메뉴 건너뛰기




Volumn 9, Issue 3, 2016, Pages 354-375

New and emerging therapies for the treatment of irritable bowel syndrome: An update for gastroenterologists

Author keywords

asimadoline; functional bowel disorder; linaclotide; rifaximin

Indexed keywords

ASIMADOLINE; DELTA OPIATE RECEPTOR; IBODUTANT; KAPPA OPIATE RECEPTOR; LINACLOTIDE; MU OPIATE RECEPTOR; RIFAXIMIN;

EID: 84963744541     PISSN: 1756283X     EISSN: 17562848     Source Type: Journal    
DOI: 10.1177/1756283X16633050     Document Type: Review
Times cited : (33)

References (166)
  • 1
    • 84893018340 scopus 로고    scopus 로고
    • Psychological trauma and functional somatic syndromes: A systematic review and meta-analysis
    • Afari N., Ahumada S., Wright L., Mostoufi S., Golnari G., Reis V., et al. (2014) Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosom Med 76: 2-11.
    • (2014) Psychosom Med , vol.76 , pp. 2-11
    • Afari, N.1    Ahumada, S.2    Wright, L.3    Mostoufi, S.4    Golnari, G.5    Reis, V.6
  • 2
    • 84899905703 scopus 로고    scopus 로고
    • Colonic mucosal immune activity in irritable bowel syndrome: Comparison with healthy controls and patients with ulcerative colitis
    • Ahn J., Lee K., Choi C., Kim J., Lee H., Kim J., et al. (2014) Colonic mucosal immune activity in irritable bowel syndrome: comparison with healthy controls and patients with ulcerative colitis. Dig Dis Sci 59: 1001-1011.
    • (2014) Dig Dis Sci , vol.59 , pp. 1001-1011
    • Ahn, J.1    Lee, K.2    Choi, C.3    Kim, J.4    Lee, H.5    Kim, J.6
  • 3
    • 67649537590 scopus 로고    scopus 로고
    • An evidence-based systematic review on the management of irritable bowel syndrome
    • American College of Gastroenterology Task Force on IBS
    • American College of Gastroenterology Task Force on IBS (2009) An evidence-based systematic review on the management of irritable bowel syndrome. Am J Gastroenterol 104: S1-S35.
    • (2009) Am J Gastroenterol , vol.104 , pp. S1-S35
  • 4
    • 0031559923 scopus 로고    scopus 로고
    • Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract
    • Bagnol D., Mansour A., Akil H., Watson S.J., (1997) Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 81: 579-591.
    • (1997) Neuroscience , vol.81 , pp. 579-591
    • Bagnol, D.1    Mansour, A.2    Akil, H.3    Watson, S.J.4
  • 5
    • 84875670330 scopus 로고    scopus 로고
    • Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    • Bajaj J., Heuman D., Sanyal A., Hylemon P., Sterling R., Stravitz R., et al. (2013) Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 8: e60042.
    • (2013) PLoS One , vol.8 , pp. e60042
    • Bajaj, J.1    Heuman, D.2    Sanyal, A.3    Hylemon, P.4    Sterling, R.5    Stravitz, R.6
  • 8
    • 0033963225 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome
    • Bardhan K., Bodemar G., Geldof H., Schütz E., Heath A., Mills J., et al. (2000) A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 14: 23-34.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 23-34
    • Bardhan, K.1    Bodemar, G.2    Geldof, H.3    Schütz, E.4    Heath, A.5    Mills, J.6
  • 10
    • 0013942352 scopus 로고
    • A pharmacological study of the motility of the human gastrointestinal tract
    • Bennett A., Whitney B., (1966) A pharmacological study of the motility of the human gastrointestinal tract. Gut 7: 307-316.
    • (1966) Gut , vol.7 , pp. 307-316
    • Bennett, A.1    Whitney, B.2
  • 11
    • 84945571052 scopus 로고    scopus 로고
    • Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: A randomized controlled trial
    • Böhn L., Störsrud S., Liljebo T., Collin L., Lindfors P., Tornblom H., et al. (2015) Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology 149: 1399-1407.
    • (2015) Gastroenterology , vol.149 , pp. 1399-1407
    • Böhn, L.1    Störsrud, S.2    Liljebo, T.3    Collin, L.4    Lindfors, P.5    Tornblom, H.6
  • 13
    • 73849128046 scopus 로고    scopus 로고
    • Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles
    • Brown E., Xue Q., Jiang Z., Xu Y., DuPont H., (2010) Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles. Antimicrob Agents Chemother 54: 388-396.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 388-396
    • Brown, E.1    Xue, Q.2    Jiang, Z.3    Xu, Y.4    DuPont, H.5
  • 14
    • 84930965725 scopus 로고    scopus 로고
    • Effects of birth cohorts on the irritable bowel syndrome support early-life risk factors
    • Brummond N., Locke G. III, Choung R., Chang J., Schleck C., Zinsmeister A., et al. (2015) Effects of birth cohorts on the irritable bowel syndrome support early-life risk factors. Dig Dis Sci 60: 2112-2118.
    • (2015) Dig Dis Sci , vol.60 , pp. 2112-2118
    • Brummond, N.1    Locke, G.2    Choung, R.3    Chang, J.4    Schleck, C.5    Zinsmeister, A.6
  • 15
    • 84867828617 scopus 로고    scopus 로고
    • Peripheral mechanisms in irritable bowel syndrome
    • Camilleri M., (2012) Peripheral mechanisms in irritable bowel syndrome. N Engl J Med 367: 1626-1635.
    • (2012) N Engl J Med , vol.367 , pp. 1626-1635
    • Camilleri, M.1
  • 16
    • 84891547487 scopus 로고    scopus 로고
    • Irritable bowel syndrome-diarrhea: Characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit
    • Camilleri M., Klee E., Shin A., Carlson P., Li Y., Grover M., et al. (2014) Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit. Am J Physiol Gastrointest Liver Physiol 306: G13-G26.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , pp. G13-G26
    • Camilleri, M.1    Klee, E.2    Shin, A.3    Carlson, P.4    Li, Y.5    Grover, M.6
  • 17
    • 0032848856 scopus 로고    scopus 로고
    • Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist
    • Camilleri M., Mayer E., Drossman D., Heath A., Dukes G., McSorley D., et al. (1999) Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist. Aliment Pharmacol Ther 13: 1149-1159.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1149-1159
    • Camilleri, M.1    Mayer, E.2    Drossman, D.3    Heath, A.4    Dukes, G.5    McSorley, D.6
  • 18
    • 45849087283 scopus 로고    scopus 로고
    • Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome
    • Camilleri M., McKinzie S., Busciglio I., Low P., Sweetser S., Burton D., et al. (2008) Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 6: 772-781.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 772-781
    • Camilleri, M.1    McKinzie, S.2    Busciglio, I.3    Low, P.4    Sweetser, S.5    Burton, D.6
  • 19
    • 84907979161 scopus 로고    scopus 로고
    • Review article: The economic impact of the irritable bowel syndrome
    • Canavan C., West J., Card T., (2014) Review article: the economic impact of the irritable bowel syndrome. Aliment Pharmacol Ther 40: 1023-1034.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 1023-1034
    • Canavan, C.1    West, J.2    Card, T.3
  • 20
    • 80054119513 scopus 로고    scopus 로고
    • Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
    • Carroll I., Ringel-Kulka T., Keku T., Chang Y., Packey C., Sartor R., et al. (2011) Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 301: G799-G807.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G799-G807
    • Carroll, I.1    Ringel-Kulka, T.2    Keku, T.3    Chang, Y.4    Packey, C.5    Sartor, R.6
  • 21
    • 84888293106 scopus 로고    scopus 로고
    • Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate
    • Castro J., Harrington A., Hughes P., Martin C., Ge P., Shea C., et al. (2013) Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Gastroenterology 145: 1334-1346.
    • (2013) Gastroenterology , vol.145 , pp. 1334-1346
    • Castro, J.1    Harrington, A.2    Hughes, P.3    Martin, C.4    Ge, P.5    Shea, C.6
  • 22
    • 0036083346 scopus 로고    scopus 로고
    • Activation of the mucosal immune system in irritable bowel syndrome
    • Chadwick V., Chen W., Shu D., Paulus B., Bethwaite P., Tie A., et al. (2002) Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 122: 1778-1783.
    • (2002) Gastroenterology , vol.122 , pp. 1778-1783
    • Chadwick, V.1    Chen, W.2    Shu, D.3    Paulus, B.4    Bethwaite, P.5    Tie, A.6
  • 23
    • 13744263696 scopus 로고    scopus 로고
    • A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
    • Chang L., Ameen V., Dukes G., McSorley D., Carter E., Mayer E., (2005) A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS. Am J Gastroenterol 100: 115-123.
