메뉴 건너뛰기




Volumn 46, Issue 5, 2016, Pages 1091-1100

Interleukin 33: An innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer

Author keywords

Cytokines; Immune regulation; Innate immunity; Interleukin 33

Indexed keywords

INTERLEUKIN 33; ALARMIN; CYTOKINE; IL33 PROTEIN, HUMAN;

EID: 84963685500     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545780     Document Type: Article
Times cited : (57)

References (95)
  • 1
    • 27744446058 scopus 로고    scopus 로고
    • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    • Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G. et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005. 23: 479-490.
    • (2005) Immunity , vol.23 , pp. 479-490
    • Schmitz, J.1    Owyang, A.2    Oldham, E.3    Song, Y.4    Murphy, E.5    McClanahan, T.K.6    Zurawski, G.7
  • 3
    • 53249093714 scopus 로고    scopus 로고
    • Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket
    • Roussel, L., Erard, M., Cayrol, C. and Girard, J. P., Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 2008. 9: 1006-1012.
    • (2008) EMBO Rep. , vol.9 , pp. 1006-1012
    • Roussel, L.1    Erard, M.2    Cayrol, C.3    Girard, J.P.4
  • 4
    • 80051926552 scopus 로고    scopus 로고
    • The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription
    • Ali, S., Mohs, A., Thomas, M., Klare, J., Ross, R., Schmitz, M. L. and Martin, M. U., The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J. Immunol. 2011. 187: 1609-1616.
    • (2011) J. Immunol. , vol.187 , pp. 1609-1616
    • Ali, S.1    Mohs, A.2    Thomas, M.3    Klare, J.4    Ross, R.5    Schmitz, M.L.6    Martin, M.U.7
  • 5
    • 70349759672 scopus 로고    scopus 로고
    • Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors-insight into heterotrimeric IL-1 signaling complexes
    • Lingel, A., Weiss, T. M., Niebuhr, M., Pan, B., Appleton, B. A., Wiesmann, C., Bazan, J. F. et al., Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors-insight into heterotrimeric IL-1 signaling complexes. Structure 2009. 17: 1398-1410.
    • (2009) Structure , vol.17 , pp. 1398-1410
    • Lingel, A.1    Weiss, T.M.2    Niebuhr, M.3    Pan, B.4    Appleton, B.A.5    Wiesmann, C.6    Bazan, J.F.7
  • 7
    • 84859378165 scopus 로고    scopus 로고
    • Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain
    • Pichery, M., Mirey, E., Mercier, P., Lefrancais, E., Dujardin, A., Ortega, N. and Girard, J. P., Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J. Immunol. 2012. 188: 3488-3495.
    • (2012) J. Immunol. , vol.188 , pp. 3488-3495
    • Pichery, M.1    Mirey, E.2    Mercier, P.3    Lefrancais, E.4    Dujardin, A.5    Ortega, N.6    Girard, J.P.7
  • 8
    • 67049158193 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    • Cayrol, C. and Girard, J. P., The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc. Natl. Acad. Sci. USA 2009. 106: 9021-9026.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9021-9026
    • Cayrol, C.1    Girard, J.P.2
  • 9
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
    • Moussion, C., Ortega, N. and Girard, J. P., The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One 2008. 3: e3331.
    • (2008) PLoS One , vol.3 , pp. e3331
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 10
    • 79955040263 scopus 로고    scopus 로고
    • The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    • Kouzaki, H., Iijima, K., Kobayashi, T., O'Grady, S. M. and Kita, H., The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J. Immunol. 2011. 186: 4375-4387.
    • (2011) J. Immunol. , vol.186 , pp. 4375-4387
    • Kouzaki, H.1    Iijima, K.2    Kobayashi, T.3    O'Grady, S.M.4    Kita, H.5
  • 13
    • 64849087206 scopus 로고    scopus 로고
    • The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response
    • Bulek, K., Swaidani, S., Qin, J., Lu, Y., Gulen, M. F., Herjan, T., Min, B., Kastelein, R. A. et al., The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J. Immunol. 2009. 182: 2601-2609.
