    Petters, C.2    Bulcke, F.3    Kaltz, A.4    Thiel, K.5    Bickmeyer, U.6    Dringen, R.7
  • 104
    • 84884179447 scopus 로고    scopus 로고
    • Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells
    • COI: 1:CAS:528:DC%2BC2cXhtVWju7%2FJ, PID: 24047432
    • Wu HY, Chung MC, Wang CC, Huang CH, Liang HJ, Jan TR (2013) Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells. Part Fibre Toxicol 10:46–56
    • (2013) Part Fibre Toxicol , vol.10 , pp. 46-56
    • Wu, H.Y.1    Chung, M.C.2    Wang, C.C.3    Huang, C.H.4    Liang, H.J.5    Jan, T.R.6
  • 105
    • 84878680889 scopus 로고    scopus 로고
    • Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering
    • COI: 1:CAS:528:DC%2BC3sXos1yqt7s%3D
    • Jenkins SI, Pickard MR, Furness DN, Yiu HH, Chari DM (2013) Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond) 8:951–968
    • (2013) Nanomedicine (Lond) , vol.8 , pp. 951-968
    • Jenkins, S.I.1    Pickard, M.R.2    Furness, D.N.3    Yiu, H.H.4    Chari, D.M.5
  • 106
    • 77950869739 scopus 로고    scopus 로고
    • Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: implications for particle uptake in mixed neural cell populations
    • COI: 1:CAS:528:DC%2BC3cXjsVequ7k%3D, PID: 20479995
    • Pickard MR, Chari DM (2010) Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: implications for particle uptake in mixed neural cell populations. Int J Mol Sci 11:967–981
    • (2010) Int J Mol Sci , vol.11 , pp. 967-981
    • Pickard, M.R.1    Chari, D.M.2
  • 107
    • 84896904596 scopus 로고    scopus 로고
    • Microglia development and function
    • COI: 1:CAS:528:DC%2BC2cXovVemt7o%3D, PID: 24471431
    • Nayak D, Roth TL, McGavern DB (2014) Microglia development and function. Annu Rev Immunol 32:367–402
    • (2014) Annu Rev Immunol , vol.32 , pp. 367-402
    • Nayak, D.1    Roth, T.L.2    McGavern, D.B.3
  • 108
    • 84866292862 scopus 로고    scopus 로고
    • Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro
    • COI: 1:CAS:528:DC%2BC38XhsVemt7%2FI, PID: 22939914
    • Xue Y, Wu J, Sun J (2012) Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. Toxicol Lett 214:91–98
    • (2012) Toxicol Lett , vol.214 , pp. 91-98
    • Xue, Y.1    Wu, J.2    Sun, J.3
  • 110
    • 0030017964 scopus 로고    scopus 로고
    • OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures
    • COI: 1:CAS:528:DyaK28XkvFWjsbs%3D, PID: 8843033
    • Richter-Landsberg C, Heinrich M (1996) OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures. J Neurosci Res 45:161–173
    • (1996) J Neurosci Res , vol.45 , pp. 161-173
    • Richter-Landsberg, C.1    Heinrich, M.2
  • 111
    • 77955560497 scopus 로고    scopus 로고
    • Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells
    • COI: 1:CAS:528:DC%2BC3cXmtVSmtLs%3D, PID: 20467895
    • Hohnholt M, Geppert M, Dringen R (2010) Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells. Neurochem Res 35:1259–1268
    • (2010) Neurochem Res , vol.35 , pp. 1259-1268
    • Hohnholt, M.1    Geppert, M.2    Dringen, R.3
  • 112
    • 84857041829 scopus 로고    scopus 로고
    • Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells
    • COI: 1:CAS:528:DC%2BC3MXhs1SqtL%2FJ
    • Hohnholt MC, Dringen R (2011) Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells. J Nanopart Res 13:6761–6774
