Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation

Mucosal Immunology

Volumn 6, Issue 5, 2013, Pages 911-920

  Waern, I ^a   Lundequist, A ^a   Pejler, G ^a   Wernersson, S ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 33; MAST CELL PROTEASE 4; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME RELEASE; EOSINOPHIL; EOSINOPHILIA; HOUSE DUST ALLERGY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; INFLAMMATORY CELL; LUNG PARENCHYMA; LYMPHOCYTE; MACROPHAGE; MAST CELL; MAST CELL DEGRANULATION; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SPLEEN CELL;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, DERMATOPHAGOIDES; CELL DEGRANULATION; CELLS, CULTURED; CHYMASES; EOSINOPHILS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN E; INTERLEUKINS; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYROGLYPHIDAE; RESPIRATORY HYPERSENSITIVITY; SECRETORY VESICLES;

EID: 84883190168     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.129     Document Type: Article

References (41)

1. Galli, S.J. & Tsai, M. IgE and mast cells in allergic disease. Nat. Med. 18, 693-704 (2012
2. Lundequist, A. & Pejler, G. Biological implications of preformed mast cell mediators. Cell. Mol. Life Sci. 68, 965-975 (2011
3. Pejler, G., Ronnberg, E., Waern, I. & Wernersson, S. Mast cell proteases: Multifaceted regulators of inflammatory disease. Blood 115, 4981-4990 (2010
4. Boyce, J.A. Eicosanoid mediators of mast cells: Receptors, regulation of synthesis, and pathobiologic implications. Chem. Immunol. Allergy 87, 59-79 (2005
5. Tchougounova, E., Pejler, G. & Abrink, M. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role formouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J. Exp. Med. 198, 423-431 (2003
6. Waern, I. et al. Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J. Immunol. 183, 6369-6376 (2009
7. Bates, J.H., Rincon, M. & Irvin, C.G. Animal models of asthma. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L401-L410 (2009
8. Boyce, J.A. & Austen, K.F.No audiblewheezing: Nuggets and conundrums from mouse asthma models. J. Exp. Med. 201, 1869-1873 (2005
9. Galli, S.J., Tsai, M. & Piliponsky, A.M. The development of allergic inflammation. Nature 454, 445-454 (2008
10. Gregory, L.G. et al. Inhaled house dust mite induces pulmonary T helper 2 cytokine production. Clin. Exp. Allergy 39, 1597-1610 (2009
11. Johnson, J.R. et al. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am. J. Respir. Crit. Care Med. 169, 378-385 (2004
12. Malbec, O. et al. Peritoneal cell-derived mast cells: An in vitro model of mature serosal-type mouse mast cells. J. Immunol. 178, 6465-6475 (2007
13. Yu,M. et al. Identification of an ifn-gamma/mast cell axis in amouse model of chronic asthma. J. Clin. Invest. 121, 3133-3143 (2011
14. Yu, M., Tsai, M., Tam, S.Y., Jones, C., Zehnder, J. & Galli, S.J. Mast cells can promote the development of multiple features of chronic asthma in mice. J. Clin. Invest. 116, 1633-1641 (2006
15. Brightling, C.E., Bradding, P., Symon, F.A., Holgate, S.T., Wardlaw, A.J. & Pavord, I.D. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 346, 1699-1705 (2002
16. Amin, K., Janson, C., Boman, G. & Venge, P. The extracellular deposition of mast cell products is increased in hypertrophic airways smooth muscles in allergic asthma but not in nonallergic asthma. Allergy 60, 1241-1247 (2005
17. Andersson,C.K., Bergqvist, A.,Mori,M.,Mauad,T., Bjermer, L.&Erjefält, J.S. Mast cell-Associated alveolar inflammation in patients with atopic uncontrolled asthma. J. Allergy Clin. Immunol. 127, 905-912. e901-907 (2011
