Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Nucleic Acids Research

Volumn 44, Issue 6, 2016, Pages 2782-2794

  Miller, Colton M ^a   Donner, Aaron J ^b   Blank, Emma E ^a   Egger, Andrew W ^a   Kellar, Brianna M ^a   Østergaard, Michael E ^b   Seth, Punit P ^b   Harris, Edward N ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CLATHRIN; MALAT 1; PHOSPHOROTHIOIC ACID; SCAVENGER RECEPTOR; STABILIN 1; STABILIN 2; UNCLASSIFIED DRUG; UNTRANSLATED RNA; ISOPROTEIN; LONG UNTRANSLATED RNA; MALAT1 LONG NON-CODING RNA, MOUSE; NERVE CELL ADHESION MOLECULE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; STAB1 PROTEIN, MOUSE; STAB2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENDOCYTOSIS; INTERNALIZATION; LIVER PARENCHYMA; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CLATHRIN-COATED VESICLE; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; LIVER; METABOLISM; PRIMARY CELL CULTURE; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; CELL ADHESION MOLECULES, NEURONAL; CLATHRIN-COATED VESICLES; ENDOCYTOSIS; ENDOTHELIAL CELLS; GENE EXPRESSION; HEK293 CELLS; HUMANS; KINETICS; LIVER; MICE; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; PRIMARY CELL CULTURE; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RNA, LONG NONCODING;

EID: 84963861008     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw112     Document Type: Article

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