    • (2009) J. Immunol. , vol.182 , pp. 2601-2609
    • Bulek, K.1    Swaidani, S.2    Qin, J.3    Lu, Y.4    Gulen, M.F.5    Herjan, T.6    Min, B.7    Kastelein, R.A.8
  • 14
    • 84937605509 scopus 로고    scopus 로고
    • Proteolytic processing of interleukin-1 family cytokines: variations on a common theme
    • Afonina, I. S., Muller, C., Martin, S. J. and Beyaert, R., Proteolytic processing of interleukin-1 family cytokines: variations on a common theme. Immunity 2015. 42: 991-1004.
    • (2015) Immunity , vol.42 , pp. 991-1004
    • Afonina, I.S.1    Muller, C.2    Martin, S.J.3    Beyaert, R.4
  • 15
    • 67651053209 scopus 로고    scopus 로고
    • Interleukin-33 is biologically active independently of caspase-1 cleavage
    • Talabot-Ayer, D., Lamacchia, C., Gabay, C. and Palmer, G., Interleukin-33 is biologically active independently of caspase-1 cleavage. J. Biol. Chem. 2009. 284: 19420-19426.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19420-19426
    • Talabot-Ayer, D.1    Lamacchia, C.2    Gabay, C.3    Palmer, G.4
  • 19
    • 84863268229 scopus 로고    scopus 로고
    • Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity
    • Bae, S., Kang, T., Hong, J., Lee, S., Choi, J., Jhun, H., Kwak, A. et al., Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity. J. Biol. Chem. 2012. 287: 8205-8213.
    • (2012) J. Biol. Chem. , vol.287 , pp. 8205-8213
    • Bae, S.1    Kang, T.2    Hong, J.3    Lee, S.4    Choi, J.5    Jhun, H.6    Kwak, A.7
  • 20
    • 84883190168 scopus 로고    scopus 로고
    • Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
    • Waern, I., Lundequist, A., Pejler, G. and Wernersson, S., Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation. Mucosal Immunol. 2013. 6: 911-920.
    • (2013) Mucosal Immunol. , vol.6 , pp. 911-920
    • Waern, I.1    Lundequist, A.2    Pejler, G.3    Wernersson, S.4
  • 21
    • 84891705895 scopus 로고    scopus 로고
    • Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation
    • Roy, A., Ganesh, G., Sippola, H., Bolin, S., Sawesi, O., Dagalv, A., Schlenner, S. M. et al., Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J. Biol. Chem. 2014. 289: 237-250.
    • (2014) J. Biol. Chem. , vol.289 , pp. 237-250
    • Roy, A.1    Ganesh, G.2    Sippola, H.3    Bolin, S.4    Sawesi, O.5    Dagalv, A.6    Schlenner, S.M.7
  • 22
    • 84908541933 scopus 로고    scopus 로고
    • Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
    • Lefrancais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C. and Girard, J. P., Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc. Natl. Acad. Sci. USA 2014. 111: 15502-15507.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 15502-15507
    • Lefrancais, E.1    Duval, A.2    Mirey, E.3    Roga, S.4    Espinosa, E.5    Cayrol, C.6    Girard, J.P.7
  • 24
    • 85006101005 scopus 로고    scopus 로고
    • The role of IL-33 and mast cells in allergy and inflammation
    • eCollection 2015.
    • Saluja, R., Khan, M., Church, M. K. and Maurer, M., The role of IL-33 and mast cells in allergy and inflammation. Clin. Transl. Allergy 2015. 5: 33. eCollection 2015.
    • (2015) Clin. Transl. Allergy , vol.5 , pp. 33
    • Saluja, R.1    Khan, M.2    Church, M.K.3    Maurer, M.4
  • 26
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J. et al., Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010. 463: 540-544.
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6    Furusawa, J.7
  • 27
    • 84907983938 scopus 로고    scopus 로고
    • Innate lymphoid cells in inflammation and immunity
    • McKenzie, A. N., Spits, H. and Eberl, G., Innate lymphoid cells in inflammation and immunity. Immunity 2014. 41: 366-374.
    • (2014) Immunity , vol.41 , pp. 366-374
    • McKenzie, A.N.1    Spits, H.2    Eberl, G.3
  • 29
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky, A. B., Nussbaum, J. C., Liang, H. E., Van Dyken, S. J., Cheng, L. E., Mohapatra, A., Chawla, A. et al., Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 2013. 210: 535-549.