    • (2005) Am J Gastroenterol , vol.100 , pp. 115-123
    • Chang, L.1    Ameen, V.2    Dukes, G.3    McSorley, D.4    Carter, E.5    Mayer, E.6
  • 24
    • 84908274811 scopus 로고    scopus 로고
    • American Gastroenterological Association technical review on the pharmacological management of irritable bowel syndrome
    • Chang L., Lembo A., Sultan S., (2014) American Gastroenterological Association technical review on the pharmacological management of irritable bowel syndrome. Gastroenterology 147: 1149-1172.
    • (2014) Gastroenterology , vol.147 , pp. 1149-1172
    • Chang, L.1    Lembo, A.2    Sultan, S.3
  • 25
    • 58849159264 scopus 로고    scopus 로고
    • Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome
    • Chang L., Sundaresh S., Elliott J., Anton P., Baldi P., Licudine A., et al. (2009) Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 21: 149-159.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 149-159
    • Chang, L.1    Sundaresh, S.2    Elliott, J.3    Anton, P.4    Baldi, P.5    Licudine, A.6
  • 26
    • 77950520996 scopus 로고    scopus 로고
    • Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: Clinical characteristics, outcomes, and incidences
    • Chang L., Tong K., Ameen V., (2010) Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidences. Am J Gastroenterol 105: 866-875.
    • (2010) Am J Gastroenterol , vol.105 , pp. 866-875
    • Chang, L.1    Tong, K.2    Ameen, V.3
  • 27
    • 77957236383 scopus 로고    scopus 로고
    • Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activation
    • Cheng J., Shah Y., Ma X., Pang X., Tanaka T., Kodama T., et al. (2010) Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther 335: 32-41.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 32-41
    • Cheng, J.1    Shah, Y.2    Ma, X.3    Pang, X.4    Tanaka, T.5    Kodama, T.6
  • 28
    • 80053912847 scopus 로고    scopus 로고
    • A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation
    • Chey W., Camilleri M., Chang L., Rikner L., Graffner H., (2011) A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation. Am J Gastroenterol 106: 1803-1812.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1803-1812
    • Chey, W.1    Camilleri, M.2    Chang, L.3    Rikner, L.4    Graffner, H.5
  • 29
    • 84869491248 scopus 로고    scopus 로고
    • Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
    • Chey W., Lembo A., Lavins B., Shiff S., Kurtz C., Currie M., et al. (2012) Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 107: 1702-1712.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1702-1712
    • Chey, W.1    Lembo, A.2    Lavins, B.3    Shiff, S.4    Kurtz, C.5    Currie, M.6
  • 30
    • 40949115076 scopus 로고    scopus 로고
    • Early life risk factors that contribute to irritable bowel syndrome in adults: A systematic review
    • Chitkara D., van Tilburg M., Blois-Martin N., Whitehead W., (2008) Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol 103: 765-774.
    • (2008) Am J Gastroenterol , vol.103 , pp. 765-774
    • Chitkara, D.1    Van Tilburg, M.2    Blois-Martin, N.3    Whitehead, W.4
  • 31
    • 67650423948 scopus 로고    scopus 로고
    • Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: A psychological component is the rule
    • Choung R., Locke G. III, Zinsmeister A., Schleck C., Talley N., (2009) Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychological component is the rule. Am J Gastroenterol 104: 1772-1779.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1772-1779
    • Choung, R.1    Locke, G.2    Zinsmeister, A.3    Schleck, C.4    Talley, N.5
  • 32
    • 33746104091 scopus 로고    scopus 로고
    • Major depressive disorder, antidepressants, and sexual dysfunction
    • (Suppl. 6)
    • Clayton A., Montejo A., (2006) Major depressive disorder, antidepressants, and sexual dysfunction. J Clin Psychiatry 67 (Suppl. 6): 33-37.
    • (2006) J Clin Psychiatry , vol.67 , pp. 33-37
    • Clayton, A.1    Montejo, A.2
  • 33
    • 2942525747 scopus 로고    scopus 로고
    • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    • Coates M., Mahoney C., Linden D., Sampson J., Chen J., Blaszyk H., et al. (2004) Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126: 1657-1664.
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.1    Mahoney, C.2    Linden, D.3    Sampson, J.4    Chen, J.5    Blaszyk, H.6
  • 34
    • 76849116160 scopus 로고    scopus 로고
    • A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome
    • Codling C., O'Mahony L., Shanahan F., Quigley E., Marchesi J., (2010) A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome. Dig Dis Sci 55: 392-397.
    • (2010) Dig Dis Sci , vol.55 , pp. 392-397
    • Codling, C.1    O'Mahony, L.2    Shanahan, F.3    Quigley, E.4    Marchesi, J.5
  • 36
    • 44849089446 scopus 로고    scopus 로고
    • Effects of rifaximin on bacterial virulence mechanisms at supra- and sub-inhibitory concentrations
    • Debbia E., Maioli E., Roveta S., Marchese A., (2008) Effects of rifaximin on bacterial virulence mechanisms at supra- and sub-inhibitory concentrations. J Chemother 20: 186-194.
    • (2008) J Chemother , vol.20 , pp. 186-194
    • Debbia, E.1    Maioli, E.2    Roveta, S.3    Marchese, A.4
  • 37
    • 3242878696 scopus 로고    scopus 로고
    • Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome
    • Delvaux M., Beck A., Jacob J., Bouzamondo H., Weber F., Frexinos J., (2004) Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 20: 237-246.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 237-246
    • Delvaux, M.1    Beck, A.2    Jacob, J.3    Bouzamondo, H.4    Weber, F.5    Frexinos, J.6
  • 38
    • 0031658491 scopus 로고    scopus 로고
    • Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
    • Delvaux M., Louvel D., Mamet J., Campos-Oriola R., Frexinos J., (1998) Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 12: 849-855.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 849-855
    • Delvaux, M.1    Louvel, D.2    Mamet, J.3    Campos-Oriola, R.4    Frexinos, J.5
  • 39
    • 80052946869 scopus 로고    scopus 로고
    • Colonic hypersensitivity is a major determinant of the efficacy of bloating treatment in constipation-predominant irritable bowel syndrome
    • Di Stefano M., Tana P., Mengoli C., Miceli E., Pagani E., Corazza G., (2011) Colonic hypersensitivity is a major determinant of the efficacy of bloating treatment in constipation-predominant irritable bowel syndrome. Intern Emerg Med 6: 403-411.
    • (2011) Intern Emerg Med , vol.6 , pp. 403-411
    • Di Stefano, M.1    Tana, P.2    Mengoli, C.3    Miceli, E.4    Pagani, E.5    Corazza, G.6
  • 40
    • 84924977705 scopus 로고    scopus 로고
    • Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis
    • Didari T., Mozaffari S., Nikfar S., Abdollahi M., (2015) Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol 21: 3072-3084.
    • (2015) World J Gastroenterol , vol.21 , pp. 3072-3084
    • Didari, T.1    Mozaffari, S.2    Nikfar, S.3    Abdollahi, M.4
  • 41
    • 84909949432 scopus 로고    scopus 로고
    • Complementary and alternative medicine use by US adults with gastrointestinal conditions: Results from the 2012 National Health Interview Survey
    • Dossett M., Davis R., Lembo A., Yeh G., (2014) Complementary and alternative medicine use by US adults with gastrointestinal conditions: results from the 2012 National Health Interview Survey. Am J Gastroenterol 109: 1705-1711.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1705-1711
    • Dossett, M.1    Davis, R.2    Lembo, A.3    Yeh, G.4
  • 42
    • 84880633982 scopus 로고    scopus 로고
    • Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study
    • Dove L., Lembo A., Randall C., Fogel R., Andrae D., Davenport J., et al. (2013) Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study. Gastroenterology 145: 329-338.
    • (2013) Gastroenterology , vol.145 , pp. 329-338
    • Dove, L.1    Lembo, A.2    Randall, C.3    Fogel, R.4    Andrae, D.5    Davenport, J.6
  • 43
    • 84970934250 scopus 로고    scopus 로고
    • Rome III diagnostic criteria for functional gastrointestinal disorders
    • MacLean, VA: Degnon Associates, Inc
    • Drossman D., (2006) Rome III diagnostic criteria for functional gastrointestinal disorders. In: Rome III: The functional GI disorders. MacLean, VA: Degnon Associates, Inc., pp 885-897.
