Ribavirin suppresses elF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 52, 2004, Pages 18105-18110

  Kentsis, Alex ^a   Topisirovic, Ivan ^a,b   Culjkovic, Biljana ^a,b   Shao, Ling ^a   Borden, Katherine L B ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cancer; Drug; Oncogenic network; Virus

Indexed keywords

7 METHYLGUANOSINE; CYCLIN D1; INITIATION FACTOR 4E; MESSENGER RNA; RIBAVIRIN; 7-METHYLGUANOSINE; ANTIVIRUS AGENT; CAPPED RNA; DRUG DERIVATIVE; GUANOSINE; LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA TRANSLATION; RNA TRANSPORT; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; ANIMAL; BINDING SITE; CELL STRAIN 3T3; CELL TRANSFORMATION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; KINETICS; METABOLISM; PROTEIN BINDING; PROTEIN SYNTHESIS; TIME; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALIA; EUKARYOTA; MURINAE;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-4E; GUANOSINE; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RIBAVIRIN; RNA CAPS; RNA, MESSENGER; TIME FACTORS;

EID: 11144220618     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406927102     Document Type: Article

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