Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 237-250

  Roy, Ananya ^a   Ganesh, Goutham ^a   Sippola, Helena ^a   Bolin, Sara ^a   Sawesi, Osama ^a   Dagälv, Anders ^a   Schlenner, Susan M ^b   Feyerabend, Thorsten ^c   Rodewald, Hans Reimer ^c   Kjellén, Lena ^a   Hellman, Lars ^a   Åbrink, Magnus ^d  

^a UPPSALA UNIVERSITY   (Sweden)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; MACROPHAGES; MAMMALS; PATHOLOGY; RECOMBINANT PROTEINS;

CARBOXYPEPTIDASE; HEAT SHOCK PROTEIN 70; INFLAMMATORY MEDIATORS; PRO-INFLAMMATORY CYTOKINES; PROTEIN EXTRACT; TARGET-SUBSTRATE; TRICHINELLA SPIRALIS; VIRULENCE FACTORS;

CYTOLOGY;

BIGLYCAN; CHYMASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 22; INTERLEUKIN 33; INTERLEUKIN 7; MAST CELL PROTEASE 4; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BGN PROTEIN, HUMAN; BGN PROTEIN, MOUSE; HELMINTH PROTEIN; HMGB1 PROTEIN, HUMAN; HMGB1 PROTEIN, MOUSE; IL33 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-33, MOUSE; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MAST CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; TRICHINELLA SPIRALIS;

ANIMALS; BIGLYCAN; CHYMASES; HELMINTH PROTEINS; HMGB1 PROTEIN; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION; INTERLEUKINS; MAST CELLS; MICE; MICE, KNOCKOUT; PROTEOLYSIS; TRICHINELLA SPIRALIS; VIRULENCE FACTORS;

EID: 84891705895     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.435156     Document Type: Article

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