    • (2011) J Nanopart Res , vol.13 , pp. 6761-6774
    • Hohnholt, M.C.1    Dringen, R.2
  • 113
    • 80053573858 scopus 로고    scopus 로고
    • Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells
    • COI: 1:CAS:528:DC%2BC3MXht1Ggu7fF, PID: 21763792
    • Hohnholt MC, Geppert M, Dringen R (2011) Treatment with iron oxide nanoparticles induces ferritin synthesis but not oxidative stress in oligodendroglial cells. Acta Biomater 7:3946–3954
    • (2011) Acta Biomater , vol.7 , pp. 3946-3954
    • Hohnholt, M.C.1    Geppert, M.2    Dringen, R.3
  • 114
    • 79951575703 scopus 로고    scopus 로고
    • Enhancement of neurite outgrowth in PC12 cells by iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXitFeht70%3D, PID: 21288566
    • Kim JA, Lee N, Kim BH, Rhee WJ, Yoon S, Hyeon T, Park TH (2011) Enhancement of neurite outgrowth in PC12 cells by iron oxide nanoparticles. Biomaterials 32:2871–2877
    • (2011) Biomaterials , vol.32 , pp. 2871-2877
    • Kim, J.A.1    Lee, N.2    Kim, B.H.3    Rhee, W.J.4    Yoon, S.5    Hyeon, T.6    Park, T.H.7
  • 115
    • 84894048503 scopus 로고    scopus 로고
    • Fabrication and neuron cytocompatibility of iron oxide nanoparticles coated with silk-fibroin peptides
    • Deng M, Huang Z, Zou Y, Yin G, Liu J, Gu J (2014) Fabrication and neuron cytocompatibility of iron oxide nanoparticles coated with silk-fibroin peptides. Colloids Surf B Biointerfaces 116C:465–471
    • (2014) Colloids Surf B Biointerfaces , vol.116C , pp. 465-471
    • Deng, M.1    Huang, Z.2    Zou, Y.3    Yin, G.4    Liu, J.5    Gu, J.6
  • 116
    • 33847652942 scopus 로고    scopus 로고
    • Nanotoxicity of iron oxide nanoparticle internalization in growing neurons
    • COI: 1:CAS:528:DC%2BD2sXis1CrsLk%3D, PID: 17320946
    • Pisanic TR 2nd, Blackwell JD, Shubayev VI, Finones RR, Jin S (2007) Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials 28:2572–2581
    • (2007) Biomaterials , vol.28 , pp. 2572-2581
    • Pisanic, T.R.1    Blackwell, J.D.2    Shubayev, V.I.3    Finones, R.R.4    Jin, S.5
  • 117
    • 78349312714 scopus 로고    scopus 로고
    • Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling
    • COI: 1:CAS:528:DC%2BC3cXhsVWhu7rP, PID: 20863560
    • Soenen SJ, Himmelreich U, Nuytten N, De Cuyper M (2011) Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials 32:195–205
    • (2011) Biomaterials , vol.32 , pp. 195-205
    • Soenen, S.J.1    Himmelreich, U.2    Nuytten, N.3    De Cuyper, M.4
  • 118
    • 84855860055 scopus 로고    scopus 로고
    • Altering iron oxide nanoparticle surface properties induce cortical neuron cytotoxicity
    • COI: 1:CAS:528:DC%2BC3MXhsFait7bN, PID: 22111864
    • Rivet CJ, Yuan Y, Borca-Tasciuc DA, Gilbert RJ (2012) Altering iron oxide nanoparticle surface properties induce cortical neuron cytotoxicity. Chem Res Toxicol 25:153–161
    • (2012) Chem Res Toxicol , vol.25 , pp. 153-161
    • Rivet, C.J.1    Yuan, Y.2    Borca-Tasciuc, D.A.3    Gilbert, R.J.4
  • 120
    • 84870543583 scopus 로고    scopus 로고
    • The use of nanoparticles as contrast media in neuroimaging: a statement on toxicity
    • PID: 22120308
