Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 11, 2012, Pages 4263-4268

  Hirose, Yoshikazu ^a   Saijou, Eiko ^a   Sugano, Yasuyoshi ^a   Takeshita, Fumitaka ^b   Nishimura, Satoshi ^a   Nonaka, Hidenori ^a   Chen, Yen Rong ^a   Sekine, Keisuke ^a   Kido, Taketomo ^a   Nakamura, Takashi ^a   Kato, Shigeaki ^a   Kanke, Toru ^c   Nakamura, Koji ^c   Nagai, Ryozo ^a   Ochiya, Takahiro ^b   Miyajima, Atsushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c LivTech Inc   (Japan)

Author keywords

Antibody therapy; Cancer; Hyaluronan; Imaging; Sinusoid

Indexed keywords

ANTIBODY; HYALURONIC ACID; SCAVENGER RECEPTOR; STABILIN 2; STABILIN 2 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MEGADOSE; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME INHIBITION; LUNG ENDOTHELIUM; MAMMARY GLAND; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; CELL ADHESION; CELL ADHESION MOLECULES, NEURONAL; HUMANS; HYALURONIC ACID; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM METASTASIS;

MUS;

EID: 84863229377     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117560109     Document Type: Article

References (32)

1. Fraser JR, Alcorn D, Laurent TC, Robinson AD, Ryan GB (1985) Uptake of circulating hyaluronic acid by the rat liver: Cellular localization in situ. Cell Tissue Res 242: 505-510. (Pubitemid 16202958)
2. Schledzewski K, et al. (2011) Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest 121:703-714.
3. Politz O, et al. (2002) Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J 362:155-164. (Pubitemid 34174473)
4. Adachi H, Tsujimoto M (2002) FEEL-1, a novel scavenger receptor with in vitro bacteria- binding and angiogenesis-modulating activities. J Biol Chem 277:34264-34270.
5. Hansen B, et al. (2005) Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. Exp Cell Res 303:160-173. (Pubitemid 39575152)
6. Kzhyshkowska J, et al. (2005) Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL. Immunobiology 210:161-173. (Pubitemid 41025157)
7. Kzhyshkowska J, et al. (2008) Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis. J Immunol 180:3028-3037.
8. Kzhyshkowska J, et al. (2006) Novel function of alternatively activated macrophages: Stabilin-1-mediated clearance of SPARC. J Immunol 176:5825-5832.
9. Salmi M, Koskinen K, Henttinen T, Elima K, Jalkanen S (2004) CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Blood 104: 3849-3857. (Pubitemid 39620128)
10. Nonaka H, Tanaka M, Suzuki K, Miyajima A (2007) Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Dev Dyn 236:2258-2267. (Pubitemid 47293768)
11. Park SY, et al. (2008) Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ 15:192-201.
12. Gustafson S, Björkman T (1997) Circulating hyaluronan, chondroitin sulphate and dextran sulphate bind to a liver receptor that does not recognize heparin. Glycoconj J 14:561-568. (Pubitemid 27353199)
13. Harris EN, Weigel PH (2008) The ligand-binding profile of HARE: Hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate and CS-E. Glycobiology 18:638-648.
14. Kogan G, Soltés L, Stern R, Gemeiner P (2007) Hyaluronic acid: A natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 29: 17-25. (Pubitemid 44950153)
15. Fraser JR, Laurent TC, Laurent UB (1997) Hyaluronan: Its nature, distribution, functions and turnover. J Intern Med 242:27-33. (Pubitemid 27323862)
16. Stern R, Asari AA, Sugahara KN (2006) Hyaluronan fragments: An information-rich system. Eur J Cell Biol 85:699-715. (Pubitemid 44070579)
17. Almond A (2007) Hyaluronan. Cell Mol Life Sci 64:1591-1596.
18. Jiang D, et al. (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11:1173-1179. (Pubitemid 43093664)
19. DeGrendele HC, Estess P, Siegelman MH (1997) Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science 278:672-675. (Pubitemid 27464963)
20. Zöller M(2011) CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 11:254-267.
21. Banerji S, et al. (1999) LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144:789-801. (Pubitemid 29234556)
22. Kim S, et al. (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457:102-106.
23. Sironen RK, et al. (2011) Hyaluronan in human malignancies. Exp Cell Res 317: 383-391.
24. Toole BP (2004) Hyaluronan: From extracellular glue to pericellular cue. Nat Rev Cancer 4:528-539.
25. Twarock S, et al. (2011) Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis. Mol Cancer 10:30.
26. Kudo D, et al. (2004) Effect of a hyaluronan synthase suppressor, 4-methyl-umbelliferone, on B16F-10 melanoma cell adhesion and locomotion. Biochem Biophys Res Commun 321:783-787. (Pubitemid 39044378)
27. Zhou B, Weigel JA, Fauss L, Weigel PH (2000) Identification of the hyaluronan receptor for endocytosis (HARE). J Biol Chem 275:37733-37741. (Pubitemid 32004888)
28. Harris EN, Weigel JA, Weigel PH (2008) The human hyaluronan receptor for endocytosis (HARE/Stab2) is a systemic clearance receptor for heparin. J Biol Chem 283: 21453-21461.
29. Gale NW, et al. (2007) Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Mol Cell Biol 27:595-604. (Pubitemid 46080127)
30. Yoshihara S, et al. (2005) A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett 579:2722-2726. (Pubitemid 40615683)
31. Takeshita F, et al. (2005) Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci USA 102:12177-12182. (Pubitemid 41291148)
32. Jenkins DE, Hornig YS, Oei Y, Dusich J, Purchio T (2005) Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 7:R444-R454.