    • (2006) Rome III: The Functional GI Disorders , pp. 885-897
    • Drossman, D.1
  • 45
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies
    • Drossman D., Chey W., Johanson J., Fass R., Scott C., Panas R., et al. (2009a) Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 29: 329-341.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 329-341
    • Drossman, D.1    Chey, W.2    Johanson, J.3    Fass, R.4    Scott, C.5    Panas, R.6
  • 46
    • 67349084855 scopus 로고    scopus 로고
    • International survey of patients with IBS: Symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit
    • Drossman D., Morris C., Schneck S., Hu Y., Norton N., Norton W., et al. (2009b) International survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit. J Clin Gastroenterol 43: 541-550.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 541-550
    • Drossman, D.1    Morris, C.2    Schneck, S.3    Hu, Y.4    Norton, N.5    Norton, W.6
  • 47
    • 9444286424 scopus 로고    scopus 로고
    • Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and Enterococci
    • DuPont H., Jiang Z., (2004) Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and Enterococci. Clin Microbiol Infect 10: 1009-1011.
    • (2004) Clin Microbiol Infect , vol.10 , pp. 1009-1011
    • DuPont, H.1    Jiang, Z.2
  • 49
    • 84858604441 scopus 로고    scopus 로고
    • Structural alterations of faecal and mucosa-associated bacterial communities in irritable bowel syndrome
    • Durbán A., Abellán J., Jimenéz-Hernández N., Salgado P., Ponce M., Ponce J., et al. (2012) Structural alterations of faecal and mucosa-associated bacterial communities in irritable bowel syndrome. Environ Microbiol Rep 4: 242-247.
    • (2012) Environ Microbiol Rep , vol.4 , pp. 242-247
    • Durbán, A.1    Abellán, J.2    Jimenéz-Hernández, N.3    Salgado, P.4    Ponce, M.5    Ponce, J.6
  • 50
    • 84947569017 scopus 로고    scopus 로고
    • Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts
    • [published online ahead of print 23, 2014 ]
    • Ek W., Reznichenko A., Ripke S., Niesler B., Zucchelli M., Rivera N., et al. (2015) Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. [published online ahead of print 23, 2014 ]. Gut 64: 1774-1782.
    • (2015) Gut , vol.64 , pp. 1774-1782
    • Ek, W.1    Reznichenko, A.2    Ripke, S.3    Niesler, B.4    Zucchelli, M.5    Rivera, N.6
  • 51
    • 84942257551 scopus 로고    scopus 로고
    • Safety and efficacy of an oral inhibitor of the purinergic receptor P2X7 in adult patients with moderately to severely active Crohn's disease: A randomized placebo-controlled, double-blind, phase IIa study
    • Eser A., Colombel J., Rutgeerts P., Vermeire S., Vogelsang H., Braddock M., et al. (2015) Safety and efficacy of an oral inhibitor of the purinergic receptor P2X7 in adult patients with moderately to severely active Crohn's disease: a randomized placebo-controlled, double-blind, phase IIa study. Inflamm Bowel Dis 21: 2247-2253.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 2247-2253
    • Eser, A.1    Colombel, J.2    Rutgeerts, P.3    Vermeire, S.4    Vogelsang, H.5    Braddock, M.6
  • 52
    • 84873137028 scopus 로고    scopus 로고
    • Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis
    • CD000543
    • Feagan B., Macdonald J., (2012) Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 10: CD000543.
    • (2012) Cochrane Database Syst Rev , vol.10
    • Feagan, B.1    MacDonald, J.2
  • 53
    • 84897351953 scopus 로고    scopus 로고
    • Anxiety and depression comorbidities in irritable bowel syndrome (IBS): A systematic review and meta-analysis
    • Fond G., Loundou A., Hamdani N., Boukouaci W., Dargel A., Oliveira J., et al. (2014) Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci 264: 651-660.
    • (2014) Eur Arch Psychiatry Clin Neurosci , vol.264 , pp. 651-660
    • Fond, G.1    Loundou, A.2    Hamdani, N.3    Boukouaci, W.4    Dargel, A.5    Oliveira, J.6
  • 54
    • 79953770843 scopus 로고    scopus 로고
    • Efficacy of 5-aminosalicylates in ulcerative colitis: Systematic review and meta-analysis
    • Ford A., Achkar J., Khan K., Kane S., Talley N., Marshall J., et al. (2011) Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol 106: 601-616.
    • (2011) Am J Gastroenterol , vol.106 , pp. 601-616
    • Ford, A.1    Achkar, J.2    Khan, K.3    Kane, S.4    Talley, N.5    Marshall, J.6
  • 55
    • 84905442940 scopus 로고    scopus 로고
    • American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation
    • Task Force on the Management of Functional Bowel Disorders
    • Ford A., Moayyedi P., Lacy B., Lembo A., Saito Y., Schiller L., et al.; Task Force on the Management of Functional Bowel Disorders. (2014a) American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol 109: S2-S26.
    • (2014) Am J Gastroenterol , vol.109 , pp. S2-S26
    • Ford, A.1    Moayyedi, P.2    Lacy, B.3    Lembo, A.4    Saito, Y.5    Schiller, L.6
  • 56
    • 84908228349 scopus 로고    scopus 로고
    • Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: Systematic review and meta-analysis
    • Ford A., Quigley E., Lacy B., Lembo A., Saito Y., Schiller L., et al. (2014b) Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol 109: 1350-1365.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1350-1365
    • Ford, A.1    Quigley, E.2    Lacy, B.3    Lembo, A.4    Saito, Y.5    Schiller, L.6
  • 58
    • 85000243038 scopus 로고    scopus 로고
    • Evidence-based clinical practice guidelines for irritable bowel syndrome
    • Fukudo S., Kaneko H., Akiho H., Inamori M., Endo Y., Okumura T., et al. (2015) Evidence-based clinical practice guidelines for irritable bowel syndrome. J Gastroenterol 50: 11-30.
    • (2015) J Gastroenterol , vol.50 , pp. 11-30
    • Fukudo, S.1    Kaneko, H.2    Akiho, H.3    Inamori, M.4    Endo, Y.5    Okumura, T.6
  • 59
    • 84907499626 scopus 로고    scopus 로고
    • A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea
    • Garsed K., Chernova J., Hastings M., Lam C., Marciani L., Singh G., et al. (2014) A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut 63: 1617-1625.
    • (2014) Gut , vol.63 , pp. 1617-1625
    • Garsed, K.1    Chernova, J.2    Hastings, M.3    Lam, C.4    Marciani, L.5    Singh, G.6
  • 60
    • 0032919084 scopus 로고    scopus 로고
    • Review article: Roles played by 5-hydroxytryptamine in the physiology of the bowel
    • Gershon M., (1999) Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 13 (Suppl. 2): 15-30.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 15-30
    • Gershon, M.1
  • 61
    • 10644290207 scopus 로고    scopus 로고
    • Review article: Serotonin receptors and transporters - Roles in normal and abnormal gastrointestinal motility
    • Gershon M., (2004) Review article: serotonin receptors and transporters-roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 20 (Suppl. 7): 3-14.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 3-14
    • Gershon, M.1
  • 62
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon M., Tack J., (2007) The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397-414.
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.1    Tack, J.2
  • 63
    • 84928403431 scopus 로고    scopus 로고
    • Food components and irritable bowel syndrome
    • Gibson P., Varney J., Malakar S., Muir J., (2015) Food components and irritable bowel syndrome. Gastroenterology 148: 1158-1174.
    • (2015) Gastroenterology , vol.148 , pp. 1158-1174
    • Gibson, P.1    Varney, J.2    Malakar, S.3    Muir, J.4
  • 65
    • 84887230206 scopus 로고    scopus 로고
    • Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes
    • Grasberger H., Chang L., Shih W., Presson A., Sayuk G., Newberry R., et al. (2013) Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Am J Gastroenterol 108: 1766-1774.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1766-1774
    • Grasberger, H.1    Chang, L.2    Shih, W.3    Presson, A.4    Sayuk, G.5    Newberry, R.6
  • 66
    • 33846989359 scopus 로고    scopus 로고
    • Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    • Guilarte M., Santos J., de Torres I, Alonso C., Vicario M., Ramos L., et al. (2007) Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 56: 203-209.
    • (2007) Gut , vol.56 , pp. 203-209
    • Guilarte, M.1    Santos, J.2    De Torres, I.3    Alonso, C.4    Vicario, M.5    Ramos, L.6
  • 67
    • 79954423054 scopus 로고    scopus 로고
    • Irritable bowel syndrome symptoms among German students: Prevalence, characteristics, and associations to somatic complaints, sleep, quality of life, and childhood abdominal pain
    • Gulewitsch M., Enck P., Hautzinger M., Schlarb A., (2011) Irritable bowel syndrome symptoms among German students: prevalence, characteristics, and associations to somatic complaints, sleep, quality of life, and childhood abdominal pain. Eur J Gastroenterol Hepatol 23: 311-316.
