Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome

Neurogastroenterology and Motility

Volumn 21, Issue 2, 2009, Pages 149-159

  Chang, L ^a,b,c   Sundaresh, S ^d   Elliott, J ^b   Anton, P A ^b   Baldi, P ^d   Licudine, A ^b   Mayer, M ^b   Vuong, T ^b   Hirano, M ^b   Naliboff, B D ^b,c   Ameen, V Z ^e,f   Mayer, E A ^b  

^a Center for Neurobiology of Stress   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e GLAXOSMITHKLINE   (United States)

^f Prometheus Laboratories   (United States)

Author keywords

Adrenocorticotropin hormone; Corticotrophin releasing factor; Cortisol; Cytokines; Hypothalamic pituitary adrenal axis; Irritable bowel syndrome

Indexed keywords

CATECHOLAMINE; CORTICOTROPIN; HYDROCORTISONE; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; NORADRENALIN;

ADULT; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; FEMALE; HORMONE RELEASE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IRRITABLE COLON; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADRENOCORTICOTROPIC HORMONE; ADULT; CIRCADIAN RHYTHM; COLON; CYTOKINES; EPINEPHRINE; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IRRITABLE BOWEL SYNDROME; NOREPINEPHRINE; PITUITARY-ADRENAL SYSTEM; SIGMOIDOSCOPY; STRESS, PSYCHOLOGICAL;

EID: 58849159264     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01171.x     Document Type: Article

References (53)

