Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

Nature Immunology

Volumn 17, Issue 1, 2016, Pages 57-64

  Halim, Timotheus Y F ^a   Hwang, You Yi ^a   Scanlon, Seth T ^a   Zaghouani, Habib ^b   Garbi, Natalio ^c   Fallon, Padraic G ^d,e   Mckenzie, Andrew N J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b University of Missouri   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALTERNARIA ALTERNATA EXTRACT; CD103 ANTIGEN; CD11B ANTIGEN; DIPHTHERIA TOXIN; FUNGAL EXTRACT; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 33; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; PAPAIN; TETRAMER; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ALLERGIC REACTION; ALTERNARIA ALTERNATA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL HOMING; CELL INFILTRATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG RECHALLENGE; ENZYME ACTIVITY; EOSINOPHILIA; FLOW CYTOMETRY; GRAFT RECIPIENT; HELMINTHIASIS; IMMUNOLOGICAL MEMORY; INNATE IMMUNITY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LYMPHOID CELL; MEMORY T LYMPHOCYTE; MONOCYTE; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SENSITIZATION; SKIN; T LYMPHOCYTE ACTIVATION; TH2 CELL; WILD TYPE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DNA MICROARRAY; HYPERSENSITIVITY; IMMUNOLOGY; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HYPERSENSITIVITY; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TH2 CELLS;

EID: 84952637013     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3294     Document Type: Article

References (46)

1. Kim, H.Y., DeKruyff, R.H., & Umetsu, D.T. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol. 11, 577-584 (2010
2. Lambrecht B.N., & Hammad, H. The immunology of asthma. Nat. Immunol. 16, 45-56 (2015
3. Islam S.A., & Luster, A.D. T cell homing to epithelial barriers in allergic disease. Nat. Med. 18, 705-715 (2012
4. McKenzie, A.N., Spits, H., & Eberl, G. Innate lymphoid cells in inflammation and immunity. Immunity 41, 366-374 (2014
5. Moro K., et al. Innate production of T(H)2 cytokines by adipose tissue-Associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463, 540-544 (2010
6. Neill D.R., et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010
7. Price A.E., et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA 107, 11489-11494 (2010
8. Chang Y.J., et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 12, 631-638 (2011
9. Halim, T.Y., Krauss, R.H., Sun, A.C., & Takei, F. Lung natural helper cells are a critical source of Th2 cell-Type cytokines in protease allergen-induced airway inflammation. Immunity 36, 451-463 (2012
10. Monticelli L.A., et al. Innate lymphoid cells promote lung-Tissue homeostasis after infection with influenza virus. Nat. Immunol. 12, 1045-1054 (2011
11. Drake, L.Y., Iijima, K., & Kita, H. Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice. Allergy 69, 1300-1307 (2014
12. Gold, M.J., et al. Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures. J. Allergy Clin. Immunol. 133, 1142-1148 (2014
13. Halim T.Y., et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40, 425-435 (2014
14. Mirchandani A.S., et al. Type 2 innate lymphoid cells drive CD4+ Th2 cell responses. J. Immunol. 192, 2442-2448 (2014
15. Oliphant C.J., et al. MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity 41, 283-295 (2014
16. van Rijt L.S., et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981-991 (2005
17. Crapster-Pregont, M., Yeo, J., Sanchez, R.L., & Kuperman, D.A. Dendritic cells and alveolar macrophages mediate IL-13-induced airway inflammation and chemokine production. J. Allergy Clin. Immunol. 129, 1621-1627.e3 (2012
18. Mikhak Z., et al. Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammation. J. Allergy Clin. Immunol. 123, 67-73.e3 (2009
19. Imai T., et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11, 81-88 (1999
20. Novey, H.S., Marchioli, L.E., Sokol, W.N., & Wells, I.D. Papain-induced asthma-physiological and immunological features. J. Allergy Clin. Immunol. 63, 98-103 (1979
21. Mottram, J.C., Helms, M.J., Coombs, G.H., & Sajid, M. Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol. 19, 182-187 (2003
22. Kamijo S., et al. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J. Immunol. 190, 4489-4499 (2013
23. Zheng, W., & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997
24. Moon J.J., et al. Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27, 203-213 (2007
25. Medoff B.D., et al. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J. Immunol. 182, 623-635 (2009
26. Plantinga M., et al. Conventional and monocyte-derived CD11b+ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity 38, 322-335 (2013
27. Gao Y., et al. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity 39, 722-732 (2013
28. Williams J.W., et al. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat. Commun. 4, 2990 (2013
29. Halim T.Y., et al. Retinoic-Acid-receptor-related orphan nuclear receptor-α is required for natural helper cell development and allergic inflammation. Immunity 37, 463-474 (2012
30. Wong S.H., et al. Transcription factor RORα is critical for nuocyte development. Nat. Immunol. 13, 229-236 (2012
31. Kim B.S., et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci. Transl. Med. 5, 170ra116 (2013
32. Roediger B., et al. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat. Immunol. 14, 564-573 (2013
33. Salimi M., et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J. Exp. Med. 210, 2939-2950 (2013
34. Maizels, R.M., Hewitson, J.P., & Smith, K.A. Susceptibility and immunity to helminth parasites. Curr. Opin. Immunol. 24, 459-466 (2012
35. Kumar, R.K., Herbert, C., & Foster, P.S. The classical ovalbumin challenge model of asthma in mice. Curr. Drug Targets 9, 485-494 (2008
36. Stephens, R., & Chaplin, D.D. IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigen. J. Immunol. 169, 5468-5476 (2002
37. Hammad H., et al. Inflammatory dendritic cells-not basophils-Are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J. Exp. Med. 207, 2097-2111 (2010
38. MacDonald, A.S., Straw, A.D., Dalton, N.M., & Pearce, E.J. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J. Immunol. 168, 537-540 (2002
39. Ito T., et al. TSLP-Activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202, 1213-1223 (2005
40. Eiwegger, T., & Akdis, C.A. IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur. J. Immunol. 41, 1535-1538 (2011
41. Wills-Karp, M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202, 175-190 (2004
42. Fahy, J.V. Type 2 inflammation in asthma-present in most, absent in many. Nat. Rev. Immunol. 15, 57-65 (2015
43. Tittel A.P., et al. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat. Methods 9, 385-390 (2012
44. Haymaker C.L., et al. Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage. J. Immunol. 188, 3208-3216 (2012
45. Schlenner S.M., et al. Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity 32, 426-436 (2010
46. Heng, T.S., & Painter, M.W. Immunological Genome Project C. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091-1094 (2008