    • (2011) Eur J Gastroenterol Hepatol , vol.23 , pp. 311-316
    • Gulewitsch, M.1    Enck, P.2    Hautzinger, M.3    Schlarb, A.4
  • 68
    • 84903162923 scopus 로고    scopus 로고
    • A case-control study of childhood trauma in the development of irritable bowel syndrome
    • Halland M., Almazar A., Lee R., Atkinson E., Larson J., Talley N., et al. (2014) A case-control study of childhood trauma in the development of irritable bowel syndrome. Neurogastroenterol Motil 26: 990-998.
    • (2014) Neurogastroenterol Motil , vol.26 , pp. 990-998
    • Halland, M.1    Almazar, A.2    Lee, R.3    Atkinson, E.4    Larson, J.5    Talley, N.6
  • 69
    • 80055091135 scopus 로고    scopus 로고
    • Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: The Cooper Center longitudinal study
    • Hoang M., Defina L., Willis B., Leonard D., Weiner M., Brown E., (2011) Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clin Proc 86: 1050-1055.
    • (2011) Mayo Clin Proc , vol.86 , pp. 1050-1055
    • Hoang, M.1    Defina, L.2    Willis, B.3    Leonard, D.4    Weiner, M.5    Brown, E.6
  • 70
    • 84899811901 scopus 로고    scopus 로고
    • Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome
    • Holliday E., Attia J., Hancock S., Koloski N., McEvoy M., Peel R., et al. (2014) Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. Am J Gastroenterol 109: 770-772.
    • (2014) Am J Gastroenterol , vol.109 , pp. 770-772
    • Holliday, E.1    Attia, J.2    Hancock, S.3    Koloski, N.4    McEvoy, M.5    Peel, R.6
  • 71
    • 67349119441 scopus 로고    scopus 로고
    • Opioid receptors in the gastrointestinal tract
    • Holzer P., (2009) Opioid receptors in the gastrointestinal tract. Regul Pept 155: 11-17.
    • (2009) Regul Pept , vol.155 , pp. 11-17
    • Holzer, P.1
  • 72
    • 84899512137 scopus 로고    scopus 로고
    • In vitro activity of rifaximin against clinical isolates of Escherichia coli and other enteropathogenic bacteria isolated from travellers returning to the UK
    • Hopkins K., Mushtaq S., Richardson J., Doumith M., de Pinna E., Cheasty T., et al. (2014) In vitro activity of rifaximin against clinical isolates of Escherichia coli and other enteropathogenic bacteria isolated from travellers returning to the UK. Int J Antimicrob Agents 45: 431-437.
    • (2014) Int J Antimicrob Agents , vol.45 , pp. 431-437
    • Hopkins, K.1    Mushtaq, S.2    Richardson, J.3    Doumith, M.4    De Pinna, E.5    Cheasty, T.6
  • 73
    • 84902297192 scopus 로고    scopus 로고
    • Increased kappa-opioid receptor expression and function during chronic visceral hypersensitivity
    • Hughes P., Castro J., Harrington A., Isaacs N., Moretta M., Hicks G., et al. (2014a) Increased kappa-opioid receptor expression and function during chronic visceral hypersensitivity. Gut 63: 1199-1200.
    • (2014) Gut , vol.63 , pp. 1199-1200
    • Hughes, P.1    Castro, J.2    Harrington, A.3    Isaacs, N.4    Moretta, M.5    Hicks, G.6
  • 74
    • 84908618118 scopus 로고    scopus 로고
    • Immune derived opioidergic inhibition of viscerosensory afferents is decreased in irritable bowel syndrome patients
    • Hughes P., Moretta M., Lim A., Grasby D., Bird D., Brierley S., et al. (2014b) Immune derived opioidergic inhibition of viscerosensory afferents is decreased in irritable bowel syndrome patients. Brain Behav Immun 42: 191-203.
    • (2014) Brain Behav Immun , vol.42 , pp. 191-203
    • Hughes, P.1    Moretta, M.2    Lim, A.3    Grasby, D.4    Bird, D.5    Brierley, S.6
  • 75
    • 84908372316 scopus 로고    scopus 로고
    • Systematic review: The perceptions, diagnosis and management of irritable bowel syndrome in primary care - A Rome Foundation working team report
    • Hungin A., Molloy-Bland M., Claes R., Heidelbaugh J., Cayley W. Jr, Muris J., et al. (2014) Systematic review: the perceptions, diagnosis and management of irritable bowel syndrome in primary care-a Rome Foundation working team report. Aliment Pharmacol Ther 40: 1133-1145.
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 1133-1145
    • Hungin, A.1    Molloy-Bland, M.2    Claes, R.3    Heidelbaugh, J.4    Cayley, W.5    Muris, J.6
  • 76
    • 20444464327 scopus 로고    scopus 로고
    • Irritable bowel syndrome in the United States: Prevalence, symptom patterns and impact
    • Hungin A., Chang L., Locke G., Dennis E., Barghout V., (2005) Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment Pharmacol Ther 21: 1365-1375.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1365-1375
    • Hungin, A.1    Chang, L.2    Locke, G.3    Dennis, E.4    Barghout, V.5
  • 77
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    • Jeffery I., O'Toole P., Ohman L., Claesson M., Deane J., Quigley E., et al. (2012) An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 61: 997-1006.
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.1    O'Toole, P.2    Ohman, L.3    Claesson, M.4    Deane, J.5    Quigley, E.6
  • 78
    • 77950393582 scopus 로고    scopus 로고
    • In vitro susceptibility of Clostridium difficile to rifaximin and rifampin in 359 consecutive isolates at a university hospital in Houston, Texas
    • Jiang Z., DuPont H., La Rocco M., Garey K., (2010a) In vitro susceptibility of Clostridium difficile to rifaximin and rifampin in 359 consecutive isolates at a university hospital in Houston, Texas. J Clin Pathol 63: 355-358.
    • (2010) J Clin Pathol , vol.63 , pp. 355-358
    • Jiang, Z.1    DuPont, H.2    La Rocco, M.3    Garey, K.4
  • 79
    • 73849137110 scopus 로고    scopus 로고
    • Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei
    • Jiang Z., Ke S., DuPont H., (2010b) Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei. Int J Antimicrob Agents 35: 278-281.
    • (2010) Int J Antimicrob Agents , vol.35 , pp. 278-281
    • Jiang, Z.1    Ke, S.2    DuPont, H.3
  • 80
    • 79955595435 scopus 로고    scopus 로고
    • Physical activity improves symptoms in irritable bowel syndrome: A randomized controlled trial
    • Johannesson E., Simren M., Strid H., Bajor A., Sadik R., (2011) Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial. Am J Gastroenterol 106: 915-922.
    • (2011) Am J Gastroenterol , vol.106 , pp. 915-922
    • Johannesson, E.1    Simren, M.2    Strid, H.3    Bajor, A.4    Sadik, R.5
  • 81
    • 81855220303 scopus 로고    scopus 로고
    • The effects of lifestyle modification on symptoms and quality of life in patients with irritable bowel syndrome: A prospective observational study
    • Kang S., Choi S., Lee S., Chung W., Lee H., Chung K., et al. (2011) The effects of lifestyle modification on symptoms and quality of life in patients with irritable bowel syndrome: a prospective observational study. Gut Liver 5: 472-477.
    • (2011) Gut Liver , vol.5 , pp. 472-477
    • Kang, S.1    Choi, S.2    Lee, S.3    Chung, W.4    Lee, H.5    Chung, K.6
  • 83
    • 84937965242 scopus 로고    scopus 로고
    • Low-FODMAP diet for irritable bowel syndrome: Is it ready for prime time?
    • Khan M., Nusrat S., Khan M., Nawras A., Bielefeldt K., (2015) Low-FODMAP diet for irritable bowel syndrome: is it ready for prime time? Dig Dis Sci 60: 1169-1177.
    • (2015) Dig Dis Sci , vol.60 , pp. 1169-1177
    • Khan, M.1    Nusrat, S.2    Khan, M.3    Nawras, A.4    Bielefeldt, K.5
  • 84
    • 84902468429 scopus 로고    scopus 로고
    • Peppermint oil for the treatment of irritable bowel syndrome: A systematic review and meta-analysis
    • Khanna R., Macdonald J., Levesque B., (2014) Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol 48: 505-512.
    • (2014) J Clin Gastroenterol , vol.48 , pp. 505-512
    • Khanna, R.1    MacDonald, J.2    Levesque, B.3
  • 85
    • 77956102855 scopus 로고    scopus 로고
    • The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
    • Klooker T., Braak B., Koopman K., Welting O., Wouters M., van der Heide S., et al. (2010) The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59: 1213-1221.
