Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′,5′- monophosphate

Gastroenterology

Volumn 145, Issue 6, 2013, Pages

  Castro, Joel ^a,b   Harrington, Andrea M ^a,b   Hughes, Patrick A ^a,b   Martin, Christopher M ^a   Ge, Pei ^c   Shea, Courtney M ^c   Jin, Hong ^c   Jacobson, Sarah ^c   Hannig, Gerhard ^c   Mann, Elizabeth ^d   Cohen, Mitchell B ^d   Macdougall, James E ^c   Lavins, Bernard J ^c   Kurtz, Caroline B ^c   Silos Santiago, Inmaculada ^c   Johnston, Jeffrey M ^c   Currie, Mark G ^c   Blackshaw, L Ashley ^a,b   Brierley, Stuart M ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b Radiology Department   (United States)

^c Ironwood Pharmaceuticals   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Analgesia; CRD; CVH; Signaling Transduction

Indexed keywords

CYCLIC GMP; GUANYLATE CYCLASE; GUANYLATE CYCLASE C; LINACLOTIDE; MESSENGER RNA; PLACEBO; UNCLASSIFIED DRUG; UROGUANYLIN;

ABDOMINAL PAIN; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CHRONIC VISCERAL HYPERSENSITIVITY; COLON; COLON DILATATION; COLON MUCOSA; CONSTIPATION; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; HYPERSENSITIVITY; IN SITU HYBRIDIZATION; INTESTINE CELL; IRRITABLE COLON; MAJOR CLINICAL STUDY; MOUSE; NEUROTRANSMISSION; NONHUMAN; PAIN RECEPTOR; PHASE 3 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL (TOPIC); POST HOC ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE; SPINAL CORD DORSAL HORN;

EID: 84888293106     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.08.017     Document Type: Article

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