    • (2013) J. Exp. Med. , vol.210 , pp. 535-549
    • Molofsky, A.B.1    Nussbaum, J.C.2    Liang, H.E.3    Van Dyken, S.J.4    Cheng, L.E.5    Mohapatra, A.6    Chawla, A.7
  • 31
    • 84896332584 scopus 로고    scopus 로고
    • Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells
    • Van Dyken, S. J., Mohapatra, A., Nussbaum, J. C., Molofsky, A. B., Thornton, E. E., Ziegler, S. F., McKenzie, A. N. et al., Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity 2014. 40: 414-424.
    • (2014) Immunity , vol.40 , pp. 414-424
    • Van Dyken, S.J.1    Mohapatra, A.2    Nussbaum, J.C.3    Molofsky, A.B.4    Thornton, E.E.5    Ziegler, S.F.6    McKenzie, A.N.7
  • 32
    • 84857768885 scopus 로고    scopus 로고
    • Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    • Yasuda, K., Muto, T., Kawagoe, T., Matsumoto, M., Sasaki, Y., Matsushita, K., Taki, Y. et al., Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc. Natl. Acad. Sci. USA 2012. 109: 3451-3456.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 3451-3456
    • Yasuda, K.1    Muto, T.2    Kawagoe, T.3    Matsumoto, M.4    Sasaki, Y.5    Matsushita, K.6    Taki, Y.7
  • 33
    • 79959380307 scopus 로고    scopus 로고
    • Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
    • Chang, Y. J., Kim, H. Y., Albacker, L. A., Baumgarth, N., McKenzie, A. N., Smith, D. E., Dekruyff, R. H. et al., Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 2011. 12: 631-638.
    • (2011) Nat. Immunol. , vol.12 , pp. 631-638
    • Chang, Y.J.1    Kim, H.Y.2    Albacker, L.A.3    Baumgarth, N.4    McKenzie, A.N.5    Smith, D.E.6    Dekruyff, R.H.7
  • 35
    • 84883537459 scopus 로고    scopus 로고
    • Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease
    • Byers, D. E., Alexander-Brett, J., Patel, A. C., Agapov, E., Dang-Vu, G., Jin, X., Wu, K. et al., Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J. Clin. Invest. 2013. 123: 3967-3982.
    • (2013) J. Clin. Invest. , vol.123 , pp. 3967-3982
    • Byers, D.E.1    Alexander-Brett, J.2    Patel, A.C.3    Agapov, E.4    Dang-Vu, G.5    Jin, X.6    Wu, K.7
  • 36
    • 84885456137 scopus 로고    scopus 로고
    • IL-33 markedly activates murine eosinophils by an NF-kappaB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop
    • Bouffi, C., Rochman, M., Zust, C. B., Stucke, E. M., Kartashov, A., Fulkerson, P. C., Barski, A. et al., IL-33 markedly activates murine eosinophils by an NF-kappaB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J. Immunol. 2013. 191: 4317-4325.
    • (2013) J. Immunol. , vol.191 , pp. 4317-4325
    • Bouffi, C.1    Rochman, M.2    Zust, C.B.3    Stucke, E.M.4    Kartashov, A.5    Fulkerson, P.C.6    Barski, A.7
  • 37
    • 84934993044 scopus 로고    scopus 로고
    • Eosinophil-specific deletion of IkappaBalpha in mice reveals a critical role of NF-kappaB-induced Bcl-xL for inhibition of apoptosis
    • Schwartz, C., Willebrand, R., Huber, S., Rupec, R. A., Wu, D., Locksley, R. and Voehringer, D., Eosinophil-specific deletion of IkappaBalpha in mice reveals a critical role of NF-kappaB-induced Bcl-xL for inhibition of apoptosis. Blood 2015. 125: 3896-3904.
    • (2015) Blood , vol.125 , pp. 3896-3904
    • Schwartz, C.1    Willebrand, R.2    Huber, S.3    Rupec, R.A.4    Wu, D.5    Locksley, R.6    Voehringer, D.7
  • 38
    • 84907370454 scopus 로고    scopus 로고
    • MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
    • Oliphant, C. J., Hwang, Y. Y., Walker, J. A., Salimi, M., Wong, S. H., Brewer, J. M., Englezakis, A. et al., MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity 2014. 41: 283-295.