    • (2010) Gut , vol.59 , pp. 1213-1221
    • Klooker, T.1    Braak, B.2    Koopman, K.3    Welting, O.4    Wouters, M.5    Van Der Heide, S.6
  • 86
    • 84922861518 scopus 로고    scopus 로고
    • Family history of mental illness or alcohol abuse and the irritable bowel syndrome
    • Knight J., Locke G. III, Zinsmeister A., Schleck C., Talley N., (2015) Family history of mental illness or alcohol abuse and the irritable bowel syndrome. J Psychosom Res 78: 237-241.
    • (2015) J Psychosom Res , vol.78 , pp. 237-241
    • Knight, J.1    Locke, G.2    Zinsmeister, A.3    Schleck, C.4    Talley, N.5
  • 87
    • 84860649408 scopus 로고    scopus 로고
    • The brain-gut pathway in functional gastrointestinal disorders is bidirectional: A 12-year prospective population-based study
    • Koloski N., Jones M., Kalantar J., Weltman M., Zaguirre J., Talley N., (2012) The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut 61: 1284-1290.
    • (2012) Gut , vol.61 , pp. 1284-1290
    • Koloski, N.1    Jones, M.2    Kalantar, J.3    Weltman, M.4    Zaguirre, J.5    Talley, N.6
  • 88
    • 83855160849 scopus 로고    scopus 로고
    • Diagnosis, comorbidities, and management of irritable bowel syndrome in patients in a large health maintenance organization
    • Ladabaum U., Boyd E., Zhao W., Mannalithara A., Sharabidze A., Singh G., et al. (2012) Diagnosis, comorbidities, and management of irritable bowel syndrome in patients in a large health maintenance organization. Clin Gastroenterol Hepatol 10: 37-45.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 37-45
    • Ladabaum, U.1    Boyd, E.2    Zhao, W.3    Mannalithara, A.4    Sharabidze, A.5    Singh, G.6
  • 89
    • 0020962071 scopus 로고
    • A study of gastrointestinal opiate receptors: The role of the Mu receptor on gastric emptying: Concise communication
    • Lamki L., Sullivan S., (1983) A study of gastrointestinal opiate receptors: the role of the Mu receptor on gastric emptying: concise communication. J Nucl Med 24: 689-692.
    • (1983) J Nucl Med , vol.24 , pp. 689-692
    • Lamki, L.1    Sullivan, S.2
  • 90
    • 84857633645 scopus 로고    scopus 로고
    • Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome
    • Larsson M., Tillisch K., Craig A., Engstrom M., Labus J., Naliboff B., et al. (2012) Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology 142: 463-472.
    • (2012) Gastroenterology , vol.142 , pp. 463-472
    • Larsson, M.1    Tillisch, K.2    Craig, A.3    Engstrom, M.4    Labus, J.5    Naliboff, B.6
  • 91
    • 84892893221 scopus 로고    scopus 로고
    • Review article: Linaclotide for the management of irritable bowel syndrome with constipation
    • Layer P., Stanghellini V., (2014) Review article: linaclotide for the management of irritable bowel syndrome with constipation. Aliment Pharmacol Ther 39: 371-384.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 371-384
    • Layer, P.1    Stanghellini, V.2
  • 92
    • 84952883628 scopus 로고    scopus 로고
    • Efficacy and safety of repeat treatment with rifaximin for diarrhea-predominant irritable bowel syndrome (IBS-D): Results of the TARGET 3 study
    • Philadelphia, PA, 17-22 October 2014
    • Lembo A., Pimentel M., Rao S., Schoenfeld P., Cash B., Weinstock L., et al. (2014) Efficacy and safety of repeat treatment with rifaximin for diarrhea-predominant irritable bowel syndrome (IBS-D): results of the TARGET 3 study. Presented at: American College of Gastroenterology (ACG) 2014 Annual Scientific Meeting, Philadelphia, PA, 17-22 October 2014.
    • (2014) American College of Gastroenterology (ACG) 2014 Annual Scientific Meeting
    • Lembo, A.1    Pimentel, M.2    Rao, S.3    Schoenfeld, P.4    Cash, B.5    Weinstock, L.6
  • 93
    • 0034788730 scopus 로고    scopus 로고
    • Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology
    • Levy R., Jones K., Whitehead W., Feld S., Talley N., Corey L., (2001) Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology 121: 799-804.
    • (2001) Gastroenterology , vol.121 , pp. 799-804
    • Levy, R.1    Jones, K.2    Whitehead, W.3    Feld, S.4    Talley, N.5    Corey, L.6
  • 94
    • 84927698743 scopus 로고    scopus 로고
    • Prevalence, investigational pathways and diagnostic outcomes in differing irritable bowel syndrome subtypes
    • Lin S., Mooney P., Kurien M., Aziz I., Leeds J., Sanders D., (2014) Prevalence, investigational pathways and diagnostic outcomes in differing irritable bowel syndrome subtypes. Eur J Gastroenterol Hepatol 26: 1176-1180.
    • (2014) Eur J Gastroenterol Hepatol , vol.26 , pp. 1176-1180
    • Lin, S.1    Mooney, P.2    Kurien, M.3    Aziz, I.4    Leeds, J.5    Sanders, D.6
  • 95
    • 0033827386 scopus 로고    scopus 로고
    • Familial association in adults with functional gastrointestinal disorders
    • Locke G. III, Zinsmeister A., Talley N., Fett S., Melton L. III., (2000) Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 75: 907-912.
    • (2000) Mayo Clin Proc , vol.75 , pp. 907-912
    • Locke, G.1    Zinsmeister, A.2    Talley, N.3    Fett, S.4    Melton, L.5
  • 97
    • 84863716817 scopus 로고    scopus 로고
    • Effect of gender on prevalence of irritable bowel syndrome in the community: Systematic review and meta-analysis
    • Lovell R., Ford A., (2012) Effect of gender on prevalence of irritable bowel syndrome in the community: systematic review and meta-analysis. Am J Gastroenterol 107: 991-1000.
    • (2012) Am J Gastroenterol , vol.107 , pp. 991-1000
    • Lovell, R.1    Ford, A.2
  • 98
    • 78149477874 scopus 로고    scopus 로고
    • Rifaximin modulates the colonic microbiota of patients with Crohn's disease: An in vitro approach using a continuous culture colonic model system
    • Maccaferri S., Vitali B., Klinder A., Kolida S., Ndagijimana M., Laghi L., et al. (2010) Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system. J Antimicrob Chemother 65: 2556-2565.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 2556-2565
    • MacCaferri, S.1    Vitali, B.2    Klinder, A.3    Kolida, S.4    Ndagijimana, M.5    Laghi, L.6
  • 99
    • 84878015362 scopus 로고    scopus 로고
    • An evaluation of the FDA responder endpoint for IBS-C clinical trials: Analysis of data from linaclotide Phase 3 clinical trials
    • Macdougall J., Johnston J., Lavins B., Nelson L., Williams V., Carson R., et al. (2013) An evaluation of the FDA responder endpoint for IBS-C clinical trials: analysis of data from linaclotide Phase 3 clinical trials. Neurogastroenterol Motil 25: 481-486.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 481-486
    • MacDougall, J.1    Johnston, J.2    Lavins, B.3    Nelson, L.4    Williams, V.5    Carson, R.6
  • 100
    • 1342310220 scopus 로고    scopus 로고
    • Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial
    • Madisch A., Holtmann G., Plein K., Hotz J., (2004) Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial. Aliment Pharmacol Ther 19: 271-279.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 271-279
    • Madisch, A.1    Holtmann, G.2    Plein, K.3    Hotz, J.4
  • 101
    • 45549083888 scopus 로고    scopus 로고
    • Clinical trial: Asimadoline in the treatment of patients with irritable bowel syndrome
    • Mangel A., Bornstein J., Hamm L., Buda J., Wang J., Irish W., et al. (2008) Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome. Aliment Pharmacol Ther 28: 239-249.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 239-249
    • Mangel, A.1    Bornstein, J.2    Hamm, L.3    Buda, J.4    Wang, J.5    Irish, W.6
  • 102
    • 84856789344 scopus 로고    scopus 로고
    • Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: A review
    • Mangel A., Hicks G., (2012) Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review. Clin Exp Gastroenterol 5: 1-10.
    • (2012) Clin Exp Gastroenterol , vol.5 , pp. 1-10
    • Mangel, A.1    Hicks, G.2
  • 103
    • 84862336762 scopus 로고    scopus 로고
    • The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations
    • Martínez C., Vicario M., Ramos L., Lobo B., Mosquera J., Alonso C., et al. (2012) The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations. Am J Gastroenterol 107: 736-746.
    • (2012) Am J Gastroenterol , vol.107 , pp. 736-746
    • Martínez, C.1    Vicario, M.2    Ramos, L.3    Lobo, B.4    Mosquera, J.5    Alonso, C.6
  • 104
    • 48049093262 scopus 로고    scopus 로고
    • A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome
    • Matsueda K., Harasawa S., Hongo M., Hiwatashi N., Sasaki D., (2008a) A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome. Digestion 77: 225-235.