18. Waern, I. et al. Mast cells limit extracellular levels of IL13 via a serglycin proteoglycan-serine protease axis. Biol. Chem. 393, 1555-1567 (2012
19. Akahoshi, M. et al. Mast cell chymase reduces the toxicity of gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J. Clin. Invest. 121, 4180-4191 (2011
20. Piliponsky, A.M. et al. The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am. J. Pathol. 181, 875-886 (2012
21. Zhao, W., Oskeritzian, C.A., Pozez, A.L. & Schwartz, L.B. Cytokine production by skin-derived mast cells: Endogenous proteases are responsible for degradation of cytokines. J. Immunol. 175, 2635-2642 (2005
22. Sugimoto, K. et al. The alphavbeta6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J. Clin. Invest. 122, 748-758 (2012
23. Balzar, S., Chu, H.W., Strand,M. & Wenzel, S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am. J. Respir. Crit. Care Med. 171, 431-439 (2005
24. Zanini, A. et al. Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma. J. Allergy Clin. Immunol. 120, 329-333 (2007
25. Dougherty, R.H. et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(h)2-high asthma. J. Allergy Clin. Immunol. 125, 1046-1053 e1048 (2010
26. Andersson, C.K., Mori, M., Bjermer, L., Lofdahl, C.G. & Erjefalt, J.S. Novel site-specific mast cell subpopulations in the human lung. Thorax 64, 297-305 (2009
27. Yu, C.K. & Chen, C.L. Activation of mast cells is essential for development of house dust mite dermatophagoides farinae-induced allergic airway inflammation in mice. J. Immunol. 171, 3808-3815 (2003
28. An, S.S. et al. Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma. Eur. Respir. J. 29, 834-860 (2007
29. Smithgall, M.D., Comeau, M.R., Yoon, B.R., Kaufman, D., Armitage, R. & Smith, D.E. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, INKTandNK cells. Int. Immunol. 20, 1019-1030 (2008
30. Stolarski, B., Kurowska-Stolarska, M., Kewin, P., Xu, D. & Liew, F.Y. IL-33 exacerbates eosinophil-mediated airway inflammation. J. Immunol. 185, 3472-3480 (2010
31. Kurowska-Stolarska, M. et al. IL33 induces antigen-specific IL5+ T cells and promotes allergic-induced airway inflammation independent of IL4. J. Immunol. 181, 4780-4790 (2008
32. Schmitz, J. et al. Il-33, an interleukin-1-like cytokine that signals via the IL1 receptor-related protein ST2 and induces T helper type 2-Associated cytokines. Immunity 23, 479-490 (2005
33. Kondo, Y. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int. Immunol. 20, 791-800 (2008
34. Liu, X., Li, M., Wu, Y., Zhou, Y., Zeng, L. & Huang, T. Anti-IL-33 antibody treatment inhibits airway inflammation in amurine model of allergic asthma. Biochem. Biophys. Res. Commun. 386, 181-185 (2009
35. Sakashita, M. et al. Association of serum interleukin-33 level and the interleukin-33 genetic variant with japanese cedar pollinosis. Clin. Exp. Allergy 38, 1875-1881 (2008
36. Pushparaj, P.N. et al. The cytokine interleukin-33 mediates anaphylactic shock. Proc. Natl. Acad. Sci. USA 106, 9773-9778 (2009
37. Waern, I. et al. Accumulation of ym1and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase. Mol. Immunol. 47, 1467-1475 (2010
38. Braga, T., Grujic, M., Lukinius, A., Hellman, L., Abrink, M. & Pejler, G. Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem. J. 403, 49-57 (2007
39. Rö nnberg, E. & Pejler, G. Serglycin: The master of the mast cell. Methods Mol. Biol. 836, 201-217 (2012
40. Lundequist, A. et al. Prostaglandin e(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J. Immunol. 184, 433-441 (2010
41. Pejler, G. & Karlstrom, A. Thrombin is inactivated by mast cell secretory granule chymase. J. Biol. Chem. 268, 11817-11822 (1993