Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells

Neoplasia (United States)

Volumn 18, Issue 2, 2016, Pages 100-110

  Ochnik, Aleksandra M ^a   Peterson, Mark S ^b   Avdulov, Svetlana V ^b   Oh, Annabell S ^a   Bitterman, Peter B ^b   Yee, Douglas ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Division of Pulmonary and Critical Care Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AIB1; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; EIF4EBP1 PROTEIN, HUMAN; ESTROGEN RECEPTOR ALPHA, HUMAN; MTOR PROTEIN, HUMAN; NCOA3 PROTEIN, HUMAN; PHOSPHOPROTEIN; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STEROID RECEPTOR COACTIVATOR 3; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BREAST CANCER; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE MAPPING; HUMAN; HUMAN CELL; MCF 7 CELL LINE; ONTOLOGY; POLYSOME; PRIORITY JOURNAL; RNA TRANSLATION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MCF-7 CELL LINE; PATHOLOGY; PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MCF-7 CELLS; NUCLEAR RECEPTOR COACTIVATOR 3; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84963976251     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2016.01.001     Document Type: Article

References (44)

1. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997, 277:965-968.
2. Xu J, Wu RC, O'Malley BW Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 2009, 9:615-630.
3. Oh AS, Lahusen JT, Chien CD, Fereshteh MP, Zhang X, Dakshanamurthy S, Xu J, Kagan BL, Wellstein A, Riegel AT Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Mol Cell Biol 2008, 28:6580-6593.
4. Lahusen T, Henke RT, Kagan BL, Wellstein A, Riegel AT The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer. Breast Cancer Res Treat 2009, 116:225-237.
5. Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell 2004, 15:937-949.
6. Louie MC, Zou JX, Rabinovich A, Chen HW ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol 2004, 24:5157-5171.
7. Sachdev D, Yee D Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 2007, 6:1-12.
8. Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, et al. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol 2003, 23:8862-8877.
9. Jefferies HB, Fumagalli S, Dennis PB, Reinhard C, Pearson RB, Thomas G Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J 1997, 16:3693-3704.
10. Holz MK, Ballif BA, Gygi SP, Blenis J mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005, 123:569-580.
11. Silvera D, Formenti SC, Schneider RJ Translational control in cancer. Nat Rev Cancer 2010, 10:254-266.
12. Braunstein S, Karpisheva K, Pola C, Goldberg J, Hochman T, Yee H, Cangiarella J, Arju R, Formenti SC, Schneider RJ A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell 2007, 28:501-512.
13. Gingras AC, Raught B, Sonenberg N Regulation of translation initiation by FRAP/mTOR. Genes Dev 2001, 15:807-826.
14. Engelman JA Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009, 9:550-562.
15. Becker MA, Ibrahim YH, Cui X, Lee AV, Yee D The IGF pathway regulates ERalpha through a S6K1-dependent mechanism in breast cancer cells. Mol Endocrinol 2011, 25:516-528.
16. Maag D, Algire M, Lorsch J Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection. J Mol Biol 2006, 356:724-737.
17. Jennings M, Pavitt G eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 2010, 465:378-381.
18. Gingras AC, Raught B, Sonenberg N eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999, 68:913-963.
19. Cole MD, Cowling VH Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors. Oncogene 2009, 28:1169-1175.
20. Hannan KM, Sanij E, Hein N, Hannan RD, Pearson RB Signaling to the ribosome in cancer--It is more than just mTORC1. IUBMB Life 2011, 63:79-85.
21. Devlin JR, Hannan KM, Ng PY, Bywater MJ, Shortt J, Cullinane C, McArthur GA, Johnstone RW, Hannan RD, Pearson RB AKT signalling is required for ribosomal RNA synthesis and progression of Emu-Myc B-cell lymphoma in vivo. FEBS J 2013, 280(21):5307-5316.
22. Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, et al. AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. Sci Signal 2011, 4:ra56.
23. Rajasekhar V, Viale A, Socci N, Wiedmann M, Hu X, Holland E Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell 2003, 12:889-901.
24. Xu Y, Chen Q, Li W, Su X, Chen TK, Liu Y, Zhao Y, Yu CT Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness. Oncogene 2010, 10:3386-3397.
25. Maae E, Andersen R, Steffensen K, Jakobsen E, Brandslund I, Sørensen F, Jakobsen A Prognostic impact of VEGFA germline polymorphisms in patients with HER2-positive primary breast cancer. Anticancer Res 2012, 32:3619-3627.
26. Barillé-Nion S, Bah N, Véquaud E, Juin P Regulation of cancer cell survival by BCL2 family members upon prolonged mitotic arrest: opportunities for anticancer therapy. Anticancer Res 2012, 32:4225-4233.
27. Fukuda M, Miyoshi M, Nadano D The role of bystin in embryo implantation and in ribosomal biogenesis. Cell Mol Life Sci 2008, 65:92-99.
28. Miyoshi M, Okajima T, Matsuda T, Fukuda M, Nadano D Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Biochem J 2007, 404:373-381.
29. Chambers AF MDA-MB-435 and M14 cell lines: identical but not M14 melanoma?. Cancer Res 2009, 69:5292-5293.
30. Hollestelle A, Schutte M Comment Re: MDA-MB-435 and M14 cell lines: identical but not M14 Melanoma?. Cancer Res 2009, 69:7893.
31. Polunovsky VA, Gingras AC, Sonenberg N, Peterson M, Tan A, Rubins JB, Manivel JC, Bitterman PB Translational control of the antiapoptotic function of Ras. J Biol Chem 2000, 275:24776-24780.
32. Pettersson F, Yau C, Dobocan MC, Culjkovic-Kraljacic B, Retrouvey H, Puckett R, Flores LM, Krop IE, Rousseau C, Cocolakis E, et al. Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer. Clin Cancer Res 2011, 17:2874-2884.
33. Li S, Takasu T, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Bitterman PB, Polunovsky VA Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem 2003, 278:3015-3022.
34. Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A 1996, 93:1065-1070.
35. Baselga J, Campone M, Piccart M, Burris HA, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012, 366:520-529.
36. Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KL Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A 2004, 101:18105-18110.
37. Boussemart L, Malka-Mahieu H, Girault I, Allard D, Hemmingsson O, Tomasic G, Thomas M, Basmadjian C, Ribeiro N, Thuaud F, et al. eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies. Nature 2014, 513:105-109.
38. Tong ZT, Wei JH, Zhang JX, Liang CZ, Liao B, Lu J, Fan S, Chen ZH, Zhang F, Ma HH, et al. AIB1 predicts bladder cancer outcome and promotes bladder cancer cell proliferation through AKT and E2F1. Br J Cancer 2013, 108:1470-1479.
39. Devlin JR, Hannan KM, Ng PY, Bywater MJ, Shortt J, Cullinane C, McArthur GA, Johnstone RW, Hannan RD, Pearson RB AKT signalling is required for ribosomal RNA synthesis and progression of Emu-Myc B-cell lymphoma in vivo. FEBS J 2013, 280:5307-5316.
40. Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, George AJ, Shortt J, Bywater MJ, Poortinga G, et al. Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma. Cancer Discovery 2016, 6(1):59-70.
41. Drygin D, Lin A, Bliesath J, Ho CB, O'Brien SE, Proffitt C, Omori M, Haddach M, Schwaebe MK, Siddiqui-Jain A, et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res 2011, 71:1418-1430.
42. Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, et al. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 2004, 5:553-563.
43. Pons B, Peg V, Vazquez-Sanchez MA, Lopez-Vicente L, Argelaguet E, Coch L, Martinez A, Hernandez-Losa J, Armengol G, Ramon YCS The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model. Int J Oncol 2011, 39:1337-1345.
44. Yee D Insulin-like growth factor receptor inhibitors: baby or the bathwater?. J Natl Cancer Inst 2012, 104:975-981.