1. Elenkov IJ, Wilder RL, Chrousos GP et al. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000 52 : 585 638.
2. Fish EW, Shahrokh D, Bagot R et al. Epigenetic programming of stress responses through variations in maternal care. Ann N Y Acad Sci 2004 1036 : 167 80.
3. Esler MD, Goulston KJ. Levels of anxiety in colonic disorders. N Engl J Med 1973 288 : 16 20.
4. Heim C, Newport DJ, Heit S et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. J Am Med Assoc 2000 284 : 592 7.
5. Dinan TG, Quigley EM, Ahmed SM et al. Hypothalmic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential marker? Gastroenterology 2006 130 : 304 11.
6. Elsenbruch S, Orr WC. Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am J Gastroenterol 2001 96 : 460 6.
7. Elsenbruch S, Holtmann G, Oezcan D et al. Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome? Am J Gastroenterol 2004 99 : 703 10.
8. Fukudo S, Nomura T, Hongo M. Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut 1999 42 : 845 9.
9. Dickhaus B, Mayer EA, Firooz N et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol 2003 98 : 135 43.
10. Heitkemper M, Jarrett M, Cain K et al. Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am J Gastroenterol 1996 91 : 906 13.
11. Heitkemper M, Jarrett M, Cain KC et al. Autonomic nervous system function in women with irritable bowel syndrome. Dig Dis Sci 2001 46 : 1276 84.
12. Cain KC, Jarrett ME, Burr RL et al. Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome. Neurogastroenterol Motil 2007 19 : 110 8.
13. Chadwick VS, Chen W, Shu D et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002 122 : 1778 83.
14. Barbara G, Stanghellini V, De Giorgio R et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004 126 : 693 702.
15. Martinez V, Taché Y. CRF1 receptors as a therapeutic target for irritable bowel syndrome. Curr Pharm Des 2006 12 : 4071 88.
16. Dunlop SP, Jenkins D, Neal KR et al. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 2003 125 : 1651 9.
17. Bohmelt AH, Nater UM, Franke S et al. Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosom Med 2005 67 : 288 94.
18. Posserud I, Agerforz P, Ekman R et al. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004 53 : 1102 8.
19. Elsenbruch S, Lovallo WR, Orr WC. Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome. Psychosom Med 2001 63 : 805 10.
20. Heim C, Newport DJ, Bonsall R et al. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatr 2001 158 : 575 81.
21. Thompson WG, Longstreth GF, Drossman DA et al. Functional bowel disorders and functional abdominal pain. Gut 1999 45 : II43 7.
22. Wolfe F, Smythe HA, Yunus MB et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia, a report of the Multicenter Criteria Committee. Arthritis Rheum 1990 33 : 160 72.
23. Sperber AD, Atzmon Y, Neumann L et al. Fibromyalgia in the irritable bowel syndrome: studies of prevalence and clinical implications. Am J Gastroenterol 1999 94 : 3541 6.
24. Whitehead WE, Palsson O, Jones KR. Systemic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology 2002 122 : 1140 56.
25. Talley NJ, Phillips SF, Wiltgen CM et al. Assessment of functional gastrointestinal disease: the bowel disease questionnaire. Mayo Clin Proc 1990 65 : 1456 79.
26. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983 67 : 361 70.
27. Spitzer RL, Williams JBW, Gibbon M et al. Structured Clinical Interview for DSM-III-R. Washington, DC : American Psychiatric Press, 1990.
28. Green BL. The Trauma History Questionnaire (THQ). In : Stamm BH, ed. Measurement of Stress, Trauma, and Adaptation. Lutherville : Sidran Press, 1996 : 366 9.
29. Gracely RH, McGrath P, Dubner R. Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: manipulation of affect by diazepam. Pain 1976 5 : 19 29.
30. Posener JA, Charles D, Veldhuis JD et al. Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder. Psychoneuroendocrinology 2004 29 : 1129 37.
31. Guo W, Wang Y, Brown MB. A signal extraction approach to modeling hormone time series with pulses and a changing baseline. J Am Stat Assoc 1999 94 : 746 56.
32. Young EA, Carlson NE, Brown MB. Twenty-four-hour ACTH and cortisol pulsatility in depressed women. Neuropsychopharmacology 2001 25 : 267 76.
33. Crofford LJ, Young EA, Engleberg NC et al. Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain Behav Immun 2004 18 : 314 25.
34. McGowan I, Elliott J, Fuerst M et al. Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation. J Acquir Immune Defic Syndr 2004 37 : 1228 36.
35. Yehuda R, Yang RK, Buchsbaum MS et al. Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD. Psychoneuroendocrinology 2006 31 : 447 51.
36. Chrousos GP. Regulation and dysregulation of the hypothalamic-pituitary- adrenal axis. The corticotropin-releasing hormone perspective. Endocrinol Metab Clin North Am 1992 21 : 833 58.
37. Yehuda R, Giller EL Jr., Levengood RA et al. Hypothalamic-Pituitary- Adrenal Functioning in Post-Traumatic Stress Disorder: Expanding the Concept of the Stress Response Spectrum. Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder. Philadelphia : Lippincott-Raven Publishers, 1995 : 351 66.
38. Klerman EB, Goldenberg DL, Brown EN et al. Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab 2001 86 : 1034 9.
39. Munakata J, Naliboff B, Harraf F et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997 112 : 55 63.
40. Videlock EJ, Yuan PQ, Taché Y et al. Stress-induced cortisol response and colonic mucosal CRF-1 mRNA receptor expression correlate with symptoms of chronic stress and quality of life in irritable bowel syndrome (IBS). Gastroenterology 2007 132 : A-72.
41. Dinan TG, O'Keane V, O'Boyle C et al. A comparison of the mental status, personality profiles and life events of patients with irritable bowel syndrome and peptic ulcer disease. Acta Psychiatr Scand 1991 84 : 26 8.
42. Sagami Y, Shimada Y, Tayama J et al. Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut 2004 53 : 958 64.
43. Quigley EM, McSharry J, O'Mahoney L et al. Mucosal cytokine imbalance in irritable bowel syndrome (IBS). Am J Gastroenterol 2007 102 (Suppl. 632.
44. Barbara G, Wang B, Grundy D et al. Mast cells are increased in the colonic mucosa of patients with irritable bowel syndrome and excite visceral sensory pathways. Gastroenterology 2005 128 : A-626.
45. O'Mahony L, McCarthy J, Kelly P et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005 128 : 541 51.
46. Liebregts T, Adam B, Bredack C et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007 132 : 913 20.
47. Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun 2007 21 : 736 45.
48. Nielsen OH, Vainer B, Madsen SM et al. Established and emerging biological activity markers of inflammatory bowel disease. Am J Gastroenterol 2000 95 : 359 67.
49. Calcagni E, Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann N Y Acad Sci 2006 1069 : 62 76.
50. Mastorakos G, Ilias I. Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress. Ann N Y Acad Sci 2006 1088 : 373 81.
51. Gwee KA, Collins SM, Read NW et al. Increased rectal mucosal expression of interleukin 1á in recently acquired post-infectious irritable bowel syndrome. Gut 2003 52 : 523 6.
52. Caballero T, Nogueras F, Medina MT et al. Intraepithelial and lamina propria leucocyte subsets in inflammatory bowel disease: an immunohistochemical study of colon and rectal biopsy specimens. J Clin Pathol 1995 48 : 743 8.
53. Tracey KJ. The inflammatory reflex. Nature 2002 420 : 853 9.