Antibiotic treatment of constipation-predominant irritable bowel syndrome

Digestive Diseases and Sciences

Volumn 59, Issue 6, 2014, Pages 1278-1285

  Pimentel, Mark ^a   Chang, Christopher ^a   Chua, Kathleen Shari ^a   Mirocha, James ^a   DiBaise, John ^b   Rao, Satish ^c   Amichai, Meridythe ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

^c AUGUSTA UNIVERSITY   (United States)

Author keywords

Antibiotics; Breath methane; Constipation; Irritable bowel syndrome

Indexed keywords

METHANE; NEOMYCIN; PLACEBO; RIFAXIMIN;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BLOATING; BREATH ANALYSIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DEFECATION URGENCY; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HEARING IMPAIRMENT; HUMAN; IRRITABLE COLON; MALE; NAUSEA; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SYMPTOMATOLOGY; TINNITUS; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADULT; ANTI-INFECTIVE AGENTS; BREATH TESTS; CONSTIPATION; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; METHANE; MIDDLE AGED; NEOMYCIN; RIFAMYCINS;

EID: 84902269125     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3157-8     Document Type: Article

References (17)

1. Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the Unites States. Gastroenterology. 2002;122:1500-1511. (Pubitemid 34465190)
2. Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut. 1999;45:II43-II47. (Pubitemid 29434812)
3. Halvorson HA, Schlett CD, Riddle MS. Post-infectious irritable bowel syndrome: a meta-analysis. Am J Gastroenterol. 2006;101:1894-1899.
4. Thabane M, Kottachchi DT, Marshall JK. Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment Pharmacol Ther. 2007;26:535-544. (Pubitemid 47174284)
5. Shah ED, Basseri RJ, Chong K, et al. Abnormal breath testing in IBS: a meta-analysis. Dig Dis Sci . 2010;55:2441-2449.
6. Posserud I, Stotzer PO, Björnsson ES, et al. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut. 2007;56:802-808. (Pubitemid 46854194)
7. Pyleris E, Giamarellos-Bourboulis EJ, Tzivras D, et al. The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome. Dig Dis Sci. 2012;57:1321-1329.
8. Chang C, Funari V, Giamarellos-Bourboulis EJ, et al. Deep sequencing reveals that the microbiome of the human duodenum is unique and unrelated to stool bacterial profiling. Gastroenterology. 2013;144:S908.
9. Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for the treatment of irritable bowel syndrome without constipation. N Engl J Med. 2011;364:22-32.
10. Kunkel D, Basseri RJ, Makhani MD, et al. Methane on breath test is associated with constipation: a systematic review and meta-analysis. Dig Dis Sci. 2011;56:1612-1618.
11. Attaluri A, Jackson M, Valestin J, et al. Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipationwithout IBS. AmJGastroenterol. 2010;105:1407-1411.
12. Pimentel M, Lin HC, Enayati P, et al. Methane, a gas produced by enteric bacteria, slows intestinal transit, an augments small intestinal contractile activity. Am J Physiol. 2006;290:G1089-G1095. (Pubitemid 43788289)
13. Chatterjee S, Park S, Low K, et al. The degree of methane production in IBS correlates with the severity of constipation. Am J Gastroenterol . 2007;102:837-841. (Pubitemid 46496615)
14. Pimentel M, Chatterjee S, Chow EJ, et al. Neomycin improves constipation predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: sub-analysis of a double blind randomized controlled study. Dig Dis Sci. 2006;51:1297-1301. (Pubitemid 44315794)
15. Low K, Hwang L, Hua J, et al. A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test. J Clin Gastroenterol. 2010;44:547-550.
16. Kim G, Deepinder F, Morales W, et al. Methanobrevibacter smithii is the predominant methanogen in patients with constipation predominant IBS and methane on breath. Dig Dis Sci. 2012;57:3213-3218.
17. Menees SB, Maneerattannaporn M, Kim HM, et al. The effect and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis. Am J Gastroenterol. 2012;107:28-35.