    • (2014) Immunity , vol.41 , pp. 283-295
    • Oliphant, C.J.1    Hwang, Y.Y.2    Walker, J.A.3    Salimi, M.4    Wong, S.H.5    Brewer, J.M.6    Englezakis, A.7
  • 40
    • 84951317602 scopus 로고    scopus 로고
    • Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses
    • Moro, K., Kabata, H., Tanabe, M., Koga, S., Takeno, N., Mochizuki, M., Fukunaga, K. et al., Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat. Immunol. 2016. 17: 76-86.
    • (2016) Nat. Immunol. , vol.17 , pp. 76-86
    • Moro, K.1    Kabata, H.2    Tanabe, M.3    Koga, S.4    Takeno, N.5    Mochizuki, M.6    Fukunaga, K.7
  • 41
    • 84951317601 scopus 로고    scopus 로고
    • Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
    • Duerr, C. U., McCarthy, C. D., Mindt, B. C., Rubio, M., Meli, A. P., Pothlichet, J., Eva, M. M. et al., Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat. Immunol. 2016. 17: 65-75.
    • (2016) Nat. Immunol. , vol.17 , pp. 65-75
    • Duerr, C.U.1    McCarthy, C.D.2    Mindt, B.C.3    Rubio, M.4    Meli, A.P.5    Pothlichet, J.6    Eva, M.M.7
  • 42
    • 84875409549 scopus 로고    scopus 로고
    • Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity
    • Yang, Z., Grinchuk, V., Urban, J. F., Jr., Bohl, J., Sun, R., Notari, L., Yan, S. et al., Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One 2013. 8: e59441.
    • (2013) PLoS One , vol.8 , pp. e59441
    • Yang, Z.1    Grinchuk, V.2    Urban, J.F.3    Bohl, J.4    Sun, R.5    Notari, L.6    Yan, S.7
  • 43
    • 84919866420 scopus 로고    scopus 로고
    • IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice
    • e1411.
    • Li, D., Guabiraba, R., Besnard, A. G., Komai-Koma, M., Jabir, M. S., Zhang, L., Graham, G. J. et al., IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J. Allergy Clin. Immunol. 2014. 134: 1422-1432 e1411.
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 1422-1432
    • Li, D.1    Guabiraba, R.2    Besnard, A.G.3    Komai-Koma, M.4    Jabir, M.S.5    Zhang, L.6    Graham, G.J.7
  • 44
    • 78049367774 scopus 로고    scopus 로고
    • Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2
    • Huber, S., Hoffmann, R., Muskens, F. and Voehringer, D., Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 2010. 116: 3311-3320.
    • (2010) Blood , vol.116 , pp. 3311-3320
    • Huber, S.1    Hoffmann, R.2    Muskens, F.3    Voehringer, D.4
  • 45
    • 70349337464 scopus 로고    scopus 로고
    • IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production
    • Schneider, E., Petit-Bertron, A. F., Bricard, R., Levasseur, M., Ramadan, A., Girard, J. P., Herbelin, A. et al., IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production. J. Immunol. 2009. 183: 3591-3597.
    • (2009) J. Immunol. , vol.183 , pp. 3591-3597
    • Schneider, E.1    Petit-Bertron, A.F.2    Bricard, R.3    Levasseur, M.4    Ramadan, A.5    Girard, J.P.6    Herbelin, A.7
  • 46
    • 70049104738 scopus 로고    scopus 로고
    • IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway
    • Kroeger, K. M., Sullivan, B. M. and Locksley, R. M., IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J. Leukoc. Biol. 2009. 86: 769-778.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 769-778
    • Kroeger, K.M.1    Sullivan, B.M.2    Locksley, R.M.3
  • 47
    • 84925304130 scopus 로고    scopus 로고
    • IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation
    • Rivellese, F., Suurmond, J., de Paulis, A., Marone, G., Huizinga, T. W. and Toes, R. E., IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation. Eur. J. Immunol. 2014. 44: 3045-3055.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 3045-3055
    • Rivellese, F.1    Suurmond, J.2    de Paulis, A.3    Marone, G.4    Huizinga, T.W.5    Toes, R.E.6
  • 49
    • 79957571971 scopus 로고    scopus 로고
    • IL-33-activated dendritic cells are critical for allergic airway inflammation
    • Besnard, A. G., Togbe, D., Guillou, N., Erard, F., Quesniaux, V. and Ryffel, B., IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol. 2011. 41: 1675-1686.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1675-1686
    • Besnard, A.G.1    Togbe, D.2    Guillou, N.3    Erard, F.4    Quesniaux, V.5    Ryffel, B.6
  • 50
    • 84907569702 scopus 로고    scopus 로고
    • IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells
    • Matta, B. M., Lott, J. M., Mathews, L. R., Liu, Q., Rosborough, B. R., Blazar, B. R. and Turnquist, H. R., IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J. Immunol. 2014. 193: 4010-4020.