    • Winer JL, Liu CY, Apuzzo MLJ (2012) The use of nanoparticles as contrast media in neuroimaging: a statement on toxicity. World Neurosurg 78:709–711
    • (2012) World Neurosurg , vol.78 , pp. 709-711
    • Winer, J.L.1    Liu, C.Y.2    Apuzzo, M.L.J.3
  • 121
    • 80053333203 scopus 로고    scopus 로고
    • Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell “vision” versus physicochemical properties of nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXhtVGmsr%2FE, PID: 21838310
    • Mahmoudi M, Laurent S, Shokrgozar MA, Hosseinkhani M (2011) Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell “vision” versus physicochemical properties of nanoparticles. ACS Nano 5:7263–7276
    • (2011) ACS Nano , vol.5 , pp. 7263-7276
    • Mahmoudi, M.1    Laurent, S.2    Shokrgozar, M.A.3    Hosseinkhani, M.4
  • 122
    • 84897952229 scopus 로고    scopus 로고
    • The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders
    • PID: 24653700
    • Urrutia PJ, Mena NP, Nunez MT (2014) The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders. Front Pharmacol 5:38
    • (2014) Front Pharmacol , vol.5 , pp. 38
    • Urrutia, P.J.1    Mena, N.P.2    Nunez, M.T.3
  • 123
    • 84901058201 scopus 로고    scopus 로고
    • The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders
    • PID: 24795635
    • Wong BX, Duce JA (2014) The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol 5:81
    • (2014) Front Pharmacol , vol.5 , pp. 81
    • Wong, B.X.1    Duce, J.A.2
  • 124
    • 33847105184 scopus 로고    scopus 로고
    • Advances in the treatment of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2sXitFOrsLg%3D, PID: 17258379
    • Singh N, Pillay V, Choonara YE (2007) Advances in the treatment of Parkinson’s disease. Prog Neurobiol 81:29–44
    • (2007) Prog Neurobiol , vol.81 , pp. 29-44
    • Singh, N.1    Pillay, V.2    Choonara, Y.E.3
  • 125
    • 84858407826 scopus 로고    scopus 로고
    • Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy
    • COI: 1:CAS:528:DC%2BC38XlvVKhtrg%3D, PID: 22390560
    • Wankhede M, Bouras A, Kaluzova M, Hadjipanayis CG (2012) Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy. Expert Rev Clin Pharmacol 5:173–186
    • (2012) Expert Rev Clin Pharmacol , vol.5 , pp. 173-186
    • Wankhede, M.1    Bouras, A.2    Kaluzova, M.3    Hadjipanayis, C.G.4
  • 126
    • 84897067703 scopus 로고    scopus 로고
    • Fighting fire with fire: the revival of thermotherapy for gliomas
    • PID: 24510985
    • Lee Titsworth W, Murad GJ, Hoh BL, Rahman M (2014) Fighting fire with fire: the revival of thermotherapy for gliomas. Anticancer Res 34:565–574
    • (2014) Anticancer Res , vol.34 , pp. 565-574
    • Lee Titsworth, W.1    Murad, G.J.2    Hoh, B.L.3    Rahman, M.4
  • 128
    • 77952916810 scopus 로고    scopus 로고
    • Cell-specific cytotoxicity of dextran-stabilized magnetite nanoparticles
    • COI: 1:CAS:528:DC%2BC3cXmsVOnsrY%3D, PID: 20427159
    • Ding J, Tao K, Li J, Song S, Sun K (2010) Cell-specific cytotoxicity of dextran-stabilized magnetite nanoparticles. Colloids Surf B Biointerfaces 79:184–190
    • (2010) Colloids Surf B Biointerfaces , vol.79 , pp. 184-190
    • Ding, J.1    Tao, K.2    Li, J.3    Song, S.4    Sun, K.5


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