    • (2008) Digestion , vol.77 , pp. 225-235
    • Matsueda, K.1    Harasawa, S.2    Hongo, M.3    Hiwatashi, N.4    Sasaki, D.5
  • 105
    • 52149088774 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome
    • Matsueda K., Harasawa S., Hongo M., Hiwatashi N., Sasaki D., (2008b) A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome. Scand J Gastroenterol 43: 1202-1211.
    • (2008) Scand J Gastroenterol , vol.43 , pp. 1202-1211
    • Matsueda, K.1    Harasawa, S.2    Hongo, M.3    Hiwatashi, N.4    Sasaki, D.5
  • 107
    • 77957902464 scopus 로고    scopus 로고
    • Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells
    • Mencarelli A., Migliorati M., Barbanti M., Cipriani S., Palladino G., Distrutti E., et al. (2010) Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. Biochem Pharmacol 80: 1700-1707.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1700-1707
    • Mencarelli, A.1    Migliorati, M.2    Barbanti, M.3    Cipriani, S.4    Palladino, G.5    Distrutti, E.6
  • 108
    • 80052052440 scopus 로고    scopus 로고
    • Inhibition of NF-kB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells
    • Mencarelli A., Renga B., Palladino G., Claudio D., Ricci P., Distrutti E., et al. (2011) Inhibition of NF-kB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells. Eur J Pharmacol 668: 317-324.
    • (2011) Eur J Pharmacol , vol.668 , pp. 317-324
    • Mencarelli, A.1    Renga, B.2    Palladino, G.3    Claudio, D.4    Ricci, P.5    Distrutti, E.6
  • 109
    • 84855462831 scopus 로고    scopus 로고
    • The efficacy and safety of rifaximin for the irritable bowel syndrome: A systematic review and meta-analysis
    • Menees S., Maneerattannaporn M., Kim H., Chey W., (2012) The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis. Am J Gastroenterol 107: 28-35.
    • (2012) Am J Gastroenterol , vol.107 , pp. 28-35
    • Menees, S.1    Maneerattannaporn, M.2    Kim, H.3    Chey, W.4
  • 110
    • 11144306503 scopus 로고    scopus 로고
    • Suicidal ideation in patients with irritable bowel syndrome
    • Miller V., Hopkins L., Whorwell P., (2004) Suicidal ideation in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2: 1064-1068.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1064-1068
    • Miller, V.1    Hopkins, L.2    Whorwell, P.3
  • 111
    • 84964712710 scopus 로고    scopus 로고
    • 1831. Plecanatide, a novel uroguanylin analog: A 12-week, randomized, double-blind, placebo-controlled, dose-ranging trail to evaluate efficacy and safety in patients with irritable bowel syndrome with constipation (IBS-C)
    • Miner P., DeLuca R., La Portilla M., Padila E., Koltun W., Wiltz O., et al. (2014) 1831. Plecanatide, a novel uroguanylin analog: a 12-week, randomized, double-blind, placebo-controlled, dose-ranging trail to evaluate efficacy and safety in patients with irritable bowel syndrome with constipation (IBS-C). Am J Gastroenterol: S541-S541.
    • (2014) Am J Gastroenterol , pp. S541-S541
    • Miner, P.1    DeLuca, R.2    La Portilla, M.3    Padila, E.4    Koltun, W.5    Wiltz, O.6
  • 112
    • 0023340701 scopus 로고
    • Survey of the AGA membership relating to patients with functional gastrointestinal disorders
    • Mitchell C., Drossman D., (1987) Survey of the AGA membership relating to patients with functional gastrointestinal disorders. Gastroenterology 92: 1282-1284.
    • (1987) Gastroenterology , vol.92 , pp. 1282-1284
    • Mitchell, C.1    Drossman, D.2
  • 113
    • 84880901307 scopus 로고    scopus 로고
    • The low FODMAP diet for treatment of irritable bowel syndrome and other gastrointestinal disorders
    • Muir J., Gibson P., (2013) The low FODMAP diet for treatment of irritable bowel syndrome and other gastrointestinal disorders. Gastroenterol Hepatol (N Y) 9: 450-452.
    • (2013) Gastroenterol Hepatol (N Y) , vol.9 , pp. 450-452
    • Muir, J.1    Gibson, P.2
  • 115
    • 79960575909 scopus 로고    scopus 로고
    • Outcome of biofeedback therapy in dyssynergic defecation patients with and without irritable bowel syndrome
    • Patcharatrakul T., Gonlachanvit S., (2011) Outcome of biofeedback therapy in dyssynergic defecation patients with and without irritable bowel syndrome. J Clin Gastroenterol 45: 593-598.
    • (2011) J Clin Gastroenterol , vol.45 , pp. 593-598
    • Patcharatrakul, T.1    Gonlachanvit, S.2
  • 116
    • 84921884584 scopus 로고    scopus 로고
    • Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which
    • drive bloating
    • Patel P., Bercik P., Morgan D., Bolino C., Pintos-Sanchez M., Moayyedi P., et al. (2015) Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which. drive bloating. Aliment Pharmacol Ther 41: 449-458.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 449-458
    • Patel, P.1    Bercik, P.2    Morgan, D.3    Bolino, C.4    Pintos-Sanchez, M.5    Moayyedi, P.6
  • 117
    • 58849136276 scopus 로고    scopus 로고
    • Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators
    • Piche T., Barbara G., Aubert P., Bruley des Varannes S., Dainese R., Nano J., et al. (2009) Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 58: 196-201.
    • (2009) Gut , vol.58 , pp. 196-201
    • Piche, T.1    Barbara, G.2    Aubert, P.3    Bruley Des Varannes, S.4    Dainese, R.5    Nano, J.6
  • 118
    • 84902269125 scopus 로고    scopus 로고
    • Antibiotic treatment of constipation-predominant irritable bowel syndrome
    • Pimentel M., Chang C., Chua K., Mirocha J., DiBaise J., Rao S., et al. (2014) Antibiotic treatment of constipation-predominant irritable bowel syndrome. Dig Dis Sci 59: 1278-1285.
    • (2014) Dig Dis Sci , vol.59 , pp. 1278-1285
    • Pimentel, M.1    Chang, C.2    Chua, K.3    Mirocha, J.4    DiBaise, J.5    Rao, S.6
  • 119
    • 78650864077 scopus 로고    scopus 로고
    • Rifaximin therapy for patients with irritable bowel syndrome without constipation
    • TARGET Study Group
    • Pimentel M., Lembo A., Chey W., Zakko S., Ringel Y., Yu J., et al.; TARGET Study Group. (2011) Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 364: 22-32.
    • (2011) N Engl J Med , vol.364 , pp. 22-32
    • Pimentel, M.1    Lembo, A.2    Chey, W.3    Zakko, S.4    Ringel, Y.5    Yu, J.6
  • 120
    • 33750721328 scopus 로고    scopus 로고
    • The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: A randomized trial
    • Pimentel M., Park S., Mirocha J., Kane S., Kong Y., (2006) The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 145: 557-563.
    • (2006) Ann Intern Med , vol.145 , pp. 557-563
    • Pimentel, M.1    Park, S.2    Mirocha, J.3    Kane, S.4    Kong, Y.5
  • 121
    • 34848856669 scopus 로고    scopus 로고
    • Altered rectal perception in irritable bowel syndrome is associated with symptom severity
    • Posserud I., Syrous A., Lindstrom L., Tack J., Abrahamsson H., Simren M., (2007) Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology 133: 1113-1123.
    • (2007) Gastroenterology , vol.133 , pp. 1113-1123
    • Posserud, I.1    Syrous, A.2    Lindstrom, L.3    Tack, J.4    Abrahamsson, H.5    Simren, M.6
  • 123
    • 77953350539 scopus 로고    scopus 로고
    • Relationships between pelvic floor symptoms and function in irritable bowel syndrome
    • Prott G., Shim L., Hansen R., Kellow J., Malcolm A., (2010) Relationships between pelvic floor symptoms and function in irritable bowel syndrome. Neurogastroenterol Motil 22: 764-769.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 764-769
    • Prott, G.1    Shim, L.2    Hansen, R.3    Kellow, J.4    Malcolm, A.5
  • 124
    • 84870601331 scopus 로고    scopus 로고
    • Randomised clinical trials: Linaclotide phase 3 studies in IBS-C - A prespecified further analysis based on European Medicines Agency-specified endpoints
    • Quigley E., Tack J., Chey W., Rao S., Fortea J., Falques M., et al. (2013) Randomised clinical trials: linaclotide phase 3 studies in IBS-C-a prespecified further analysis based on European Medicines Agency-specified endpoints. Aliment Pharmacol Ther 37: 49-61.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 49-61
    • Quigley, E.1    Tack, J.2    Chey, W.3    Rao, S.4    Fortea, J.5    Falques, M.6
  • 125
    • 84885328733 scopus 로고    scopus 로고
    • Pro-inflammatory and anti-inflammatory cytokine response in diarrhoea-predominant irritable bowel syndrome patients
    • Rana S., Sharma S., Sinha S., Parsad K., Malik A., Singh K., (2012) Pro-inflammatory and anti-inflammatory cytokine response in diarrhoea-predominant irritable bowel syndrome patients. Trop Gastroenterol 33: 251-256.