    • (2014) J. Immunol. , vol.193 , pp. 4010-4020
    • Matta, B.M.1    Lott, J.M.2    Mathews, L.R.3    Liu, Q.4    Rosborough, B.R.5    Blazar, B.R.6    Turnquist, H.R.7
  • 51
    • 84922995819 scopus 로고    scopus 로고
    • The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway
    • Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N. et al., The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 2015. 42: 294-308.
    • (2015) Immunity , vol.42 , pp. 294-308
    • Endo, Y.1    Hirahara, K.2    Iinuma, T.3    Shinoda, K.4    Tumes, D.J.5    Asou, H.K.6    Matsugae, N.7
  • 52
    • 48449089903 scopus 로고    scopus 로고
    • IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    • Smithgall, M. D., Comeau, M. R., Yoon, B. R., Kaufman, D., Armitage, R. and Smith, D. E., IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int. Immunol. 2008. 20: 1019-1030.
    • (2008) Int. Immunol. , vol.20 , pp. 1019-1030
    • Smithgall, M.D.1    Comeau, M.R.2    Yoon, B.R.3    Kaufman, D.4    Armitage, R.5    Smith, D.E.6
  • 53
    • 65449146468 scopus 로고    scopus 로고
    • The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production
    • Bourgeois, E., Van, L. P., Samson, M., Diem, S., Barra, A., Roga, S., Gombert, J. M. et al., The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production. Eur. J. Immunol. 2009. 39: 1046-1055.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1046-1055
    • Bourgeois, E.1    Van, L.P.2    Samson, M.3    Diem, S.4    Barra, A.5    Roga, S.6    Gombert, J.M.7
  • 54
    • 84937618997 scopus 로고    scopus 로고
    • Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation
    • Molofsky, A. B., Van Gool, F., Liang, H. E., Van Dyken, S. J., Nussbaum, J. C., Lee, J., Bluestone, J. A. et al., Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation. Immunity 2015. 43: 161-174.
    • (2015) Immunity , vol.43 , pp. 161-174
    • Molofsky, A.B.1    Van Gool, F.2    Liang, H.E.3    Van Dyken, S.J.4    Nussbaum, J.C.5    Lee, J.6    Bluestone, J.A.7
  • 56
    • 84923607143 scopus 로고    scopus 로고
    • The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
    • Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S. et al., The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat. Immunol. 2015. 16: 276-285.
    • (2015) Nat. Immunol. , vol.16 , pp. 276-285
    • Vasanthakumar, A.1    Moro, K.2    Xin, A.3    Liao, Y.4    Gloury, R.5    Kawamoto, S.6    Fagarasan, S.7
  • 57
    • 66949123901 scopus 로고    scopus 로고
    • A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
    • Newcomb, D. C., Zhou, W., Moore, M. L., Goleniewska, K., Hershey, G. K., Kolls, J. K. and Peebles, R. S., Jr., A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 2009. 182: 5317-5321.
    • (2009) J. Immunol. , vol.182 , pp. 5317-5321
    • Newcomb, D.C.1    Zhou, W.2    Moore, M.L.3    Goleniewska, K.4    Hershey, G.K.5    Kolls, J.K.6    Peebles, R.S.7
  • 58
    • 80054884522 scopus 로고    scopus 로고
    • IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells
    • Yang, Q., Li, G., Zhu, Y., Liu, L., Chen, E., Turnquist, H., Zhang, X. et al., IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur. J. Immunol. 2011. 41: 3351-3360.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 3351-3360
    • Yang, Q.1    Li, G.2    Zhu, Y.3    Liu, L.4    Chen, E.5    Turnquist, H.6    Zhang, X.7
  • 62
    • 84899106298 scopus 로고    scopus 로고
    • IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut
    • Sattler, S., Ling, G. S., Xu, D., Hussaarts, L., Romaine, A., Zhao, H., Fossati-Jimack, L. et al., IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut. J. Autoimmun. 2014. 50: 107-122.
