Fields and field cancerization: The preneoplastic origins of cancer: Asymptomatic hyperplastic fields are precursors of neoplasia, and their progression to tumors can be tracked by saturation density in culture

BioEssays

Volumn 33, Issue 3, 2011, Pages 224-231

  Rubin, Harry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Contact inhibition; Darwinian selection; Hyperplasia; Saturation density; Spontaneous transformation

Indexed keywords

BENZO[A]PYRENE; DIMETHYLBENZ[A]ANTHRACENE; FLOXURIDINE; HYDROCARBON; PROTEIN P53;

CANCER CELL CULTURE; CANCER RECURRENCE; CANCER STAGING; CARCINOGENESIS; CELL ASSAY; CELL DENSITY; CELL DIVISION; CELL ISOLATION; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMICAL CARCINOGENESIS; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; COLON CANCER; COLON CARCINOGENESIS; EARLY CANCER; EPIDERMIS HYPERPLASIA; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEAD AND NECK TUMOR; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HYPERPLASIA; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; NONHUMAN; PRECANCER; REVIEW; SKIN CANCER; SKIN CARCINOGENESIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; HUMANS; HYPERPLASIA; MICE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; PRECANCEROUS CONDITIONS; SELECTION, GENETIC;

EID: 79951550303     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201000067     Document Type: Review

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