    • (2012) Trop Gastroenterol , vol.33 , pp. 251-256
    • Rana, S.1    Sharma, S.2    Sinha, S.3    Parsad, K.4    Malik, A.5    Singh, K.6
  • 126
    • 78049476939 scopus 로고    scopus 로고
    • Chenodeoxycholate in females with irritable bowel syndrome-constipation: A pharmacodynamic and pharmacogenetic analysis
    • 1558
    • Rao A., Wong B., Camilleri M., Odunsi-Shiyanbade S., McKinzie S., Ryks M., et al. (2010) Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. Gastroenterology 139: 1549-58, 1558.
    • (2010) Gastroenterology , vol.139 , pp. 1549-1558
    • Rao, A.1    Wong, B.2    Camilleri, M.3    Odunsi-Shiyanbade, S.4    McKinzie, S.5    Ryks, M.6
  • 127
    • 84869493876 scopus 로고    scopus 로고
    • A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
    • Rao S., Lembo A., Shiff S., Lavins B., Currie M., Jia X., et al. (2012) A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 107: 1714-1724.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1714-1724
    • Rao, S.1    Lembo, A.2    Shiff, S.3    Lavins, B.4    Currie, M.5    Jia, X.6
  • 128
    • 84896082720 scopus 로고    scopus 로고
    • Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation
    • Rao S., Quigley E., Shiff S., Lavins B., Kurtz C., Macdougall J., et al. (2014) Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation. Clin Gastroenterol Hepatol 12: 616-623.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 616-623
    • Rao, S.1    Quigley, E.2    Shiff, S.3    Lavins, B.4    Kurtz, C.5    MacDougall, J.6
  • 129
    • 84921412366 scopus 로고    scopus 로고
    • Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population
    • Rasmussen S., Jensen T., Henriksen S., Haastrup P., Larsen P., Sondergaard J., et al. (2015) Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population. Scand J Gastroenterol 50: 162-169.
    • (2015) Scand J Gastroenterol , vol.50 , pp. 162-169
    • Rasmussen, S.1    Jensen, T.2    Henriksen, S.3    Haastrup, P.4    Larsen, P.5    Sondergaard, J.6
  • 131
    • 80054116264 scopus 로고    scopus 로고
    • The rationale and clinical effectiveness of probiotics in irritable bowel syndrome
    • Ringel Y., Ringel-Kulka T., (2011) The rationale and clinical effectiveness of probiotics in irritable bowel syndrome. J Clin Gastroenterol 45: S145-S148.
    • (2011) J Clin Gastroenterol , vol.45 , pp. S145-S148
    • Ringel, Y.1    Ringel-Kulka, T.2
  • 132
    • 58049213488 scopus 로고    scopus 로고
    • Prevalence, characteristics, and impact of bloating symptoms in patients with irritable bowel syndrome
    • Ringel Y., Williams R., Kalilani L., Cook S., (2009) Prevalence, characteristics, and impact of bloating symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 7: 68-72.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 68-72
    • Ringel, Y.1    Williams, R.2    Kalilani, L.3    Cook, S.4
  • 133
    • 84875513134 scopus 로고    scopus 로고
    • Rifaximin in irritable bowel syndrome: Rationale, evidence and clinical use
    • Saadi M., McCallum R., (2013) Rifaximin in irritable bowel syndrome: rationale, evidence and clinical use. Ther Adv Chronic Dis 4: 71-75.
    • (2013) Ther Adv Chronic Dis , vol.4 , pp. 71-75
    • Saadi, M.1    McCallum, R.2
  • 134
    • 0036678922 scopus 로고    scopus 로고
    • The epidemiology of irritable bowel syndrome in North America: A systematic review
    • Saito Y., Schoenfeld P., Locke G. III,. (2002) The epidemiology of irritable bowel syndrome in North America: a systematic review. Am J Gastroenterol 97: 1910-1915.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1910-1915
    • Saito, Y.1    Schoenfeld, P.2    Locke, G.3
  • 137
    • 41849095624 scopus 로고    scopus 로고
    • Balancing drug risk and benefit: Toward refining the process of FDA decisions affecting patient care
    • Schiller L., Johnson D., (2008) Balancing drug risk and benefit: toward refining the process of FDA decisions affecting patient care. Am J Gastroenterol 103: 815-819.
    • (2008) Am J Gastroenterol , vol.103 , pp. 815-819
    • Schiller, L.1    Johnson, D.2
  • 138
    • 0032820843 scopus 로고    scopus 로고
    • Symptom differences in moderate to severe IBS patients based on predominant bowel habit
    • Schmulson M., Lee O., Chang L., Naliboff B., Mayer E., (1999) Symptom differences in moderate to severe IBS patients based on predominant bowel habit. Am J Gastroenterol 94: 2929-2935.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2929-2935
    • Schmulson, M.1    Lee, O.2    Chang, L.3    Naliboff, B.4    Mayer, E.5
  • 139
    • 84880834586 scopus 로고    scopus 로고
    • Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis
    • Schrodt C., McHugh E., Gawinowicz M., DuPont H., Brown E., (2013) Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis. PLoS One 8: e68550.
    • (2013) PLoS One , vol.8 , pp. e68550
    • Schrodt, C.1    McHugh, E.2    Gawinowicz, M.3    DuPont, H.4    Brown, E.5
  • 140
    • 84893690803 scopus 로고    scopus 로고
    • In-patient discharge rates for the irritable bowel syndrome - An analysis of national trends in the United States from 1997 to 2010
    • Sethi S., Wadhwa V., LeClair J., Mikami S., Park R., Jones M., et al. (2013) In-patient discharge rates for the irritable bowel syndrome-an analysis of national trends in the United States from 1997 to 2010. Aliment Pharmacol Ther 38: 1338-1346.
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 1338-1346
    • Sethi, S.1    Wadhwa, V.2    LeClair, J.3    Mikami, S.4    Park, R.5    Jones, M.6
  • 141
    • 84858958766 scopus 로고    scopus 로고
    • Evaluation of harm in the pharmacotherapy of irritable bowel syndrome
    • Shah E., Kim S., Chong K., Lembo A., Pimentel M., (2012) Evaluation of harm in the pharmacotherapy of irritable bowel syndrome. Am J Med 125: 381-393.
    • (2012) Am J Med , vol.125 , pp. 381-393
    • Shah, E.1    Kim, S.2    Chong, K.3    Lembo, A.4    Pimentel, M.5
  • 142
    • 84884905656 scopus 로고    scopus 로고
    • Meta-analysis: Antibiotic therapy for small intestinal bacterial overgrowth
    • Shah S., Day L., Somsouk M., Sewell J., (2013) Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther 38: 925-934.
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 925-934
    • Shah, S.1    Day, L.2    Somsouk, M.3    Sewell, J.4
  • 143
    • 84872839242 scopus 로고    scopus 로고
    • Psychiatric, somatic and other functional gastrointestinal disorders in patients with irritable bowel syndrome at a tertiary care center
    • Singh P., Agnihotri A., Pathak M., Shirazi A., Tiwari R., Sreenivas V., et al. (2012) Psychiatric, somatic and other functional gastrointestinal disorders in patients with irritable bowel syndrome at a tertiary care center. J Neurogastroenterol Motil 18: 324-331.
    • (2012) J Neurogastroenterol Motil , vol.18 , pp. 324-331
    • Singh, P.1    Agnihotri, A.2    Pathak, M.3    Shirazi, A.4    Tiwari, R.5    Sreenivas, V.6
  • 144
    • 84872578774 scopus 로고    scopus 로고
    • Vitamin D3 as a novel treatment for irritable bowel syndrome: Single case leads to critical analysis of patient-centered data
    • Sprake E., Grant V., Corfe B., (2012) Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centered data. BMJ Case Rep.
    • (2012) BMJ Case Rep
    • Sprake, E.1    Grant, V.2    Corfe, B.3
  • 145
    • 84890137978 scopus 로고    scopus 로고
    • Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern
    • Su A., Shih W., Presson A., Chang L., (2014) Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern. Neurogastroenterol Motil 26: 36-45.