    • (2014) J. Autoimmun. , vol.50 , pp. 107-122
    • Sattler, S.1    Ling, G.S.2    Xu, D.3    Hussaarts, L.4    Romaine, A.5    Zhao, H.6    Fossati-Jimack, L.7
  • 63
    • 84888132144 scopus 로고    scopus 로고
    • Role of interleukin-13 in fibrosis, particularly systemic sclerosis
    • O'Reilly, S., Role of interleukin-13 in fibrosis, particularly systemic sclerosis. Biofactors 2013. 39: 593-596.
    • (2013) Biofactors , vol.39 , pp. 593-596
    • O'Reilly, S.1
  • 64
    • 33746054494 scopus 로고    scopus 로고
    • Interleukin-5 regulates genes involved in B-cell terminal maturation
    • Horikawa, K. and Takatsu, K., Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology 2006. 118: 497-508.
    • (2006) Immunology , vol.118 , pp. 497-508
    • Horikawa, K.1    Takatsu, K.2
  • 65
    • 10544250249 scopus 로고    scopus 로고
    • Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse
    • Morawetz, R. A., Gabriele, L., Rizzo, L. V., Noben-Trauth, N., Kuhn, R., Rajewsky, K., Muller, W. et al., Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 1996. 184: 1651-1661.
    • (1996) J. Exp. Med. , vol.184 , pp. 1651-1661
    • Morawetz, R.A.1    Gabriele, L.2    Rizzo, L.V.3    Noben-Trauth, N.4    Kuhn, R.5    Rajewsky, K.6    Muller, W.7
  • 66
    • 84937557838 scopus 로고    scopus 로고
    • Interleukin-33 in tissue homeostasis, injury, and inflammation
    • Molofsky, A. B., Savage, A. K. and Locksley, R. M., Interleukin-33 in tissue homeostasis, injury, and inflammation. Immunity 2015. 42: 1005-1019.
    • (2015) Immunity , vol.42 , pp. 1005-1019
    • Molofsky, A.B.1    Savage, A.K.2    Locksley, R.M.3
  • 67
    • 84940953781 scopus 로고    scopus 로고
    • The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation
    • Wensveen, F. M., Valentic, S., Sestan, M., Turk Wensveen, T. and Polic, B., The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation. Eur. J. Immunol. 2015. 45: 2446-2456.
    • (2015) Eur. J. Immunol. , vol.45 , pp. 2446-2456
    • Wensveen, F.M.1    Valentic, S.2    Sestan, M.3    Turk Wensveen, T.4    Polic, B.5
  • 68
    • 84959111173 scopus 로고    scopus 로고
    • The helminth T2 RNase omega1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism
    • Hams, E., Bermingham, R., Wurlod, F. A., Hogan, A. E., O'Shea, D., Preston, R. J., Rodewald, H. R. et al., The helminth T2 RNase omega1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism. FASEB J. 2016. 30(2): 824-835.
    • (2016) FASEB J. , vol.30 , Issue.2 , pp. 824-835
    • Hams, E.1    Bermingham, R.2    Wurlod, F.A.3    Hogan, A.E.4    O'Shea, D.5    Preston, R.J.6    Rodewald, H.R.7
  • 69
    • 65549163320 scopus 로고    scopus 로고
    • IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
    • Wood, I. S., Wang, B. and Trayhurn, P., IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem. Biophys. Res. Commun. 2009. 384: 105-109.
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , pp. 105-109
    • Wood, I.S.1    Wang, B.2    Trayhurn, P.3
  • 71
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D., Molofsky, A. B., Liang, H. E., Ricardo-Gonzalez, R. R., Jouihan, H. A., Bando, J. K., Chawla, A. et al., Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011. 332: 243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5    Bando, J.K.6    Chawla, A.7
  • 72
    • 84929093918 scopus 로고    scopus 로고
    • IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance
    • Han, J. M., Wu, D., Denroche, H. C., Yao, Y., Verchere, C. B. and Levings, M. K., IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance. J. Immunol. 2015. 194: 4777-4783.
    • (2015) J. Immunol. , vol.194 , pp. 4777-4783
    • Han, J.M.1    Wu, D.2    Denroche, H.C.3    Yao, Y.4    Verchere, C.B.5    Levings, M.K.6
  • 73
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang, Y., Su, M. A. and Wan, Y. Y., An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 2011. 35: 337-348.
    • (2011) Immunity , vol.35 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 74
    • 15744373027 scopus 로고    scopus 로고
    • T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3
    • Hayakawa, M., Yanagisawa, K., Aoki, S., Hayakawa, H., Takezako, N. and Tominaga, S., T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3. Biochim. Biophys. Acta 2005. 1728: 53-64.
    • (2005) Biochim. Biophys. Acta , vol.1728 , pp. 53-64
    • Hayakawa, M.1    Yanagisawa, K.2    Aoki, S.3    Hayakawa, H.4    Takezako, N.5    Tominaga, S.6
  • 75
    • 84949257630 scopus 로고    scopus 로고
    • Depletion of fat-resident T cells prevents age-associated insulin resistance
    • Bapat, S. P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C. et al., Depletion of fat-resident T cells prevents age-associated insulin resistance. Nature 2015. 528: 137-141.
    • (2015) Nature , vol.528 , pp. 137-141
    • Bapat, S.P.1    Myoung Suh, J.2    Fang, S.3    Liu, S.4    Zhang, Y.5    Cheng, A.6    Zhou, C.7
  • 77
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
    • Hams, E., Locksley, R. M., McKenzie, A. N. and Fallon, P. G., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 2013. 191: 5349-5353.
    • (2013) J. Immunol. , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 78
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D. et al., Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 2014. 157: 1292-1308.
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1    Nguyen, K.D.2    Odegaard, J.I.3    Cui, X.4    Tian, X.5    Locksley, R.M.6    Palmiter, R.D.7
  • 79
    • 84866386408 scopus 로고    scopus 로고
    • IL-33 attenuates development and perpetuation of chronic intestinal inflammation
    • Grobeta, P., Doser, K., Falk, W., Obermeier, F. and Hofmann, C., IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflamm. Bowel Dis. 2012. 18: 1900-1909.
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 1900-1909
    • Grobeta, P.1    Doser, K.2    Falk, W.3    Obermeier, F.4    Hofmann, C.5
  • 82
    • 84940527399 scopus 로고    scopus 로고
    • IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions
    • Monticelli, L. A., Osborne, L. C., Noti, M., Tran, S. V., Zaiss, D. M. and Artis, D., IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc. Natl. Acad. Sci. USA 2015. 112: 10762-10767.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 10762-10767
    • Monticelli, L.A.1    Osborne, L.C.2    Noti, M.3    Tran, S.V.4    Zaiss, D.M.5    Artis, D.6
  • 86
    • 84941878812 scopus 로고    scopus 로고
    • Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity
    • Kim, J. Y., Lim, S. C., Kim, G., Yun, H. J., Ahn, S. G. and Choi, H. S., Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity. Oncogene 2015. 34: 4928-4938.
    • (2015) Oncogene , vol.34 , pp. 4928-4938
    • Kim, J.Y.1    Lim, S.C.2    Kim, G.3    Yun, H.J.4    Ahn, S.G.5    Choi, H.S.6
  • 87
    • 84892612433 scopus 로고    scopus 로고
    • Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells
    • Jovanovic, I. P., Pejnovic, N. N., Radosavljevic, G. D., Pantic, J. M., Milovanovic, M. Z., Arsenijevic, N. N. and Lukic, M. L., Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells. Int. J. Cancer 2014. 134: 1669-1682.