    • (2014) Neurogastroenterol Motil , vol.26 , pp. 36-45
    • Su, A.1    Shih, W.2    Presson, A.3    Chang, L.4
  • 146
    • 35548931920 scopus 로고    scopus 로고
    • Efficacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome
    • Szarka L., Camilleri M., Burton D., Fox J., McKinzie S., Stanislav T., et al. (2007) Efficacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome. Clin Gastroenterol Hepatol 5: 1268-1275.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1268-1275
    • Szarka, L.1    Camilleri, M.2    Burton, D.3    Fox, J.4    McKinzie, S.5    Stanislav, T.6
  • 147
    • 84883206015 scopus 로고    scopus 로고
    • Takeda Pharmaceuticals America, Inc. Deerfield, IL: Takeda Pharmaceuticals America, Inc
    • Takeda Pharmaceuticals America, Inc. (2013) Amitiza (lubiprostone) capsules [package insert]. Deerfield, IL: Takeda Pharmaceuticals America, Inc.
    • (2013) Amitiza (Lubiprostone) Capsules [Package Insert]
  • 149
    • 84893871549 scopus 로고    scopus 로고
    • Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
    • Terc J., Hansen A., Alston L., Hirota S., (2014) Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis. Eur J Pharm Sci 55: 12-19.
    • (2014) Eur J Pharm Sci , vol.55 , pp. 12-19
    • Terc, J.1    Hansen, A.2    Alston, L.3    Hirota, S.4
  • 150
    • 78650505214 scopus 로고    scopus 로고
    • Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome
    • Tillisch K., Mayer E., Labus J., (2011) Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology 140: 91-100.
    • (2011) Gastroenterology , vol.140 , pp. 91-100
    • Tillisch, K.1    Mayer, E.2    Labus, J.3
  • 151
    • 84883376111 scopus 로고    scopus 로고
    • A 9-year evaluation of temporal trends in alosetron postmarketing safety under the risk management program
    • Tong K., Nicandro J., Shringarpure R., Chuang E., Chang L., (2013) A 9-year evaluation of temporal trends in alosetron postmarketing safety under the risk management program. Therap Adv Gastroenterol 6: 344-357.
    • (2013) Therap Adv Gastroenterol , vol.6 , pp. 344-357
    • Tong, K.1    Nicandro, J.2    Shringarpure, R.3    Chuang, E.4    Chang, L.5
  • 153
    • 84927582757 scopus 로고    scopus 로고
    • Medication management of irritable bowel syndrome
    • Trinkley K., Nahata M., (2014) Medication management of irritable bowel syndrome. Digestion 89: 253-267.
    • (2014) Digestion , vol.89 , pp. 253-267
    • Trinkley, K.1    Nahata, M.2
  • 154
    • 84876481254 scopus 로고    scopus 로고
    • A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: Effects on bowel frequency and intestinal function
    • Vazquez-Roque M., Camilleri M., Smyrk T., Murray J., Marietta E., O'Neill J., et al. (2013) A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 144: 903-911.
    • (2013) Gastroenterology , vol.144 , pp. 903-911
    • Vazquez-Roque, M.1    Camilleri, M.2    Smyrk, T.3    Murray, J.4    Marietta, E.5    O'Neill, J.6
  • 155
    • 84941299655 scopus 로고    scopus 로고
    • Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations
    • Vicario M., Gonzalez-Castro A., Martinez C., Lobo B., Pigrau M., Guilarte M., et al. (2014) Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations. Gut 64: 1379-1388.
    • (2014) Gut , vol.64 , pp. 1379-1388
    • Vicario, M.1    Gonzalez-Castro, A.2    Martinez, C.3    Lobo, B.4    Pigrau, M.5    Guilarte, M.6
  • 156
    • 84855463406 scopus 로고    scopus 로고
    • Combination of allergic factors can worsen diarrheic irritable bowel syndrome: Role of barrier defects and mast cells
    • Vivinus-Nébot M., Dainese R., Anty R., Saint-Paul M., Nano J., Gonthier N., et al. (2012) Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 107: 75-81.
    • (2012) Am J Gastroenterol , vol.107 , pp. 75-81
    • Vivinus-Nébot, M.1    Dainese, R.2    Anty, R.3    Saint-Paul, M.4    Nano, J.5    Gonthier, N.6
  • 157
    • 84897985897 scopus 로고    scopus 로고
    • Functional bowel symptoms in quiescent inflammatory bowel diseases: Role of epithelial barrier disruption and low-grade inflammation
    • Vivinus-Nébot M., Frin-Mathy G., Bzioueche H., Dainese R., Bernard G., Anty R., et al. (2014) Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut 63: 744-752.
    • (2014) Gut , vol.63 , pp. 744-752
    • Vivinus-Nébot, M.1    Frin-Mathy, G.2    Bzioueche, H.3    Dainese, R.4    Bernard, G.5    Anty, R.6
  • 158
    • 0029885161 scopus 로고    scopus 로고
    • Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
    • Wade P., Chen J., Jaffe B., Kassem I., Blakely R., Gershon M., (1996) Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci 16: 2352-2364.
    • (1996) J Neurosci , vol.16 , pp. 2352-2364
    • Wade, P.1    Chen, J.2    Jaffe, B.3    Kassem, I.4    Blakely, R.5    Gershon, M.6
  • 159
    • 84867314129 scopus 로고    scopus 로고
    • Modulation of gastrointestinal function by MuDelta, a mixed micro opioid receptor agonist/ micro opioid receptor antagonist
    • Wade P., Palmer J., McKenney S., Kenigs V., Chevalier K., Moore B., et al. (2012) Modulation of gastrointestinal function by MuDelta, a mixed micro opioid receptor agonist/ micro opioid receptor antagonist. Br J Pharmacol 167: 1111-1125.
    • (2012) Br J Pharmacol , vol.167 , pp. 1111-1125
    • Wade, P.1    Palmer, J.2    McKenney, S.3    Kenigs, V.4    Chevalier, K.5    Moore, B.6
  • 160
    • 61849182973 scopus 로고    scopus 로고
    • Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
    • Walker M., Talley N., Prabhakar M., Pennaneac'h C., Aro P., Ronkainen J., et al. (2009) Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther 29: 765-773.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 765-773
    • Walker, M.1    Talley, N.2    Prabhakar, M.3    Pennaneac'H, C.4    Aro, P.5    Ronkainen, J.6
  • 161
    • 84924925844 scopus 로고    scopus 로고
    • Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics
    • Whelan K., (2014) Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics. Am J Gastroenterol 109: 1563-1565.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1563-1565
    • Whelan, K.1
  • 162
    • 77957826668 scopus 로고    scopus 로고
    • Inability of the Rome III criteria to distinguish functional constipation from constipation-subtype irritable bowel syndrome
    • Wong R., Palsson O., Turner M., Levy R., Feld A., Von K., et al. (2010) Inability of the Rome III criteria to distinguish functional constipation from constipation-subtype irritable bowel syndrome. Am J Gastroenterol 105: 2228-2234.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2228-2234
    • Wong, R.1    Palsson, O.2    Turner, M.3    Levy, R.4    Feld, A.5    Von, K.6
  • 163
    • 84902264271 scopus 로고    scopus 로고
    • Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome
    • Wouters M., Lambrechts D., Knapp M., Cleynen I., Whorwell P., Agreus L., et al. (2014) Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. Gut 63: 1103-1111.
    • (2014) Gut , vol.63 , pp. 1103-1111
    • Wouters, M.1    Lambrechts, D.2    Knapp, M.3    Cleynen, I.4    Whorwell, P.5    Agreus, L.6
  • 164
    • 84892825869 scopus 로고    scopus 로고
    • Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats
    • Xu D., Gao J., Gillilland M. III, Wu X., Song I., Kao J., et al. (2014) Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats. Gastroenterology 146: 484-496.
    • (2014) Gastroenterology , vol.146 , pp. 484-496
    • Xu, D.1    Gao, J.2    Gillilland, M.3    Wu, X.4    Song, I.5    Kao, J.6
  • 165
    • 84901791944 scopus 로고    scopus 로고
    • Vitamin D and inflammatory diseases
    • Yin K., Agrawal D., (2014) Vitamin D and inflammatory diseases. J Inflamm Res 7: 69-87.
    • (2014) J Inflamm Res , vol.7 , pp. 69-87
    • Yin, K.1    Agrawal, D.2
  • 166
    • 84904744161 scopus 로고    scopus 로고
    • Advances in the management of constipation-predominant irritable bowel syndrome: The role of linaclotide
    • Yu S., Rao S., (2014) Advances in the management of constipation-predominant irritable bowel syndrome: the role of linaclotide. Therap Adv Gastroenterol 7: 193-205.
    • (2014) Therap Adv Gastroenterol , vol.7 , pp. 193-205
    • Yu, S.1    Rao, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.