    • (2014) Int. J. Cancer , vol.134 , pp. 1669-1682
    • Jovanovic, I.P.1    Pejnovic, N.N.2    Radosavljevic, G.D.3    Pantic, J.M.4    Milovanovic, M.Z.5    Arsenijevic, N.N.6    Lukic, M.L.7
  • 88
    • 84937965873 scopus 로고    scopus 로고
    • IL-33 promotes gastric cancer cell invasion and migration via ST2-ERK1/2 pathway
    • Yu, X. X., Hu, Z., Shen, X., Dong, L. Y., Zhou, W. Z. and Hu, W. H., IL-33 promotes gastric cancer cell invasion and migration via ST2-ERK1/2 pathway. Dig. Dis. Sci. 2015. 60: 1265-1272.
    • (2015) Dig. Dis. Sci. , vol.60 , pp. 1265-1272
    • Yu, X.X.1    Hu, Z.2    Shen, X.3    Dong, L.Y.4    Zhou, W.Z.5    Hu, W.H.6
  • 89
    • 84953356581 scopus 로고    scopus 로고
    • Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways
    • Tong, X., Barbour, M., Hou, K., Gao, C., Cao, S., Zheng, J., Zhao, Y. et al., Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways. Mol. Oncol. 2016. 10(1): 113-125.
    • (2016) Mol. Oncol. , vol.10 , Issue.1 , pp. 113-125
    • Tong, X.1    Barbour, M.2    Hou, K.3    Gao, C.4    Cao, S.5    Zheng, J.6    Zhao, Y.7
  • 90
    • 84940705480 scopus 로고    scopus 로고
    • Circulating IL-33 level is associated with the progression of lung cancer
    • Kim, M. S., Kim, E., Heo, J. S., Bae, D. J., Lee, J. U., Lee, T. H., Lee, H. J. et al., Circulating IL-33 level is associated with the progression of lung cancer. Lung Cancer 2015. 90: 346-351.
    • (2015) Lung Cancer , vol.90 , pp. 346-351
    • Kim, M.S.1    Kim, E.2    Heo, J.S.3    Bae, D.J.4    Lee, J.U.5    Lee, T.H.6    Lee, H.J.7
  • 91
    • 84922319724 scopus 로고    scopus 로고
    • Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue
    • Ishikawa, K., Yagi-Nakanishi, S., Nakanishi, Y., Kondo, S., Tsuji, A., Endo, K., Wakisaka, N. et al., Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Auris Nasus Larynx 2014. 41: 552-557.
    • (2014) Auris Nasus Larynx , vol.41 , pp. 552-557
    • Ishikawa, K.1    Yagi-Nakanishi, S.2    Nakanishi, Y.3    Kondo, S.4    Tsuji, A.5    Endo, K.6    Wakisaka, N.7
  • 92
    • 84919663306 scopus 로고    scopus 로고
    • Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells
    • Gao, X., Wang, X., Yang, Q., Zhao, X., Wen, W., Li, G., Lu, J. et al., Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells. J. Immunol. 2015. 194: 438-445.
    • (2015) J. Immunol. , vol.194 , pp. 438-445
    • Gao, X.1    Wang, X.2    Yang, Q.3    Zhao, X.4    Wen, W.5    Li, G.6    Lu, J.7
  • 93
    • 84878261769 scopus 로고    scopus 로고
    • Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice
    • Gao, K., Li, X., Zhang, L., Bai, L., Dong, W., Gao, K., Shi, G. et al., Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice. Cancer Lett. 2013. 335: 463-471.
    • (2013) Cancer Lett. , vol.335 , pp. 463-471
    • Gao, K.1    Li, X.2    Zhang, L.3    Bai, L.4    Dong, W.5    Gao, K.6    Shi, G.7
  • 94
    • 84924353713 scopus 로고    scopus 로고
    • IL-33 isoforms: their future as vaccine adjuvants
    • Villarreal, D. O. and Weiner, D. B., IL-33 isoforms: their future as vaccine adjuvants? Expert Rev. Vaccines 2015. 14: 489-492.
    • (2015) Expert Rev. Vaccines , vol.14 , pp. 489-492
    • Villarreal, D.O.1    Weiner, D.B.2
  • 95
    • 69249212321 scopus 로고    scopus 로고
    • Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective
    • Guex, N., Peitsch, M. C. and Schwede, T., Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective. Electrophoresis 2009. 30 Suppl 1: S162-S173.
    • (2009) Electrophoresis , vol.30 , pp. S162-S173
    • Guex, N.1    Peitsch, M.C.2    Schwede, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.